Atopic dermatitis and its association with serum immunoglobulin E levels: our experience in KVG medical college and hospital, Karnataka

Background: Eczema is an inflammatory skin reaction which presents as acute, subacute and chronic forms. Eczemas persisting for more than 6 weeks or characterized by thickening and discoloration of skin is typical of chronic eczema. Atopic dermatitis (AD) is a type of chronic or chronically relapsing eczematous skin disorder. To determine the percentage of AD in all forms of chronic eczema by using HRC. We also estimated serum immunoglobulin E (IgE) levels and determined its correlation with chronic eczemas and with various clinical parameters of HRC.Methods: A total of 50 patients with chronic eczema meeting defined inclusion and exclusion criteria were enrolled in this cross-sectional study after taking an informed consent and approval of institutional ethical committee. All patients were subjected to a detailed history based on a questionnaire. A thorough clinical examination was done to determine all major and minor clinical parameters of HRC for AD. Blood samples were collected and AEC and total serum IgE levels were determined.Results: Most of our study patients were females (64%). Majority of males (77.7%) were farmers and majority of females (56.2%) were housewives assisting in fieldwork activities. Various causes of chronic eczema were clinically diagnosed AD (34%), chronic actinic dermatitis (8%), polymorphic light eruption (4%), airborne contact dermatitis (10%), phyto-photodermatitis (10%), chronic hand and/or foot eczema (16%) and seborrheic dermatitis (2%). Thirty-two patients (64%) satisfied HRC. Among all clinical parameters of HRC, pruritus and xerosis were the commonest in AD patients. Serum IgE level was raised in 58% of chronic eczema and 68.7% of AD patients.Conclusions: Serum IgE levels showed significant association with typical morphology and distribution of lesions, early age of onset and perifollicular accentuation.<h2> </h2>

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Total serum IgE levels in soil-transmitted helminth infected children with atopy symptoms

Paediatrica Indonesiana ◽

10.14238/pi54.3.2014.149-54 ◽

2014 ◽

Vol 54 (3) ◽

pp. 149

Author(s):

Hendri Wijaya ◽

Lily Irsa ◽

Supriatmo Supriatmo ◽

Sjabaroeddin Loebis ◽

Rita Evalina

Keyword(s):

Immunoglobulin E ◽

Positive Association ◽

Serum Immunoglobulin ◽

Total Serum ◽

Significant Positive Association ◽

Cross Sectional ◽

Serum Ige ◽

Asthma Symptoms ◽

High Prevalence ◽

Soil Transmitted Helminthiasis

Background High total serum immunoglobulin E (IgE) levelsand eosinophilia are markers for atopy, but other factors mayalso play a key role in affecting atopy, such as intestinal parasiticinfection. Helminthiasis has been associated with a reduced riskof atopy and asthma symptoms in areas with high prevalence ofparasitic infections.Objective To assess for associations between total serum IgElevel and soil-transmitted helminthiasis (STH) infection, as wellas between STH infection and allergy symptoms.Methods We conducted a cross-sectional stu dy on 84consecutively-enrolled children , aged 7- 13 years, in theSecanggang Subdistrict, Langkat District, North SumateraProvince. Subjects were enrolled into one of two groups, with orwithout STH infection. Total serum IgE measurements and stoolSTH examinations were performed in all subjects. Data on atopyor allergy symptoms were obtained by parental interview.Results The 42 subjects with STH infection had significantlyhigher mean total serum lg E levels than the 42 subjects withoutinfec tion, 1,13 1.26 IU/mL and 744.76 IU/mL, respectiv ely(P = 0.029). We also fo und significant positive association sbetween STH infection and asthma symptoms (P= 0.049), as wellas eczema symptoms (P=0.044).Conclusion Mean total serum IgE level is higher in STHinfectedsubjects than in those without infection. In addition,STH infection is positively associated with asthma and eczemasymptoms.

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Dose-Dependent Effect of Cotinine-Verified Tobacco Smoking on Serum Immunoglobulin E Levels in Korean Adult Males

Nicotine & Tobacco Research ◽

10.1093/ntr/ntx247 ◽

2017 ◽

Vol 21 (6) ◽

pp. 813-817 ◽

Cited By ~ 3

Author(s):

Jae-June Dong ◽

Jay J Shen ◽

Yong-Jae Lee

Keyword(s):

Tobacco Smoking ◽

Immunoglobulin E ◽

Allergic Diseases ◽

Serum Immunoglobulin ◽

Total Serum ◽

Adult Males ◽

Serum Ige ◽

Korean Adult ◽

Dose Dependent ◽

Dose Dependent Effect

Abstract Background Smoking is one of the risk factors to exacerbate allergic diseases, and it may affect serum immunoglobulin E (IgE) levels. However, few studies have relied on an objective biomarker to examine the effect of tobacco smoking on serum IgE levels. Method A nationwide cross-sectional study was conducted to examine the relationship between urinary cotinine (Ucot) concentrations and IgE levels in 973 males using data from the 2010 Korean National Health and Nutrition Examination Survey (KNHANES). Ucot was classified into four groups based on concentration (ng/mL) as follows: nonsmoker group (Ucot <50 ng/mL) and three tertile groups in smokers (T1 [Ucot: 50.00–921.28 ng/mL]; T2 [Ucot: 921.29–1869.36 ng/mL]; and T3 [Ucot ≥1869.37 ng/mL]). The dose-response relationships between Ucot concentrations and total serum IgE level were estimated using analysis of covariance (ANCOVA) and multiple linear regression analysis after adjusting for confounding variables. Results We found a significant and positive dose-related effect of cigarette smoking as measured by Ucot concentrations on the total serum IgE level. The multivariate adjusted means of total serum IgE levels (SE) were 321.0 (36.3), 404.4 (102.7), 499.2 (79.2), and 534.7 (82.7) IU/mL, after adjusting for age, body mass index, alcohol ingestion, physical exercise, job, and household income. The regression coefficient β for total serum IgE was β = 68.6 with increasing level of Ucot group after adjusting for the same covariables (p = .009). Conclusion These findings suggest that the amount of smoking may have a dose-dependent effect on total serum IgE levels. Implication Smoking is one of the risk factors to exacerbate allergic diseases, and it may affect serum immunoglobulin E (IgE) levels, which is closely related to type 1 mediated allergic diseases. However, few studies have relied on an objective biomarker to examine the effect of tobacco smoking on serum IgE levels. We found that tobacco exposure, as measured by Ucot concentrations, increased the serum IgE levels in a dose-response manner in a representative sample of Korean adult males.

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Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma pneumoniae-related Extra-pulmonary Diseases

Iranian Journal of Allergy Asthma and Immunology ◽

10.18502/ijaai.v17i5.307 ◽

2018 ◽

Cited By ~ 1

Author(s):

Dimitri Poddighe ◽

Elena Virginia Comi ◽

Ilaria Brambilla ◽

Amelia Licari ◽

Paola Bruni ◽

...

Keyword(s):

Mycoplasma Pneumoniae ◽

Immunoglobulin E ◽

Respiratory Infections ◽

Pulmonary Diseases ◽

Serum Immunoglobulin ◽

Total Serum ◽

Significant Elevation ◽

Serum Ige ◽

Group I ◽

Extra Pulmonary

Mycoplasma pneumoniae has been recognized to be involved in several extra-pulmonary diseases, but the underlying immunologic mechanisms are still largely unknown. Recently, we observed a significant elevation of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE levels in children affected with Mycoplasma pneumoniae-related extra-pulmonary diseases. We prospectively collected the data of 162 children admitted to the hospital (because of respiratory infections or extra-pulmonary diseases) who were evaluated for Mycoplasma pneumoniae serology and total serum IgE levels, concomitantly. Based upon clinical and serology aspects, 3 groups of children were identified: I) with non-mycoplasma respiratory disease; II) with mycoplasma-related respiratory diseases; III) with extra-pulmonary diseases related to concomitant/recent Mycoplasma pneumoniae infection. Interestingly, children with Mycoplasma pneumoniae-related extra-pulmonary diseases showed a significant elevation of total serum IgE. In particular, patients developing Mycoplasma pneumoniae-related extra-pulmonary diseases (group III) showed significantly higher level of IgE than both previous groups (p<0.001 vs. group I; p<0.01 vs. group II). In conclusion, hospitalized children diagnosed with Mycoplasma pneumoniae-related extra-pulmonary diseases resulted to have significantly increased serum IgE compared to children developing respiratory illnesses only.

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Difference in Total Serum Immunoglobulin E Level Among Patients With and Without Intravenous Contrast Media Adverse Reaction on Computed Tomography Scan Examination

Sumatera Medical Journal ◽

10.32734/sumej.v2i1.713 ◽

2019 ◽

Vol 2 (1) ◽

pp. 10-14

Author(s):

Yulikha Ikhmawati ◽

Zuhrial Zubir ◽

Elvita Rahmi Daulay

Keyword(s):

Computed Tomography ◽

Adverse Reaction ◽

Contrast Media ◽

Adverse Reactions ◽

Immunoglobulin E ◽

Total Serum ◽

Intravenous Contrast ◽

Cross Sectional ◽

Serum Ige ◽

Intravenous Contrast Media

The adverse reaction (AR) to intravenous contrast media (ICM) are relatively common. Various opinions pro-posed in the mechanism of the incidence of ICM AR. Suspected that the role of Immunoglobulin E (IgE) me-diates allergic conditions that are part of the AR. Objective:To determine the difference in total serum IgE level among subjects with and without ICM AR on computed tomography (CT) scan examination. To ob-serve difference in total serum IgE levels in subjects undergoing ICM adverse reaction based on the degree of severity. Method: An analytical study with cross-sectional design of 104 subjects undergoing CT scans with ICM, examined IgE levels before and after ICM was administered, then measured the severity of adverse re-actions of contrast media. Result: In this study, subjects undergoing adverse reactions, prior to administration Iopamidol had a higher mean IgE 1270.79 mg / dl compared with those who having AR 1174.90 mg / dl and after administration of Iopamidol a mean of Ig E is still higher in subjects having AR 1507.96 mg/dl com-pared with those having negative AR that is 1325.88 mg/dl, p = 0.696, statistically, not significant. Mild reac-tions in 40 subjects (38.5%) with cough, nausea, dizziness, itching, and sweating. Conclusion: Increase in total IgE levels in subjects with positive adverse reactions are independent(p=0.696).

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LINKAGE ANALYSIS OF IL-4 AND OTHER CHROMOSOME 5q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN E (IgE) CONCENTRATIONS

PEDIATRICS ◽

10.1542/peds.96.2.379 ◽

1995 ◽

Vol 96 (2) ◽

pp. 379-379

Author(s):

Arden Levy

Keyword(s):

Linkage Analysis ◽

Immunoglobulin E ◽

Specific Ige ◽

Serum Immunoglobulin ◽

Total Serum ◽

Serum Ige ◽

Sib Pair Analysis ◽

Pair Analysis

This group found evidence linking five markers in chromosome 5q31.1 with a gene modulating total serum IgE concentration in a sib-pair analysis of 170 individuals in 11 Amish families. Evidence was found for the linkage of 5q31. I and the IL-4 gene. Specific IgE concentrations were not linked to these markers. Thus, this study suggests that IL-4 or a nearby gene in 5q31.1 regulates overall IgE production.

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Role of serum Immunoglobulin E level in diagnosis of severity of cough variant asthma

Journal of Analytical Research in Clinical Medicine ◽

10.15171/jarcm.2018.024 ◽

2018 ◽

Vol 6 (4) ◽

pp. 149-152

Author(s):

Bilan Nemat ◽

Hannaneh Orang-Poor ◽

Azar Dastranji

Keyword(s):

Immunoglobulin E ◽

Cross Sectional Study ◽

Serum Immunoglobulin ◽

Variant Form ◽

Cross Sectional ◽

Serum Ige ◽

Clinical Criteria ◽

Cough Variant Asthma ◽

Significant Difference

Introduction: Cough variant asthma (CVA) is known by airway Hyper responsiveness and nonproductive chronic cough without wheezing for a minimum duration of 8 weeks. It is less common form of asthma. This study was conducted aiming to diagnose the role of serum Immunoglobulin E (IgE) in diagnosis of cough variant form of the disease. Methods: In this cross sectional study, 80 patients with an age range of 5-14 years were included with clinical criteria for CVA who referred to pulmonology clinic of Tabriz Children Hospital, Tabriz, Iran. Serum IgE level was measured and severity of CVA based on Global Initiative for Asthma (GINA) classification was determined, finally the relationship between serum IgE level and severity of CVA was evaluated. Results: In patients with CVA without history of allergic disease, mean serum titer of IgE was 138.2 ± 17.5. Significant difference of serum IgE level in different severities of CVA was detected (P = 0.001). Conclusion: Serum IgE level in patients with CVA is a reliable marker for diagnosis and evaluation of the severity of disease.

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Effects of mineral complex material treatment on 2,4- dinitrochlorobenzene-induced atopic dermatitis like-skin lesions in mice model

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03259-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Johny Bajgai ◽

Jing Xingyu ◽

Ailyn Fadriquela ◽

Rahima Begum ◽

Dong Heui Kim ◽

...

Keyword(s):

Atopic Dermatitis ◽

Water Loss ◽

Immunoglobulin E ◽

Skin Barrier ◽

Skin Lesions ◽

Total Serum ◽

Skin Barrier Function ◽

Barrier Dysfunction ◽

Complex Material ◽

Mineral Complex

Abstract Background Atopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by complex pathogenesis including skin barrier dysfunction, immune-redox disturbances, and pruritus. Prolonged topical treatment with medications such as corticosteroids, calcineurin inhibitors, and T-cell inhibitors may have some potential side-effects. To this end, many researchers have explored numerous alternative therapies using natural products and mineral compounds with antioxidant or immunomodulatory effects to minimize toxicity and adverse-effects. In the current study, we investigated the effects of mineral complex material (MCM) treatment on 2, 4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in SKH-1 hairless mice. Methods Animals were divided into four groups; normal control (NC), negative control treated with DNCB only (DNCB only), positive control treated with DNCB and tacrolimus ointment (PC) and experimental group treated with DNCB and MCM patch (MCM). Skin inflammation and lesion severity were investigated through analyses of skin parameters (barrier score and strength, moisture and trans-epidermal water loss level), histopathology, immunoglobulin E, and cytokines. In addition, reactive oxygen species (ROS), nitric oxide (NO), glutathione peroxidase (GPx), and catalase (CAT) levels were measured in both serum and skin lysate. Results Our results demonstrates that MCM patch improved the progression of AD-like skin lesions by significantly increasing skin barrier strength and decreasing trans-epidermal water loss. Additionally, dermal administration of MCM patch significantly reduced epidermal thickness, ROS, and NO levels in skin lysate. Furthermore, we found that MCM suppressed the levels of AD-involved (Th1 and Th2) cytokines such as IL-2, IFN-γ, and IL-4 in blood. In addition, the levels of other Th1, and Th2 and inflammatory cytokines such as IL-1β, TNF-α, IL-6, IL-12(p70) and IL-10 were found lowest in the MCM group than in the DNCB only and PC groups. Moreover, we found total serum IgE level significantly increased after DNCB treatment, but decreased in the PC and MCM groups. Conclusion Taken together, our findings suggest that MCM application may have beneficial effects either systemic or regional on DNCB-induced AD lesional skin via regulation of the skin barrier function and immune-redox response.

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Molecular pathogenesis and clinical implications of eczema herpeticum

Expert Reviews in Molecular Medicine ◽

10.1017/s1462399408000756 ◽

2008 ◽

Vol 10 ◽

Cited By ~ 27

Author(s):

Caroline Bussmann ◽

Wen-Ming Peng ◽

Thomas Bieber ◽

Natalija Novak

Keyword(s):

Atopic Dermatitis ◽

Age Of Onset ◽

Current Knowledge ◽

Allergen Challenge ◽

Skin Lesions ◽

Molecular Pathogenesis ◽

Type I Interferons ◽

Total Serum ◽

Type I ◽

Eczema Herpeticum

A subgroup of patients with atopic dermatitis develops one or more episodes of a severe viral skin infection caused by herpes simplex virus superimposed on eczematous skin lesions. This condition is named atopic dermatitis complicated by eczema herpeticum. Characteristic features of patients developing eczema herpeticum include an early age of onset of atopic dermatitis with a persistent and severe course into adulthood, predilection for eczematous skin lesions in the head and neck area, elevated total serum IgE levels and increased allergen sensitisation. Deficiencies at the level of both the innate and the adaptive immune system, which have been identified in atopic dermatitis, are much more pronounced in this subgroup. Predisposing cellular factors include a reduced number of plasmacytoid dendritic cells in the epidermis and a modified capacity of these cells to produce type I interferons after allergen challenge. In addition, lower levels of antimicrobial peptides in the skin of atopic dermatitis patients, resulting in part from a Th2-prone micromilieu, contribute to the lack of an effective defence against viral attack. In this review, we summarise the current knowledge of the molecular pathogenesis of eczema herpeticum.

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