scholarly journals Synthesis, Spectral Characterization and Biological Studies of Lanthanum(III) Complexes with 3-Substituted-4-Amino-5-Mercapo-1,4-Triazoles Schiff Bases

2013 ◽  
Vol 17 ◽  
pp. 94-104
Author(s):  
Mallikarjun S. Yadawe ◽  
Shrishila N. Unki ◽  
Sangamesh A. Patil
Keyword(s):  
Chemical Analysis ◽  
Metal Complexes ◽  
Organic Solvents ◽  
Schiff Bases ◽  
Metal Salt ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Biological Studies ◽  
Antibacterial And Antifungal

Some lanthanum(III) complexes have been synthesized by reacting lanthanum(III) metal salt with Schiff bases derived from 3-substituted-4-amino-5-mercapto-1,2,4-triazole and glyoxal/biacetyl/benzyl. All these complexes are not soluble in common organic solvents. However sparingly soluble in DMF and DMSO. The chemical analysis of the complexes confirmed to the stoichiometry of the type La(III)LNO3·H2O. La(III)LCl·H2O and La(III)LNCS·H2O respectively. The chelation of the complexes has been proposed in the light of analytical, spectral studies. The measured molar conductance values indicate that, the complexes are non-electrolytes. The Schiff bases and their complexes have been screened for their antibacterial and antifungal activities. The results of these studies show the metal complexes to be more antibacterial and antifungal as compared to the uncomplexed coumarins.

scholarly journals Physico-chemical characterization and biological screening of metal complexes with Cyanex 301

1970 ◽  
Vol 34 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Tarun Kumar Pal ◽  
Md Ashraful Alam ◽  
Suchitra Rani Paul
Keyword(s):  
Metal Complexes ◽  
Magnetic Measurements ◽  
Chemical Characterization ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Physico Chemical ◽  
Dithiophosphinic Acid ◽  
Cyanex 301 ◽  
Antibacterial And Antifungal

New metal complexes of Mg(II), VO(II), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Pd(II) with cyanex 301(L) i.e., bis(2,4,4-trimethylpentyl) dithiophosphinic acid were synthesized. The complexes have been characterized by elemental analysis, molar conductivity, molecular mass determination, magnetic measurements, infrared and electronic spectral studies. The prepared metal complexes have the compositions: 2. [MgL2].H2O, 3. [VOL2], 4. K[MnL3].H2O, 5. [FeL3], 6. K[CoL3].H2O, 7. K[NiL3], 8. K[CuL3] and 9. [PdL2]. The complexes 2, 3 and 9 are assumed to have tetrahedral, square pyramidal and square planar geometries, respectively but the complexes 4 - 8 are octahedral based on experimental data. From magnetic measurements the complexes 2 and 9 are found to be diamagnetic and others are paramagnetic. Measured molar conductance showed that the complexes 2, 3, 5 and 9 are non-electrolytes and rest are electrolytes. Besides, some complexes have shown good antibacterial and antifungal activities. Key words: Cyanex 301; Antibacterial; Antifungal; DMSO; Bis (2, 4, 4-trimethylpentyl) dithiophosphinic acid DOI: 10.3329/jbas.v34i2.6859Journal of Bangladesh Academy of Sciences, Vol. 34, No. 2, 153-161, 2010

scholarly journals Transition Metal Complexes of Omeprazole An Anti-Ulcerative Drug

2017 ◽  
Vol 36 (3) ◽  
pp. 31 ◽  
Author(s):  
Suman Malik ◽  
Supriya Das ◽  
Bharti Jain
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Complexes ◽  
Analytical Data ◽  
Molar Conductance ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
Antibacterial And Antifungal Activities ◽  
Metal Ratio ◽  
Uv Visible ◽  
Antibacterial And Antifungal

Omeprazole (OME) is a proton pump inhibitor (PPI). PPI’s have enabled to improve the treatment of various acidpeptic disorders. OME is a weak base and it can form several complexes with transition and non-transitions metal ions. In the present paper, we are describing series of trantion metal complexes of omeprazole i.e.,5-methoxy-2[(4methoxy-3,5dimethyl-2-pyridinyl)methylsulfinyl]–1H–benzimidazole with CuII, MnII, CoII, NiII, FeII, ZnII and HgII. These complexes were characterized by elemental analysis, molar conductance, IR, NMR, magnetic susceptibility, UV-visible spectral studies, ESR, SEM and X-ray diffraction. Based on the above studies, the ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and S=O groups .The complexes were found to non-electrolytic in nature on the basis of low values of molar conductance . Analytical data and stochiometry suggest ligand metal ratio of 2:1 for all the complexes. Electronic Spectra and Magnetic susceptibility measurements reveal octahedral geometry for Mn(II),Co(II), Ni(II),Fe(II) and Cu(II) complexes and tetrahedral for Hg(II) and Zn(II) complexes. Ligands and their metal complexes have been screened for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus Aureus and fungi Aspergillus niger and A. flavous.

scholarly journals Physico-chemical and biological studies of Cu(II), Co(II) and Ni(II) complexes of an N4 coordinating ligand derived from diacetylbisethylenediamine and benzoic acid

2012 ◽  
Vol 77 (5) ◽  
pp. 627-637 ◽  
Author(s):  
Pal Singh ◽  
Nanda Srivastava
Keyword(s):  
Benzoic Acid ◽  
Metal Complexes ◽  
Magnetic Moment ◽  
Biological Activities ◽  
Molar Conductance ◽  
Planar Geometry ◽  
Cyclic Voltammetric Study ◽  
Biological Studies ◽  
Antibacterial And Antifungal

Mononuclear metal complexes of the type [ML1]Cl2 (where, M = = Cu(II), Co(II) or Ni(II) and L1 = ligand) were synthesized by the reaction of a new N4 coordinating ligand, derived from diacetylbisethylenediamine with benzoic acid, and the corresponding hydrated metal chloride salts. The metal complexes were characterized by elemental analysis, melting point determination, molar conductance and magnetic moment measurements, IR, UV-Vis, 1H- and 13C-NMR, and ESR spectroscopy. The ligand and all the metal complexes were stable in the solid state at room temperature. From the analytical and spectroscopic investigations, the stoichiometry of the complexes was found to be 1:1 (metal:ligand). Based on the electronic spectra and magnetic moment data, the metal complexes had a square planar geometry. The molar conductance values show the 1:2 electrolytic nature of the metal complexes. A cyclic voltammetric study of the Cu(II) metal complex has also performed, which showed one electron quasi-reversible reduction around -0.92 to -1.10 V. In vitro biological activities of the ligand and metal complexes was checked against two bacteria Bacillus subtilis and Escherichia coli and two fungi Aspirgillus niger and A. flavus which showed the antibacterial and antifungal properties of the ligand and its metal complexes.

scholarly journals FIRST-ROW TRANSITION METAL COMPLEXES OF OMEPRAZOLE AS ANTI-ULCERATIVE DRUGS

2010 ◽  
Vol 10 (3) ◽  
pp. 382-389
Author(s):  
Suman Malik ◽  
Supriya Das ◽  
Bharti Jain
Keyword(s):  
Magnetic Susceptibility ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Analytical Data ◽  
Transition Metal Ions ◽  
Molar Conductivity ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Omeprazole (OME) is a proton pump inhibitor (PPI). PPIs have enabled to improve the treatment of various acid-peptic disorders. OME is a weak base and it can form several complexes with transition and non-transition metal ions. In the present paper, we are describing series of transition metal complexes of omeprazole i.e., 5-methoxy-2[(4methoxy-3, 5dimethyl-2-pyridinyl) methylsulfinyl]-1H-benzimidazole with CuII, MnII, CoII, NiII, FeII, ZnII and HgII. These complexes were characterized by elemental analysis, molar conductivity, IR, NMR, magnetic susceptibility, UV-visible spectral studies, ESR, SEM and X-ray diffraction. Based on the above studies, the ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and S=O groups. The complexes were found to non-electrolytic in nature on the basis of low values of molar conductivity. Analytical data and stoichiometry analysis suggest ligand to metal ratio of 2:1 for all the complexes. Electronic spectra and magnetic susceptibility measurements reveal octahedral geometry for Mn(II),Co(II), Ni(II),Fe(II) and Cu(II) complexes and tetrahedral for Hg(II) and Zn(II) complexes. Ligands and their metal complexes have been screened for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus aureus and fungi Aspergillus niger and A. flavous.

scholarly journals Spectroscopic and Biological Studies on Newly Synthesized Cobalt (II) and Nickel (II) Complexes with 2-Acetyl Coumarone Semicarbazone and 2-Acetyl Coumarone Thiosemicarbazone

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Sanjay Goel ◽  
Sulekh Chandra ◽  
Sudhanshu Dhar Dwivedi
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Complexes ◽  
Antioxidant Activities ◽  
Molar Conductance ◽  
Metal Salts ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Square Planar ◽  
Biological Studies ◽  
Infrared Spectral

Co(II) and Ni(II) complexes of general composition ML2X2(M = Co(II), Ni(II); X = Cl−,NO3 −) were synthesized by the condensation of metal salts with semicarbazone/thiosemicarbazone derived from 2-acetyl coumarone. The ligands and metal complexes were characterized by NMR, elemental analysis, molar conductance, magnetic susceptibility measurements, IR, and atomic absorption spectral studies. On the basis of electronic, molar conductance and infrared spectral studies, the complexes were found to have square planar geometry. The Schiff bases and their metal complexes were tested for their antibacterial and antioxidant activities.

scholarly journals Metal (II) Complexes Derived from Naphthofuran-2-carbohydrazide and Diacetylmonoxime Schiff Base: Synthesis, Spectroscopic, Electrochemical, and Biological Investigation

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
R. B. Sumathi ◽  
M. B. Halli
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Thermal Studies ◽  
Analytical Data ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
Biological Investigation ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Chloride Salts

A new Schiff base and a new series of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) complexes were synthesized by the condensation of naphthofuran-2-carbohydrazide and diacetylmonoxime. Metal complexes of the Schiff base were prepared from their chloride salts of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) in ethanol. The ligand along with its metal complexes have been characterized on the basis of analytical data, IR, electronic, mass,1HNMR, ESR spectral data, thermal studies, magnetic susceptibility, and molar conductance measurements. The nonelectrolytic behaviour of the complexes was assessed from the measured low conductance data. The elemental analysis of the complexes confirm the stoichiometry of the type CuL2Cl2and MLCl2where M = Ni(II), Co(II), Cd(II), and Hg(II) and L = Schiff base. The redox property of the Cu(II) complex was investigated by electrochemical method using cyclic voltammetry. In the light of these results, Co(II), Ni(II), and Cu(II) complexes are assigned octahedral geometry, Cd(II), and Hg(II) complexes tetrahedral geometry. In order to evaluate the effect of metal ions upon chelation, both the ligand and its metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleaving capacity of all the complexes was analysed by agarose gel electrophoresis method.

scholarly journals Synthesis, Spectroscopic Characterization And Antimicrobial Evaluation of Novel Nitrogen Containing Metal Complexes

2019 ◽  
Vol 16 ◽  
pp. 6313-6324
Author(s):  
Hanaa A. El-Boraey ◽  
Aballah El-domiaty
Keyword(s):  
Metal Complexes ◽  
Spectroscopic Characterization ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Magnetic Studies ◽  
Antibacterial And Antifungal Activities ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

Four novel Mn(II), Co(II), Cu(II) complexes with nitrogen containing ligand (L) i.e. N,N-((Z)-ethane-1,2-diylidine)bis(2-amino benzo hydrazide) have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), molar conductance and magnetic susceptibility measurements. From the spectroscopic and magnetic studies it has been concluded that all complexes have a six coordinated octahedral geometry. The Schiff base and their metal complexes have also been screened for their antibacterial and antifungal activities by using a modified Kirby-Bauer disc diffusion method.

scholarly journals Synthesis and Antimicrobial Screening of the Metal Complexes with Cyanex 302

2009 ◽  
Vol 1 (3) ◽  
pp. 647-654
Author(s):  
M. A. Alam ◽  
T. K. Pal
Keyword(s):  
Metal Complexes ◽  
Magnetic Measurements ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Central Metal ◽  
Tetrahedral Geometry ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Cyanex 302 ◽  
Antibacterial And Antifungal

The synthesis and characterization of metal complexes of the Cyanex 302 [bis(2, 4, 4-trimethylpentyl) monothiophosphinic acid] are reported. The complexes have been characterized by elemental analyses, molar conductivity, molecular mass determination and magnetic measurements, infrared and electronic spectral studies. The antibacterial and antifungal activities of the ligand and metal complexes have also been investigated. They have the stoichiometry of the type 1. [MgL2].H2O, 2. [Ca L2].H2O, 3. [ZrOL2].H2O, 4. [FeL3] and 5. [NiL2]. Electronic spectral data and the magnetic moment values suggested the complexes 1 and 2 are tetrahedral geometry, while the complexes 3, 4 and 5 are square pyramidal, octahedral and square planar geometry around the central metal ions, respectively. Besides, magnetic susceptibility measurements of the complexes also revealed that complexes 1-3 and 5 are diamagnetic in nature, except complex 4, which is paramagnetic. The metal complexes showed stronger antibacterial and antifungal activities than the ligand.  Keywords: Antibacterial, antifungal; Bis(2, 4, 4-trimethylpentyl) mothiophosphinic acid; Cyanex 302. © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v1i3.2259              J. Sci. Res. 1 (3), 647-654 (2009) 

scholarly journals Biological and Spectral Studies of Newly Synthesized Triazole Schiff Bases and Their Si(IV), Sn(IV) Complexes

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Kiran Singh ◽  
Parvesh Puri ◽  
Yogender Kumar ◽  
Chetan Sharma ◽  
Kamal Rai Aneja
Keyword(s):  
Nmr Spectroscopy ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Trigonal Bipyramidal ◽  
Elemental Analyses ◽  
Bacteria And Fungi

The Schiff bases HL1-3have been prepared by the reaction of 5-bromothiophene-2-carboxaldehyde with 4-amino-5-mercapto-3-methyl/propyl/isopropyl-s-triazole, respectively. Organosilicon(IV) and organotin(IV) complexes of formulae (CH3)2MCl(L1-3), (CH3)2M(L1-3)2were synthesized from the reaction of (CH3)2MCl2and the Schiff bases in 1 : 1 and 1 : 2 molar ratio, where and Sn. The synthesized Schiff bases and their metal complexes have been characterized with the aid of various physicochemical techniques like elemental analyses, molar conductance, UV, IR,1H,13C,29Si, and119Sn NMR spectroscopy. Based on these studies, the trigonal bipyramidal and octahedral geometries have been proposed for these complexes. The ligands and their metal complexes have been screenedin vitroagainst some bacteria and fungi.

Synthesis, Characterization and Biological Studies of Some Transition Metal Complexes with Pyrazine Schiff Base Hydra zone Ligand

2020 ◽  
Vol 15 (2) ◽  
pp. 61-72
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Metal Salt ◽  
Free Ligand ◽  
Spectroscopic Studies ◽  
Fungal Species ◽  
Molar Conductance ◽  
Central Metal ◽  
Biological Studies

New pyrazine carbohydra zone ligand N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene) pyrazine-2-carbohydrazide (H2L), prepared by the condensation of equimolar amounts of pyrazine-2-carbohydrazide with 2-hydroxy-5-chloroacetophenone in methanol, reacts with suitable metal salt precursors to give complexes of two general formulae: [M(HL)(Cl)(H2O)2] {M = Mn(II), Co(II), Ni(II) and Cu(II)} and [M(L)(H2O)] {M = Zn(II) and Cd(II)}. Structure of ligand was confirmed by elemental analysis, IR, 1H and 13C NMR and mass spectroscopy, while synthesized complexes were additionally characterized by magnetic susceptibility measurements, molar conductivity measurements, XRD, ESR (for Cu(II)), SEM and thermogravimetric analysis. Spectroscopic studies confirmed a tridentate ONO donor behavior of the ligand towards the central metal ion. The molar conductance (12–17 W–1 cm2 mol–1) measurements in DMSO indicated non-electrolytic nature. Thermal behavior of the complexes suggests their extended stability and the thermal decomposition generally proceeds via partial loss of the organic moiety and ends with the formation of respective metal oxide as a final product. Various kinetic and thermodynamic parameters were evaluated using the Coats-Redfern method. The solid-state electrical conductivity of the complexes measured in the temperature range 303-463 K suggested their semiconducting behavior. The ligand and its metal complexes were screened in vitro for their antibacterial activity against the Gram-positive bacteria S. aureus and B. subtilis, the Gram-negative bacteria E. coli and S. typhi and the fungi C. albicans and A. niger. The obtained results indicated improved activity of the complexes compared to the free ligand against all studied bacterial and fungal species.

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