scholarly journals Study of rifampicin resistance among newly diagnosed pulmonary tuberculosis patients with type 2 diabetes mellitus: a prospective observational study

2021 ◽  
Vol 9 (7) ◽  
pp. 2035
Author(s):  
Vipul Kumar ◽  
Jyoti Yadav ◽  
Aparna Parmar ◽  
Ritu Aggarwal ◽  
K. B. Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Prospective Observational Study ◽  
Rifampicin Resistance ◽  
Age Group ◽  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Mdr Tb ◽  
A Prospective Study

Background: Rifampicin (RIF) resistance in new cases of pulmonary tuberculosis is a matter of concern. Diabetes Mellitus triples the risk of developing tuberculosis. Early detection of TB and its resistance status in diabetics can help in improving the care and treatment outcomes of both diseases.Methods: It was a prospective study conducted from February 2019 to March 2020 in PGIMS, Rohtak on 50 patients of DM with newly diagnosed Pulmonary TB. Rifampicin resistance was detected by CBNAAT on sputum, induced sputum and BAL samples. Results: Mean age of study subjects was 51.24±10.421 (in years) with M: F ratio of 3:1 and maximum patients in 50-59 age group. The average BMI in patients was 22.49±2.42 kg/m2. The most common presenting complaint was cough (92%) followed by fever (68%). Mean serum HBA1c was 9.66±2.24 and mean FBS and PPBS was 195.81±59.08 and 302.02±99.01 mg/dl respectively. Out of 36 cases who gave sputum, 29 (80.55%) were detected rifampicin sensitive and 7 (19.44%) were rifampicin resistant whereas out of 11 who were induced, 9 (81.8%) were rifampicin sensitive and 2(18.18%) were rifampicin resistant. Out of 3 cases detected by BAL CBNAAT, 2 (66.6%) were rifampicin sensitive and 1 (33.33%) was rifampicin resistant. Overall, 10(20%) patients were detected Rifampicin resistant by CBNAAT.Conclusions: We found that TB-DM patients had a higher proportion of drug resistance (20%), so DM should be considered as an independent risk factor for MDR-TB and effective measures are required for early diagnosis of MDR-TB.

scholarly journals A prospective study of complications in newly diagnosed type 2 diabetes mellitus patients of lower socioeconomic group with special reference to microvascular complication and metabolic syndrome

2019 ◽  
Vol 7 (6) ◽  
pp. 2227
Author(s):  
K. Satya Anand ◽  
Ruksana . ◽  
Anand Acharya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Age Group ◽  
Socioeconomic Group ◽  
Newly Diagnosed ◽  
The Mean ◽  
Symptomatic Neuropathy

Background: All these metabolic derangements exist for many years in the asymptomatic phase of type 2 diabetes and they predispose to development of complications even before clinical diagnosis. Metabolic syndrome is considered to be a precursor of type 2 diabetes. Present study is primarily aimed to study the prevalence of micro vascular complications and metabolic syndrome in newly diagnosed type 2 diabetes mellitus patients of low socio-economic group.Methods: This is a cross sectional prospective study conducted in the dept. of general medicine Konaseema institute of medical science Amalapuram, Andhra Pradesh, India from November 2016 to October 2018. Based on exclusion and inclusion criteria 103 patients were enrolled for this study. Various parameters like age, sex, body mass index, waist circumference, lipid profile, systolic and diastolic blood pressure, neuropathy, nephropathy and retinopathy was measured.Results: The mean age of the patient was 48±10.0 years. Fasting and 2 hours OGTT was 174.6±46.8 mg/dl and 255.6±75.6 mg/dl. The mean of total cholesterol was 204.7±41.9 (mg/dl), Triglycerides was 218±83.4 (mg/dl) and HDL was 44±5.3 (mg/dl). Symptomatic neuropathy constituted 35.6% in 51-60 age group and 27.1% in 31-40 and 41-50 age groups. Objective neuropathy constituted highest (36.6%) in 51-60 age group. Retinopathy constituted highest (60%) in 51-60 age group and nephropathy constituted 26.3 % in 21-30 and 51-60 age groups.Conclusions: Prevalence of microvascular complications in newly diagnosed diabetics of low socioeconomic group were as follows: symptomatic neuropathy-57.3%, objective neuropathy-39.8%, retinopathy-4.9%, nephropathy-18.4%. These were similar to published studies from general population from the same geographical area.

scholarly journals TO STUDY THE ASSOCIATION BETWEEN DIFFERENT TYPES OF MICROVASCULAR COMPLICATIONS WITH EACH OTHER AND DYSLIPIDEMIA IN NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Kaushal Kumar Sinha ◽  
Abhay Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Communicable Disease ◽  
Microvascular Complications ◽  
Developed Countries ◽  
Age Group ◽  
Newly Diagnosed ◽  
Different Types

Background: Diabetes is one of the commonest chronic non communicable disease affecting the society at large both in developing and developed countries. Present study aimed to study the association between different types of microvascular complications with each other and dyslipidemia  in newly diagnosed type 2 diabetes mellitus.   Subjects and Methods: In this study, 100 newly diagnosed cases of type 2 diabetes mellitus patients were evaluated. A cross section of both male and female diabetes patients diagnosed within the last 3 months (new onset) was taken into study. A detailed history, clinical examination and relevant investigations were performed. Collected data were analysed by using appropriate software. Results: In our study 60% were male and 40% were female. Majority of cases were in the age group of 46-55 years, followed by in age group 56-65 years. Association was found between Dyslipidemia and nephropathy and also between retinopathy and nephropathy. Conclusion: Endeavour should be made to control hyperglycemia and dyslipidemia tightly by appropriate therapeutic measures so that the occurrence and worsening of complications could be mitigated.

scholarly journals INSIDENSI TB PARU KASUS BARU PADA PASIEN DENGAN DM TIPE 2 DI SALAH SATU RUMAH SAKIT SWASTA CIKAMPEK

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Himyatul Hidayah ◽  
Surya Amal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Private Hospital ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Hiv Aids

Penyakit tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis, menjadi penyakit infeksi penyebab kematian kedua di dunia setelah HIV-AIDS. Prevalensi kejadian TB di Indonesia menempati urutan ketiga setelah India dan China. Diabetes mellitus diperkirakan penyebab 15% kasus tuberkulosis saat ini, karena penyakit diabetes mellitus dapat merusak pertahanan host. Tujuan penelitian ini untuk mengetahui insidensi TB paru kasus baru dengan DM tipe 2 di salah satu rumah sakit swasta Cikampek. Instrumen penelitian yang digunakan adalah data sekunder rekam medik pasien TB paru kasus baru yang menjalani rawat jalan selama bulan April – September 2017 di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek. Hasil penelitian ini menunjukkan bahwa dari 83 pasien TB paru kasus baru terdapat 26 pasien TB paru kasus baru dengan DM Tipe 2.  Frekuensi TB paru kasus baru dengan DM tipe 2 lebih banyak pada kelompok jenis kelamin perempuan (53,85%), usia >54 tahun (65,39%), hasil pemeriksaan BTA sputum negatif (61,50%), lamanya pengobatan yang dianjurkan >8 bulan (53,85%).  Disimpulkan bahwa insidensi tuberkulosis paru kasus baru dengan DM tipe 2 rawat jalan di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek selama bulan April – September 2017 adalah sebesar 31,33%. Kata Kunci: Insidensi, Tuberkulosis paru, Diabetes mellitus tipe 2 Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis, it became the second leading cause of death in the world after HIV-AIDS. The prevalence of incidence of TB in Indonesia ranked third after India and China. Diabetes mellitus thought to be the cause 15 % the case of tuberculosis at the present time, due to disease of diabetes mellitus can be damaging to defense host. The purpose of this study was to know the incidence of new cases of pulmonary TB with type 2 diabetes mellitus in one of the private hospital Cikampek. The research instrument used was secondary data from the medical records of new TB pulmonary outpatients during April - September 2017 in the polyclinic internal medicine in one of the private hospital Cikampek. The result of study indicate that of the 83 new cases of pulmonary tuberculosis patients there were 26 new cases of pulmonary tuberculosis patients with type 2 diabetes mellitus. The frequency of pulmonary tuberculosis a new case with type 2 DM be greater among a group of the female sex (53,85 %), the age of >54 years (65,39%), results smear sputum negative (61,50%), length of treatment recommended >8 months (53,85%). It was concluded that the incidence of new cases of pulmonary TB with type 2 diabetes mellitus outpatients care in one of the private hospital Cikampek during the month of April – September2017 was recorded at 31,33 %. Keywords: Incidence, Pulmonary tuberculosis, Type 2 diabetes mellitus

scholarly journals Impact of diabetes mellitus on clinical parameters and treatment outcomes of newly diagnosed pulmonary tuberculosis patients in Thailand

2013 ◽  
Vol 67 (11) ◽  
pp. 1199-1209 ◽  
Author(s):  
D. Duangrithi ◽  
V. Thanachartwet ◽  
V. Desakorn ◽  
P. Jitruckthai ◽  
K. Phojanamongkolkij ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Treatment Outcomes ◽  
Clinical Parameters ◽  
Newly Diagnosed ◽  
Tuberculosis Patients
Sign in / Sign up

Export Citation Format

Share Document