Impact of diabetes mellitus on clinical parameters and treatment outcomes of newly diagnosed pulmonary tuberculosis patients in Thailand

Background: Rifampicin (RIF) resistance in new cases of pulmonary tuberculosis is a matter of concern. Diabetes Mellitus triples the risk of developing tuberculosis. Early detection of TB and its resistance status in diabetics can help in improving the care and treatment outcomes of both diseases.Methods: It was a prospective study conducted from February 2019 to March 2020 in PGIMS, Rohtak on 50 patients of DM with newly diagnosed Pulmonary TB. Rifampicin resistance was detected by CBNAAT on sputum, induced sputum and BAL samples. Results: Mean age of study subjects was 51.24±10.421 (in years) with M: F ratio of 3:1 and maximum patients in 50-59 age group. The average BMI in patients was 22.49±2.42 kg/m2. The most common presenting complaint was cough (92%) followed by fever (68%). Mean serum HBA1c was 9.66±2.24 and mean FBS and PPBS was 195.81±59.08 and 302.02±99.01 mg/dl respectively. Out of 36 cases who gave sputum, 29 (80.55%) were detected rifampicin sensitive and 7 (19.44%) were rifampicin resistant whereas out of 11 who were induced, 9 (81.8%) were rifampicin sensitive and 2(18.18%) were rifampicin resistant. Out of 3 cases detected by BAL CBNAAT, 2 (66.6%) were rifampicin sensitive and 1 (33.33%) was rifampicin resistant. Overall, 10(20%) patients were detected Rifampicin resistant by CBNAAT.Conclusions: We found that TB-DM patients had a higher proportion of drug resistance (20%), so DM should be considered as an independent risk factor for MDR-TB and effective measures are required for early diagnosis of MDR-TB.

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Diabetes Mellitus among Newly Diagnosed Tuberculosis Patients during COVID-19 Pandemic Period in a Secondary Health Institution

International Journal of Science and Healthcare Research ◽

10.52403/20210417 ◽

2021 ◽

Vol 6 (2) ◽

pp. 88-91

Author(s):

Parul Bhardwaj ◽

Shivbrat Sharma

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Pulmonary Tuberculosis ◽

Impaired Fasting Glucose ◽

Fasting Glucose ◽

Fasting Blood Glucose ◽

Newly Diagnosed ◽

Tuberculosis Patients ◽

Civil Hospital ◽

Keywords Tuberculosis

Introduction: Tuberculosis is one of the major public health problems worldwide and it is a major cause of morbidity and mortality. The risk of TB infection not only rises in diabetes patients, but is also associated with a higher risk of an increased number of diabetes complications. This study was conducted to determine the prevalence of Diabetes Mellitus (DM) among patients with newly diagnosed TB in Civil hospital Dehra, district Kangra (HP) a secondary health institute. AIM: To study the prevalence of DM in newly diagnosed pulmonary tuberculosis patients. Materials and Methods: Total 40 newly diagnosed patients with pulmonary tuberculosis (TB) who came in medicine OPD, Civil hospital Dehra from August 2020 to April 2021 during COVID -19 pandemic period were enrolled in the study. Their fasting blood glucose (FBG) was done. Screening and diagnosis of DM was done according to American diabetes association (ADA) guidelines. Results: The prevalence of DM and impaired fasting glucose (IFG) in newly diagnosed tubercular patients was 10% and 12.5% respectively in our study. Conclusion: The prevalence of FBS was found to be higher in patients with TB than the general population. Hence it is very important to screen these patients timely to prevent further complications. Keywords: Tuberculosis (TB), diabetes mellitus (DM), impaired fasting glucose (IFG), fasting blood glucose (FBG).

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Hyperglycaemia in newly diagnosed pulmonary tuberculosis patients: a cross-sectional study of the Agona District Hospital

Annals of Medical Laboratory Science ◽

10.51374/annalsmls.2021.1.2.0042 ◽

2021 ◽

Vol 1 (2) ◽

pp. 50-58

Author(s):

Richard K.D. Ephraim

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Tuberculosis ◽

Cross Sectional Study ◽

Newly Diagnosed ◽

Sectional Study ◽

Cross Sectional ◽

Duration Of Symptoms ◽

Tuberculosis Patients ◽

Increased Risk ◽

History Of

Background: Diabetes mellitus is an important risk factor associated with tuberculosis (TB). This study investigated the prevalence and determinants of hyperglycemia among newly diagnosed pulmonary tuberculosis patients in the Agona Swedru Municipality. Method: A hospital-based cross-sectional study was conducted from December 2015 to April 2016. One hundred (100) newly diagnosed pulmonary tuberculosis patients at the Agona Swedru Municipal Hospital (ASMH) were enrolled for the study. Socio-demographic, clinical and anthropometric measurements were collected and fasting blood glucose (FBG) measured using standard protocols. Data was analyzed using Statistical Package for Social Sciences (SPSS) software version 20.0. Result: Of the 100 participants, 26% had hyperglycemia. The significant factors associated with increased risk of hyperglycemia among participants were history of diabetes mellitus (OR = 8.17, p= 0.004), severity of infection (OR = 23.64, p < 0.001) and duration of symptoms (OR= 2.63, p= 0.042). Conclusion: Hyperglycemia was common among newly diagnosed pulmonary tuberculosis patients. History of diabetes mellitus, severity of infection, and duration of symptoms were the determinants of hyperglycemia in pulmonary tuberculosis. Regular screening of hyperglycemia is essential in the management of tuberculosis. Finally, further studies should be conducted on glucose levels among pulmonary tuberculosis patients using higher sample size to increase the understanding of the subject.

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