Clinical and socio-demographic profile of treatment on osteoarthritis patients in Tirupathi, Andhra Pradesh, India

Background: Osteoarthritis is a chronic degenerative joint disease and it is slowly progressive with signs and symptoms being pain. It is a common cause of disability affecting 60-70% of the population in the age of 60 years. It usually affects the hand, large weight bearing joints, often the knee and the hip.Methods: A prospective study was carried out in S.V Ayurvedic Medical College and Hospital. Collected the data of Socio-demographic and risk factors (age, diet, history, marital status, religion, occupation etc.) during the treatment of osteoarthritis among the patients in hospital.Results: The data reveals that majority of the patients belongs to the age group of 51-60 (43.33%) and 41-50 years (33.33%) followed by 61-70years (16.66%), 31-40 years (6.66%), and 70 % of females, 30% patients were Males in present study. 90% were married 10% were widows. 63.33% of Hindu, 23.33 % were Muslims and only 13.33% were Christians. 40%, of labour, 33.33% Businessmen, 13.33% Servicemen and 13.33% House wives. 53.33% rural, 46.66% urban area. 50% were belonging to middle class while 23.33% were very poor status, 16.66% Rich only 10 % patients were from upper middle class families. 43.33% were Primary level education, 36.66% were illiterates, 10% up to Graduation, 6.66% Post-Graduation and 3.33% up to Matriculation. 63.33% mixed diet, 36.66% vegetarian.Conclusions: Present study reveals that, incidence of osteoarthritis was very high especially in elder female, married, Hindu, labour, rural area, middle class with very poor, primary education, mixed diet (vegetarian with non-vegetarian) patients.

Download Full-text

Osteotomy for Correction of Premature Growth Plate Closure in 24 Dogs

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1633134 ◽

1994 ◽

Vol 07 (03) ◽

pp. 129-135 ◽

Cited By ~ 8

Author(s):

C.W. Miller ◽

P.W. Morgan

Keyword(s):

Corrective Osteotomy ◽

Functional Results ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Angular Deformity ◽

Dynamic Correction ◽

Age At Surgery ◽

Limb Deformities ◽

The Mean ◽

A Prospective Study

SummaryTwenty-four dogs (27 limbs) were evaluated after surgery for correction of forelimb angular limb deformities. Partial ulnar ostectomies or definitive corrective osteotomies were performed depending upon the age of the dog. According to owner assessment nine of fourteen limbs were considered functionally good, or excellent, after partial ulnar ostectomies. Younger dogs appeared to have better functional results after dynamic correction with the mean age at surgery of dogs with good to excellent results being 6.5 months contrasted to the mean age at surgery of dogs with fair to poor results being 9.75 months. Ten of fourteen limbs were considered functionally good or excellent after definitive corrective osteotomy. One dog had definitive osteotomy after partial ulnar ostectomy in order to further correct a residual angular deformity. However, 58% of the limbs with radiographic follow-up had signs of degenerative joint disease (DJD). There were not significant differences between neither degree of angulation remaining after surgery and the functional result nor the degree of angulation remaining after surgery and the development of DJD. A prospective study is warranted to more objectively assess the efficacy of surgical correction of angular limb deformities in dogs.Twenty-four dogs were evaluated after surgery for correction of forelimb angular limb deformities. The results are described.

Download Full-text

Incidence of writing double NSAIDs in a single prescription for osteoarthritis.

The Professional Medical Journal ◽

10.29309/tpmj/2021.28.05.4872 ◽

2021 ◽

Vol 28 (05) ◽

pp. 702-706

Author(s):

Niaz Hussain Keerio ◽

Nasrullah Aamir ◽

Nuresh Kumar ◽

Masood Ahmad Qureshi ◽

Hassan Amir us Saqlain ◽

...

Keyword(s):

Elderly Population ◽

Cross Sectional Study ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Medical College ◽

Bleeding Ulcers ◽

Study Setting

Objective: To determine how frequent NSAIDs are used for osteoarthritic patients because OA is common old age patients and NSAIDs can cause divesting complications on their health. In our study we tried to identify the main reasons and suggest a best possible solution. Study Design: Community Based Cross-sectional study. Setting: Mohammad Medical College and Hospital Mirpurkhas Pakistan. Period: June 2018 to August 2018. Material & Methods: In this study, we included more than 300 prescriptions written for Osteoarthritis, a degenerative joint disease. Prescriptions collected from hospital pharmacy (80%) and from other pharmacies (20%). Data was collected on preformed proforma and was analyzed in SPSS version 25. Results: Osteoarthritis mainly affects elderly population. NSAIDs are used for pain relief but can cause acute renal failure and GIT bleeding ulcers. In our study 69% patients were prescribed double NSAIDs. Traditional NSAIDs were used 95% of the time and only 5% percent of the time selective cox 2 were used. Along with these NSAIDS only 20% patient were given prophylactically gastroprotective agents like PPI and other medications. Conclusion: Prescription osteoarthritis include multiple NSAID without any protocol and over dosage was observed commonly.

Download Full-text

Andrographis paniculata Extract Relieves Pain and Inflammation in Monosodium Iodoacetate-Induced Osteoarthritis and Acetic Acid-Induced Writhing in Animal Models

Processes ◽

10.3390/pr8070873 ◽

2020 ◽

Vol 8 (7) ◽

pp. 873

Author(s):

Donghun Lee ◽

Chae Yun Baek ◽

Ji Hong Hwang ◽

Mi-Yeon Kim

Keyword(s):

Acetic Acid ◽

Weight Bearing ◽

Cartilage Damage ◽

Degenerative Joint Disease ◽

Andrographis Paniculata ◽

Joint Disease ◽

Tnf Α ◽

Monosodium Iodoacetate ◽

History Of

Osteoarthritis (OA), being the most prominent degenerative joint disease is affecting millions of elderly people worldwide. Although Andrographis paniculata is an ethnic medicine with a long history of being used as analgesic agent, no study using a monosodium iodoacetate (MIA) model has investigated its potential activities against OA. In this study, experimental OA was induced in rats with a knee injection of MIA, which represents the pathological characteristics of OA in humans. A. paniculata extract (APE) substantially reversed the loss of hind limb weight-bearing and the cartilage damage resulted from the OA induction in rats. Additionally, the levels of serum pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α as well as the concentration of matrix metalloproteinases, including MMP-1, MMP-3, MMP-8, and MMP-13 were decreased by APE administration. Acetic acid-induced writhing responses in mice which quantitatively measure pain were significantly reduced by APE. In vitro, APE inhibited the generation of NO and downregulated the expression of IL-1β, IL-6, COX-2, and iNOS in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The above results suggest the potential use APE as a therapeutic agent against OA.

Download Full-text

Efficacy of intraarticular steroid injection in knee osteoarthritis using knee society score and visual analog score

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20190795 ◽

2019 ◽

Vol 5 (2) ◽

pp. 299

Author(s):

Shriram Sampath ◽

J. K. Giriraj Harshavardhan

Keyword(s):

Knee Society Score ◽

Steroid Injection ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Post Injection ◽

Osteoarthritis Of Knee ◽

Osteoarthritis Knee ◽

The Mean ◽

A Prospective Study

Background: Osteoarthritis of knee is a chronic degenerative joint disease which leads to pain, swelling, stiffness and decreased quality of life. The purpose of this study was to assess the effect of intra-articular steroid injection for osteoarthritis knee by using knee society score (KSS) and visual analog scale (VAS).Methods: A prospective study of 38 patients (44 knees) diagnosed with osteoarthritis of knee were given 80mg of intra-articular methylprednisolone injection. The outcome was assessed using KSS and VAS before the injection and 3 months post injection.Results: The mean VAS improved 3 months post injection whereas there was no improvement in the mean KSS. The scores of VAS 3 months post injection were statistically significant whereas the KSS scores were statistically insignificant compared with the pre injection values.Conclusions: Intra-articular steroid injection for osteoarthritis of knee produces significant pain relief for most patients even in severe cases but this not translate to better functional outcomes.

Download Full-text

Rate of Development of Hallucal Interphalangeal Degenerative Joint Disease After First Metatarsophalangeal Joint Arthrodesis

Foot & Ankle Orthopaedics ◽

10.1177/2473011418s00259 ◽

2018 ◽

Vol 3 (3) ◽

pp. 2473011418S0025

Author(s):

Christopher Hyer ◽

Nisha Shah ◽

Marcus Richardson

Keyword(s):

Surgical Procedures ◽

Weight Bearing ◽

Subsequent Development ◽

Metatarsophalangeal Joint ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Inclusion Criteria ◽

First Metatarsophalangeal Joint ◽

Post Surgery

Category: Midfoot/Forefoot Introduction/Purpose: The first metatarsophalangeal joint (MTPJ) is an integral part of the foot during the gait cycle. Arthrodesis of this joint is gold standard, especially in patients with rheumatoid arthritis. The development of IPJ arthritis after an arthrodesis of the MTPJ has been established in the literature; however, the significance of this has not. The purpose of this study was to determine the rate of IPJ degenerative joint disease (DJD) in patients who underwent first MTPJ fusion by evaluating the degree of IPJ arthritic degeneration through 2 years post-surgery and to compare radiographic parameters over time among patients with and without DJD in order to determine whether non-fusion (less than 50% fusion) or the hallucal position was associated with the subsequent development of DJD. Methods: Retrospective clinical and radiographic review of patients who had undergone a first metatarsophalangeal joint arthrodesis was performed. Inclusion criteria were adult patients 18 and older who underwent first MPJ arthrodesis between January 2012 and January 2015 with internal fixation of any type. Patients were excluded if they were under 18 years of age, underwent concomitant procedures that would affect postoperative weight bearing course, suspected or diagnosed with osteomyelitis of the foot, had prior surgical procedures of the MTPJ or IPJ joints, or concomitant hallucal IPJ arthritis or preexisting IPJ fusion. Postoperative radiographs were obtained immediately following surgery and at approximately 6 weeks, 3 months, 6 months, 12 months, and 24 months. Results: Ultimately, 103 patients met all the inclusion criteria and none of the exclusion criteria. Four of the 103 patients (3.9%) had undergone bilateral procedures, thus providing 107 surgical procedures. Demographic characteristics can be found on Table 1. The hallux abductus (HA) angle and hallux abductus interphalangeus (HAI) angle were measured preoperatively and postoperatively (Fig. 1-2). The average postoperative follow-up radiograph was taken at 22.9 weeks. The HA angle average preoperatively was 31.4 degrees, which decreased to 11.8 degrees postoperatively. The HAI angle average preoperatively measured 10.8 degrees and increased to 11.9 degrees postoperatively. No patients had symptomatic hallux IPJ postoperatively within the study period. However, 7 patients needed hardware removal and second surgery at an average of 36.3 weeks due to hardware pain and nonunion. Conclusion: Arthrodesis is often the treatment of choice for first MTPJ pathology, which is commonly arthritis or hallux valgus. We found the incidence of IPJ arthritis to be lower than the reported literature and unchanged over the postoperative period. Furthermore, no patients reported symptomatic hallux IPJ within the study period. Also, we found the HA angle had decreased in the patients postoperatively; however, there was a mixed trend with HAI increasing after first MTPJ fusion. The significance of this trend is unclear, but the increase of the HAI could possibly cause further pain and deterioration of the joint in the future.

Download Full-text

A clinical study on the surgical management of intestinal obstruction

International Surgery Journal ◽

10.18203/2349-2902.isj20195961 ◽

2019 ◽

Vol 7 (1) ◽

pp. 150

Author(s):

Jyotsna Choudary Gogineni ◽

Trupti Tonape ◽

V. S. Athavale ◽

Sree Kumar ◽

Shweta Achuthan Kutty ◽

...

Keyword(s):

Intestinal Obstruction ◽

Surgical Management ◽

Signs And Symptoms ◽

Abdominal Distension ◽

Abdominal Adhesions ◽

Medical College ◽

Common Causes ◽

General Surgeons ◽

The Common ◽

A Prospective Study

Background: Intestinal obstruction remains one of the common emergencies encountered by general surgeons all over the world. Acute intestinal obstruction occurs when there is a disruption in the frontward flow of intestinal contents.Methods: This study is a prospective study conducted in Dr. D Y Patil Medical College and Hospital, Pimpri, Pune. Patients coming to the hospital with signs and symptoms suggestive of intestinal obstruction and willing for surgical management in our hospital were included after taking written and informed consent.Results: In our study, pain abdomen and abdominal distension was the most common presenting complaints in 90% and 92% of the patients respectively. On palpation, 96% of the patients had abdominal tenderness, 72% of the patients had guarding and 12% of the patients had rigidity. On auscultation, all patients had some abnormality with regard to bowel sounds. It has been noted that intestinal strictures and abdominal adhesions were amongst the most common causes of intestinal obstruction in our study.Conclusions: Prompt clinical assessment aided by radiological imaging is of crucial importance in reaching the diagnosis of intestinal obstruction. Decision regarding surgical intervention is taken based on the initial presentation of the patient, and his/her response to first line conservative management and fluid resuscitation

Download Full-text

Sodium Monoiodoacetate Dose-Dependent Changes in Matrix Metalloproteinases and Inflammatory Components as Prognostic Factors for the Progression of Osteoarthritis

Frontiers in Pharmacology ◽

10.3389/fphar.2021.643605 ◽

2021 ◽

Vol 12 ◽

Author(s):

Marta Bryk ◽

Jakub Chwastek ◽

Jakub Mlost ◽

Magdalena Kostrzewa ◽

Katarzyna Starowicz

Keyword(s):

Matrix Metalloproteinases ◽

Synovial Membrane ◽

Weight Bearing ◽

Joint Inflammation ◽

Cartilage Degeneration ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Inflammatory Factors ◽

Behavioral Studies ◽

Bone Degradation

Osteoarthritis (OA) is a degenerative joint disease that primarily affects people over 65 years old. During OA progression irreversible cartilage, synovial membrane and subchondral bone degradation is observed, which results in the development of difficult-to-treat chronic pain. One of the most important factors in OA progression is joint inflammation. Both proinflammatory and anti-inflammatory factors, as well as extracellular matrix degradation enzymes (matrix metalloproteinases (MMPs), play an important role in disease development. One of the most widely used animal OA models involves an intra-articular injection of sodium monoiodoacetate (MIA) directly into the joint capsule, which results in glycolysis inhibition in chondrocytes and cartilage degeneration. This model mimics the degenerative changes observed in OA patients. However, the dose of MIA varies in the literature, ranging from 0.5 to 4.8 mg. The aim of our study was to characterize grading changes after injection of 1, 2 or 3 mg of MIA at the behavioral and molecular levels over a 28-day period. In the behavioral studies, MIA injection at all doses resulted in a gradual increase in tactile allodynia and resulted in abnormal weight bearing during free walking sequences. At several days post-OA induction, cartilage, synovial membrane and synovial fluid samples were collected, and qPCR and Western blot analyses were performed. We observed significant dose- and time-dependent changes in both gene expression and protein secretion levels. Inflammatory factors (CCL2, CXCL1, IL-1β, COMP) increased at the beginning of the experiment, indicating a transient inflammatory state connected to the MIA injection and, in more severe OA, also in the advanced stages of the disease. Overall, the results in the 1 mg MIA group were not consistently clear, indicating that the lowest tested dose may not be sufficient to induce long-lasting OA-like changes at the molecular level. In the 2 mg MIA group, significant alterations in the measured factors were observed. In the 3 mg MIA group, MMP-2, MMP-3, MMP-9, and MMP-13 levels showed very strong upregulation, which may cause overly strong reactions in animals. Therefore, a dose of 2 mg appears optimal, as it induces significant but not excessive OA-like changes in a rat model.

Download Full-text

A report of the Maquet procedure for the management of cranial cruciate ligament rupture in a dog - a case report

Semina Ciências Agrárias ◽

10.5433/1679-0359.2017v38n1p321 ◽

2017 ◽

Vol 38 (1) ◽

pp. 321

Author(s):

Danilo Roberto Custódio Marques ◽

José Fernando Ibañez ◽

Juliana Fonseca Monteiro ◽

Ana Carolina Valentim Hespanha ◽

Mayara Eggert ◽

...

Keyword(s):

Cruciate Ligament ◽

Weight Bearing ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Cranial Cruciate Ligament ◽

Early Weight Bearing ◽

Ligament Rupture ◽

Cruciate Ligament Rupture ◽

Increased Risk ◽

Cranial Cruciate Ligament Rupture

Cranial cruciate ligament rupture is the major cause of lameness and degenerative joint disease in the canine stifle. The cause of this disease is multifactorial, especially involving degenerative and inflammatory changes. Many techniques have been described for the management of this condition, and current recommendations include the use of corrective osteotomies, most recently using the Maquet (or modified Maquet) procedure. This technique is fundamentally similar to the classical tibial tuberosity advancement (TTA), but without the use of the bone plate. The main advantages of using this technique are a shorter operative time and less use of implants. The main complication of this technique is an increased risk of tibial crest fracture. This report describes the Maquet technique for the treatment of a three-year-old male West White Terrier dog with rupture of the cranial cruciate ligament. Cruciate ligament rupture was diagnosed by a positive cranial tibial drawer test. Mediolateral stifle radiography performed under anesthesia with the stifle in 135° of extension demonstrated a tibial plateau angle of 22°. A cage of six millimeters was necessary to allow advancement. The Maquet technique produced excellent post-operative results, including early weight-bearing and neutralization of the cranial tibial drawer. The consolidation time of the osteotomy was 63 days.

Download Full-text

The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine

BioMed Research International ◽

10.1155/2018/7402947 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 14

Author(s):

Maria De Santis ◽

Berardo Di Matteo ◽

Emanuele Chisari ◽

Gilberto Cincinelli ◽

Peter Angele ◽

...

Keyword(s):

Total Joint Replacement ◽

Platelet Rich Plasma ◽

Weight Bearing ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Loss Of Function ◽

Biological Drugs ◽

Therapeutic Implications ◽

Pubmed Database

Introduction. Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, subchondral damage, and bone remodelling, affecting most commonly weight-bearing joints, such as the knee and hip. The loss of cartilage leads to joint space narrowing, pain, and loss of function which could ultimately require total joint replacement. The Wnt/β catenin pathway is involved in the pathophysiology of OA and has been proposed as a therapeutic target. Endogenous and pharmacological inhibitors of this pathway were recently investigated within innovative therapies including the use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs). Methods. A review of the literature was performed on the PubMed database based on the following inclusion criteria: article written in English language in the last 20 years and dealing with (1) the role of Wnt-β catenin pathway in the pathogenesis of osteoarthritis and (2) pharmacologic or biologic strategies modulating the Wnt-β catenin pathway in the OA setting. Results. Evidences support that Wnt signalling pathway is likely linked to OA progression and severity. Its inhibition through natural antagonists and new synthetic or biological drugs shares the potential to improve the clinical condition of the patients by affecting the pathological activity of Wnt/β-catenin signalling. Conclusions. While further research is needed to better understand the mechanisms regulating the molecular interaction between OA regenerative therapies and Wnt, it seems that biologic therapies for OA exert modulation on Wnt/β catenin pathway that might be relevant in achieving the beneficial clinical effect of those therapeutic strategies.

Download Full-text

A comparative study to assess the safety and efficacy of etoricoxib versus aceclofenac in osteoarthritis

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20183939 ◽

2018 ◽

Vol 7 (10) ◽

pp. 2010

Author(s):

Harsimrat S. Waraich ◽

Vikas Kumar ◽

Ashok Goel ◽

Jatinder Singh

Keyword(s):

Clinical Efficacy ◽

Safety Profile ◽

Signs And Symptoms ◽

Severity Index ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Open Label ◽

Intention To Treat ◽

Safety Parameters ◽

The Government

Background: Osteoarthritis (OA) is most common form of arthritis; also referred as degenerative joint disease or “wear and tear” arthritis. Cyclooxygenase-2 (COX-2) inhibitors are effective for pain and inflammation in OA and gained importance over conventional non-steroidal anti-inflammatory agents (NSAIDs), as causes significantly less toxicity, particularly, in gastrointestinal tract. The objective of the present research was to study the short-term comparative clinical efficacy of aceclofenac and etoricoxib in patients with osteoarthritis and to compare the safety profile of the two drugs i.e. aceclofenac and etoricoxib.Methods: The present study was a prospective, open label, parallel, intention to treat 80 patients out of 102 screened for osteoarthritis in the Department of Orthopaedics, Guru Nanak Dev Hospital attached to the Government Medical College, Amritsar. Patients were randomly divided in two groups with 40 patients each. Group A patients received Tab etoricoxib 60mg once daily and Group B patients received Tab. Aceclofenac 100mg twice daily. Patients were followed up after three weeks and at six weeks for clinical efficacy and safety.Results: Both the groups found to have significant improvement in signs and symptoms of osteoarthritis. However, aceclofenac was superior to etoricoxib in terms of change in visual analogue scale score, osteoarthritic severity index, patients’ and physicians’ global assessment while, etoricoxib was superior in terms of WOMAC osteoarthritic index and safety parameters in terms of ADR.Conclusions: Etoricoxib was better than conventional NSAIDs for the symptomatic management of osteoarthritis in terms of safety profile and clinical efficacy.

Download Full-text