scholarly journals Mineral metabolism and COVID-19: is there a connection?

2021 ◽  
Vol 93 (10) ◽  
pp. 1227-1233
Author(s):  
Irina S. Maganeva ◽  
Anna M. Gorbacheva ◽  
Ekaterina E. Bibik ◽  
Elizaveta A. Aboisheva ◽  
Anna K. Eremkina ◽  
...  
Keyword(s):  
Calcium Metabolism ◽  
Respiratory Diseases ◽  
Clinical Course ◽  
Mineral Metabolism ◽  
Clinical Implications ◽  
Phosphorus Metabolism ◽  
Preventive Interventions ◽  
Global Spread ◽  
Calcium Phosphorus ◽  
Acute Respiratory Diseases

Due to global spread of COVID-19, the search for new factors that could influence its clinical course becomes highly important. This review summarize the relevant publications on the association between immune system and the main regulators of mineral homeostasis including. In addition, we have highlighted the various aspects of phosphorus-calcium metabolism related to the acute respiratory diseases and in particular to COVID-19. The data about the calcium-phosphorus metabolism in SARS-CoV-2 infection is required to understand the possible clinical implications and to develop new therapeutic and preventive interventions.

Observations on the mineral metabolism of pullets. II

1936 ◽  
Vol 26 (1) ◽  
pp. 85-100 ◽  
Author(s):  
R. H. Common
Keyword(s):  
Calcium Carbonate ◽  
Egg Production ◽  
Mineral Metabolism ◽  
Ammonium Phosphate ◽  
Ammonia Nitrogen ◽  
Egg Laying ◽  
Phosphorus Metabolism ◽  
Phosphorus Excretion ◽  
Calcium Phosphorus ◽  
Digestible Protein

1. Where heavy phosphorus excretion accompanies egg laying in the pullet the excretion of ammonia nitrogen is simultaneously increased. It is probable that this indicates an excretion of excess phosphate in the urine as ammonium phosphate.2. It is shown that heavy phosphorus excretion does not accompany egg laying provided the calcium carbonate intake is sufficiently high.3. The origin of the excess of phosphorus excretion is discussed in relation to calcium-phosphorus metabolism.4. Pullets on a ration containing 5 per cent, calcium carbonate laid eggs containing a higher percentage of P2O5 than pullets receiving a similar ration but from which the calcium carbonate supplement was omitted.5. Some evidence is put forward in support of the view that current standards pitch the requirements of digestible protein for egg production at too high a level.

scholarly journals Modern problems of hyper- and hypoparathyroidism

2021 ◽  
Vol 93 (10) ◽  
pp. 1149-1154
Author(s):  
Natalia G. Mokrysheva ◽  
Anna K. Eremkina ◽  
Elena V. Kovaleva ◽  
Julia A. Krupinova ◽  
Olga K. Vikulova
Keyword(s):  
Primary Hyperparathyroidism ◽  
Mineral Metabolism ◽  
Parathyroid Glands ◽  
Endocrine Gland ◽  
Phosphorus Metabolism ◽  
Tertiary Hyperparathyroidism ◽  
The World ◽  
Calcium Phosphorus ◽  
Epidemiological Trends

The parathyroid glands are the most important regulators of mineral metabolism. The parathyroid glands were first discovered only in 1880 and their function went the long way unrecognized. Even the term "parathyroid gland" itself speaks of the initial misconception of it as an underdeveloped part of the thyroid. To date, there is a large amount of data regarding the role of this endocrine gland in the human body and the significant changes associated with their dysfunction, including such widespread diseases such primary, secondary and tertiary hyperparathyroidism, hypoparathyroidism. This review covers the problem of the main disturbances in calcium-phosphorus metabolism, presents the results of databases of patients with primary hyperparathyroidism and hypoparathyroidism, as well as current epidemiological trends in Russia and in the world.

scholarly journals Analysis of the calcium-phosphorus metabolism and function of the parathyroid glands in patients with type 1 diabetes mellitus

2013 ◽  
Vol 16 (4) ◽  
pp. 33-37 ◽  
Author(s):  
Ekaterina Alexandrovna Khantakova ◽  
Larisa Yur'evna Khamnueva ◽  
Galina Mikhailovna Orlova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Secondary Hyperparathyroidism ◽  
Calcium Metabolism ◽  
Parathyroid Glands ◽  
Phosphorus Metabolism ◽  
Target Values ◽  
Calcium Phosphorus

Objective. To analyze the calcium-phosphorus metabolism in patients with diabetes mellitus (DM) type 1 depending on the functional state of the kidneys. Materials and Methods. The study involved 235 patients with type 1 diabetic (males). One hundred and thirty-four patients entered the group without diabetic nephropathy (DN) and 101 patients entered the group with DN. To study the phosphorous-calcium metabolism in patients with type 1 diabetes there were studied the following parameters in blood plasma: the level of intact parathyroid hormone (PTH), total calcium (Ca), ionized calcium (Ca2+), serum phosphorus (P), as well as calculated CaxP product. Results.  In patients with type 1 diabetes in the progression of DN the increase of P was observed from stage 4 CKD and reduction of Ca ? from CKD stage 5. The increase of the level of PTH was observed from the stage of CKD 3, although isolated cases of secondary hyperparathyroidism were registered in patients with stage CKD 2. At the same time in a large group of the patients with type 1 diabetes there was observed level of PTH below the target values of the stages CKD 3, 4, 5. The deterioration of glycemic control in patients with type 1 diabetes is associated with decreased level of PTH. In patients with type 1 diabetes without DN and with DN there was observed inverse relationship between the level of glycated hemoglobin (HbA. 1c). Conclusion. In patients with type 1 diabetes the progression of DN leads to various disorders of phosphorus-calcium metabolism: reduction of Ca, higher level of P, alter the function of the parathyroid glands (secondary hyperparathyroidism and reduction of PTH below the target value). Deterioration of glycemic control in patients with type 1 diabetes is associated with a reduction of PTH.

Observations on the mineral metabolism of pullets: VI. The mobilization of body calcium for shell formation

1941 ◽  
Vol 31 (4) ◽  
pp. 415-437 ◽  
Author(s):  
R. H. Common ◽  
R. W. Hale
Keyword(s):  
Mineral Metabolism ◽  
Phosphorus Metabolism ◽  
Shell Formation ◽  
Mineral Balance ◽  
Tentative Hypothesis ◽  
Recent Developments ◽  
Calcium Phosphorus ◽  
Skeletal Calcium ◽  
Normal Feature ◽  
Actual Ratio

1. Some recent developments of mineral balance studies on laying fowl are discussed and applied to the interpretation of the average results of twenty-six balance experiments with pullets.2. Several of the experiments are re-examined in detail from the same standpoint.3. A tentative hypothesis covering the relations between the calcium metabolism of shell formation and the calcium-phosphorus metabolism of bone is put forward on the basis of this reconsideration of available data. It is suggested that some degree of mobilization of skeletal calcium is a normal feature of shell formation in the fowl, the fraction of bone mineral material mobilized always having a higher Ca: P ratio than the skeleton as a whole, although the actual ratio may vary with the calcium in the diet and with the form in which the calcium is provided.

scholarly journals The investigation of changes of indexes of calcium metabolism in rats with decreased function of thyroid gland under the influence of physical loading

2014 ◽  
Vol 18 (3 (71)) ◽  
Author(s):  
N. G. Pobigun
Keyword(s):  
Bone Mineral Density ◽  
Thyroid Gland ◽  
Calcium Metabolism ◽  
Inorganic Phosphorus ◽  
Phosphorus Metabolism ◽  
Mineral Density ◽  
Thyroid Status ◽  
Greater Trochanter ◽  
Physical Loading ◽  
Calcium Phosphorus

The changes of indexes of calcium-phosphorus metabolism and data of densitometry of bone tissue in experimental hypofunction of thyroid gland in conditions of action of physical loading have been revealed. In these conditions worsening of thyroid status was accompanied by the increase of content of inorganic phosphorus and albumins in blood serum on the background of increase of bone mineral density in the area of greater trochanter of femurs in comparison with the similar indexes in animals with hypothyroid dysfunction.

scholarly journals The effect of acetylation phenotype on the dynamic changes of indices of calcium metabolism and iron levels in liver detoxification on the background of experimental hypothyroidism

2017 ◽  
Vol 6 (4) ◽  
pp. 739
Author(s):  
Saidamir Saidov ◽  
Asilbek Ahmadjonuv ◽  
Anvar Mavlonov
Keyword(s):  
Calcium Ions ◽  
Calcium Metabolism ◽  
Serum Iron ◽  
Calcium Concentration ◽  
Phosphorus Metabolism ◽  
Acetylation Phenotype ◽  
Dynamic Changes ◽  
Calcium Phosphorus ◽  
Degree Of Severity ◽  
Slow Metabolizers

Background: Some studies of the characteristics of the calcium-phosphorus metabolism changes in experimental hypothyroidism given the phenotype of acetylation will allow to more effectively diagnose, predict the course and to carry out prevention and treatment of hypothyroidism and the accompanying pathological changes.The aim is to trace the dynamics of phosphorus-calcium metabolism and the level of serum iron in experimental hypothyroidism and to determine the severity of it changes depending on the type of acetylation.Methods: In experiments were used rats weighing 180-220g, who were divided into 2 main groups depending on the type of acetylation on α - slow and β - fast metabolizer (acetylators). Each group was modelled experimental hypothyroidism by the introduction of mercazolil at a dose of 5 mg, for 14 days. Each group was divided into 5 subgroups depending on the time of the study. Group of α-slow metabolizers (acetylators) were divided into the following subgroups: Iα - intact IIα - at the 4th hour of the study, IIIα - on the 1st week of the study, IVα - 2-week studies, Vα - on the 3rd week of the study.Results: In the study of the calcium concentration at the 4th hour of the study in subgroups with α - and β - acetylation phenotypes were observed the decrease by 12.0% and 10.5% respectively, and its level in the IIβ - subgroup was 5.3% lower than the IIα- subgroup. The concentration of calcium ions in Vα subgroup was lower than in the Iα sub-group was 12.0%, and the level of calcium in the blood serum of animals Vβ was lower compared to Iβ IIβ IIIβ Ivβ-90.9%, 72.7%, 80.0%, 80.9% respectively. Also relatively, Vα Vβ subgroups in the subgroup calcium concentration were lower at 81.8 percent.Conclusions: Belonging to a particular phenotype of acetylation affects the degree of severity of the changes of indices of calcium-phosphorus metabolism and serum iron in experimental hypothyroidism, the most significant differences between the values of their indicators were detected early and deadlines of the study.

Abstract #1017 Parathyroid Function in Hyperthyroidism in Relation to Calcium-Phosphorus Metabolism

2018 ◽  
Vol 24 ◽  
pp. 226-227
Author(s):  
Ayotunde Ale ◽  
Olatunbosum Olawale ◽  
Onyido Okwuchi ◽  
Sunday Ogundele ◽  
Anthonia Ogbera
Keyword(s):  
Phosphorus Metabolism ◽  
Parathyroid Function ◽  
Calcium Phosphorus

Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist

2019 ◽  
Vol 1 (9) ◽  
pp. 38-46
Author(s):  
A. P. Babkin ◽  
A. A. Zuikova ◽  
O. N. Krasnorutskaya ◽  
Yu. A. Kotova ◽  
D. Yu. Bugrimov ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Pharmacological Action ◽  
The Body ◽  
Natural Resistance ◽  
Acute Respiratory Diseases ◽  
T Helpers ◽  
T Killers ◽  
Stimulation Of

The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in the epithelial component of antiviral protection of the body. Based on the above, the study of the clinical efficacy of Derinat® in the form of spray in the treatment of acute respiratory viral infections is relevant.

Vitamin D Provision in High-Yield Dairy Cows During the Winter Housing Period

2014 ◽  
Vol 1 (1) ◽  
pp. 42-46
Author(s):  
L. Yuskiv ◽  
V. Vlizlo
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase Level ◽  
Mineral Metabolism ◽  
Physiological State ◽  
Blood Parameters ◽  
Postnatal Period ◽  
High Yield ◽  
Oral Supplementation ◽  
Calcium Phosphorus ◽  
Vitamin D 3

Aim. To investigate the vitamin D status in highly productive cows during winter housing period and effect of cholecalciferol by various ways of vitamin D 3 injection to cows in last days of gestation and after calving. Methods. Enzyme-linked immunoassay, spectrophotometry. Results. It has been stated that intramuscular injection of cholecalciferol into cows caused increase of the vitamin D 3 active metabolite – 25-OHD 3 , calcium, phosphorus and magnesium levels together with decrease of alkaline phosphatase level in pre- and post-natal periods. Oral supplementation makes little infl uence on the studied blood parameters of cows. Conclusions. Extrabuccal administration and oral supplementation of cholecalciferol in winter housing period to high-yield cows in the last days of gestation and after calving is accompanied by increased levels of its metabolites and their effect on mineral metabolism in the postnatal period. The nature of these changes depends on the mode of vitamin D administration and the physiological state of the cows.

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