scholarly journals Relation of ABO blood group with blood pressure in 25 – 35 years of age group in normal population of Agra

2019 ◽  
Vol 6 (1) ◽  
pp. 5-9
Author(s):  
Amit Upadhyay ◽  
◽  
Richa Srivastava ◽  
Keyword(s):  
Blood Pressure ◽  
Blood Group ◽  
Normal Population ◽  
Abo Blood Group ◽  
Age Group

scholarly journals A phenome-wide association study of ABO blood groups

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Shun Li ◽  
C. M. Schooling
Keyword(s):  
Blood Pressure ◽  
Body Composition ◽  
Association Study ◽  
Blood Group ◽  
Density Lipoprotein ◽  
Blood Group Antigen ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Nucleotide Polymorphisms ◽  
Tag Snp

Abstract Background ABO blood group is associated with differences in lifespan, cardiovascular disease, and some cancers, for reasons which are incompletely understood. To gain sex-specific additional insight about potential mechanisms driving these common conditions for future interventions, we characterized associations of ABO blood group antigen across the phenotype sex-specifically. Methods We performed a phenome-wide association study (PheWAS) assessing the association of tag single nucleotide polymorphisms (SNPs) for ABO blood group antigens (O, B, A1, and A2) with 3873 phenotypes. Results The tag SNP for the O antigen was inversely associated with diseases of the circulatory system (particularly deep vein thrombosis (DVT)), total cholesterol, low-density lipoprotein cholesterol (LDL-C), and ovarian cancer, and positively associated with erythrocyte traits, leukocyte counts, diastolic blood pressure (DBP), and healthy body composition; the tag SNP for the A1 antigen tended to have associations in reverse to O. Stronger associations were more apparent for men than women for DVT, DBP, leukocyte traits, and some body composition traits, whereas larger effect sizes were found for women than men for some erythrocyte and lipid traits. Conclusion Blood group has a complex association with cardiovascular diseases and its major risk factors, including blood pressure and lipids, as well as with blood cell traits and body composition, with some differences by sex. Lower LDL-C may underlie some of the benefits of blood group O, but the complexity of associations with blood group antigen suggests overlooked drivers of common chronic diseases.

scholarly journals The effect of ABO blood group on the diagnosis of von Willebrand disease

Blood ◽  
1987 ◽  
Vol 69 (6) ◽  
pp. 1691-1695 ◽  
Author(s):  
JC Gill ◽  
J Endres-Brooks ◽  
PJ Bauer ◽  
WJ Jr Marks ◽  
RR Montgomery
Keyword(s):  
Blood Group ◽  
Normal Population ◽  
Genetic Defect ◽  
Von Willebrand Disease ◽  
Blood Type ◽  
Abo Blood Group ◽  
Type I ◽  
Group A ◽  
Group B ◽  
Von Willebrand

Abstract In order to firmly establish a normal range for von Willebrand factor antigen (vWF:Ag), we determined plasma vWF:Ag concentrations in 1,117 volunteer blood donors by quantitative immunoelectrophoresis. The presence of the ABO blood group has a significant influence on vWF:Ag values; individuals with blood group O had the lowest mean vWF:Ag level (74.8 U/dL), followed by group A (105.9 U/dL), then group B (116.9 U/dL), and finally group AB (123.3 U/dL). Multiple regression analysis revealed that age significantly correlated with vWF:Ag levels in each blood group. We then performed reverse ABO typing on stored plasma from 142 patients with the diagnosis of von Willebrand disease (vWd). Of 114 patients with type I vWd, blood group O was found in 88 (77%), group A in 21 (18%), group B in 5 (4%), and group AB in none (0%), whereas the frequency of these blood groups in the normal population is significantly different (45%, 45%, 7% and 3%, respectively) (P less than .001). Patients with type II or III vWd had ABO blood group frequencies that were not different from the expected distribution. There may be a subset of symptomatic vWd patients with decreased concentrations of structurally normal vWf (vWd, type I) on the basis of blood group O. Some individuals of blood group AB with a genetic defect of vWF may have the diagnosis overlooked because vWF levels are elevated due to blood type.

Distribution of von Willebrand factor levels in young women with and without bleeding symptoms. Influence of ABO blood group and promoter haplotypes

2008 ◽  
Vol 99 (06) ◽  
pp. 1013-1018 ◽  
Author(s):  
Andreas Hillarp ◽  
Caroline Ekholm ◽  
Eva Mattson ◽  
Christer Halldén ◽  
Britt Friberg ◽  
...  
Keyword(s):  
Blood Group ◽  
Von Willebrand Factor ◽  
Control Group ◽  
Study Group ◽  
Abo Blood Group ◽  
Age Group ◽  
Young Females ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Promoter Haplotypes

SummaryThe normal distribution of von Willebrand factor (VWF) levels is wide. Low levels are associated with bleeding symptoms and von Willebrand disease (VWD). We have recently described a high prevalence of bleeding symptoms in a whole age group of young females (n = 1,019) from Malmo, Sweden. It was the objective of the present study to evaluate the distribution of VWF levels in young females with or without bleeding symptoms in this population, and the influence of ABO blood group and promoter haplotypes on VWF levels and to identify a possible increased prevalence of VWD in females with bleeding symptoms. A random selection of the female age group (n = 246), into a study group (n = 176) with, and a control group (n = 70) without bleeding symptoms, was evaluated. Eighteen girls had VWF:RCo below the reference range, of which 17 belonged to the study group (17/176, 9.7%), and one to the control group (1/70, 1.4%) (p = 0.017). Blood group O was found in 14/18 girls with low VWF:RCo. There was a highly significant correlation between VWF:RCo and blood group O and non-O genotypes. Two common VWF promoter haplotypes did not contribute to the VWF:RCo variation. VWF levels did not correlate with time during menstrual cycle, or the use of oral contraceptives. No case fulfilled the diagnostic criteria for VWD. In conclusion, low VWF:RCo was significantly more frequent in females with bleeding symptoms. However, we found no case fulfilling strict diagnostic criteria for VWD. The ABO blood group was a strong modifier, but VWF promoter haplotypes had no association to VWF levels in this population.

scholarly journals The effect of ABO blood group on the diagnosis of von Willebrand disease

Blood ◽  
1987 ◽  
Vol 69 (6) ◽  
pp. 1691-1695 ◽  
Author(s):  
JC Gill ◽  
J Endres-Brooks ◽  
PJ Bauer ◽  
WJ Jr Marks ◽  
RR Montgomery
Keyword(s):  
Blood Group ◽  
Normal Population ◽  
Genetic Defect ◽  
Von Willebrand Disease ◽  
Blood Type ◽  
Abo Blood Group ◽  
Type I ◽  
Group A ◽  
Group B ◽  
Von Willebrand

In order to firmly establish a normal range for von Willebrand factor antigen (vWF:Ag), we determined plasma vWF:Ag concentrations in 1,117 volunteer blood donors by quantitative immunoelectrophoresis. The presence of the ABO blood group has a significant influence on vWF:Ag values; individuals with blood group O had the lowest mean vWF:Ag level (74.8 U/dL), followed by group A (105.9 U/dL), then group B (116.9 U/dL), and finally group AB (123.3 U/dL). Multiple regression analysis revealed that age significantly correlated with vWF:Ag levels in each blood group. We then performed reverse ABO typing on stored plasma from 142 patients with the diagnosis of von Willebrand disease (vWd). Of 114 patients with type I vWd, blood group O was found in 88 (77%), group A in 21 (18%), group B in 5 (4%), and group AB in none (0%), whereas the frequency of these blood groups in the normal population is significantly different (45%, 45%, 7% and 3%, respectively) (P less than .001). Patients with type II or III vWd had ABO blood group frequencies that were not different from the expected distribution. There may be a subset of symptomatic vWd patients with decreased concentrations of structurally normal vWf (vWd, type I) on the basis of blood group O. Some individuals of blood group AB with a genetic defect of vWF may have the diagnosis overlooked because vWF levels are elevated due to blood type.

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