scholarly journals Primary tubal choriocarcinoma

2018 ◽  
Vol 7 (6) ◽  
pp. 2509
Author(s):  
Neetha Nandan ◽  
Kishan Prasad ◽  
Mubeena Begum ◽  
Supriya Rai
Keyword(s):  
Adjuvant Chemotherapy ◽  
Ectopic Pregnancy ◽  
Malignant Transformation ◽  
Histopathological Examination ◽  
Gestational Trophoblastic Disease ◽  
Common Site ◽  
Chorionic Villi ◽  
Trophoblastic Disease ◽  
Aggressive Form ◽  
Β Hcg

Choriocarcinoma is extremely aggressive form of gestational trophoblastic disease. It occurs due to neoplastic changes in the chorionic villi. The most common site of origin is uterus but rarely can occur in tube, cervix or ovary. Tubal choriocarcinoma may develop either by malignant transformation of a tubal pregnancy or can arise denovo without an ectopic pregnancy. The reported incidence of tubal choriocarcinoma is approximately 1.5/1,000,000 births. Here, we report a case in which salphingectomy was done thinking it was an acute ectopic pregnancy, but histopathological examination showed tubal choriocarcinoma. This tubal choriocarcinoma occurred denovo and was not secondary to an ectopic pregnancy. Patient did not need adjuvant chemotherapy as it was detected early and is being followed up by β-hcg monitoring.

Contrast-Enhanced Dynamic MR Imaging of Postmolar Gestational Trophoblastic Disease

1995 ◽  
Vol 36 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Y. Yamashita ◽  
M. Torashima ◽  
M. Takahashi ◽  
H. Mizutani ◽  
K. Miyazaki ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Spin Echo ◽  
Gestational Trophoblastic Disease ◽  
Initial Examination ◽  
Trophoblastic Disease ◽  
Dynamic Mr Imaging ◽  
Contrast Enhanced ◽  
Β Hcg ◽  
Conventional Spin Echo ◽  
Dynamic Mr

Conventional spin-echo (SE) and contrast-enhanced dynamic MR imaging were performed on a 1.5 T superconductive unit for evaluation of myometrial lesions in postmolar gestational trophoblastic disease (GTD) in 10 women. MR imaging was done at the time of the initial examination (n=10), during (n=6), and after repeated courses of chemotherapy (n=10). The T2-weighted SE image revealed an enlarged uterus (n=7), disappearance of zonal anatomy (n=6), and heterogeneous signal intensities (n=8) with prominent flow voids (n=7). However, these abnormalities remained after repeated courses of chemotherapy, when the S-β-HCG level returned to the normal range. Myometrial lesions characteristically had marked enhancement with areas of unenhancement on dynamic MR images in patients with highly elevated S-β-HCG. Areas of contrast enhancement correlated with changes in S-β-HCG level. The enhancement was reduced with decrease in S-β-HCG level after repeated courses of chemotherapy. Six of 8 masses seen on T2-weighted images proved to be active trophoblastic lesions and 2 masses proved to be hematoma or necrosis. In 2 patients, abnormal myometrial lesions were detected only on contrast-enhanced dynamic MR imaging. These preliminary data indicate that contrast-enhanced dynamic MR imaging more clearly demonstrates myometrial involvement of postmolar GTD than conventional SE imaging.

scholarly journals Gestational Trophoblastic Disease Presents as an Ectopic Tubal Pregnancy, a Rare Entity

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Haneen Al-Maghrabi ◽  
Daniyah Saleh ◽  
Abdelrazak Meliti
Keyword(s):  
Gold Standard ◽  
Histopathological Examination ◽  
Lower Abdominal Pain ◽  
Gestational Trophoblastic Disease ◽  
Low Grade ◽  
Molar Pregnancy ◽  
Fallopian Tubes ◽  
Rare Entity ◽  
Trophoblastic Disease ◽  
Laboratory Investigations

Ectopic molar pregnancy is an uncommon event in clinical practice. In this paper, we report a case of ectopic complete molar pregnancy in a 39-year-old lady who presented to the emergency department with lower abdominal pain, abdominal distention, and low-grade fever. Based on radiological and laboratory investigations, the differential diagnosis included ruptured ectopic pregnancy versus metastatic diseases. Ectopic hydatidiform molar pregnancies can occur at any extrauterine pelvic sites, yet more frequently affecting fallopian tubes. The histopathological examination remains the gold standard for the diagnosis.

Pregnancy-Related Emergencies

2019 ◽  
Author(s):  
Amy Hideko Kaji
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Hyperemesis Gravidarum ◽  
Gestational Trophoblastic Disease ◽  
Treatment Modalities ◽  
Free Fluid ◽  
Molar Pregnancy ◽  
Hypertensive Disorders Of Pregnancy ◽  
Trophoblastic Disease ◽  
Hypertensive Disorders

This review provides an overview of spontaneous abortion, ectopic pregnancy, gestational trophoblastic disease or molar pregnancy, hyperemesis gravidarum, placental abruption, placental previa, hypertensive disorders of pregnancy, and amniotic fluid embolism. Assessment and stabilization, diagnosis, treatment and disposition, and outcomes are discussed. Tables include classifications of abortion or miscarriage, differential diagnosis of patients presenting with vaginal bleeding during pregnancy, risk factors for ectopic pregnancy, treatment modalities for hyperemesis gravidarum, classification of hypertensive disorders of pregnancy, and risk factors for preeclampsia and eclampsia. Figures show ectopic pregnancy on a sonogram, free fluid in hepatorenal fossa on a focused abdominal sonogram in trauma, double decidual sign in a normal intrauterine pregnancy, pseudogestational sac in an ectopic pregnancy, and “snowstorm” appearance of molar pregnancy on a sonogram. This review 5 figures, 13 tables, and 68 references. Keywords: abortion, ectopic, gestational trophoblastic disease, abruption, previa, ecclampsia

Malignant disease in pregnancy

2020 ◽  
pp. 2696-2700
Author(s):  
Robin A.F. Crawford
Keyword(s):  
Malignant Transformation ◽  
Uterine Cervix ◽  
Malignant Disease ◽  
Pituitary Tumour ◽  
Gestational Trophoblastic Disease ◽  
Fetal Circulation ◽  
Live Births ◽  
Trophoblastic Disease ◽  
Cancer In Pregnancy ◽  
In Pregnancy

Cancer in pregnancy is rare, affecting less than 1 in 1,000 live births. It may be specific to pregnancy (gestational trophoblastic disease) or incidental to it, the less infrequent conditions being melanoma, lymphoma, and cervical malignancy. Tumours of the uterine cervix, ovary, breast, or thyroid can metastasize to the placenta, but not to the fetus. Gestational trophoblastic disease arises from fetal chorion and is a malignant transformation of the placenta. Melanoma and haematological tumours, which also can invade the placenta, may cross into the fetal circulation. Pregnancy may cause enlargement of a pituitary tumour and a previously silent tumour may present with symptoms in pregnancy. Rare cases of colonic and neurological cancers developing in pregnancy have also been reported.

scholarly journals Study of clinical significance and histopathological correlation of serum β- hCG level

2017 ◽  
Vol 5 (6) ◽  
pp. 2310
Author(s):  
Faruq Ibrahimbhai Mulla ◽  
Kailash Sukhram Inaniya
Keyword(s):  
Germ Cell ◽  
Tumor Marker ◽  
Spontaneous Abortion ◽  
Germ Cell Tumors ◽  
Gestational Trophoblastic Disease ◽  
P Value ◽  
Trophoblastic Disease ◽  
Ectopic Gestation ◽  
Β Hcg ◽  
Malignant Germ Cell Tumors

Background: β-hCG is a marker useful in diagnosis of gestational trophoblastic disease (GTD), ectopic gestation (EG), spontaneous abortion (SA) and malignant germ cell tumors (MGCT) and it is helpful to clinician as an excellent tumor marker. It is useful to monitor treatment whether tumor is responding to treatment or the disease is progressing.Methods: β-hCG is a marker useful in diagnosis of gestational trophoblastic disease (GTD), ectopic gestation (EG), spontaneous abortion (SA) and malignant germ cell tumors (MGCT) and it is helpful to clinician as an excellent tumor marker. It is useful to monitor treatment whether tumor is responding to treatment or the disease is progressing.Results: p value is highly significant in Gestational Trophoblastic Diseases, EG and SA, as p value is < 0.005 in all these three categories. But in case of MGCT it is 0.452 which is not significant because study group was very small and one case who developed recurrence affected the value significantly. These findings suggest that β-hCG has definitive prognostic role (p value<0.005) in GTD, EG and SA.Conclusions: ELISA is rapid, sensitive, reliable and cost effective test for measurement of β-hCG. Pre-and post-therapeutic β-hCG serum levels seem to be useful in the therapy monitoring of trophoblastic gynaecological conditions i.e. GTD, EG and SA.

scholarly journals Gestational choriocarcinoma with hemorrhagic pleural effusion

2010 ◽  
Vol 18 (3) ◽  
pp. 86-87
Author(s):  
Biljana Lazovic ◽  
Vera Milenkovic
Keyword(s):  
Pleural Effusion ◽  
Blood Vessels ◽  
Gestational Trophoblastic Disease ◽  
Common Site ◽  
Left Half ◽  
Trophoblastic Disease ◽  
Gestational Choriocarcinoma ◽  
Hemorrhagic Pleural Effusion ◽  
Timely Treatment ◽  
Trophoblastic Tissue

Gestational trophoblastic disease (GTD) consists of a spectrum of disorders that are characterized by an abnormal proliferation of trophoblastic tissue. By virtue of their high vascularity and affinity of trophoblast for blood vessels, metastases often occur early and the most common site of such metastases is the lung. We described a case of a 34-year-old patient with pain in the left half of the chest, occasional, brief hemoptysis, and amenorrhea occurring in the period of 3 months. This presentation highlights the importance of analysis of HCG in the pleural puncture, for quick diagnosis and timely treatment.

Placental site trophoblastic tumour: the rarest subtype of gestational trophoblastic disease

2020 ◽  
Vol 13 (10) ◽  
pp. e235756
Author(s):  
Mariana M Chaves ◽  
Tiago Maia ◽  
Teresa Margarida Cunha ◽  
Vera Furtado Veiga
Keyword(s):  
Late Onset ◽  
Transvaginal Ultrasound ◽  
Elevated Serum ◽  
Metastatic Potential ◽  
Final Diagnosis ◽  
Gestational Trophoblastic Disease ◽  
Endometrial Biopsy ◽  
Trophoblastic Disease ◽  
Placental Site ◽  
Β Hcg

Placental site trophoblastic tumour (PSTT) is a very rare form of gestational trophoblastic disease that grows slowly, secretes low levels of beta-subunit of human chorionic gonadotropin (β-hCG), presents late-onset metastatic potential and is resistant to several chemotherapy regimens. Here, we report a case of PSTT in a 36-year-old woman who presented with amenorrhea and persistently elevated serum level of β-hCG after a miscarriage. Transvaginal ultrasound revealed a hypovascular ill-defined solid lesion of the uterine fundus and MRI showed a tumour infiltrating the external myometrium with discrete early enhancement and signal restriction on diffusion-weighted imaging. PSTT was suspected, and after endometrial biopsy by hysteroscopy and posterior hysterectomy, microscopic examination allowed the final diagnosis. The level of β-hCG dropped significantly in about a month after surgical treatment. Due to the rarity of PSTT, reporting new cases is crucial to improve the diagnosis and managing of these patients.

Gestational Trophoblastic Disease

2013 ◽  
Vol 3 (2) ◽  
pp. 4-11
Author(s):  
JP Deep ◽  
LB Sedhai ◽  
J Napit ◽  
J Pariyar
Keyword(s):  
Placental Tissue ◽  
Gestational Trophoblastic Disease ◽  
Diagnosis And Treatment ◽  
Gestational Trophoblastic Neoplasia ◽  
Medical College ◽  
Trophoblastic Disease ◽  
Β Hcg ◽  
Invasive Mole

Gestational trophoblastic disease (GTD) is a group of tumors that arise from placental tissue and secrete β-hCG. GTD is a combination of benign or invasive mole and malignant known as Gestational Trophoblastic Neoplasia (GTN). Prevalence, diagnosis and treatment of GTD have drastically changed in recent years. DOI: http://dx.doi.org/10.3126/jcmc.v3i2.8434 Journal of Chitwan Medical College Vol.3(2) 2013 4-11

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