scholarly journals Correlation of clinical, radiological and histopathological cervical lymph node involvement in oral cancer

2020 ◽  
Vol 6 (2) ◽  
pp. 311
Author(s):  
Mada Lakshmi Narayana ◽  
B. N. Kumarguru ◽  
Hameed Arafath A. ◽  
Urvashi Gaur ◽  
P. Lakshmi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cancer ◽  
Lymph Nodes ◽  
Lymph Node Involvement ◽  
Cervical Lymph Nodes ◽  
Oral Cancers ◽  
Lymph Node Enlargement ◽  
Oral Cancer Patients ◽  
Enhanced Computed Tomography ◽  
Malignant Lymph Nodes

<p class="abstract"><strong>Background:</strong> Lymph node metastasis is the most important factor in the prognosis of oral cancers and survival drops by 50% in the presence of malignant lymph nodes. Most of the lymph node enlargement in oral cancers is due to tumor-associated inflammation rather than metastasis. The aim and objectives of the study was to assess the enlarged reactive and positive cervical lymph nodes clinically and radiologically with the histopathology of neck nodes.</p><p class="abstract"><strong>Methods:</strong> All the oral cancer patients were examined clinically for enlarged neck nodes and subjected to contrast-enhanced computed tomography (CECT) oral cavity and neck. In CECT, all the characteristics of nodes were recorded, and after neck dissection, all levels of lymph nodes were assessed histopathologically.  </p><p class="abstract"><strong>Results:</strong> In our study, 24 patients were included; among them, 31 enlarged lymph nodes were seen clinically. CECT showed a total of 90 enlarged lymph nodes which includes 21 positive nodes. In histopathology 538 lymph nodes were isolated, and among them, only 32 lymph nodes were found to be positive for malignancy.</p><p class="abstract"><strong>Conclusions:</strong> The detection rate of enlarged lymph nodes is more with histopathology than radiological and clinical examination. In our study, 94% of lymph node enlargement was proven to be reactive, which shows more tumor-associated inflammation.</p>

scholarly journals Prostate Cancer Metastatic to the Cervical Lymph Nodes

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Luis Sepúlveda ◽  
Tiago Gorgal ◽  
Vanessa Pires ◽  
Filipe Rodrigues
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Regional Lymph Node ◽  
Lymph Node Involvement ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Cervical Lymph Nodes ◽  
Lymph Node Enlargement

Prostate cancer is the most common cancer in men, often presenting with regional lymph node or bone metastasis and rarely with supradiaphragmatic lymph node involvement. Most metastatic cancers involving the cervical lymph nodes are from cancers of the upper aerodigestive tract. In this report, we describe two cases with cervical lymph node enlargement due to metastatic prostate cancer as the initial clinical presentation: a 43-year-old male, initially misdiagnosed with a tumor of the upper aerodigestive tract and an 87-year-old male with right lobe pneumonia and cervical lymph node enlargement, initially attributed to be an acute inflammatory lymph node reaction. To the best of our knowledge, there are less than 50 cases reported in the literature of adenocarcinoma of prostate metastatic to the cervical lymph nodes and only one case presenting in men younger than 45 years. The authors intend to highlight the importance of digital rectal exam and PSA test in case of persistent left cervical lymph node enlargement, including men younger than 45 years of age.

scholarly journals Cervical lymph node enlargement as the initial manifestation of rectal cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tong-Hui Xie ◽  
Peng Su ◽  
Jian-Guo Hong ◽  
Hui Zhang
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Clinical Manifestations ◽  
Initial Symptom ◽  
Cervical Lymph Nodes ◽  
Supraclavicular Lymph Nodes ◽  
Lymph Node Enlargement

Abstract Background Colorectal cancer is a very common malignant tumor worldwide. The clinical manifestations of advanced colorectal cancer include the changes in bowel habits, hematochezia, diarrhea, local abdominal pain and other symptoms. However, the colorectal cancer with an initial symptom of cervical lymph node enlargement is extremely rare. In this article, we report a case of rectal cancer presenting with cervical lymph nodes enlargement as the initial symptom. Case presentation A 57-year-old woman was admitted to our hospital for cervical lymph node enlargement which was accidentally detected during physical examination. Computed tomography scan revealed multiple enlarged lymph nodes in the neck. Cervical ultrasound showed normal thyroid gland and multiple left supraclavicular lymph nodes enlargement. The patient underwent lymph nodes biopsy and pathologic results showed metastatic adenocarcinoma. The subsequent lower gastrointestinal endoscopy revealed a mucosal bulge lesion located at rectus and biopsy revealed adenocarcinoma. The patient underwent rectal cancer resection. She is alive with no evidence of recurrence or new tumors 2 years after surgery. Conclusions Cervical lymph node metastasis is a rare metastatic way in colorectal cancer. This is the first case of rectal cancer presenting with cervical lymph nodes metastases as the initial symptom. Surgical resection combined with postoperative chemotherapy improved long-term prognosis of the patient. This rare metastatic way of rectal cancer should be paid attention for clinicians.

scholarly journals Determination of Cervical Metastases by Lymphoscintigraphy in Patients with Oral Cancer: A Single Institute Experience

2019 ◽  
Vol 21 (1) ◽  
pp. 12-15
Author(s):  
Md Ahsan Habib ◽  
Quazi Billur Rahman ◽  
Pupree Mutsuddy ◽  
Shamim MF Begum ◽  
Sadia Sultana ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cancer ◽  
Predictive Value ◽  
Cervical Lymph Node Metastasis ◽  
Lymph Node Involvement ◽  
Nodal Metastasis ◽  
Histopathological Diagnosis ◽  
Regional Lymph Nodes ◽  
Oral Cancer Patients ◽  
Lymphatic Obstruction

Background: Oral cancer is the sixth most common cancer in the world. Cervical metastasis is an important adverse prognostic factor and about 40% of the patients with oral cancer develop lymphatic metastasis. Lymphoscintigraphy is the minimally invasive method for the detection of cervical nodal metastasis. The aim of the study was to detect the lymphatic involvement with the aid of lymphoscnitigraphy in patient with oral cancer undergoing surgical procedure and to find out the accuracy of the findings with the post operative histopathological diagnosis. Patients and methods: A total of 30 patients with histologically proven oral cancer underwent lymphoscintigraphic evaluation to detect the lymphatic spread of the tumor. The findings and results of lymphoscintigraphy were compared with the postoperative histopathological diagnosis. Results: Among the 30 patients, lymphatic obstruction was observed in 19 patients of whom 15 patients had perfusion defect and 4 patients had gap defect. No lymphatic obstruction was evident in the rest 11 patients by lymphoscintigraphy. The calculated sensitivity of lymphoscintigraphy in diagnosis of cervical lymph node metastasis was 100%, specificity 78.6%, accuracy 90% and positive predictive value was 84.2% and negative predictive value was 100%. Conclusion: Lymphoscintigraphy was found to be an effective method in detecting lymph node involvement and can be used as an alternative to identify regional lymph nodes metastases pre-operatively in oral cancer patients. Thereby, it will help the surgeon to plan the extent of dissection before surgery which may decrease postoperative complications related to unnecessary extensive lymph node dissection and morbidity. Bangladesh J. Nuclear Med. 21(1): 12-15, January 2018  

Clinical Usefulness of Telomerase Assay for the Detection of Lymph Node Metastasis in Patients With Oral Malignancy

2000 ◽  
Vol 124 (3) ◽  
pp. 398-400
Author(s):  
Tomoki Sumida ◽  
Hiroyuki Hamakawa ◽  
Hiroaki Kayahara ◽  
Hirofumi Zen ◽  
Kenichi Sogawa ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cancer ◽  
Lymph Nodes ◽  
Cancer Cell Line ◽  
Telomerase Activity ◽  
Cervical Lymph Nodes ◽  
Node Metastasis ◽  
Significant Difference ◽  
Oral Malignancy

Abstract Objective.—Telomerase is considered a diagnostic marker of malignancy. We investigated the usefulness of telomerase assay for the detection of lymph node micrometastasis. Methods.—Sixteen cervical lymph nodes with metastasis of oral cancer and 20 benign lymph nodes were studied. The oral cancer cell line was used to estimate the sensitivity for telomerase assay. Telomerase activity was measured by semiquantitative telomeric repeat amplification protocol. Results.—There was a significant difference between malignant and benign lymph nodes. The telomerase activity of 50 mg of lymph nodes with 103 or more cancer cells differed from that of control lymph nodes. Lymph nodes with 102 or fewer tumor cells expressed similar levels as benign lymph nodes. Conclusions.—In addition to routine histologic examination, telomerase assay is considered a useful tool for the detection of lymph node metastasis in patients with oral malignancy.

The chemokine receptor CCR7 and α4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes

Blood ◽  
2002 ◽  
Vol 99 (8) ◽  
pp. 2977-2984 ◽  
Author(s):  
Kathleen J. Till ◽  
Ke Lin ◽  
Mirko Zuzel ◽  
John C. Cawley
Keyword(s):  
Lymph Node ◽  
Chronic Lymphocytic Leukemia ◽  
Lymph Nodes ◽  
Lymph Node Involvement ◽  
Lymphocytic Leukemia ◽  
Lymphocyte Migration ◽  
High Endothelial Venules ◽  
Lymph Node Enlargement ◽  
Node Involvement

Abstract Malignant lymphocyte migration into lymph nodes is an important aspect of chronic lymphocytic leukemia (CLL), yet little is known about the processes involved. Here we demonstrate that CLL cells migrate across vascular endothelium in response to at least 3 chemokines, namely, CCL21, CCL19, and CXCL12. Moreover, transendothelial cell migration (TEM) in response to CCL21 and CCL19 was significantly higher for the malignant B cells of patients who had clinical lymph node involvement as compared with those of patients lacking such organomegaly. Furthermore, the expression of CCR7, the receptor for both CCL21 and CCL19, correlated with clinical lymphadenopathy, and blocking of CCR7 inhibited CLL cell TEM. By using immunohistochemistry we demonstrated that CCL21 and CCL19, but not CXCL12, are located in high endothelial venules and are, therefore, in an appropriate location to induce TEM. Regarding the adhesion receptors involved in TEM, α4 (most likely in association with β1) and αLβ2 were shown to be important in CLL cell TEM in vitro, but only the level of α4 expression correlated with the presence of clinical lymphadenopathy. The present studies are the first to shed light on the factors determining CLL cell entry into nodes and define the phenotype of circulating malignant cells likely to determine the pattern of lymph node enlargement in the disease.

scholarly journals Additional non-sentinel lymph node metastases in early oral cancer patients with positive sentinel lymph nodes

2016 ◽  
Vol 274 (2) ◽  
pp. 961-968 ◽  
Author(s):  
Inne J. Den Toom ◽  
Elisabeth Bloemena ◽  
Stijn van Weert ◽  
K. Hakki Karagozoglu ◽  
Otto S. Hoekstra ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Sentinel Lymph Nodes ◽  
Oral Cancer Patients ◽  
Node Metastases

scholarly journals “Unusual” course of lymphadenopathy in patients with Kawasaki disease: clinical case and literature data

2018 ◽  
Vol 9 (3) ◽  
pp. 111-117
Author(s):  
Maria A. Kaneva ◽  
Ksenia V. Borovleva ◽  
Veronika S. Peredereeva ◽  
Elena P. Fedotova ◽  
Larisa N. Melnikova ◽  
...  
Keyword(s):  
Lymph Node ◽  
Kawasaki Disease ◽  
Lymph Nodes ◽  
Clinical Case ◽  
Febrile Illness ◽  
Disease Diagnosis ◽  
Lymph Node Involvement ◽  
Lymphoproliferative Disease ◽  
Cervical Lymph Nodes ◽  
Characteristic Features

Kawasaki disease is an acute febrile illness of childhood, one of its characteristic features is lymphadenopathy. Most often it manifests unilateral painful more than 1.5 sm in diameter enlargement of single or several cervical lymph nodes. In some cases increase in size can be observed in other lymph nodes groups: axillary, inguinal, paratracheal, para-aortic, retroperitoneal, mesenteric. In that case the dimension is smaller than 1.5 sm in diameter. Usually it occurs at the same time as fever and fades away after inflammation is terminated. Most typical morphological features are non-purulent necrotic changes with subcapsular necrotic lesions and non-specific changes: presence of enlargement of paracortical zone and expansion of sinus. The article presents a clinical case of Kawasaki disease diagnosis accompanied by severe lymphadenopathy, persistence of fever and progression of lymphadenopathy, appearance of supraclavicular lymph node after the introduction of intravenous immunoglobulin. This reflects the non-smooth course of the disease and required differential diagnosis, primarily with lymphoproliferative disease. A review of “unusual” cases of lymphadenopathy in patients with Kawasaki disease described in the literature is presented. The importance of carrying out a histological examination of the lymph node in a nonsmooth course of the disease is underlined. Histological variants of lymph node involvement in patients with Kawasaki disease are described.

THE EFFICACY OF CLINICAL EXAMINATION, ULTRASONOGRAPHY AND CT SCAN IN DETECTING MALIGNANT LYMPH NODES OF THE NECK IN ORAL CANCER AND CONFIRMATION WITH FINAL HISTOPATHOLOGY REPORT

2021 ◽  
pp. 60-61
Author(s):  
Kaustubh Bendale ◽  
Shiva Bharani ◽  
Subha Lakshmi ◽  
Rinsha Gireesh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Ct Scan ◽  
Clinical Evaluation ◽  
Incisional Biopsy ◽  
Cervical Lymph Nodes ◽  
Malignant Lymph Nodes

To evaluate and compare the diagnostic accuracy of detecting malignant cervical lymph nodes using Clinical evaluation, CT scan and Ultrasonography and conrmation with histopathology in patients with squamous cell carcinoma. Atotal number of 30 patients, of both sexes, with carcinoma of different regions of the oral cavity, conrmed with incisional biopsy were included in this study. We found USG to be most sensitive (83.5%), followed by CT (78.3%) and clinical evaluation (63.7%). Similarly, CT scan was found to be most specic (81.5%), followed by USG (78.2%) and clinical evaluation (60.7%).

Sign in / Sign up

Export Citation Format

Share Document