scholarly journals The effect of acetylation phenotype on the dynamic changes of indices of calcium metabolism and iron levels in liver detoxification on the background of experimental hypothyroidism

2017 ◽  
Vol 6 (4) ◽  
pp. 739
Author(s):  
Saidamir Saidov ◽  
Asilbek Ahmadjonuv ◽  
Anvar Mavlonov
Keyword(s):  
Calcium Ions ◽  
Calcium Metabolism ◽  
Serum Iron ◽  
Calcium Concentration ◽  
Phosphorus Metabolism ◽  
Acetylation Phenotype ◽  
Dynamic Changes ◽  
Calcium Phosphorus ◽  
Degree Of Severity ◽  
Slow Metabolizers

Background: Some studies of the characteristics of the calcium-phosphorus metabolism changes in experimental hypothyroidism given the phenotype of acetylation will allow to more effectively diagnose, predict the course and to carry out prevention and treatment of hypothyroidism and the accompanying pathological changes.The aim is to trace the dynamics of phosphorus-calcium metabolism and the level of serum iron in experimental hypothyroidism and to determine the severity of it changes depending on the type of acetylation.Methods: In experiments were used rats weighing 180-220g, who were divided into 2 main groups depending on the type of acetylation on α - slow and β - fast metabolizer (acetylators). Each group was modelled experimental hypothyroidism by the introduction of mercazolil at a dose of 5 mg, for 14 days. Each group was divided into 5 subgroups depending on the time of the study. Group of α-slow metabolizers (acetylators) were divided into the following subgroups: Iα - intact IIα - at the 4th hour of the study, IIIα - on the 1st week of the study, IVα - 2-week studies, Vα - on the 3rd week of the study.Results: In the study of the calcium concentration at the 4th hour of the study in subgroups with α - and β - acetylation phenotypes were observed the decrease by 12.0% and 10.5% respectively, and its level in the IIβ - subgroup was 5.3% lower than the IIα- subgroup. The concentration of calcium ions in Vα subgroup was lower than in the Iα sub-group was 12.0%, and the level of calcium in the blood serum of animals Vβ was lower compared to Iβ IIβ IIIβ Ivβ-90.9%, 72.7%, 80.0%, 80.9% respectively. Also relatively, Vα Vβ subgroups in the subgroup calcium concentration were lower at 81.8 percent.Conclusions: Belonging to a particular phenotype of acetylation affects the degree of severity of the changes of indices of calcium-phosphorus metabolism and serum iron in experimental hypothyroidism, the most significant differences between the values of their indicators were detected early and deadlines of the study.

scholarly journals Effects of dialysate calcium concentration on calcium-phosphorus metabolism in hemodialysis patients

2010 ◽  
Vol 43 (11) ◽  
pp. 933-938
Author(s):  
Nobuo Shinkai ◽  
Masahiro Yanase ◽  
Yuki Kyoda ◽  
Motoi Takeuchi ◽  
Fumiyasu Takei ◽  
...  
Keyword(s):  
Calcium Concentration ◽  
Hemodialysis Patients ◽  
Phosphorus Metabolism ◽  
Calcium Phosphorus ◽  
Dialysate Calcium

scholarly journals Analysis of the calcium-phosphorus metabolism and function of the parathyroid glands in patients with type 1 diabetes mellitus

2013 ◽  
Vol 16 (4) ◽  
pp. 33-37 ◽  
Author(s):  
Ekaterina Alexandrovna Khantakova ◽  
Larisa Yur'evna Khamnueva ◽  
Galina Mikhailovna Orlova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Secondary Hyperparathyroidism ◽  
Calcium Metabolism ◽  
Parathyroid Glands ◽  
Phosphorus Metabolism ◽  
Target Values ◽  
Calcium Phosphorus

Objective. To analyze the calcium-phosphorus metabolism in patients with diabetes mellitus (DM) type 1 depending on the functional state of the kidneys. Materials and Methods. The study involved 235 patients with type 1 diabetic (males). One hundred and thirty-four patients entered the group without diabetic nephropathy (DN) and 101 patients entered the group with DN. To study the phosphorous-calcium metabolism in patients with type 1 diabetes there were studied the following parameters in blood plasma: the level of intact parathyroid hormone (PTH), total calcium (Ca), ionized calcium (Ca2+), serum phosphorus (P), as well as calculated CaxP product. Results.  In patients with type 1 diabetes in the progression of DN the increase of P was observed from stage 4 CKD and reduction of Ca ? from CKD stage 5. The increase of the level of PTH was observed from the stage of CKD 3, although isolated cases of secondary hyperparathyroidism were registered in patients with stage CKD 2. At the same time in a large group of the patients with type 1 diabetes there was observed level of PTH below the target values of the stages CKD 3, 4, 5. The deterioration of glycemic control in patients with type 1 diabetes is associated with decreased level of PTH. In patients with type 1 diabetes without DN and with DN there was observed inverse relationship between the level of glycated hemoglobin (HbA. 1c). Conclusion. In patients with type 1 diabetes the progression of DN leads to various disorders of phosphorus-calcium metabolism: reduction of Ca, higher level of P, alter the function of the parathyroid glands (secondary hyperparathyroidism and reduction of PTH below the target value). Deterioration of glycemic control in patients with type 1 diabetes is associated with a reduction of PTH.

scholarly journals The investigation of changes of indexes of calcium metabolism in rats with decreased function of thyroid gland under the influence of physical loading

2014 ◽  
Vol 18 (3 (71)) ◽  
Author(s):  
N. G. Pobigun
Keyword(s):  
Bone Mineral Density ◽  
Thyroid Gland ◽  
Calcium Metabolism ◽  
Inorganic Phosphorus ◽  
Phosphorus Metabolism ◽  
Mineral Density ◽  
Thyroid Status ◽  
Greater Trochanter ◽  
Physical Loading ◽  
Calcium Phosphorus

The changes of indexes of calcium-phosphorus metabolism and data of densitometry of bone tissue in experimental hypofunction of thyroid gland in conditions of action of physical loading have been revealed. In these conditions worsening of thyroid status was accompanied by the increase of content of inorganic phosphorus and albumins in blood serum on the background of increase of bone mineral density in the area of greater trochanter of femurs in comparison with the similar indexes in animals with hypothyroid dysfunction.

scholarly journals Mineral metabolism and COVID-19: is there a connection?

2021 ◽  
Vol 93 (10) ◽  
pp. 1227-1233
Author(s):  
Irina S. Maganeva ◽  
Anna M. Gorbacheva ◽  
Ekaterina E. Bibik ◽  
Elizaveta A. Aboisheva ◽  
Anna K. Eremkina ◽  
...  
Keyword(s):  
Calcium Metabolism ◽  
Respiratory Diseases ◽  
Clinical Course ◽  
Mineral Metabolism ◽  
Clinical Implications ◽  
Phosphorus Metabolism ◽  
Preventive Interventions ◽  
Global Spread ◽  
Calcium Phosphorus ◽  
Acute Respiratory Diseases

Due to global spread of COVID-19, the search for new factors that could influence its clinical course becomes highly important. This review summarize the relevant publications on the association between immune system and the main regulators of mineral homeostasis including. In addition, we have highlighted the various aspects of phosphorus-calcium metabolism related to the acute respiratory diseases and in particular to COVID-19. The data about the calcium-phosphorus metabolism in SARS-CoV-2 infection is required to understand the possible clinical implications and to develop new therapeutic and preventive interventions.

Abstract #1017 Parathyroid Function in Hyperthyroidism in Relation to Calcium-Phosphorus Metabolism

2018 ◽  
Vol 24 ◽  
pp. 226-227
Author(s):  
Ayotunde Ale ◽  
Olatunbosum Olawale ◽  
Onyido Okwuchi ◽  
Sunday Ogundele ◽  
Anthonia Ogbera
Keyword(s):  
Phosphorus Metabolism ◽  
Parathyroid Function ◽  
Calcium Phosphorus

Observations on the mineral metabolism of pullets. II

1936 ◽  
Vol 26 (1) ◽  
pp. 85-100 ◽  
Author(s):  
R. H. Common
Keyword(s):  
Calcium Carbonate ◽  
Egg Production ◽  
Mineral Metabolism ◽  
Ammonium Phosphate ◽  
Ammonia Nitrogen ◽  
Egg Laying ◽  
Phosphorus Metabolism ◽  
Phosphorus Excretion ◽  
Calcium Phosphorus ◽  
Digestible Protein

1. Where heavy phosphorus excretion accompanies egg laying in the pullet the excretion of ammonia nitrogen is simultaneously increased. It is probable that this indicates an excretion of excess phosphate in the urine as ammonium phosphate.2. It is shown that heavy phosphorus excretion does not accompany egg laying provided the calcium carbonate intake is sufficiently high.3. The origin of the excess of phosphorus excretion is discussed in relation to calcium-phosphorus metabolism.4. Pullets on a ration containing 5 per cent, calcium carbonate laid eggs containing a higher percentage of P2O5 than pullets receiving a similar ration but from which the calcium carbonate supplement was omitted.5. Some evidence is put forward in support of the view that current standards pitch the requirements of digestible protein for egg production at too high a level.

Changes in phosphorus metabolism of sheep in response to the increased demands for P associated with an intravenous infusion of calcium

1984 ◽  
Vol 102 (1) ◽  
pp. 135-139 ◽  
Author(s):  
G. D. Braithwaite
Keyword(s):  
Intravenous Infusion ◽  
Calcium Metabolism ◽  
Research Council ◽  
Agricultural Research ◽  
Close Association ◽  
High Rate ◽  
Phosphorus Metabolism ◽  
Agricultural Research Council ◽  
P Absorption ◽  
P Retention

SummaryThe effect on phosphorus and calcium metabolism of a high rate of Ca infused directly into the blood of 10-month-old sheep, already receiving an adequate Ca and P intake, has been studied by a combination of balance and radioisotope techniques. Ca retention was significantly increased during the infusion and most of the extra Ca was retained in bone. Urinary Ca excretion also showed a small but significant increase and the efficiency of Ca absorption a small but significant decrease. Because of the close association of Ca and P in bone, the increased skeletal retention of Ca resulted in an increased skeletal P retention and hence an increased demand for P. This increased P demand was met partly by a decrease in the rate of endogenous faecal loss of P and partly by an increase in the rate and efficiency of P absorption. Because the increase in P demand was relatively small, it was not possible to decide whether the endogenous faecal loss of P can be reduced in response to increased demands to the level found at zero P intake as suggested by the Agricultural Research Council (1980) or whether higher losses at normal P intakes are inevitable.

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