A Study on Polypharmacy and Potential Drug-Drug Interactions among Elderly Patients Admitted in Department of Medicine of a Tertiary Care Hospital in Puducherry

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India. Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used. Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs. Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed. Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.

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Potential drug–drug interactions in medical intensive care unit of a tertiary care hospital in Pakistan

International Journal of Clinical Pharmacy ◽

10.1007/s11096-016-0340-3 ◽

2016 ◽

Vol 38 (5) ◽

pp. 1052-1056 ◽

Cited By ~ 8

Author(s):

Mohammad Ismail ◽

Farmanullah Khan ◽

Sidra Noor ◽

Iqbal Haider ◽

Inam-ul Haq ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Drug Interactions ◽

Tertiary Care Hospital ◽

Medical Intensive Care Unit ◽

Tertiary Care ◽

Care Hospital ◽

Potential Drug ◽

Medical Intensive Care

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Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study

BMC Health Services Research ◽

10.1186/s12913-018-3579-7 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 5

Author(s):

Mohammad Ismail ◽

Sidra Noor ◽

Umme Harram ◽

Inamul Haq ◽

Iqbal Haider ◽

...

Keyword(s):

Drug Interactions ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Cross Sectional Study ◽

Outpatient Department ◽

Care Hospital ◽

Potential Drug ◽

Sectional Study ◽

Cross Sectional

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Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital

Journal of Aging Research ◽

10.1155/2018/5728957 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Varsha Shetty ◽

Mukta N. Chowta ◽

Nithyananda Chowta K ◽

Ashok Shenoy ◽

Ashwin Kamath ◽

...

Keyword(s):

Elderly Patients ◽

Drug Interactions ◽

Tertiary Care ◽

Educational Status ◽

The Elderly ◽

Risk Category ◽

Care Hospital ◽

Potential Drug ◽

Cross Sectional ◽

The Mean

Background and Objectives. The drugs most commonly implicated in major potential interactions are those used in the day-to-day clinical management of elderly patients with chronic diseases. This study is planned to evaluate the profile of drug-drug interactions in the medications prescribed to elderly population and also to identify the possible predictors for potential drug-drug interactions in the elderly. Methods. This cross-sectional study included patients aged above 60 years with a minimum of two drugs in the prescriptions. Data were collected from medical prescriptions and patients' medical records. The data collected included demographic characteristics such as age, gender, height, weight, educational status, socioeconomic status, medical history, and medications prescribed. The prescriptions were analyzed for the potential drug interactions using Lexi-Interact™ Online, an online software to check drug-drug interactions. Results. A total of 209 patients were included in the study, among them 104 (49.8%) were males and 105 (50.2%) were females. The mean number of medications received was 6.53 ± 2.15 per prescription. Around 138 (66%) patients received more than six medications. The mean number of potential drug interactions seen in the prescription of these patients was 3.17 ± 2.78. Around 18.2% patients had more than five drug interactions. Major drug interactions were observed in 21.42% of cases. Around 3.02% of drug interactions belonged to risk category X, i.e., to be avoided. Logistic regression analysis showed that age above 70 years was associated with the presence of drug interactions. Increased number of medication was independently associated with the occurrence of drug interactions. The presence of drug interactions was not associated with increased number of comorbidities. Conclusion. A significant number of potential drug-drug interactions were seen in the prescriptions of elderly patients. Increasing age and polypharmacy were identified as the predictors of potential drug interactions.

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A prospective observational study to evaluate potential drug-drug interactions in patients admitted in intensive care unit, at BRIMS tertiary care hospital in Bidar, India

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20181165 ◽

2018 ◽

Vol 7 (4) ◽

pp. 655 ◽

Cited By ~ 1

Author(s):

Shailander Singh ◽

Swetha K.

Keyword(s):

Observational Study ◽

Drug Interactions ◽

Prospective Observational Study ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Potential Drug ◽

Icu Patients ◽

Study Population ◽

Type C

Background: Drug interaction occurs when presence of one drug affects the activity of another when, both are co-administered. 6-30% of adverse events (AEs) with significant hospitalizations or death are by drug-drug interactions(DDI). There is increased possibility to prevent the potential drug-drug interactions (pDDIs), if their prevalence and pattern are determined accurately before their occurrence. Hence this study aimed to evaluate the prevalence of pDDIs in ICU patients at BRIMS tertiary care hospital, Bidar.Methods: This prospective observational study included 30 patients admitted in ICU of BRIMS hospital for >24hrs of either gender, aged >18yrs. The study was conducted for a period of 3 months. Data was collected from the case records of patients on the predesigned proforma. Potential drug-drug interactions were classified based on their severity and the risk of Potential drug-drug interactions was estimated by Lexicomp, inc.version; 3.0.1.drug interact android mobile application.Results: Out of 35 patients admitted in the ICU, 30 cases were included in the study. The mean age of study population was 56.3years. The study population was exposed to a total of 330 medicines during the hospital stay with an average of 11.7 drugs per patient. The prevalence of pDDI was 93.3% (28) with an average of 9.75 pDDI per patient. According to Lexicomp drug interact android mobile application majority (63%) of pDDI were found to be moderate in their severity, 67% belonged to type C risk.Conclusions: The study showed higher prevalence of pDDI among ICU patients due to the complexity of the pharmacotherapies administered.

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