scholarly journals A clinicopathological study of masses of nasal cavity paranasal sinuses and nasopharynx

2017 ◽  
Vol 3 (2) ◽  
pp. 253
Author(s):  
Rajat Sharma ◽  
Dimple Sahni ◽  
Kuljeet Uppal ◽  
Rajeev Gupta ◽  
Gifty Singla
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Benign Lesion ◽  
Malignant Lesion ◽  
Histopathological Diagnosis ◽  
Radiological Findings ◽  
Female Ratio ◽  
Road Map ◽  
Neoplastic Lesion ◽  
Nasopharyngeal Masses

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">A variety of inflammatory, non neoplastic and neoplastic masses involving nasal cavity, paranasal sinuses and nasopharynx are commonly encountered in ENT clinics. The objective was to study the demographic profile, clinical presentation, radiological findings and its correlation with the histopathological findings of masses of nasal cavity, paranasal sinuses and nasopharynx. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The study was conducted on patients having sinonasal and nasopharyngeal masses admitted in dept of ENT, GMC, Patiala from August 2014 to July 2016. The study was designed to evaluate demographic distribution, clinicopathological features, radiological findings of sinonasal and nasopharyngeal masses and to evaluate the correlation of clinical and radiological findings with histopathological diagnosis.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Analysis of 50 cases of masses in nasal cavity, paranasal sinuses and nasopharynx was done. Male to female ratio was 1.38:1. The commonest site was nasal cavity followed by paranasal sinuses. Nasal polyp was the most common non-neoplastic lesion. Among the neoplastic lesions studied, inverted papilloma was the most common benign lesion and squamous cell carcinoma was the most common malignant lesion observed. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">For proper evaluation of sinonasal and nasopharyngeal masses, clinical, radiological and histopathological evaluation should be done in all patients. Although radiology provides a road map to endoscopic surgeons for any existing or impending complications but histopathology always gives a confirmatory diagnosis.</span></p>

Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

2021 ◽  
Vol 8 (33) ◽  
pp. 3054-3059
Author(s):  
Rajendra Prasad Jagannadham ◽  
Lakshmi Latchupatula ◽  
Sravani Ponnada ◽  
Neelima Lalam ◽  
Raghunadhababu Gudipudi ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

scholarly journals Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India

2017 ◽  
Vol 10 (2) ◽  
pp. 93-98
Author(s):  
Trilok C Guleria ◽  
Shobha Mohindroo ◽  
Narender K Mohindroo ◽  
Ramesh K Azad
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Himachal Pradesh ◽  
Common Finding ◽  
Nasopharyngeal Angiofibroma ◽  
Neoplastic Lesion ◽  
Sinonasal Mass ◽  
Nasopharyngeal Masses

ABSTRACT Introduction: Nasal masses are common finding in the ear, nose, and throat outpatient department. Most patients present with complaints of nasal obstruction. A sinonasal mass can have various differential diagnoses. They may be congenital, inflammatory, neoplastic (benign or malignant), or traumatic in nature. A careful histopathological examination is necessary to decide the nature of any particular lesion. Materials and methods: The retrospective study was carried out between January 2011 and December 2013. A total of 185 cases diagnosed with masses of the nasal cavity, paranasal sinuses, and nasopharynx were included. Data from histopathological records were retrieved to confirm the diagnosis. Observations: Among 185 cases, 75% were non-neoplastic and 25% were neoplastic. Among neoplastic masses, 57% were benign and 43% were malignant. The age of presentation ranged from first to eighth decade of life (mean age 37.74 years). The lesions had a stronger predilection for males (1.68:1). Among non-neoplastic lesions, nasal polyp was the commonest lesion followed by ethmoidal mucocele (1.44%) and lupus vulgaris (0.72%). Among benign lesions, inverted papilloma (30.77%) and nasopharyngeal angiofibroma (30.77%) were the commonest followed by capillary hemangioma (15.38%), osteoma (7.68%), nasopharyngeal lymphoepithelioma (3.85%), chondroma (3.85%), pleomorphic adenoma (3.85%), and schwannoma (3.85%). Squamous cell carcinoma (40%) was the commonest malignant neoplastic lesion observed followed by adenoid cystic carcinoma (20%), malignant melanoma (15%), nasopharyngeal carcinoma (10%), esthesioneuroblastoma (10%), and non-Hodgkin lymphoma (5%). Conclusion: Among the noninflammatory lesion, nasal polyp is the commonest lesion. Nasal polyps are more common in hilly area may be due to exposure to pine pollens. There is no difference in the histopathological profile of benign and malignant lesions. How to cite this article: Guleria TC, Mohindroo S, Mohindroo NK, Azad RK, Kumar A. Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India. Clin Rhinol An Int J 2017;10(2):93-98.

scholarly journals Histomorphological spectrum of masses of the nasal cavity, paranasal sinuses and nasopharynx

2013 ◽  
Vol 3 (5) ◽  
pp. 351-355 ◽  
Author(s):  
S Parajuli ◽  
A Tuladhar
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Benign Lesion ◽  
Demographic Data ◽  
Malignant Lesion ◽  
Cross Sectional Study ◽  
Medical Intervention ◽  
Cross Sectional ◽  
Essential Components ◽  
Neoplastic Lesions

Background: Swellings of nasal cavity, paranasal sinuses and nasopharynx have infl icted man from time immemorial. Nose is the most prominent part of the face with substantial aesthetic and functional signifi cance. A variety of non-neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasophaynx, and these are very common lesions encountered in clinical practice. Materials and Methods: This retrospective cross-sectional study was done in the Department of Pathology, Kathmandu Model Hospital for a period of 5 years from August 2007 to August 2012. Demographic data including age, sex and clinical presentation were obtained from the histopathology records. Results: A total of 148 samples of tissue sent for histopathology were studied, out of which 119 were nonneoplastic and 29 were neoplastic lesions. A slight female preponderance was observed. Infl ammatory nasal polyp was the most common non-neoplastic lesions encountered accounting for a total of 106 cases (89%). Similarly, inverted papilloma was the most common benign lesion (6 cases) and nasopharyngeal carcinoma was the most common malignant lesion (5 cases). Conclusion: Sino-nasal masses have various differential diagnoses. Malignancy should be distinguished from non-malignant lesions. A detailed history, clinical examination and most importantly, thorough histopathological evaluation are essential components of workup of patients for timely medical intervention. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 351-355 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7857

scholarly journals Clinicopathological study of thyroid swelling and its management

2020 ◽  
Vol 6 (4) ◽  
pp. 727
Author(s):  
Seema Patel ◽  
Varsha J. Gattani ◽  
Ashok Z. Nitnaware
Keyword(s):  
Papillary Carcinoma ◽  
Surgical Management ◽  
False Negative ◽  
Malignant Lesion ◽  
Nodular Goiter ◽  
Follicular Neoplasm ◽  
Histopathological Diagnosis ◽  
Predictive Values ◽  
Neoplastic Lesion ◽  
Thyroid Swelling

<p class="abstract"><strong>Background:</strong> There is high prevalence of thyroid lesions in India. In this study, an attempt is made to find out the clinical spectrum of thyroid swellings in central India, diagnostic accuracy of fine needle aspiration cytology (FNAC), appropriate surgical management and to compare it with postoperative histopathological diagnosis so as to determine its role in surgical management.</p><p class="abstract"><strong>Methods:</strong> In this prospective study, 100 subjects presenting to ENT OPD of GMC, Nagpur during the period from September 2017 to August 2019 with thyroid swelling who were fit to undergo surgery and willing to participate in the study were selected. After detailed evaluation and routine investigations, thyroid function test (TFT), FNAC, ultrasonography (USG) neck, all the subjects underwent required thyroidectomy. The postoperative histopathological examination (HPE) report was correlated with cytological report.  </p><p class="abstract"><strong>Results:</strong> In 100 subjects, majority of subjects were from 4th decade (32%) with female: male ratio=6.14:1. FNAC findings were colloid goiter (61%), nodular goiter (19%), follicular neoplasm (10%), and papillary carcinoma (9%). On HPE, colloid goitre (57%) was most common non-neoplastic lesion and papillary carcinoma (65.21 %) was most common malignant lesion. Hemithyroidectomy (70%) was most common procedure done. Transient hypocalcemia (5%), recurrent laryngeal nerve (RLN) paresis (2%) were the postoperative complications encountered. Sensitivity, specificity, accuracy, positive and negative predictive values of FNAC to diagnose malignancy were 55.6%, 100%, 91%, 100% and 90% respectively.</p><p class="abstract"><strong>Conclusions:</strong> FNAC is an easy, rapid, reliable, cost-effective, minimally invasive and readily repeatable technique for diagnosis of thyroid swellings. The common false negative diagnosis is seen in follicular pattern cases, cystic papillary thyroid carcinoma (PTC) and papillary microcarcinoma.  </p>

Sinonasal Smooth Muscle Cell Tumors

2003 ◽  
Vol 127 (3) ◽  
pp. 297-304 ◽  
Author(s):  
Hsuan-Ying Huang ◽  
Cristina R. Antonescu
Keyword(s):  
Smooth Muscle ◽  
Nasal Cavity ◽  
Paranasal Sinus ◽  
Paranasal Sinuses ◽  
Surgical Excision ◽  
Low Grade ◽  
Female Ratio ◽  
Well Differentiated ◽  
Mitotic Figures ◽  
Mib 1

Abstract Context.—Smooth muscle tumors (SMTs) of the sinonasal tracts are very rare mesenchymal neoplasms, and the literature includes very limited data correlating histologic parameters with clinical outcome. As the behavior of SMTs is site-dependent, defining applicable criteria to distinguish among low-grade leiomyosarcoma, SMT of uncertain malignant potential (SMTUMP), and cellular leiomyoma is sometimes difficult and arbitrary. Objective.—To correlate the clinicopathologic features of 12 well-differentiated sinonasal SMTs with MIB-1 index and clinical outcomes so as to better classify this group of tumors. Design.—Twelve cases of sporadic well-differentiated SMTs arising from the sinonasal tract were retrieved from both institutions. High-grade leiomyosarcomas were excluded from this analysis. The histologic parameters assessed included circumscription, mucosal ulceration, cellularity, nuclear atypia, mitotic count, necrosis, and destruction of adjacent bony structures. The histologic classification of these tumors was based on the guidelines for SMTs of deep soft tissues, using greater than 4 mitotic figures (MF)/10 high-power fields (HPF) to separate SMTUMP from leiomyosarcoma and the presence of 1 to 4 MF/10 HPF to distinguish between leiomyoma and SMTUMP. Immunostaining of MIB-1 index was performed in 7 cases with available material. Results.—This study showed a 1:1.5 male-female ratio and a mean age of 40 years (range, 20–67 years). The most frequent symptoms were nasal stuffiness and/or epistaxis. The tumors involved nasal cavity in 8 cases (67%), paranasal sinus alone in 2 cases (16.5%), and both nasal cavity and paranasal sinuses in 2 cases (16.5%). The tumors ranged in size from 0.3 to 5.5 cm (mean, 2 cm) and were classified as follows: 7 leiomyomas, 2 SMTUMPs, and 3 low-grade leiomyosarcomas. All 7 leiomyomas, 1 SMTUMP, and 1 leiomyosarcoma originated from vessel walls. Bone involvement was seen in both the SMTUMPs (1 of 2) and leiomyosarcomas (2 of 3). Focal infiltrative growth was observed only in the 3 leiomyosarcomas, 1 of which also showed microscopic coagulative tumor necrosis. Mitotic figures ranged from 0 to 10 (mean, 2.3), with absence of mitosis in all 7 leiomyomas, 1 to 4 MF/10 HPF in the 2 SMTUMPs, and more than 4 MF/10 HPF in the 3 low-grade leiomyosarcomas. The MIB-1 index was low (≤5%) in both leiomyoma and SMTUMP groups, while the leiomyosarcomas showed a higher (≥15%) proliferative index. All 12 patients were treated by surgical excision, and only 1 patient with leiomyosarcoma received postoperative radiation. In all 12 tumors, there was neither local recurrence nor distant metastasis after an average of 93 months of follow-up (range, 4–221 months). Conclusion.—Well-differentiated sinonasal SMTs are rare and occur in adults with a slight female predilection. The lesions confined within the nasal cavity were more common than those involving a single paranasal sinus or both nasal cavity and paranasal sinuses. Despite variations in location, clinical manifestation, histologic features, and MIB-1 index, these tumors appear to follow a favorable course. Complete surgical excision appears to provide adequate treatment for these patients.

scholarly journals Verrucous Carcinoma of the Paranasal Sinuses: A Case Report

2010 ◽  
Vol 89 (7) ◽  
pp. E21-E23 ◽  
Author(s):  
Frederick L. Durden ◽  
Charles E. Moore ◽  
Susan Muller
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Verrucous Carcinoma ◽  
Neck Region ◽  
Low Grade ◽  
Management Options ◽  
Head And Neck Region ◽  
Neoplastic Lesion

Verrucous carcinoma is a low-grade variant of squamous cell carcinoma reported to occur in all anatomic sites in the head and neck region, most commonly the oral cavity. The tumor grows locally invasive but is histologically benign and metastasizes rarely. To date, 22 cases of verrucous carcinoma involving the nasal cavity and/or the paranasal sinuses have been reported. We present a case of verrucous carcinoma involving the paranasal sinuses, nasal cavity, cranium, and orbit. This case highlights the difficulty of pathologic diagnosis and management options for a rare neoplastic lesion.

scholarly journals Imaging review of the anterior skull base

2018 ◽  
Vol 7 (5) ◽  
pp. 205846011877648 ◽  
Author(s):  
Olivia Francies ◽  
Levan Makalanda ◽  
Dimitris Paraskevopolous ◽  
Ashok Adams
Keyword(s):  
Soft Tissue ◽  
Nasal Cavity ◽  
Skull Base ◽  
Paranasal Sinuses ◽  
Anterior Skull Base ◽  
Normal Anatomy ◽  
Radiological Findings ◽  
Cross Sectional ◽  
Cross Sectional Imaging ◽  
Sectional Imaging

The anterior skull base (ASB) is intimately associated with the unique soft tissue subtypes of the nasal cavity, paranasal sinuses, orbits, and intracranial compartment. Pathology involving the ASB is rare but the causes are manifold and can be broadly subdivided into those intrinsic to the skull base and processes extending from below or above. Sinonasal pathology is the most commonly encountered and poses significant management challenges that rely heavily on accurate interpretation of the radiological findings. We illustrate the normal anatomy of the ASB and present a cross-sectional imaging review of the pathological entities that may be encountered, focusing on the specific features that will impact on clinical and surgical management.

scholarly journals Inverted Papilloma Completely Obstructing Anterior Nasal Orifice

2020 ◽  
pp. 014556132091657
Author(s):  
Jae-Hoon Lee
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Rare Case ◽  
Benign Lesion ◽  
Attachment Site ◽  
Inverted Papilloma ◽  
Mucosal Surface ◽  
Lateral Nasal Wall ◽  
Nasal Vestibule ◽  
Sinonasal Inverted Papilloma

Sinonasal inverted papilloma is a benign lesion that occurs in the nasal cavity and paranasal sinuses. Fungiform papillomas have been described as arising from the septum or the nasal vestibule, while inverted and cylindrical papillomas have been characterized as developing from an attachment site on the lateral nasal wall or a mucosal surface in the paranasal sinuses. Here, we present a rare case of an inverted papilloma that completely obstructed the anterior nasal orifice.

scholarly journals Study of Cytodiagnosis of Head and Neck Neoplastic Lesions and Comparison with Histopathology

2013 ◽  
Vol 4 (3) ◽  
pp. 119-122
Author(s):  
Maniyar U Amit ◽  
Harshid Laxmanbhai Patel ◽  
BH Parmar
Keyword(s):  
Head And Neck ◽  
Frozen Section ◽  
Excisional Biopsy ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Age Group ◽  
Aspiration Cytology ◽  
Female Ratio ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

ABSTRACT Introduction The development of aspiration cytology is one of the biggest advances in anatomic pathology. Cancer has become one of the 10 leading causes of death in India. Head and neck neoplasia is a major form of cancer in India, accounting for 23% of all cancers in males and 6% in females. The advantages of fine needle aspiration cytology (FNAC) are: it is safe, sensitive and specific for the diagnosis of malignancy, gives a rapid report, requires little equipment, causes minimal discomfort to the patient, is an out patient procedure, repeatable and cost effective avoids the use of frozen section, reduces the rate of exploratory procedures and allows a definitive diagnosis of inoperable cases. FNAC is of particular relevance in head and neck lesions because of easy assessibility, excellent patient compliance, minimally invasive nature of procedure and helping to avoid surgery in non-neoplastic lesions, inflammatory conditions and also some tumors. Aims and objectives To test the utility of FNAC, to establish the diagnostic accuracy of cytology by comparison with histopathology diagnosis and to establish the sensitivity and specificity of this technique in head and neck neoplastic lesion. Materials and methods The present study was undertaken in the Department of Pathology, Government Medical College and Hospital, Nashik, between January 2008 and June 2009. Results In the present study, maximum number of aspirates from head and neck neoplastic lesions were found to be of lymph nodes (56.37%). Of the total 378 cases, 71.69% were malignant. 6th decade was the most common age group affected (26.46%). Mean age group was found to be 45.84 years. Males were more commonly affected (65.34%). The male to female ratio was 1.8:1. Out of 92 cases available for follow-up, 85.87% of the cases were same as histopathological diagnosis. Summary and conclusion Excisional biopsy remains the gold standard for diagnosis of head and neck neoplastic lesion, cytological study can establish the diagnosis of the majority of head and neck neoplastic lesions and can be recommended as an adjunct to histopathology. How to cite this article Amit MU, Patel HL, Parmar BH. Study of Cytodiagnosis of Head and Neck Neoplastic Lesions and Comparison with Histopathology. Int J Head Neck Surg 2013; 4(3):119-122.

scholarly journals Histopathological study of nasal masses, a one year retrospective study in a tertiary care centre of Assam

2021 ◽  
Vol 9 (4) ◽  
pp. 1122
Author(s):  
Nurul Alam ◽  
S. K. Abdullah Ahmed ◽  
Monoj K. Deka ◽  
Shah Alam Sheikh
Keyword(s):  
Nasal Cavity ◽  
Fungal Infections ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Relative Distribution ◽  
Tertiary Care Centre ◽  
Inflammatory Polyp ◽  
Nasopharyngeal Angiofibroma ◽  
Female Ratio ◽  
Neoplastic Lesion

Background: Prolapsed lining of the nasal sinuses are defined as nasal polyp. Diseases of the nasal cavity include viral, bacterial and fungal infections, nasal cavity tumors (benign and malignant) as well as inflammations of the nasal mucosa. This study was undertaken to note the various histopathological patterns of nasal masses, their classification and relative distribution of various lesions with regard to age and sex in our setting.Methods: The study is done for a period of 1 year (July 2018 to June 2019). In this study, 30 patients are selected who presented in our hospital with nasal masses and having multiple types of clinical presentations.Results: Total 30 cases presented as nasal mass. Overall male to female ratio was 2.3:1. Nonneoplastic nasal masses formed the largest group of lesions; 24 cases (80%), followed by 6 cases (20%) of neoplastic nasal masses. Inflammatory polyp was the commonest non neoplastic lesion constituting 22 cases followed by rhinosporidiosis with 2 cases. Out of the 6 neoplastic nasal masses, 5 were benign and 1 was malignant. Out of the benign neoplastic masses, inverted papilloma constituted 3 cases and nasopharyngeal angiofibroma constituted 2 cases. Malignant neoplastic mass was embryonal rhabdomyosarcoma.Conclusions: Nasal obstruction and rhinorrhea are the most common symptoms of presentation. Simple inflammatory nasal polyps are the most common histological pattern seen in our environment, and surgery is the best modality of treatment.

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