Relevance of patch testing and its correlation with clinical patterns of contact dermatitis of hand

Background: Contact dermatitis of hand is a common dermatoses with different aetiological conditions and different morphologies. The aim of our study is to identify the clinical patterns, causative allergens and the relevance of patch testing for contact dermatitis of hand.Methods: A total of 74 patients with hand eczema were included in our study after getting informed and written consent to do patch tests during December 2016 to May 2017 in our dermatology OPD. Patch test was done by using Indian standard series battery and the readings were taken at 48 hrs and 72 hrs. The results were interpreted according to International Contact Dermatitis Research Group (ICDRG) criteria.Results: The incidence of hand eczema was 3.2 percent with male: female ratio of 1.55:1. The most common age group affected was 31-40 years. The most common morphological pattern observed in our study was fissured pattern (43%) followed by unspecified pattern (23%), hyperkeratotic (12%), lichenoid (10%), pompholyx (4%), fingertip eczema (1%), ring pattern (1%) and mixed morphology (6%). In our study, current relevance of 79% (31 allergens), doubtful relevance of 15% (6 allergens), and old relevance of 3% (one allergen) was noted. Cross sensitization was observed with one allergen (3%).Conclusions: Patch testing is a very useful scientific diagnostic tool that unravels the cause of contact dermatitis of hand. Avoidance of the substances responsible for allergy can be advised to the patient.

Download Full-text

Patch Testing With Methylchloroisothiazolinone/Methylisothiazolinone Using a New Diagnostic Mix—A Multicenter Study From the International Contact Dermatitis Research Group

Dermatitis ◽

10.1097/der.0000000000000657 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Marléne Isaksson ◽

Klaus E. Andersen ◽

Peter Elsner ◽

Chee-Leok Goh ◽

Margarida Gonçalo ◽

...

Keyword(s):

Contact Dermatitis ◽

Multicenter Study ◽

Patch Testing ◽

Research Group ◽

International Contact

Download Full-text

The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center

Dermatology Research and Practice ◽

10.1155/2020/3946084 ◽

2020 ◽

Vol 2020 ◽

pp. 1-16

Author(s):

Anna Tagka ◽

George I. Lambrou ◽

Electra Nicolaidou ◽

Stamatios G. Gregoriou ◽

Alexandra Katsarou-Katsari ◽

...

Keyword(s):

Contact Dermatitis ◽

Patch Testing ◽

Cobalt Chloride ◽

Total Population ◽

Routine Data ◽

Nickel Sulphate ◽

Contact Sensitization ◽

Female Ratio ◽

History Of ◽

Balsam Of Peru

Contact dermatitis is a well-known skin condition, which is related to stimuli and environmental exposure to chemicals, affecting all ages as well as both genders. In the present work, we attempt to investigate the patterns of contact sensitization, with respect to the personal history of atopy (AT), in Greece in a large number of allergens, using patch testing. The retrospective analysis included clinical routine data of 1978 patients collected from 2014 to 2016 in the Laboratory of Patch Testing, National Referral Centre of Occupational Dermatoses. Sensitization, in all cases, was tested with 28 allergens of the European baseline series as adjusted to our local circumstances and clinical experience. A total population of 1978 patients was evaluated, with a male-to-female ratio of 0.45 (1359 females/619 males). From our patient cohort, 693 (35%) patients were evaluated with a history of atopy, while 1285 (65%) were nonatopic. The five most prevalent allergens in the total population without AT were nickel sulphate 5% (15.47%), fragrance mix (I) 8% (9.10%), balsam of Peru (6.47%), cobalt chloride 1% (4.70%), and thiomersal 0.1% (4.10%). Respectively, in the total population with AT, the five most prevalent allergens were nickel sulphate 5% (10.36%), fragrance mix (I) 8% (5.11%), balsam of Peru (3.29%), thiomersal 0.1% (3.03%), and cobalt chloride 1% (2.78%). Contact dermatitis surveillance is of great importance towards the clinical and systematic understanding of the disease. Further studies should be directed towards that end, in order to facilitate more effective health policies.

Download Full-text

Impact of Patch Testing on Quality of Life in Patients with Hand Eczema: A Follow-up Study

Kathmandu University Medical Journal ◽

10.3126/kumj.v11i3.12507 ◽

2015 ◽

Vol 11 (3) ◽

pp. 216-220 ◽

Cited By ~ 3

Author(s):

S Agrawal ◽

A Rijal ◽

S Bhattarai

Keyword(s):

Quality Of Life ◽

Patch Test ◽

Patch Testing ◽

Life Quality ◽

Hand Eczema ◽

Patch Tests ◽

Positive Patch Test ◽

Sum Score ◽

The Impact

Background Patch testing has previously been shown to influence the quality of life, although a very few studies have shown if this is dependent on the result of the patch tests. Objective To assess the impact of patch testing on the quality of life (QOL) in patients with hand eczema (HE). Methods A total of 50 patients diagnosed of hand eczema at the time of patch testing, aged 16 years and above participated in this study. Detailed demographic information and diagnosis of hand eczema were collected on the day of the patch test. After six weeks, the patients were asked about the hand eczema, knowledge of their allergies and change in their life style to avoid the relevant allergens demonstrated on the patch test. Dermatology Life Quality Index (DLQI) was used to measure the QOL on both occasions. Results The patch test positivity was found in 68% of patients to one or more allergens. The sum score of DLQI at baseline was 12.16 ± 5.58 with median 12.0. HE had most impact on symptoms and feelings. Patients with both positive patch test (mean baseline= 11.94± 5.88; mean at six weeks=2.81± 2.01; P<0.001) and negative patch test (mean baseline=12.63± 5.03; mean at 6 weeks=5.4± 3.56; P=0.001) showed significant improvement in DLQI scores, however it was more improved in patients with positive patch test than in patients with negative patch test. Conclusions Hand eczema had an appreciable impact on the QOL. Patch testing had been beneficial to most patients in improving patient quality of life considerably. DOI: http://dx.doi.org/10.3126/kumj.v11i3.12506 Kathmandu Univ Med J 2013; 43(3):216-220

Download Full-text

Allergic Contact Dermatitis Secondary to Moisturizers

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475420919396 ◽

2020 ◽

Vol 24 (4) ◽

pp. 350-359

Author(s):

Stephanie R. Cohen ◽

Jesús A. Cárdenas-de la Garza ◽

Paige Dekker ◽

Wasim Haidari ◽

Sarah S. Chisolm ◽

...

Keyword(s):

Contact Dermatitis ◽

Allergic Contact Dermatitis ◽

Patch Testing ◽

Adverse Reactions ◽

Healthcare Providers ◽

Standard Series ◽

The North ◽

Allergenic Potential ◽

Skin Conditions ◽

Allergic Contact

Background: Moisturizers are cosmetic products used routinely to manage various skin conditions. Even though moisturizers are often thought to have minimal or no adverse reactions, allergic contact dermatitis (ACD) to these products can develop in some cases. Methods: We studied ingredients included in 3 of the most commonly used moisturizer brands, identified their presence in standard patch testing series, and evaluated their allergenic potential, categorizing the allergens as frequent or infrequent. The standard patch testing series used as reference were the Thin-layer Rapid Use Epicutaneous patch test (T.R.U.E. test), the North American Contact Dermatitis Group (NACDG) screening standard series, and the American Contact Dermatitis Society (ACDS) core allergen series. Results: Aveeno, Cetaphil, and Cerave products had a total of 12, 14, and 9 potential allergens, respectively, the majority of which were infrequent and not included in standard patch testing series. Conclusion: Being aware of the allergenic potential of commonly used moisturizers may help healthcare providers when evaluating patients with ACD. Further testing is recommended in a targeted manner when suspecting ACD with negative standard patch testing series or when ACD is refractory to treatment.

Download Full-text

Patch testing with the European standard series and Compositae extracts in patients with airborne contact dermatitis

Contact Dermatitis ◽

10.1034/j.1600-0536.2001.440107-16.x ◽

2001 ◽

Vol 44 (1) ◽

pp. 41-42 ◽

Cited By ~ 8

Author(s):

Vinod Kumar Sharma

Keyword(s):

Contact Dermatitis ◽

Patch Testing ◽

Standard Series ◽

European Standard

Download Full-text

Multicenter Patch Testing With Methylisothiazolinone and Methylchloroisothiazolinone/Methylisothiazolinone Within the International Contact Dermatitis Research Group

Dermatitis ◽

10.1097/der.0000000000000272 ◽

2017 ◽

Vol 28 (3) ◽

pp. 210-214 ◽

Cited By ~ 14

Author(s):

Marléne Isaksson ◽

Iris Ale ◽

Klaus E. Andersen ◽

Peter Elsner ◽

Chee-Leok Goh ◽

...

Keyword(s):

Contact Dermatitis ◽

Patch Testing ◽

Research Group ◽

International Contact

Download Full-text

Patch Testing in Suspected Allergic Contact Dermatitis to Cosmetics

Dermatology Research and Practice ◽

10.1155/2014/695387 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Pramod Kumar ◽

Rekha Paulose

Keyword(s):

Contact Dermatitis ◽

Allergic Contact Dermatitis ◽

Patch Testing ◽

Age Group ◽

Cosmetic Products ◽

Standard Series ◽

Hair Dyes ◽

Common Allergen ◽

Cosmetic Product ◽

Allergic Contact

Background. Increasing use of cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to cosmetics. It is estimated that 1–5.4% of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients.Objectives. The aims of this study are to perform patch testing in suspected ACD to cosmetics and to identify the most common allergen and cosmetic product causing dermatitis.Methods. Fifty patients with suspected ACD to cosmetics were patch-tested with 38 antigens of the Indian Cosmetic Series and 12 antigens of the Indian Standard Series.Results. The majority (58%) of patients belonged to the 21–40 years age group. The presence of ACD to cosmetics was confirmed in 38 (76%) patients. Face creams (20%), hair dyes (14%), and soaps (12%) were the most commonly implicated. The most common allergens identified were gallate mix (40%), cetrimide (28%), and thiomersal (20%). Out of a total of 2531 patches applied, positive reactions were obtained in 3.75%.Conclusion. Incidence of ACD to cosmetics was greater in females. Face creams and hair dyes were the most common cosmetic products implicated. The principal allergens were gallate mix, cetrimide, and thiomersal.

Download Full-text

Hand eczema-Clinical patterns and role of patch testing

Indian Journal of Dermatology Venereology and Leprology ◽

10.4103/0378-6323.16244 ◽

2005 ◽

Vol 71 (3) ◽

pp. 207 ◽

Cited By ~ 5

Author(s):

NandaB Kishore ◽

AD Belliappa ◽

NarendraJ Shetty ◽

D Sukumar ◽

S Ravi

Keyword(s):

Patch Testing ◽

Hand Eczema ◽

Clinical Patterns

Download Full-text

Dermatite de Contato Alérgica aos (Meta)Acrilatos- estudo retrospetivo de sete anos num Hospital Público Português

Revista Portuguesa de Saúde Ocupacional ◽

10.31252/rpso.23.10.2020 ◽

2020 ◽

Vol 10 ◽

pp. 1-10

Author(s):

Alvaro Oliveira ◽

Filipa Almeida ◽

Regina Caldas ◽

Teresa Pereira ◽

Celeste Brito

Keyword(s):

Contact Dermatitis ◽

Building Materials ◽

Health And Safety ◽

Hand Eczema ◽

Surgical Equipment ◽

Patch Tests ◽

Nail Polish ◽

The Face ◽

Specific Regulation ◽

Allergic Contact

Introduction Acrylates are salts or esters of the acrylic acid, widely used as part of cosmetic or dental products, surgical equipment, medical devices, household items, building materials and printing inks. Allergic contact dermatitis (ACD) caused by (metha)acrylates could be described in occupational settings, mainly in beauticians using acrylic manicure and, specifically, the photo-bonded long-lasting nail polish. The use of gloves, fingertips made of Polyethylene/ Ethylvinyl-alcohol, mask, safety glasses and an appropriate uniform are recommended in these cases. Materials and methods We present a retrospective study of ACD to acrylates diagnosed at an Hospital in Braga (Portugal), between January 2012 and March 2018. In all cases the epicutaneous patch tests used included the Portuguese Contact Dermatitis Research Group baseline series and an extended series of (meth)acrylates. Results A total of 39 female patients had a sensitization to (metha)acrylates, aged between 21-66 years, with personal history of atopic eczema and allergic rhinitis in 23 and 26% of cases, respectively. The most frequent presentation was hand eczema (87%). Dorsal and palms were affected in an equal percentage of cases (38%) and nail dystrophy in 8% of patients. Ectopic lesions on the face were detected in 33% of cases, mostly with the involvement of the eyelids. Occupational related exposure due to (metha)acrylates was found in 69% of cases, mostly of them beauticians/ artificial nail technicians. The most common sensitizers among the 39 allergic individuals were 2-hydroxyethyl methacrylate (HEMA; positive in 97% of cases) and ethyleneglycol dimethacrylate (positive in 69% of cases). Conclusion In our population, we highlight the high number of cases of ACD from (meth)acrylates in relation to artificial nails. Concerning to the health and safety of workers, it certainly deserves better preventive measures at the occupational level and specific regulation from the authorities concerned with the safety of consumers. HEMA was the most frequent positive allergen (above 90% of tests) and, in agreement with previous studies, can be considered a good screening allergen.

Download Full-text