scholarly journals Vitamin D level as a predictor of pneumonia and asthma in children less than 5 years of age

2020 ◽  
Vol 7 (7) ◽  
pp. 1593
Author(s):  
Neha Sharma ◽  
Anuj Shamsher Sethi ◽  
R. S. Sethi
Keyword(s):  
Vitamin D ◽  
P Value ◽  
Healthy Children ◽  
Outpatient Services ◽  
Common Chronic Disease ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Asthma Patients ◽  
Asthma In Children ◽  
Deficient Level

Background: Childhood pneumonia is a global health problem .It the leading cause of death for children under the age of five years. 95% of all pneumonia cases under the age of five occurs in developing countries. Asthma remains the most common chronic disease of childhood in the world. The observation that vitamin D deficiency and asthma share risk factors such as urban residence, obesity and African American ethnicity has generated interest in exploring a link between these two conditions. This study was taken up to assess the role of vitamin D as a predictor of pneumonia and asthma in children less than 5 years of age.Methods: A prospective observational case control study was conducted in MLB Medical college, Jhansi from January 2015 to December 2016 (1 year 11 months). A total of 60 children including 30 asthma cases, 20 pneumonia cases and 10 controls, aged, 6-60 months were enrolled. Controls were healthy children attending outpatient services for immunization.Results: The mean age of the pneumonia patient was 1.5 years, while mean age in asthma patients was 3.1yrs. Ratio of male and female in pneumonia cases was1.5:1, while is asthma ratio was 2:1. In our study 45% pneumonia cases had deficient level of vitamin D (<20ng/ml) and mean level was 11.08±4.68 while 40% of control had deficient level of vitamin D and mean level was 16.04±1.61, p value was 0.0166 and there was significant difference in both the groups. In Asthma cases 53.33% patient had deficient level of vitamin-D and mean level was 10.62±2.908 as compared to 40% control (mean : 16.04±1.62) ‘p’ value was <0.0001 and was highly significant.Conclusions: Our study has illustrated that vitamin-D levels were significantly low in pneumonia and asthma patients as compared to control.

To screen or not to screen? Vitamin D deficiency in chronic mental illness

2017 ◽  
Vol 26 (1) ◽  
pp. 56-59
Author(s):  
Ivana Goluza ◽  
Jay Borchard ◽  
Nalin Wijesinghe ◽  
Kishan Wijesinghe ◽  
Nagesh Pai
Keyword(s):  
Vitamin D ◽  
Length Of Stay ◽  
P Value ◽  
Hydroxyvitamin D ◽  
Psychiatric Setting ◽  
Retrospective Audit ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
25 Hydroxyvitamin D ◽  
The Mean

Objectives: The objective of the current study was to examine the pathology test utilisation of 25-hydroxyvitamin D (25(OH)D) within an Australian inpatient psychiatric setting. Method: A retrospective audit of 300 random hospital files of those admitted as inpatients between Nov 2014 and Nov 2015 was undertaken. Data was quantitatively analysed and described. Results: The number of inpatients who had a vitamin D determination during their admission was 37/300 (12.33%). The mean vitamin D level of those tested was 51.63 nmol/l. Of those that were tested, 18/37 (48.6%) were mildly to moderately deficient. There was a statistically significant difference in age and length of stay between those that were and were not tested for vitamin D levels, p-value <0.001 and 0.017, respectively. In addition, a simple linear regression indicated a weak association between length of stay and vitamin D levels. Conclusion: This audit highlights vitamin D screening inadequacy. More research is recommended to establish tangible benefits of supplementation, while local practice provides valuable data for education and policy purposes.

scholarly journals Correlation between vitamin D serum level and total IgE in asthmatic children

2020 ◽  
Vol 12 (2) ◽  
pp. 37-45
Author(s):  
Vesna Micevska ◽  
Tatjana Jakovska Mareti ◽  
Ilija Kirovski ◽  
Olivera Jordanova
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
P Value ◽  
Healthy Children ◽  
Total Ige ◽  
Asthmatic Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
The Mean ◽  
Chronical Disease

Asthma is a chronical disease of the airways characterized by reversible obstruction of the bronchi and airway inflammation. In recent decades, the scientific interest of the vitamin D system and its role in development of asthma and other alergic diseases has been increased. Aims of this study are to mesure and compare the serum level of 25 OHD in asthmatic and healthy children and corelate the level of 25OHD and total IgE in asthmatic children. This prospective study includes 70 children at age 2 to 14, of which 32 are children with diagnosed asthma and 38 healthy children. In both  of the groups the serum level of 25 OHD was measured  and by the results 18 % of the healthy children (C) and 28% of the asthma children (E) had 25OHD  deficiency, 45%  of C and 50% of E were insufficient and 37 % of C / 22% of E were with normal 25 OHD serum level. The mean level of 25OHD in C was 27,83 +/- 10,24 and in E 20,9 ng/ml +/- 10,72. The mean levels in both groups had statistic significant difference with p-value < 0,05. According to age no statistic significant difference was found in both of the groups. There was a statisticaly significant decreased serum level of 25 OHD in asthmatic females.In the examined group (children with asthma) there was a negative linear correlation (association) of the level of 25OHD and total IgE serum level with r=- 0,55  Vitamin D serum level measurements in asthma patients gives the possibility for discovering the connection between its deficiency and development of asthma symptoms.

Vitamin D levels in patients with childhood cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e20000-e20000
Author(s):  
Nurdan Tacyildiz ◽  
Gulsah oktay Tanyildiz ◽  
Deniz Tekin ◽  
Can Ates ◽  
Handan Dincaslan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Inverse Correlation ◽  
Control Group ◽  
Healthy Children ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Patient Groups ◽  
Cell Growth And Differentiation ◽  
Age Range ◽  
Nonparametric Correlation

e20000 Background: There is increasing interest in the possible association between cancer incidence and vitamin D through its role as a regulator of cell growth and differentiation. Although there are several studies related cancer risk and prognosis of cancer, related vit D levels in adult patients there are only few recent studies in pediatric patients. Methods: Between 2010 and 2011, D Vit levels of 45 patients (25 boys, 20 girls; age range: 6 months-17 years, median: 11 years) have been compared to D Vit levels of 22 healthy children with similar age group. Patient groups were leukemias, lymphomas, bone tumors, retinoblastoma (RB), and other tumors. Kruskal-Wallis and Spearman nonparametric correlations test of SPSS has been used for statistics. Results: Although there was no statistically significant difference for vit D levels between control group (range: 7.2-22.8; median: 14.75 ng/ml) and patients (range: 5.5-40.2; median: 16.0 ng/ml),difference between patients groups were significant (Table). Patients with RB have statistically lower level of Vit D than leukemia (p:0.016) and lymphoma groups ( p: 0.047). “Other tumors group” has lower vit D levels than leukemia group (p: 0.024). Since RB and other tumors group have younger age than other patients, Spearsman’s nonparametric correlation has been performed to exclude age effect on the results and no statistically significant correlation between D vit levels and age (p: 0.779) was found, although there was an inverse correlation between age and vit D levels in patient group (p: 0.03). Conclusions: According to our preliminary results, most of the patients and healthy children have low level of Vit D. Especially patients with RB have statistically significant lower level of Vit D than other malignancies which can be subject to future studies for confirmation of our results. In addition, etiologic studies related RB may have a new area. [Table: see text]

scholarly journals Influence of serum vitamin D levels on control and severity of asthma in children

2020 ◽  
Vol 7 (4) ◽  
pp. 843
Author(s):  
Savitha M. R. ◽  
Gayatri R. Pawar
Keyword(s):  
Vitamin D ◽  
Solid Phase ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Asthma In Children ◽  
Gina Guidelines ◽  
Low Serum

Background: To determine the association between the serum vitamin D levels with the control and severity of asthma.Methods: A total of 113 asthmatic children were enrolled in the study who were on regular follow-up and treatment for the past 6 or more months. The demographic details, presenting complaints, aggravating factors, allergic rhinitis, atopic dermatitis, hospital and ICU stay, duration of sunlight exposure, drug compliance and detailed clinical examination findings were noted in the predesigned proforma. Control of asthma was assessed based on GINA guidelines 2018 as well controlled, partly controlled and poorly controlled. The partly controlled and the poorly controlled group were further combined and labelled as not well controlled group. Severity of asthma was categorized into intermittent, mild persistent, moderate persistent and severe persistent. Serum 25 hydroxy vitamin D was assessed by solid phase ELISA. The well controlled and partly controlled group were compared for all studied parameters.Results: Asthma status of the subjects was categorized as well controlled (59%) as partly controlled (40%) and as poorly controlled (1%). Children with partly and poorly controlled asthma had significantly more vitamin D deficiency (10.9%) and insufficiency (32.6%) compared to well controlled group (4.5% and 4.5% respectively), with p value= 0.000. Low serum vitamin D levels are significantly associated with moderate and severe persistent asthma (p value= 0.009). Exercise significantly induced symptoms in 47.8% of not well controlled group and about 25.4% in well controlled group (p value= 0.014). Examination findings such as wheeze on auscultation was significantly more in not well controlled group.Conclusions: Low serum vitamin D levels are associated with poor control of asthma in children and the severity of asthma is inversely proportional to the serum vitamin D levels.

scholarly journals Role of vitamin D, serum zinc, and serum iron deficiency in community-acquired pneumonia in children

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Asmaa Alhusseiny Ahmed Alsharkawy ◽  
Ahmed R. Rezk
Keyword(s):  
Vitamin D ◽  
Serum Iron ◽  
Serum Zinc ◽  
Community Acquired Pneumonia ◽  
Control Group ◽  
Iron Level ◽  
Healthy Children ◽  
Serum Iron Level ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract Background Community-acquired pneumonia is a major cause of death among children. Inadequate nutrition disrupts the immune system and increases the susceptibility to infections. We aimed to evaluate the association between vitamin D, serum zinc, and iron, and pneumonia. A case-control study was conducted at the outpatient clinic and emergency room of Children’s Hospital. Thirty-one patients with community-acquired pneumonia and 36 healthy children (control group) underwent serum sampling for vitamin D, zinc, and iron. Results Most patients had mild form (n = 17, 54.8%). All patients survived and were discharged. The serum iron level showed a non-significant difference between pneumonia and control groups (p ˃ 0.05). TIBC, vitamin D, and serum zinc were significantly lower in the patient group than the control group (P value = 0.04, < 0.001, and 0.03, respectively). Vitamin D deficiency was highly associated with the severity of pneumonia (P value = 0.008). Conclusion Adequate serum zinc and vitamin D levels may be protective against infection with community-acquired pneumonia in children aged from 2 months to 5 years old, but not iron.

scholarly journals Adequate Vitamin D Intake but Low Serum Levels in Pediatric Asthma Patients: A Pilot Study, Alberta Children’s Hospital

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Sarah Howe McKenna ◽  
Tanis R. Fenton ◽  
Mary Noseworthy ◽  
Mark Anselmo
Keyword(s):  
Vitamin D ◽  
Pediatric Asthma ◽  
Serum Levels ◽  
High Dose ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Vitamin D Intake ◽  
Vitamin D Levels ◽  
Asthma Patients ◽  
25 Oh Vitamin D

Background. We assessed vitamin D intakes and serum 25(OH) vitamin D levels in pediatric asthma patients on moderate-to-high dose inhaled steroids and compared them to published findings of healthy children in our city.Methods. Parents and/or patients were interviewed to estimate the children’s vitamin D intakes from foods and supplements (using an adapted validated food frequency questionnaire) and asthma duration and management. Vitamin D status: serum 25-hyroxy vitamin D (25(OH)D) was obtained from the medical records.Results. Vitamin D intakes from food and supplements of the asthma patients (n=20, 742 ± 185 IU/day) were significantly higher compared to healthy Canadian children (n=1442, 229 ± 121 IU/day). Despite higher vitamin D intakes, the children had nonsignificantly lower serum 25(OH) vitamin D levels compared to the comparison group. Serum 25(OH)D levels increased by 3.6 nmol/L with each 100 IU of vitamin D intake (95% Confidence interval = 2.0–4.0,R2= 0.931, andp=0.001).Conclusion. Since adequate vitamin D status in asthma patients is necessary to support bone mineral accretion, it is important to achieve adequate vitamin D status by checking serum 25(OH)D status and supplement accordingly.

Evaluation of serum 25-hidroxy vitamin D and zinc levels in asthmatic patients

2017 ◽  
Vol 43 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Murat Elevli ◽  
Ayşe Ergül Bozacı ◽  
Kamil Şahin ◽  
Hatice Nilgün Duru ◽  
Mahmut Çivilibal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Height ◽  
Serum Zinc ◽  
Atopic Asthma ◽  
Control Group ◽  
Healthy Children ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Zinc Levels ◽  
The Impact

AbstractIntroduction:We aimed to investigate the impact of serum zinc, and vitamin D levels on the development of asthma, and its clinical characteristics.Methods:In our cross-sectional study; 50 patients who were diagnosed as atopic asthma and 70 healthy children consisted the control group. In both groups levels of vitamin D, and zinc were analyzed.Results:A statistically significant intergroup difference was not detected as for age, gender, body height (percentile), and weight (percentile) of the patients (p>0.05). Mean vitamin D levels in the asthmatic patient, and control groups were 32.61±9.48 nmol/L, and 42.55±15.42 nmol/L, respectively. Between two groups a statistically significant difference was found (p=0.001). Zinc levels were higher in the control group without any statistically significant difference between groups (p=0.25). A statistically significant negative correlation (−0.635) was found between vitamin D levels, and severity of asthma in the patient group. As the level of vitamin D increased, a decrease in severity of asthma was seen (p=0.04).Conclusion:Though larger series are needed to arrive at definitive conclusions, we think that vitamin D deficiency rather than zinc deficiency, might convey importance in the emergence, and exacerbation of asthma.

Juvenile lupus and serum vitamin D levels: A cross-sectional study

Lupus ◽  
2020 ◽  
Vol 29 (13) ◽  
pp. 1752-1758
Author(s):  
Samar abd Alhamed Tabra ◽  
Hend Hassan Abdelnabi ◽  
Nivine Fathi Mahmoud Darwish ◽  
Amal Mohammed El-Barbary ◽  
Muhammad Tarek AbdelGhafar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Healthy Children ◽  
Z Score ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Significant Difference

Background Juvenile systemic lupus erythematosus (JSLE) is usually associated with vitamin D deficiency and low bone mineral density. Objectives To evaluate serum levels of 25-OH vitamin D in JSLE patients and to correlate these findings with disease activity and bone density. Methods This study was conducted on 100 patients with JSLE and 100 healthy children as controls. Disease duration and SLEDAI for disease activity were evaluated. CBC, anti-dsDNA, C3,C4,24hr urinary proteins, creatinine, estimated glomerular filtration rate(e-GFR),Ca,P,PTH, 25 (OH) D levels, and bone mineral density(BMD)Z score were measured. Results There were significant differences in mean 25(OH)D concentration between patients group (19.37 ± 9.72 ng/ml) and controls 35.90 ± 9.66 ng/ml(p < 0.05), with significant difference between active and inactive patients (p < 0.05).There were significant negative correlations between serum 25(OH)D and SLEDAI (r-0.545, p 0.001), steroid dose (r-0.561, p 0.001), anti-dsDNA (r-0.685, p 0.006), 24 hr-proteinuria (r-0.738, p 0.001) and PTH (r-0.335, p 0.001), significant positive correlations between 25(OH)D and C3 (r0.617, p 0.001),C4 (r0.544, p 0.001) serum Ca (r0.424, p 0.001) and Z score (r0.561, p 0.001),with non-significant correlations between 25(OH)D and serum P and both disease & steroid duration, (p > 0.05). Conclusion Vitamin D deficiency is common in JSLE, it’s correlated significantly with disease activity and bone mineral density.

scholarly journals The Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo

2021 ◽  
pp. 014556132110085
Author(s):  
Kanokporn Sarsitthithum ◽  
Tosapohn Wisupagan ◽  
Sivaporn Kiatthanabumrung ◽  
Chanchai Jariengprasert
Keyword(s):  
Vitamin D ◽  
Benign Paroxysmal Positional Vertigo ◽  
Serum Vitamin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Positional Vertigo ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Paroxysmal Positional Vertigo

Objective: This study aimed to evaluate the association between serum vitamin D levels and benign paroxysmal positional vertigo (BPPV). Participants and Methods: This prospective study consisted of 137 participants. There were 69 participants in the BPPV group compared with 68 healthy participants. Blood samples from both groups were collected from all participants to assess serum vitamin D levels. Results: No significant difference in demographic data between BPPV and control groups. The results showed that the mean serum vitamin D levels in the BPPV group was lower than that of the control group ( P value = .001). Among BPPV participants, there was no statistically significant difference between mean serum vitamin D levels of participants with recurrent BPPV, and that of newly diagnosed BPPV participants ( P value = .313). Conclusion: A statistically significant association between lower mean serum vitamin D levels in the BPPV group compared with that of the control group. Therefore, low serum vitamin D levels may be one of the risk factors for BPPV.

scholarly journals PROFIL VITAMIN D PADA PASIEN ASMA DAN NON-ASMA DEWASA DI SURABAYA

2017 ◽  
Vol 12 (1) ◽  
pp. 106
Author(s):  
Rivan Virlando Suryadinata ◽  
Amelia Lorensia ◽  
Anugrah Putri Aprilia
Keyword(s):  
Vitamin D ◽  
Young Adult ◽  
Bronchial Epithelium ◽  
Chronic Inflammatory Disease ◽  
Cross Sectional ◽  
Change Behavior ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Asthma Patients ◽  
Asthma Group

Asthma is a chronic inflammatory disease on respiratory tract, where airflow are retricted dan chronic inflammation result in bronchial epithelium damage. Pathogenesis mechanism of asthma is influenced by vitamin D as an immunomodulator. The low vitamin D levels can trigger asthmaexacerbations. The study aimed to determine the levels of vitamin D from blood sample in astmatic young adult in compared to non astmatics, to identify the risk of vitamin D deficiency, that can aggravate asthma symptoms. The study used an observational analytic cross sectional design. Subjects were chosenthrough a purposive sampling method. Population was young adults in Surabaya. Subjects were 26 asthmatic patientsdan 26 non-asthmatic young adult in South Surabaya that fulfilled inclusion dan exclusion criteria. The study was conducted in May 2015 to July 2016. The results showed vitamin Dlevels in the asthma group 24.5 ± 2.95 while in the non-asthma group 20.52 ± 2.47. All respondents in both groups had vitamin D levels > 30 ng/mL (normal value), dan there was significant difference between levels of vitamin D in asthma dan non-asthma patients (p < 0.05). Therefore, increasing knowledge about the importance of vitamin D should be done, because it can change behavior through lifestyle, diet dan physical activity in the community.Keywords: asthma, vitamin D

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