scholarly journals Total serum IgE levels in soil-transmitted helminth infected children with atopy symptoms

2014 ◽  
Vol 54 (3) ◽  
pp. 149
Author(s):  
Hendri Wijaya ◽  
Lily Irsa ◽  
Supriatmo Supriatmo ◽  
Sjabaroeddin Loebis ◽  
Rita Evalina
Keyword(s):  
Immunoglobulin E ◽  
Positive Association ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Serum Ige ◽  
Asthma Symptoms ◽  
High Prevalence ◽  
Soil Transmitted Helminthiasis

Background High total serum immunoglobulin E (IgE) levelsand eosinophilia are markers for atopy, but other factors mayalso play a key role in affecting atopy, such as intestinal parasiticinfection. Helminthiasis has been associated with a reduced riskof atopy and asthma symptoms in areas with high prevalence ofparasitic infections.Objective To assess for associations between total serum IgElevel and soil-transmitted helminthiasis (STH) infection, as wellas between STH infection and allergy symptoms.Methods We conducted a cross-sectional stu dy on 84consecutively-enrolled children , aged 7- 13 years, in theSecanggang Subdistrict, Langkat District, North SumateraProvince. Subjects were enrolled into one of two groups, with orwithout STH infection. Total serum IgE measurements and stoolSTH examinations were performed in all subjects. Data on atopyor allergy symptoms were obtained by parental interview.Results The 42 subjects with STH infection had significantlyhigher mean total serum lg E levels than the 42 subjects withoutinfec tion, 1,13 1.26 IU/mL and 744.76 IU/mL, respectiv ely(P = 0.029). We also fo und significant positive association sbetween STH infection and asthma symptoms (P= 0.049), as wellas eczema symptoms (P=0.044).Conclusion Mean total serum IgE level is higher in STHinfectedsubjects than in those without infection. In addition,STH infection is positively associated with asthma and eczemasymptoms.

scholarly journals Atopic dermatitis and its association with serum immunoglobulin E levels: our experience in KVG medical college and hospital, Karnataka

2021 ◽  
Vol 8 (1) ◽  
pp. 50
Author(s):  
Priyanka K. ◽  
Abhirup H. R. ◽  
Badrinath N. ◽  
Aishwarya K. C.
Keyword(s):  
Atopic Dermatitis ◽  
Immunoglobulin E ◽  
Age Of Onset ◽  
Seborrheic Dermatitis ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Clinical Parameters ◽  
Cross Sectional ◽  
Serum Ige ◽  
Chronic Eczema

<p><strong>Background:</strong> Eczema is an inflammatory skin reaction which presents as acute, subacute and chronic forms. Eczemas persisting for more than 6 weeks or characterized by thickening and discoloration of skin is typical of chronic eczema. Atopic dermatitis (AD) is a type of chronic or chronically relapsing eczematous skin disorder. To determine the percentage of AD in all forms of chronic eczema by using HRC. We also estimated serum immunoglobulin E (IgE) levels and determined its correlation with chronic eczemas and with various clinical parameters of HRC.</p><p><strong>Methods:</strong> A total of 50 patients with chronic eczema meeting defined inclusion and exclusion criteria were enrolled in this cross-sectional study after taking an informed consent and approval of institutional ethical committee. All patients were subjected to a detailed history based on a questionnaire. A thorough clinical examination was done to determine all major and minor clinical parameters of HRC for AD. Blood samples were collected and AEC and total serum IgE levels were determined.</p><p><strong>Results:</strong> Most of our study patients were females (64%). Majority of males (77.7%) were farmers and majority of females (56.2%) were housewives assisting in fieldwork activities. Various causes of chronic eczema were clinically diagnosed AD (34%), chronic actinic dermatitis (8%), polymorphic light eruption (4%), airborne contact dermatitis (10%), phyto-photodermatitis (10%), chronic hand and/or foot eczema (16%) and seborrheic dermatitis (2%). Thirty-two patients (64%) satisfied HRC. Among all clinical parameters of HRC, pruritus and xerosis were the commonest in AD patients. Serum IgE level was raised in 58% of chronic eczema and 68.7% of AD patients.</p><p><strong>Conclusions:</strong> Serum IgE levels showed significant association with typical morphology and distribution of lesions, early age of onset and perifollicular accentuation.</p><h2> </h2>

scholarly journals Study on prevalence of hypertension in gazetted officers

2017 ◽  
Vol 4 (2) ◽  
pp. 314
Author(s):  
Prakash Dudhani ◽  
Sanjay Khandekar
Keyword(s):  
State Government ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
High Prevalence ◽  
Chi Square Test ◽  
One Year ◽  
Mercury Sphygmomanometer

Background: There was a strong correlation between increase in hypertension and changing lifestyle factors. The problem which lies with the hypertension is that it cannot be cured completely. And its management requires lifelong medication with some life-style modifications. Decreased physical activities coupled with increased mental tension are important contributors of hypertension. They are usually seen amongst employees of the profession where working is typically sedentary.  The main objectives were to study on prevalence of hypertension and risk factors among Government Gazetted officers of Maharashtra, India.Methods: A cross sectional study was carried among gazetted officers working in various departments of state Government for a period of one year in Solapur district. 355 Gazetted Government officers of class I & class II cadre were studied. Blood pressure was measured with a standard mercury sphygmomanometer. Chi-square test was applied to assess risk factors.Results: In present study, the prevalence of hypertension among Gazetted officers was observed 20.28%. There was significant positive association was found between age and prevalence of hypertension. And also it was found significantly higher in men than women. The association between education and hypertension found to be statistically significant (P<0.001), while there was no association between socioeconomic status and hypertension was found (P=0.33). Prevalence of hypertension was noted higher at every level of BMI. Prevalence of hypertension was significantly higher in smokers, alcoholic and had significant association (P<0.05).Conclusions: We conclude that, because of high prevalence of hypertension in Gazetted officers, periodically they should be screened for the same.

Dose-Dependent Effect of Cotinine-Verified Tobacco Smoking on Serum Immunoglobulin E Levels in Korean Adult Males

2017 ◽  
Vol 21 (6) ◽  
pp. 813-817 ◽  
Author(s):  
Jae-June Dong ◽  
Jay J Shen ◽  
Yong-Jae Lee
Keyword(s):  
Tobacco Smoking ◽  
Immunoglobulin E ◽  
Allergic Diseases ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Adult Males ◽  
Serum Ige ◽  
Korean Adult ◽  
Dose Dependent ◽  
Dose Dependent Effect

Abstract Background Smoking is one of the risk factors to exacerbate allergic diseases, and it may affect serum immunoglobulin E (IgE) levels. However, few studies have relied on an objective biomarker to examine the effect of tobacco smoking on serum IgE levels. Method A nationwide cross-sectional study was conducted to examine the relationship between urinary cotinine (Ucot) concentrations and IgE levels in 973 males using data from the 2010 Korean National Health and Nutrition Examination Survey (KNHANES). Ucot was classified into four groups based on concentration (ng/mL) as follows: nonsmoker group (Ucot &lt;50 ng/mL) and three tertile groups in smokers (T1 [Ucot: 50.00–921.28 ng/mL]; T2 [Ucot: 921.29–1869.36 ng/mL]; and T3 [Ucot ≥1869.37 ng/mL]). The dose-response relationships between Ucot concentrations and total serum IgE level were estimated using analysis of covariance (ANCOVA) and multiple linear regression analysis after adjusting for confounding variables. Results We found a significant and positive dose-related effect of cigarette smoking as measured by Ucot concentrations on the total serum IgE level. The multivariate adjusted means of total serum IgE levels (SE) were 321.0 (36.3), 404.4 (102.7), 499.2 (79.2), and 534.7 (82.7) IU/mL, after adjusting for age, body mass index, alcohol ingestion, physical exercise, job, and household income. The regression coefficient β for total serum IgE was β = 68.6 with increasing level of Ucot group after adjusting for the same covariables (p = .009). Conclusion These findings suggest that the amount of smoking may have a dose-dependent effect on total serum IgE levels. Implication Smoking is one of the risk factors to exacerbate allergic diseases, and it may affect serum immunoglobulin E (IgE) levels, which is closely related to type 1 mediated allergic diseases. However, few studies have relied on an objective biomarker to examine the effect of tobacco smoking on serum IgE levels. We found that tobacco exposure, as measured by Ucot concentrations, increased the serum IgE levels in a dose-response manner in a representative sample of Korean adult males.

scholarly journals Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma pneumoniae-related Extra-pulmonary Diseases

2018 ◽  
Author(s):  
Dimitri Poddighe ◽  
Elena Virginia Comi ◽  
Ilaria Brambilla ◽  
Amelia Licari ◽  
Paola Bruni ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Immunoglobulin E ◽  
Respiratory Infections ◽  
Pulmonary Diseases ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Significant Elevation ◽  
Serum Ige ◽  
Group I ◽  
Extra Pulmonary

Mycoplasma pneumoniae has been recognized to be involved in several extra-pulmonary diseases, but the underlying immunologic mechanisms are still largely unknown. Recently, we observed a significant elevation of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE levels in children affected with Mycoplasma pneumoniae-related extra-pulmonary diseases. We prospectively collected the data of 162 children admitted to the hospital (because of respiratory infections or extra-pulmonary diseases) who were evaluated for Mycoplasma pneumoniae serology and total serum IgE levels, concomitantly. Based upon clinical and serology aspects, 3 groups of children were identified: I) with non-mycoplasma respiratory disease; II) with mycoplasma-related respiratory diseases; III) with extra-pulmonary diseases related to concomitant/recent Mycoplasma pneumoniae infection. Interestingly, children with Mycoplasma pneumoniae-related extra-pulmonary diseases showed a significant elevation of total serum IgE. In particular, patients developing Mycoplasma pneumoniae-related extra-pulmonary diseases (group III) showed significantly higher level of IgE than both previous groups (p<0.001 vs. group I; p<0.01 vs. group II). In conclusion, hospitalized children diagnosed with Mycoplasma pneumoniae-related extra-pulmonary diseases resulted to have significantly increased serum IgE compared to children developing respiratory illnesses only.

scholarly journals Difference in Total Serum Immunoglobulin E Level Among Patients With and Without Intravenous Contrast Media Adverse Reaction on Computed Tomography Scan Examination

2019 ◽  
Vol 2 (1) ◽  
pp. 10-14
Author(s):  
Yulikha Ikhmawati ◽  
Zuhrial Zubir ◽  
Elvita Rahmi Daulay
Keyword(s):  
Computed Tomography ◽  
Adverse Reaction ◽  
Contrast Media ◽  
Adverse Reactions ◽  
Immunoglobulin E ◽  
Total Serum ◽  
Intravenous Contrast ◽  
Cross Sectional ◽  
Serum Ige ◽  
Intravenous Contrast Media

The adverse reaction (AR) to intravenous contrast media (ICM) are relatively common. Various opinions pro-posed in the mechanism of the incidence of ICM AR. Suspected that the role of Immunoglobulin E (IgE) me-diates allergic conditions that are part of the AR. Objective:To determine the difference in total serum IgE level  among subjects with and without ICM AR on computed tomography (CT) scan examination. To ob-serve difference in total serum IgE levels in subjects undergoing ICM adverse reaction based on the degree of severity. Method: An analytical study with cross-sectional design of 104 subjects undergoing CT scans with ICM, examined IgE levels before and after ICM was administered, then measured the severity of adverse  re-actions of contrast media. Result: In this study, subjects undergoing adverse reactions, prior to administration Iopamidol  had a higher mean IgE 1270.79 mg / dl compared with those who having AR  1174.90 mg / dl and after administration of Iopamidol  a mean of Ig E is still higher in subjects having AR  1507.96 mg/dl com-pared with those having negative AR that is 1325.88 mg/dl, p = 0.696, statistically, not significant. Mild reac-tions in 40 subjects (38.5%) with cough, nausea, dizziness, itching, and sweating. Conclusion: Increase in total IgE levels in subjects with positive adverse reactions are independent(p=0.696).

LINKAGE ANALYSIS OF IL-4 AND OTHER CHROMOSOME 5q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN E (IgE) CONCENTRATIONS

PEDIATRICS ◽  
1995 ◽  
Vol 96 (2) ◽  
pp. 379-379
Author(s):  
Arden Levy
Keyword(s):  
Linkage Analysis ◽  
Immunoglobulin E ◽  
Specific Ige ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Serum Ige ◽  
Sib Pair Analysis ◽  
Pair Analysis

This group found evidence linking five markers in chromosome 5q31.1 with a gene modulating total serum IgE concentration in a sib-pair analysis of 170 individuals in 11 Amish families. Evidence was found for the linkage of 5q31. I and the IL-4 gene. Specific IgE concentrations were not linked to these markers. Thus, this study suggests that IL-4 or a nearby gene in 5q31.1 regulates overall IgE production.

scholarly journals Public Knowledge, Attitudes and Self-Practice towards Diabetes Mellitus in Kangar, Perlis

2021 ◽  
Vol 16 (1) ◽  
pp. 150-162
Author(s):  
Pei Pei Soo ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Tertiary Education ◽  
Self Care ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Daily Lives ◽  
High Prevalence ◽  
Public Areas

In Malaysia, the prevalence of diabetes mellitus (DM) was the second highest in Perlis. Prevention and management of DM are largely dependent on self-care in our daily lives. Nonetheless, we have little information concerning factors influencing public engagement in DM self-practice, which might have contributed to the high prevalence of DM in Perlis. This study was conducted to evaluate knowledge, attitudes, and factors associated with self-practice towards DM among the public in Kangar, Perlis. A cross-sectional study was conducted in June 2018 for three months. Eligible participants were invited to complete a selfadministered questionnaire in public areas in Kangar. Descriptive analyses on the sociodemographic, medical backgrounds, knowledge, attitudes, and self-practice towards DM were performed. Independent t-test and Spearman’s correlation were performed to assess the association between sociodemographic characteristics, medical history, knowledge, and attitudes with self-practice towards DM. Multiple linear regression was used to adjust for potential confounding variables. A total of 319 respondents consented and participated in this study. Most of the respondents were female (66.5%), Malay (94%), and had tertiary education (51.7%). Overall, most participants had good scores on knowledge (80.3%), attitudes (98.4%), and self-practice (97.2%) towards DM. A statistically significant positive association was found between age, education level, and attitudes score with DM self-practice (p<0.05). This study suggests a well-structured educational program on diabetes self-care should start as early as in school to clarify public misconceptions on DM management.

scholarly journals Role of serum Immunoglobulin E level in diagnosis of severity of cough variant asthma

2018 ◽  
Vol 6 (4) ◽  
pp. 149-152
Author(s):  
Bilan Nemat ◽  
Hannaneh Orang-Poor ◽  
Azar Dastranji
Keyword(s):  
Immunoglobulin E ◽  
Cross Sectional Study ◽  
Serum Immunoglobulin ◽  
Variant Form ◽  
Cross Sectional ◽  
Serum Ige ◽  
Clinical Criteria ◽  
Cough Variant Asthma ◽  
Significant Difference

Introduction: Cough variant asthma (CVA) is known by airway Hyper responsiveness and nonproductive chronic cough without wheezing for a minimum duration of 8 weeks. It is less common form of asthma. This study was conducted aiming to diagnose the role of serum Immunoglobulin E (IgE) in diagnosis of cough variant form of the disease. Methods: In this cross sectional study, 80 patients with an age range of 5-14 years were included with clinical criteria for CVA who referred to pulmonology clinic of Tabriz Children Hospital, Tabriz, Iran. Serum IgE level was measured and severity of CVA based on Global Initiative for Asthma (GINA) classification was determined, finally the relationship between serum IgE level and severity of CVA was evaluated. Results: In patients with CVA without history of allergic disease, mean serum titer of IgE was 138.2 ± 17.5. Significant difference of serum IgE level in different severities of CVA was detected (P = 0.001). Conclusion: Serum IgE level in patients with CVA is a reliable marker for diagnosis and evaluation of the severity of disease.

Perceived Overprotection and Its Association With Quality of Life in Dementia

GeroPsych ◽  
2019 ◽  
Vol 32 (3) ◽  
pp. 125-134
Author(s):  
Mechthild Niemann-Mirmehdi ◽  
Andreas Häusler ◽  
Paul Gellert ◽  
Johanna Nordheim
Keyword(s):  
Quality Of Life ◽  
Patient Autonomy ◽  
Positive Association ◽  
Well Being ◽  
Negative Association ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
People With Dementia ◽  
Mental Well Being

Abstract. To date, few studies have focused on perceived overprotection from the perspective of people with dementia (PwD). In the present examination, the association of perceived overprotection in PwD is examined as an autonomy-restricting factor and thus negative for their mental well-being. Cross-sectional data from the prospective DYADEM study of 82 patient/partner dyads (mean age = 74.26) were used to investigate the association between overprotection, perceived stress, depression, and quality of life (QoL). The analyses show that an overprotective contact style with PwD has a significant positive association with stress and depression, and has a negative association with QoL. The results emphasize the importance of avoiding an overprotective care style and supporting patient autonomy.

scholarly journals Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jasmin Grischke ◽  
Szymon P. Szafrański ◽  
Uthayakumar Muthukumarasamy ◽  
Susanne Haeussler ◽  
Meike Stiesch
Keyword(s):  
Bacterial Species ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Risk Indicators ◽  
Risk Indicator ◽  
Sectional Study ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Linear Discriminant ◽  
Removable Denture

Abstract Background The prevalence of peri-implantitis ranges between 7 and 38.4% depending on risk indicators such as smoking, diabetes mellitus, lack of periodontal maintenance program, and history or presence of periodontitis. Currently, the possible effect of the type of superstructure on peri-implant health is unclear. This cross-sectional study aims to investigate the influence of the superstructure on the prevalence of peri-implant mucositis, peri-implantitis and peri-implant dysbiosis. Methods During a 32-month recruitment period dental implants were assessed to diagnose healthy peri-implant tissues, mucositis or peri-implantitis. The study included 1097 implants in 196 patients. Out of all peri-implantitis cases 20 randomly chosen submucosal biofilms from implants with fixed denture (FD) originating from 13 patients and 11 biofilms from implants with removable dentures (RD) originating from 3 patients were studied for microbiome analysis. Composition of transcriptionally active biofilms was revealed by RNAseq. Metatranscriptomic profiles were created for thirty-one peri-implant biofilms suffering from peri-implantitis and microbiome changes associated with superstructure types were identified. Results 16.41% of the implants were diagnosed with peri-implantitis, 25.00% of implants with RD and 12.68% of implants with FD, respectively. Multivariate analysis showed a significant positive association on patient (p =  < 0.001) and implant level (p = 0.03) between the prevalence of peri-implantitis and RD. Eight bacterial species were associated either with FD or RD by linear discriminant analysis effect size method. However, significant intergroup confounders (e.g. smoking) were present. Conclusions Within the limitations of the present work, RDs appear to be a risk indicator for peri-implantitis and seem to facilitate expansion of specific periodontopathogens. Potential ecological and pathological consequences of shift in microbiome from RDs towards higher activity of Fusobacterium nucleatum subspecies animalis and Prevotella intermedia require further investigation.

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