Roentgen-and-morphological characteristics of shaft tibial fracture consolidation under intramedullary osteosynthesis using wires with hydroxyapatite coating

Background. In Ukraine, there has recently been an increase in the number of limb bone fractures among the population, in particular, due to increase in the number of elderly people, which is associated with the development of age-related osteoporosis and fragility of bones. Therefore, the use of artificial implants in traumatology is becoming increasingly important. The search for new bioinert and biodegradable materials, that are capable of providing rapid fracture consolidation and do not require repeated surgical intervention, continues. Objective. To elaborate a model for the research of using carbon-carbon composite nail for intramedullary osteosynthesis in laboratory rats with fractures of femur and tibia in norm and with experimental osteoporosis. Methods. The work investigated the lower limbs of 6 groups of Wistar rats. The first part of the study involved 4 groups of rats with modeled tibial fracture with subsequent osteosynthesis in norm and with experimental osteoporosis. The second part of the research included two groups of laboratory rats with modeled femur fracture. In both parts we used metal injection needle, as well as carbon-carbon composite nail for osteosynthesis. Results. All animals underwent surgery well, stepped on the injured limb. X-ray examination after the osteosynthesis demonstrated satisfactory reposition of the fragments. One month after modeled fracture in rats with experimental osteoporosis a violation of the normal consolidation of the fracture was observed, especially in the group where carbon-carbon composite nails were used for osteosynthesis. Further, until the 180th day after the surgery there were no peculiarities, function of the limbs was restored, mainly without expressed angular deformities. Conclusion. The above mentioned model was successfully elaborated for the research of using carbon-carbon composite nail for intramedullary osteosynthesis in laboratory rats with fractures of femur and tibia in norm and with experimental osteoporosis.

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Causes of tibial fracture consolidation disorders in extrafocal compression-distraction osteosynthesis and ways to prevent them

ACADEMICIA An International Multidisciplinary Research Journal ◽

10.5958/2249-7137.2021.00836.3 ◽

2021 ◽

Vol 11 (3) ◽

pp. 2119-2122

Author(s):

Sadulla Yusupovich Ibragimov ◽

Nurali Fayzievich Eranov ◽

Ilhom Gulomovich Juraev ◽

Asliddin Amiriddinovich Umarov ◽

Gayrat Tursunovich Amonov

Keyword(s):

Tibial Fracture ◽

Distraction Osteosynthesis ◽

Fracture Consolidation

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Growth factor release in extra- and intramedullary osteosynthesis following tibial fracture

Injury ◽

10.1016/j.injury.2010.11.021 ◽

2011 ◽

Vol 42 (8) ◽

pp. 772-777 ◽

Cited By ~ 6

Author(s):

K. Sarahrudi ◽

A. Thomas ◽

T. Heinz ◽

A. Krumböck ◽

V. Vécsei ◽

...

Keyword(s):

Growth Factor ◽

Tibial Fracture ◽

Intramedullary Osteosynthesis ◽

Growth Factor Release ◽

Factor Release

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Violation of consolidation of the femur after untimely dynamization of the intramedullary blocking rod

ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS ◽

10.15674/0030-59872021169-72 ◽

2021 ◽

pp. 69-72

Author(s):

Diomyd Chabanenko ◽

Oleksandr Polіvoda

Keyword(s):

Femoral Fracture ◽

Distal Part ◽

Weight Bearing ◽

Femoral Fractures ◽

Femoral Shaft ◽

Joint Control ◽

Posterior View ◽

Intramedullary Osteosynthesis ◽

Fracture Consolidation ◽

The Right

Violation of femoral fracture consolidation after blocking intramedullary osteosynthesis is a fairly common pathology, and requires the attention of physicians due to its prevalence. There are several reasons for this complication: it is the instability in the system «bone-implant», and the untimely dynamization of the locking nail. Methods. This article presents a case of fracture violated consolidation after blocking intramedullary osteosynthesis caused a nonunion due to nail failure. Results. Patient was injured on 29.12.2018, as a result of a traffic accident. 01.15.2019, the surgery was performed: closed reduction, blocking intramedullary osteosynthesis of the fracture of the middle shaft of the right thigh, static fixation of the nail. Next visit to the clinic was on 02.01.2020, because of pain in the middle third of the thigh, problems with axial weight-bearing on the right leg, limitation of the flexion in the right knee joint. Control radiographs demonstrated no signs of consolidation of the femoral shaft fracture, and migration of the distal locking screw. 08.01.2020 revision surgical treatment was performed. Given the presence of 5 mutually perpendicular holes in the distal part of the nail, two of them were locked in the anterio-posterior view by the free hand method, the migrated screw in the distal part of the nail was replaced, and the nail was dynamized in the proximal part taking into account its design features. Conclusions. To normalize the consolidation processes in patients with nonunion femoral fractures, bone physiology and the positive effect of autocompression should be considered. The described case demonstrates the necessity for timely dynamization of the blocking nail, which confirms our own observations and literature data. Despite the fact that the dynamization of the nail was performed 1 year after blocking intramedullary osteosynthesis, fracture consolidation occurred 5 months after its implementation. Key words. Femoral fracture, blocked intramedullary osteosynthesis, disorders consolidation, dynamization of the construction.

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Factors Affecting the Terms of Fracture Consolidation

N N Priorov Journal of Traumatology and Orthopedics ◽

10.32414/0869-8678-2016-2-50-56 ◽

2016 ◽

pp. 50-56

Author(s):

F. A. Matsukatov ◽

D. V. Gerasimov

Keyword(s):

Tibial Fracture ◽

Factors Affecting ◽

Fracture Consolidation ◽

Fixation Stability

Dependence of the consolidation of spiral tibial fracture treated with transosseous osteosynthesis upon the initial transverse fragments dislocation, patient’s age, remoteness of injury, reposition accuracy and fixation stability was analyzed. Priority factors that will allow realizing the maximum potentialities of the technique are determined.

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Use of Cemented Spacer with a Handmade Stem to Treat Acute Periprosthetic Tibial Fracture Infection: A Case Report

The Open Orthopaedics Journal ◽

10.2174/1874325001408010024 ◽

2014 ◽

Vol 8 (1) ◽

pp. 24-26

Author(s):

LluÍs Font-Vizcarra ◽

Oscar Izquierdo ◽

Laura GarcÍa-NuÑo ◽

Araceli GonzÁlez ◽

VicenÇ Diaz-Brito ◽

...

Keyword(s):

Tibial Fracture ◽

Joint Infection ◽

Clinical Signs ◽

Definitive Treatment ◽

Cement Spacer ◽

Metal Core ◽

Prosthetic Joint ◽

Fracture Consolidation ◽

Long Stem

We report an 85-year-old woman with dementia and dependent for normal life activities who was admitted due to a left periprosthetic tibial fracture. The tibial component was replaced by one with a long stem and she was discharged. Four weeks after the intervention the patient was re-admitted due to an acute prosthetic joint infection. All the components were removed and a bone-cement spacer with a handmade stem with a metal core was implanted. Radiological signs of fracture consolidation were observed after 3 months of follow-up. Due to the previous health status of the patient, it was decided to keep the spacer as a definitive treatment. After 24 months, the patient was able to sit without pain and to stand up with help using a knee brace. There were no radiological or clinical signs of infection.

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Factors Affecting theTerms of Fracture Consolidation

N.N. Priorov Journal of Traumatology and Orthopedics ◽

10.17816/vto201623250-56 ◽

2016 ◽

Vol 23 (2) ◽

pp. 50-56

Author(s):

F. A Matsukatov ◽

D. V Gerasimov

Keyword(s):

Tibial Fracture ◽

Factors Affecting ◽

Fracture Consolidation ◽

Fixation Stability

Dependence of the consolidation of spiral tibial fracture treated with transosseous osteosynthesis upon the initial transverse fragments dislocation, patient’s age, remoteness of injury, reposition accuracy and fixation stability was analyzed. Priority factors that will allow realizing the maximum potentialities of the technique are determined.

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Cell Wall Ultrastructure in Three Strains of a Cariogenic Streptococcus

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100065730 ◽

1971 ◽

Vol 29 ◽

pp. 338-339

Author(s):

M. J. Kramer ◽

Alan L. Coykendall

Keyword(s):

Cell Wall ◽

Dental Caries ◽

Streptococcus Mutans ◽

Microscopic Study ◽

Electron Microscopic Study ◽

Genetic Heterogeneity ◽

Morphological Characteristics ◽

Electron Microscopic ◽

Dna Reassociation ◽

Wall Ultrastructure

During the almost 50 years since Streptococcus mutans was first suggested as a factor in the etiology of dental caries, a multitude of studies have confirmed the cariogenic potential of this organism. Streptococci have been isolated from human and animal caries on numerous occasions and, with few exceptions, they are not typable by the Lancefield technique but are relatively homogeneous in their biochemical reactions. An analysis of the guanine-cytosine (G-C) composition of the DNA from strains K-1-R, NCTC 10449, and FA-1 by one of us (ALC) revealed significant differences and DNA-DNA reassociation experiments indicated that genetic heterogeneity existed among the three strains. The present electron microscopic study had as its objective the elucidation of any distinguishing morphological characteristics which might further characterize the respective strains.

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Aberrant Type C Virus Production in a Cell Line Derived from Balb/3T3

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100094693 ◽

1972 ◽

Vol 30 ◽

pp. 286-287

Author(s):

N. Savage ◽

A. Hackett

Keyword(s):

Electron Microscopy ◽

Cell Line ◽

Leukemia Virus ◽

Morphological Characteristics ◽

Virus Production ◽

Oncogenic Viruses ◽

Endogenous Virus ◽

Virus Particles ◽

Moloney Leukemia Virus ◽

A Cell

A cell line, UC1-B, which was derived from Balb/3T3 cells, maintains the same morphological characteristics of the non-transformed parental culture, and shows no evidence of spontaneous virus production. Survey by electron microscopy shows that the cell line consists of spindle-shaped cells with no unusual features and no endogenous virus particles.UC1-B cells respond to Moloney leukemia virus (MLV) infection by a change in morphology and growth pattern which is typical of cells transformed by sarcoma virus. Electron microscopy shows that the cells are now variable in shape (rounded, rhomboid, and spindle), and each cell type has some microvilli. Virtually all (90%) of the cells show virus particles developing at the cell surface and within the cytoplasm. Maturing viruses, typical of the oncogenic viruses, are found along with atypical tubular forms in the same cell.

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DNA nick end labeling: a reliable marker for apoptosis?

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100141184 ◽

1995 ◽

Vol 53 ◽

pp. 962-963

Author(s):

Anne F. Bushnell ◽

Sarah Webster ◽

Lynn S. Perlmutter

Keyword(s):

Cell Death ◽

Cultured Cells ◽

Apoptotic Cell ◽

Morphological Characteristics ◽

Detection Methods ◽

Tissue Preparation ◽

Preparation Methods ◽

Dna Laddering ◽

Disease States ◽

Reliable Marker

Apoptosis, or programmed cell death, is an important mechanism in development and in diverse disease states. The morphological characteristics of apoptosis were first identified using the electron microscope. Since then, DNA laddering on agarose gels was found to correlate well with apoptotic cell death in cultured cells of dissimilar origins. Recently numerous DNA nick end labeling methods have been developed in an attempt to visualize, at the light microscopic level, the apoptotic cells responsible for DNA laddering.The present studies were designed to compare various tissue processing techniques and staining methods to assess the occurrence of apoptosis in post mortem tissue from Alzheimer's diseased (AD) and control human brains by DNA nick end labeling methods. Three tissue preparation methods and two commercial DNA nick end labeling kits were evaluated: the Apoptag kit from Oncor and the Biotin-21 dUTP 3' end labeling kit from Clontech. The detection methods of the two kits differed in that the Oncor kit used digoxigenin dUTP and anti-digoxigenin-peroxidase and the Clontech used biotinylated dUTP and avidinperoxidase. Both used 3-3' diaminobenzidine (DAB) for final color development.

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