scholarly journals Calcifying fibrous tumour: a rare case report of an exceptional lesion localized in retroperitoneum, mesentery and pelvis

2020 ◽  
Vol 8 (5) ◽  
pp. 1924
Author(s):  
R. N. Hathila ◽  
Pinal C. Shah ◽  
Archana V. Patel ◽  
Sheetal P. Sheth
Keyword(s):  
Inflammatory Cell ◽  
Iliac Fossa ◽  
Abdominal Mass ◽  
Excisional Biopsy ◽  
Dystrophic Calcification ◽  
Benign Lesions ◽  
Spindle Cells ◽  
Rare Case Report ◽  
Children And Young Adults ◽  
Mononuclear Inflammatory Cell

Calcifying fibrous tumours are rare benign lesions affecting mostly children and young adults. A 17-year-old female presented with abdominal pain and abdominal distention. Physical examination revealed intra-abdominal mass occupying retro peritoneum and right iliac fossa. Excisional biopsy from peritoneum and mesentery were performed. Histopathologically, it was composed of hypocellular hyalinised collagenized stroma, spindle cells, psammomatous and dystrophic calcification and mononuclear inflammatory cell infiltration. Authors are here in reporting a case of calcifying fibrous tumour and discussing its clinical and morphological features with regard to the literature.

scholarly journals Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984735 ◽  
Author(s):  
Catherine F Roy ◽  
Simon F Roy ◽  
Feras M Ghazawi ◽  
Erica Patocskai ◽  
Annie Bélisle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Rare Complication ◽  
Excisional Biopsy ◽  
Necrosis Factor Alpha ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

scholarly journals Aggressive Monophasic Sarcomatoid Carcinoma of Small Intestine - A Rare Case Report With Review of Literature

2012 ◽  
Vol 02 (01) ◽  
pp. 45-47
Author(s):  
Shetty K. Padma ◽  
Harish S. Permi ◽  
C.N. Patil ◽  
Michelle Mathias
Keyword(s):  
Small Intestine ◽  
Rare Case ◽  
Spindle Cell ◽  
Correct Diagnosis ◽  
Sarcomatoid Carcinoma ◽  
Intestinal Wall ◽  
Cell Tumor ◽  
Review Of Literature ◽  
Spindle Cells ◽  
Rare Case Report

AbstractSarcomatoid carcinoma occurring in the small intestine is very rare. They can be monophasic or biphasic. We report a rare case of monophasic Sarcomatoid carcinoma of the small intestine in a 60 year old male patient. The tumor was an ulceronodular mass involving the ileum circumferentially. The tumor infiltrated the full thickness of the intestinal wall and the serosa of an adjacent loop of ileum. Microscopically, the tumor was composed of sheets of malignant spindle cells. The carcinomatous nature of the tumor was evident only after Immunohistochemistry. The diagnosis of sarcomatoid carcinoma should be considered in the differential diagnosis of malignant spindle cell tumor of small intestine and immunohistochemical stains are required for the correct diagnosis.

scholarly journals Diffuse neurofibroma - an uncommon cause of alopecia

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 166-169 ◽  
Author(s):  
Vasco Coelho Macias ◽  
Margarida Rafael ◽  
Cândida Fernandes ◽  
Joaninha Costa Rosa
Keyword(s):  
Young Adults ◽  
Subcutaneous Tissue ◽  
Neurofibromatosis Type ◽  
Benign Tumors ◽  
Nerve Sheath ◽  
Spindle Cells ◽  
Children And Young Adults ◽  
Low Incidence ◽  
Infiltrative Tumor

Although infrequent, alopecia can be caused by benign cutaneous tumours. Neurofibromas are common benign tumors that originate in the peripheral nerve sheath. Diffuse neurofibroma is a rare variant of neurofibroma that is thought to occur mainly in the head and neck of children and young adults. Histology generally shows an infiltrative tumor, composed of spindle cells in the dermis and subcutaneous tissue. Despite being rare, malignant transformation has been reported. The association between diffuse neurofibromas and neurofibromatosis type 1 still remains to be determined since some authors question the low incidence usually described. We report the case of a 42-year-old man who had a diffuse neurofibroma on the scalp presenting as alopecic plaques.

scholarly journals Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

2022 ◽  
Vol 11 ◽  
Author(s):  
Jiayi Liu ◽  
Zhijie Bai ◽  
Shuaiqi Li ◽  
Sheng Zeng ◽  
Chuang Li ◽  
...  
Keyword(s):  
Rare Case ◽  
Plasma Cells ◽  
Therapeutic Approaches ◽  
Inflammatory Pseudotumour ◽  
Alk Rearrangement ◽  
Rare Tumour ◽  
Inflammatory Infiltration ◽  
Factors Associated ◽  
Spindle Cells ◽  
Children And Young Adults

Inflammatory myofibroblastic tumour (IMT), also known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. IMT predominantly affects children and young adults, and the age at presentation ranges from 3 to 89 years. We present a very rare case of recurrent testicular IMT without ALK rearrangement. This case highlights the clinical characteristics and diagnostic factors associated with primary and recurrent foci of this rare tumour, along with key therapeutic approaches.

scholarly journals Primary Tuberculous Lymphadenitis: a Rare Case Report

2018 ◽  
Vol 22 (2) ◽  
pp. 106-110
Author(s):  
Mustafa Mert Açikgöz ◽  
Ayşem Yurtseven ◽  
Gülsüm Ak
Keyword(s):  
Case Report ◽  
Multidisciplinary Approach ◽  
Maxillofacial Surgery ◽  
Excisional Biopsy ◽  
Oral And Maxillofacial Surgery ◽  
Tuberculous Lymphadenitis ◽  
Rare Case Report ◽  
Long Term Follow Up

SummaryBackground/Aim: Our aim is to describe multidisciplinary approach to primary tuberculous lymphadenitis with a case report.Case Report: A 6-year-old boy was referred to İstanbul University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery with the symptoms of painless extra-oral abscess and lymphadenopathy. The diagnosis of primary tuberculous lymphadenitis was proved by microbiological culture and ultrasound imaging.Conclusions: Combine tuberculosis treatment should be applied and long term follow up is necessary. Excisional biopsy for tissue diagnosis and bacterial examination with culture should be performed for an early diagnosis as a delay in treatment can lead to devastating consequences.

scholarly journals Pathogenicity of severe fever with thrombocytopenia syndrome virus in mice regulated in type I interferon signaling

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Seok-Chan Park ◽  
Jun Young Park ◽  
Jin Young Choi ◽  
Sung-Geun Lee ◽  
Seong Kug Eo ◽  
...  
Keyword(s):  
Inflammatory Cell ◽  
Type I Interferon ◽  
Coagulation Necrosis ◽  
White Pulp ◽  
Type I ◽  
Interferon Signaling ◽  
Viral Shedding ◽  
Mononuclear Inflammatory Cell ◽  
Severe Fever ◽  
Deficient Mice

Abstract Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease, which causes high fever, thrombocytopenia, and death in humans and animals in East Asian countries. The pathogenicity of SFTS virus (SFTSV) remains unclear. We intraperitoneally infected three groups of mice: wild-type (WT), mice treated with blocking anti-type I interferon (IFN)-α receptor antibody (IFNAR Ab), and IFNAR knockout (IFNAR−/−) mice, with four doses of SFTSV (KH1, 5 × 105 to 5 × 102 FAID50). The WT mice survived all SFTSV infective doses. The IFNAR Ab mice died within 7 days post-infection (dpi) with all doses of SFTSV except that the mice were infected with 5 × 102 FAID50 SFTSV. The IFNAR−/− mice died after infection with all doses of SFTSV within four dpi. No SFTSV infection caused hyperthermia in any mice, whereas all the dead mice showed hypothermia and weight loss. In the WT mice, SFTSV RNA was detected in the eyes, oral swabs, urine, and feces at 5 dpi. Similar patterns were observed in the IFNAR Ab and IFNAR−/− mice after 3 dpi, but not in feces. The IFNAR Ab mice showed viral shedding until 7 dpi. The SFTSV RNA loads were higher in organs of the IFNAR−/− mice compared to the other groups. Histopathologically, coagulation necrosis and mononuclear inflammatory cell infiltration in the liver and white pulp atrophy in the spleen were seen as the main lesions in the IFN signaling lacking mice. Immunohistochemically, SFTSV antigens were mainly detected in the marginal zone of the white pulp of the spleen in all groups of mice, but more viral antigens were observed in the spleen of the IFNAR−/− mice. Collectively, the IFN signaling-deficient mice were highly susceptible to SFTSV and more viral burden could be demonstrated in various excreta and organs of the mice when IFN signaling was inhibited.

Vasculitis in MRL/1pr Mice: Model of Cell-Mediated Autoimmunity

1989 ◽  
Vol 17 (1_part_2) ◽  
pp. 122-128 ◽  
Author(s):  
Carolyn F. Moyer ◽  
Carol L. Reinisch
Keyword(s):  
Inflammatory Cell ◽  
Interleukin 1 ◽  
Function Evaluation ◽  
Lymphocyte Function ◽  
Mice Model ◽  
Experimental Conditions ◽  
Accessory Function ◽  
Accessory Cells ◽  
C3h Mice ◽  
Mononuclear Inflammatory Cell

The destruction of vascular smooth muscle cells (VSMC) in autoimmune arteritis is a poorly understood phenomenon. To approach this problem, VSMC cultures were established. The interaction of these cells (from normal or autoimmune mice) with lymphocytes was then evaluated. Specifically, splenocytes from MRL/1pr or C3H mice were co-cultivated with MRL/1pr or C3H VSMCs. Massive mononuclear inflammatory cell clusters enveloped MRL/1pr VSMCs which culminated in the detachment of MRL/1pr VSMCs from the culture plate. In contrast, the interaction of splenocytes from normal or autoimmune mice did not destroy normal VSMCs. Further investigation indicated that MRL/1pr VSMCs spontaneously expressed both Ia–k and Ia–d, as assessed by fluorescence microscopy and flow cytometry, and released interleukin-1-like factors–-characteristics of accessory cells to T-lymphocyte function. Evaluation of VSMCs accessory function in antigen presentation suggests that these cells may present antigen under specific experimental conditions. As a result of these studies, a novel mechanism of autoimmune vasculitis is proposed. Our hypothesis is that defective biological function of VSMCs from autoimmune mice stimulates a mononuclear inflammatory cell response which culminates in VSMC autodestruction.

scholarly journals Left Supraclavicular Spindle Cell Lipoma

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Oladejo Olaleye ◽  
Bertram Fu ◽  
Ram Moorthy ◽  
Charles Lawson ◽  
Myles Black ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Excisional Biopsy ◽  
Neurological Deficits ◽  
Excision Biopsy ◽  
Low Grade ◽  
Spindle Cell Lipoma ◽  
Rare Presentation ◽  
Spindle Cells ◽  
Immuno Histochemistry ◽  
Rare Benign Tumour

Background. Spindle cell lipoma (SCL) is a benign lipomatous tumour, typically occurring in the posterior neck, shoulder or upper back of elderly males. They compose of fat, CD34 positive spindle cells, and ropey collagen on a myxoid matrix. This case highlights a rare presentation of SCL and the need for pre-operative diagnosis.Case Report. A 63-year-old gentleman presented with a pre-existing left supraclavicular mass that had recently increased in size. FNA and CT Scans were performed and results discussed in the mutidisciplinary team meeting. Excisional biopsy was recommended.Radiology. CT neck showed a left supraclavicular mass of fatty density with fine internal septations. A low-grade liposarcoma could not be excluded.Histopathology. FNA was indeterminate. Histology of specimen showed bland spindle cells with no evidence of malignancy. Immuno-histochemistry showed SCL with CD34 positivity and negative staining on CDK4 and p16.Management. Excision biopsy of the mass was performed which was technically difficult as the mass invaginated around the brachial plexus. The patient recovered well post-operatively with no neurological deficits.Conclusion. Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management.

Pathology of End-stage Remodeling in a Family of Cats with Hypertrophic Cardiomyopathy

2005 ◽  
Vol 42 (4) ◽  
pp. 458-467 ◽  
Author(s):  
M. F. Cesta ◽  
C. J. Baty ◽  
B. W. Keene ◽  
I. W. Smoak ◽  
D. E. Malarkey
Keyword(s):  
Heart Failure ◽  
Hypertrophic Cardiomyopathy ◽  
Inflammatory Cell ◽  
Interventricular Septum ◽  
Coronary Vessels ◽  
Left Ventricular ◽  
Coronary Vessel ◽  
End Stage ◽  
Mononuclear Inflammatory Cell ◽  
Fractional Shortening

End-stage hypertrophic cardiomyopathy (ES-HCM), affecting 5-10% of human hypertrophic cardiomyopathy (HCM) patients, is characterized by relative thinning of the ventricular walls and septum with dilation of the ventricular lumen, decreased fractional shortening, and progression to heart failure. C. J. Baty and others recently documented similar progressive changes to ES-HCM in a family of four cats through serial echocardiograms. At the time of heart failure, these cats exhibited changes similar to those exhibited by human ES-HCM patients. Our objectives were to describe the pathologic alterations associated with ES-HCM and investigate the pathogenesis in three of the four cats. Grossly, there was left atrial dilation with relative thinning of the interventricular septum (IVS) and left ventricular free wall (LVFW). The left atrium contained large thrombi in two of the three cats, and all three cats died following thromboembolization of the aortic bifurcation. Histologically, all three cats had subendocardial and myocardial fibrosis, predominantly of the IVS and LVFW, and one cat had acute, multifocal, myocardial infarcts with mononuclear inflammatory cell infiltrates. The pathogenesis of ES-HCM is uncertain, but theories implicate occlusion of the coronary blood flow by thickening of the coronary vessels, coronary vascular thromboembolism or coronary vessel spasm, apoptosis of myocytes, and myocardial hypertrophy beyond the ability of the vasculature to supply blood. Apoptosis assays did not reveal any apoptotic myocytes. Considering the hypercoagulative state of these cats, coronary vascular thromboembolism could be a major contributing factor. We cannot exclude apoptosis or coronary vessel spasm on the basis of the data presented.

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