Study of potential drug interactions between prescribed drugs in geriatric patients attending outpatient department in a government tertiary care hospital in Maharashtra

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India. Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used. Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs. Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed. Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.

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Potential drug–drug interactions in medical intensive care unit of a tertiary care hospital in Pakistan

International Journal of Clinical Pharmacy ◽

10.1007/s11096-016-0340-3 ◽

2016 ◽

Vol 38 (5) ◽

pp. 1052-1056 ◽

Cited By ~ 8

Author(s):

Mohammad Ismail ◽

Farmanullah Khan ◽

Sidra Noor ◽

Iqbal Haider ◽

Inam-ul Haq ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Drug Interactions ◽

Tertiary Care Hospital ◽

Medical Intensive Care Unit ◽

Tertiary Care ◽

Care Hospital ◽

Potential Drug ◽

Medical Intensive Care

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EVALUATION OF DRUG-DRUG INTERACTIONS IN HOSPITALISED GERIATRIC PATIENTS AT TERTIARY CARE HOSPITAL

INDIAN DRUGS ◽

10.53879/id.58.03.12008 ◽

2021 ◽

Vol 58 (03) ◽

pp. 62-66

Author(s):

Jalpa Suthar ◽

Avni Tandel ◽

Varsha Patel ◽

◽

...

Keyword(s):

Drug Interaction ◽

Drug Interactions ◽

Prospective Observational Study ◽

Geriatric Patients ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

The Elderly ◽

Care Hospital ◽

Contributing Factors ◽

Associated Conditions

A study was planned to evaluate the prevalence, nature, and severity of drug-drug interactions (DDI) in geriatrics. A prospective observational study was carried out in hospitalized patients. DDIs were evaluated using a medscape drug interaction checker. Data of 300 patients were collected who were followed up for 3 days and analyzed over a period of 7 months. The prevalence rate of DDI was 90.3 %, as 271 out of 300 prescriptions showed drug-drug interaction. Out of 300 patients, 4797 possible DDIs were identified, of which 39 (0.81 %) were contraindicated, 290 (6.04 %) serious drug interactions, 3312 (68.85 %) significant interactions and 1156 (24.09 %) minor interactions. Out of 4797 possible DDIs, 2962 (62.91 %) were pharmacodynamics. 1835 (37.08 %) were pharmacokinetic type. Antihypertensive class of drug showed potential for DDIs. Total 244 (81.33 %) cases were found with potentially inappropriate medicines(PIM). The prevalence of DDIs in geriatric patients was 90.3 %. Poly pharmacy and multiple associated conditions in the elderly were the major contributing factors for DDIs.

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