scholarly journals Histopathological array of cardiac lesions: An autopsy based study in a tertiary care centre

2021 ◽  
Vol 6 (3) ◽  
pp. 173-180
Author(s):  
Renuka Verma ◽  
Sunita Singh ◽  
Nisha Marwah ◽  
Richa Pawar ◽  
Deepshikha Rana
Keyword(s):  
Heart Disease ◽  
Coronary Artery ◽  
Cause Of Death ◽  
Histopathological Examination ◽  
Randomized Study ◽  
Tertiary Care ◽  
Left Circumflex Artery ◽  
Triple Vessel Disease ◽  
Coronary Artery Atherosclerosis ◽  
Cardiac Lesions

Cardiac lesions are responsible for approximately 60-70% of sudden deaths. Histopathological examination of heart on autopsy plays an essential role in determining the cause of death.The present study was conducted to analyse histopathological spectrum of various cardiac lesions in autopsy specimens.This retrospective randomized study was conducted in the Department of Pathology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana. A total of 1152 autopsies were analysed, irrespective of cause of death. Among them heart was included in 1062 autopsies, out of which 62 were autolysed. Hence, 1000 specimen of whole heart were included in our study. A detailed gross and microscopic examination was done and histopathological findings were correlated clinically.Atherosclerosis was the most common cardiac lesion seen in 610 out of 1000 autopsied heart (61%), followed by ischaemic heart disease in 346 cases (34.6%). 27 cases had pericarditis, 23 cases revealed myocardial hypertrophy, 16 cases showed myocarditis, 11 cases had ventricular haemorrhage, 8 cases revealed changes of electrocution, 7 cases had tuberculosis, 6 cases had calcification of valve and 4 cases had metastasis from carcinoma. One case each of infective endocarditis, rheumatic heart disease and aortitis were also noted. The cause of death was not identified in 304 cases. Left anterior descending artery was most frequently involved vessels (35.02%) followed by left circumflex artery (33.41%) then right coronary artery (31.57%). Out of three major vessels 16.24% had single vessel involvement whereas 32.14% & 51.62% cases had two vessels and three vessels involvement respectively. Ischemic heart disease with coronary artery atherosclerosis was found to be the leading cause of death with triple vessel disease as the most common pattern of involvement.

scholarly journals Angiographic profile of young patients (≤ 40 years) in a tertiary care center of Nepal

2020 ◽  
Vol 11 (6) ◽  
pp. 68-71
Author(s):  
Binay Kumar Rauniyar ◽  
Arun Kadel ◽  
Kiran Prasad Acharya ◽  
Kartikesh Kumar Thakur ◽  
Rakesh Bahadur Adhikari ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Tertiary Care ◽  
Significant Coronary Artery Disease ◽  
Young Patients ◽  
Vessel Disease ◽  
Single Vessel ◽  
Triple Vessel Disease ◽  
Artery Disease ◽  
Single Vessel Disease

Background: With rise in prevalence of conventional risk factors like diabetes, hypertension, smoking, dyslipidemia and obesity the incidence of coronary artery disease in young patients have increased in the recent decades even in developing world. There have been multiple studies done in Nepal studying the angiographic profile of coronary disease in general population. However, only few studies has been done till date on the angiographic profile in the young population in our country. Aims and Objectives: In this study, we aim to determine the angiographic profile of young patient ≤ 40 years in a tertiary care centre of Nepal. Materials and Methods: A retrospective analytic study was done in Shahid Gangalal National Heart Centre from January 2019 to December 2019. Individuals of both genders with age ≤ 40 years who underwent coronary angiography were included. Results: Total 109 patients were included. Out of 109, 89 were male and 20 were female. The mean age for male was 35.55 ± 4.31 and for female was 38.55 ± 1.90 (P = 0.003). Among 61 (55.96%) patients who had significant coronary artery disease, 33 patients (30.27%) with single vessel disease, 15 patients (13.76%) had double vessel disease, and 13 patients (11.92%) had triple vessel disease. Left anterior descending (LAD) artery was found to be most frequently involved in all patterns of Coronary artery disease (CAD). Smoking was the most common coronary risk factor present in 29.3% of patients followed by hypertension, family history of premature CAD and diabetes in 14.6%, 7.5% and 5.5% of patients respectively. Overall, the prevalence of smoking was more in males (31.4%) than in females (20%). Conclusion: Single vessel disease (SVD) was most prevalent in young patients with significant CAD. LAD is the most commonly involved coronary artery followed by Right coronary artery (RCA) and Left Circumflex (LCX).

scholarly journals Prevalence and patterns of coronary artery disease in patients undergoing cardiac surgery for rheumatic and non- rheumatic valvular heart disease in a tertiary care center of Nepal

2018 ◽  
Vol 15 (2) ◽  
pp. 21-24
Author(s):  
Ravi Sahi ◽  
Arun Sayami ◽  
Ratna Mani Gajurel ◽  
Chandra Mani Poudel ◽  
Hemant Shrestha ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cardiac Surgery ◽  
Heart Disease ◽  
Coronary Artery ◽  
Valvular Heart Disease ◽  
Tertiary Care ◽  
Vessel Disease ◽  
Cardiovascular Morbidity And Mortality ◽  
Valvular Heart Diseases ◽  
Artery Disease

Background and Aims: Coronary artery disease (CAD) constitute a major cause of cardiovascular morbidity and mortality worldwide with an enormous burden on healthcare resources. Prevalence and pattern of CAD in patients of rheumatic and non-rhemuatic valvular heart diseases varies widely with limited data on optimal strategies for diagnosis and treatment.Methods: This study includes 97 patients with rheumatic and non-rheumatic valvular heart disease who underwent coronary angiogram (CAG) before cardiac surgery. Patients were divided into two groups based on rheumatic heart disease (RHD) & non-rheumatic disease (Non-RHD) and correlate the patterns of CAD.Results: Out of 97 patients, 22 (22.6%) patients were found to have significant CAD. In patients with non-rheumatic origin CAD was common (15 patients, 68.1%) as compared to rheumatic origin (7 patients, 31. 8%). In rheumatic origin, the prevalence was 7(12.2%) out of 57 patients while in non-rheumatic origin, was 15(37.5%) out of 40 patients. In RHD group, all patients with CAD were found to have single vessel diease (SVD) while, in non-RHD group, 11 patients (73.3%) had SVD, 3 patients (16.7%) had double vessel disease (DVD) and one patient (5.6%) had triple vessel disease (TVD).Conclusions: Prevalence of CAD is higher in patients with non-RHD in comparison to those with RHD. We also found SVD to be the most common pattern of CAD in both rheumatic and non-rheumatic valvular heart disease.

scholarly journals Risk factors and coronary angiographic profile in young STEMI patients: results from a tertiary care centre in south-central India

2021 ◽  
Vol 10 (1) ◽  
pp. 111
Author(s):  
Abhishek Golla ◽  
Parvaiz Kadloor ◽  
Rajashekar R. Gurrala ◽  
Kazi Jawwad Hussain ◽  
Kolli Sivadayal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Tertiary Care ◽  
Young Patients ◽  
Tertiary Care Centre ◽  
Circumflex Artery ◽  
Younger Patients ◽  
Left Circumflex Artery ◽  
South Central ◽  
2D Echocardiography

Background: Compared to older counterparts, a significant distinction has been found related to risk factors, clinical presentation, and prognosis of ST-segment elevation myocardial infarction (STEMI) in younger patients. To date, a lack of studies has been looked, specifically at-risk factors and angiographic profile of STEMI among younger patients; with this in mind, we conducted the present study.Methods: This hospital-based, cross-sectional, open-label study was carried out at Deccan College of Medical Sciences between April 2018 and December 2019. Patients under 40 years with the presentation of STEMI were included. All patients were subjected to electrocardiography, 2D echocardiography, and coronary angiogram. Baseline demographics, risk factors, and procedural characteristics were recorded.Results: Of 51 young STEMI patients, 41 (80.4%) were male and 10 (19.6%) were female. The most common risk factors associated with the development of STEMI in young patients were smoking (58.8%), followed by diabetes (45.1%), and dyslipidaemia (45.1%). Anterior wall MI was the most frequent presentation (84.3%). The left anterior descending artery was the most frequently (62.8%) involved vessel, followed by left circumflex artery (9.8%), and right coronary artery (5.9%).Conclusions: Insights gained from the study can aid in identifying clinical characteristics of STEMI in young patients, which may be beneficial to achieve appropriate and timely management. Further, the young population should be educated as to control modifiable risk factors and smoking cessation to prevent coronary artery disease since they belong to the highly productive group in the community.

scholarly journals Closure of coronary arterial fistula by covered stent graft during multivessel percutaneous coronary intervention: a case report

2018 ◽  
Vol 5 (6) ◽  
pp. 2361
Author(s):  
Dolly Mathew
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Coronary Artery ◽  
Stent Graft ◽  
Obstructive Coronary Artery Disease ◽  
Coronary Intervention ◽  
Covered Stent ◽  
Left Circumflex Artery ◽  
Triple Vessel Disease ◽  
Percutaneous Coronary ◽  
Covered Stent Graft

Coronary arterial fistulae are usually incidental during coronary angiography. We report a case of triple vessel disease treated by multivessel percutaneous coronary intervention using drug-eluting stents (DES) and associated coronary arterial fistula to pulmonary artery with covered stent graft. In this case the coronary fistula from right coronary artery (RCA) was opened during dilatation of the obstructive coronary lesion. RCA had significant coronary lesions in the proximal and distal coronary, mid left anterior descending coronary artery and left circumflex artery, which are revascularized with DES. This patient had coronary arterial fistula arising from right coronary and left main coronary artery. Here, the patient was symptomatic because of the obstructive coronary artery disease.

scholarly journals Prevalence of Coronary Artery Atherosclerosis in Different Age Groups: A Post-Mortem Study

2020 ◽  
Vol 15 (1) ◽  
pp. 21-23
Author(s):  
Nasir Uddin Ahmed ◽  
Suranjit Kumar Saha ◽  
Kamal Uddin Ahmed ◽  
Gias Uddin Ahmed ◽  
Syed Golam Kibria
Keyword(s):  
Coronary Artery ◽  
Left Coronary Artery ◽  
Histopathological Examination ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Post Mortem ◽  
Medical College ◽  
Younger Age ◽  
Coronary Artery Atherosclerosis

Coronary artery atherosclerosis (CAA) leads to ischemic heart disease and that is the most common cause of cardiac deaths worldwide. The incidence is more among the elderly people, but now gradually increasing among the young. The study was done to evaluate the prevalence of CAA in different age group by post-mortem study. An observational study was conducted in the department of Pathology of Faridpur Medical College (FMC). In this study total 53 postmortem histopathological examination of heart were done and analyzed, of them 37 were male and 16 were female. Among all, CAA was found in 8 cases and all were male. Regarding age, 4(50%) cases were in the age group from 41 to 50 years, 3 cases were in age of above 60 years and one case was in the age group from 51 to 60 years. Left CAA was observed in 6(75%) cases, both right and left CAA was found in remaining 2(25%) cases but none was found to involve only right coronary artery. Lowest age of involvement of CAA was 42 years that involved left coronary artery. This study shows that the prevalence of CAA is increasing among the younger age group. Faridpur Med. Coll. J. Jan 2020;15(1): 21-23

scholarly journals Risk factors for ST- Elevation Myocardial Infarction in a tertiary hospital in central Nepal

2017 ◽  
Vol 13 (4) ◽  
pp. 416-419
Author(s):  
Sachin Dhungel ◽  
Shankar Laudari ◽  
Laxman Dubey ◽  
Rajesh Panjiyar ◽  
Hari Upadhyay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Artery ◽  
Medical Science ◽  
Left Circumflex Artery ◽  
Vessel Disease ◽  
Single Vessel ◽  
Triple Vessel Disease ◽  
The Mean ◽  
Single Vessel Disease

Background & Objectives: Coronary artery disease is the common cardiac disease in Nepal. The objective of the study is to explore different risk factors for coronary artery disease.Materials & Methods: This was cross sectional  hospital based study studying the baseline clinical and angiographic characters in ST Myocardial infarction who had Primary Percutaneous coronary intervention (PPCI) in College of Medical Science Teaching Hospital (CMSTH).Results: There were 95 cases with male 77 (82.1%)   and female 18 (17.9%). The mean age overall was 60.05 ± 12.2. The mean age of male was 59.9 ± 12.5 and of female was 60.5 ± 11.2 years. Apart from chest pain, common clinical symptoms were sweating in 60 (63.2%) cases, dyspnea in 41 (43.2%), nausea/vomiting in 38 (40%), dizziness in 17 (17.9%) and epigastric pain in nine (9.5%) cases. Common risk factors were smoking in 83 (87.7%) cases, hypertension 59 in (51.6 %), diabetes in 24 (25.3%), dyslipidemia in 24 (25.3%) and family history in six (6.3%) cases. Common angiographic variables were single vessel disease (SVD) in 45 (47.4%), double vessel disease (DVD) in 20 (21.1%) and triple vessel disease (TVD) in 30 (31.6%) cases. Infarct related artery were Right coronary artery (RCA) in 43 (45.3%), Left circumflex artery (LCx) in seven (7.4 %) and Left anterior descending artery (LAD) in 45 (47.4 %) cases.Conclusion: Patients visiting CMSTH had classical symptoms and risk factors of myocardial infarction. Single vessel disease and Left anterior descending infarction was the most common vessel involved.

scholarly journals Effect of PCI on QTC Dispersion in Patients with Angina

2020 ◽  
Vol 16 (1) ◽  
pp. 33-39
Author(s):  
Md Shafiqul Islam ◽  
Shekhar Kumar Mondal ◽  
Jafrin Jahan ◽  
Minhaj Arefin ◽  
Nishat Ahmed ◽  
...  
Keyword(s):  
Heart Disease ◽  
Coronary Artery ◽  
Beta Blockers ◽  
Qt Dispersion ◽  
Circumflex Artery ◽  
Cross Sectional ◽  
Noninvasive Test ◽  
Left Circumflex Artery ◽  
Qtc Dispersion ◽  
Before And After

Background:‘Coronary heart disease (CHD) is now the leading cause of death worldwide; it is on the rise and has become a true pandemic that respects no borders. For the diagnosis of coronary artery disease, the 12 leads electrocardiogram (ECG) is the most readily available noninvasive test by which, in addition of diagnosis, localizing and estimating the size of myocardial ischemia can be determined. Abnormally high QT dispersion has been correlated with risk of arrhythmic death in various cardiac diseases including CAD. An increase in QTd is reported to predict the occurrence of life-threatening ventricular tachyarrhythmias and sudden cardiac death in patients with ischemic heart disease. Materials and Methods: This Cross sectional analytical study was conducted in Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka from January 2013 to December 2013. A total of 100 consecutive patients with angina based on predefined enrollment criteria were included in the study. .All patients were evaluated by history, clinical examination, biochemical analysis, and coronary angiogram (CAG) which was performed during index hospital admission. PCI was done only if the vessel was significantly stenosed.i,e. for LMCA - e”50%, for LAD, LCX and RCA it was e”70% as significant stenosis. Severity of stenosis of the involved vessels were categorized as severe( e”90%) and moderate(<90%). Results: Among the study population 76 (76%) patients were male and 24 (24%) patients were female. The left anterior descending artery (LAD) group comprised 37 patients and there were significant differences between before and after PCI QTc dispersion (90.5±38.9 vs 70.4±39.6 ms, p=0.001). The left circumflex artery (LCX) group was comprised of 6 patients and there were significant differences between before and after PCI QTc dispersion (62.2±41.9 vs 50.2±37.2 ms, p=0.001). The right coronary artery (RCA) group consisted of 18 patients, there being significant differences between before and after PCI QTc dispersion (84.9±40.7 vs 69.1±41.5 ms, p=0.001) Conclusion: PCI reduces QTc dispersion significantly among patients with angina. This QTc dispersion change is not influenced by sex, smoking, beta-blockers, hypertension, diabetes, renal impairment, stable or unstable angina but it depends upon the severity of coronary artery stenosis, involvement of coronary vessel and number of vessels.Reduction of QTc dispersion is a good sign of successful PCI that indicates successful reperfusion which carries an excellent prognostic value of revascularization.Further long term follow up will establish it. University Heart Journal Vol. 16, No. 1, Jan 2020; 33-39

Sign in / Sign up

Export Citation Format

Share Document