scholarly journals Risk factors and coronary angiographic profile in young STEMI patients: results from a tertiary care centre in south-central India

2021 ◽  
Vol 10 (1) ◽  
pp. 111
Author(s):  
Abhishek Golla ◽  
Parvaiz Kadloor ◽  
Rajashekar R. Gurrala ◽  
Kazi Jawwad Hussain ◽  
Kolli Sivadayal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Tertiary Care ◽  
Young Patients ◽  
Tertiary Care Centre ◽  
Circumflex Artery ◽  
Younger Patients ◽  
Left Circumflex Artery ◽  
South Central ◽  
2D Echocardiography

Background: Compared to older counterparts, a significant distinction has been found related to risk factors, clinical presentation, and prognosis of ST-segment elevation myocardial infarction (STEMI) in younger patients. To date, a lack of studies has been looked, specifically at-risk factors and angiographic profile of STEMI among younger patients; with this in mind, we conducted the present study.Methods: This hospital-based, cross-sectional, open-label study was carried out at Deccan College of Medical Sciences between April 2018 and December 2019. Patients under 40 years with the presentation of STEMI were included. All patients were subjected to electrocardiography, 2D echocardiography, and coronary angiogram. Baseline demographics, risk factors, and procedural characteristics were recorded.Results: Of 51 young STEMI patients, 41 (80.4%) were male and 10 (19.6%) were female. The most common risk factors associated with the development of STEMI in young patients were smoking (58.8%), followed by diabetes (45.1%), and dyslipidaemia (45.1%). Anterior wall MI was the most frequent presentation (84.3%). The left anterior descending artery was the most frequently (62.8%) involved vessel, followed by left circumflex artery (9.8%), and right coronary artery (5.9%).Conclusions: Insights gained from the study can aid in identifying clinical characteristics of STEMI in young patients, which may be beneficial to achieve appropriate and timely management. Further, the young population should be educated as to control modifiable risk factors and smoking cessation to prevent coronary artery disease since they belong to the highly productive group in the community.

scholarly journals Etiology and risk factors among young patients presenting with stroke in a tertiary care hospital in South India

2017 ◽  
Vol 5 (3) ◽  
pp. 1027
Author(s):  
Thiagaraj Subburaj ◽  
Subramaniyan Kumarasamy ◽  
Sundaravadivelu Velayudam
Keyword(s):  
Risk Factors ◽  
Clinical Presentation ◽  
Tertiary Care ◽  
Traumatic Injury ◽  
Young Patients ◽  
General Medicine ◽  
Abrupt Onset ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Causes Of Disease

Background: Stroke is one of the leading causes of disease and death throughout the world with the incidence rising steeply with age. The occurrence of stroke in young is rare but once it occurs the outcome is severe. Limited studies have been performed in the Indian population to describe the clinical presentation and etiology of young adults with stroke. The objective of present study is to assess the etiology, risk factors and clinical presentation among patients who visit a tertiary care centre with a clinical diagnosis of stroke in individuals less than 45 years of age.Methods: Consecutive patients visiting the Dept of General Medicine & Neurology, SRM Hospital aged between 15-45 years with abrupt onset of focal or global neurological deficit attributable to vascular cause and persisting for more than 24 hours were included into the study. Patients with traumatic injury and transient ischemic attack were excluded. The clinical features, laboratory and radiological investigations were obtained from the patient’s records.Results: The mean age of the study group was 36.42±6.92 years. The most common risk factor amongst study subjects was smoking (36%). Hemiplegia was more commonly seen in males (38 vs. 14 %, p= 0.26) than in females. Seizures were more commonly seen among subjects with hemorrhagic stroke and cortical venous thrombosis (p= 0.001). Among   subjects with ischemic stroke, the most common etiology was hypercoagulation. The most common arterial territory involved was Middle cerebral artery territory 84.84% with the  Left MCA (53.5%) being  more common than right MCA (46.4%).Conclusions: The clinical presentation and etiology among young patients with stroke appear to remain consistent with that reported earlier in the literature. The paucity of rare presentations of stroke in our study could be attributable to the limited sample size of our study. 

Clinical features and tumor mutational profile of younger versus older patients with cholangiocarcinoma (CCA).

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 240-240
Author(s):  
Lipika Goyal ◽  
Stephanie Reyes ◽  
Apurva Jain ◽  
Rachna T. Shroff ◽  
Tri Minh Le ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Patients ◽  
Tertiary Care ◽  
Tumor Biology ◽  
Young Patients ◽  
Molecular Testing ◽  
Extrahepatic Cholangiocarcinoma ◽  
Younger Patients ◽  
Molecular Features ◽  
Significant Difference

240 Background: As seen in lung cancer, young patients with cancer can have different risk factors, presentation, and tumor genotype than older patients with the same disease. The clinical and molecular features of young patients with CCA have yet to be well characterized. Methods: Retrospective chart review was performed on patients with intrahepatic (ICC) or extrahepatic cholangiocarcinoma (ECC) across 5 institutions. Data on demographics, risk factors, treatments, pathology, and overall survival (OS) were collected. Tumor genotyping results from MGH SNaPShot and Foundation Medicine were analyzed. Log-rank tests and Kaplan-Meier survival curves were used for statistical analysis. Results: Of 567 patients analyzed, 134 (23.6%) were < 50 years old (yo) and 455 (80.2%) had ICC. When assessed for risk factors, younger patients ( < 50yo) were more likely to have primary sclerosing cholangitis (PSC) (p < 0.001) and less likely to have diabetes (p = 0.05), compared to older patients ( ≥ 50yo). Surgical resection rates were similar in younger vs older patients (41.9 vs 42.6%, p = 0.890), but younger patients had larger tumors (median size 7.1 vs 5.3cm p = 0.012). Younger patients were also more likely to receive palliative systemic chemotherapy (p < 0.001) and more lines of therapy (median, 2 vs 1 line, p < 0.001). Frequency of treatment with liver directed therapy did not differ between the two groups. Molecular testing was performed on 222/567 (39.1%) patients of which 84/134 (62.7%) were younger patients and 138/433 (31.9%) were older patients. FGFR aberrations were more common in younger patients versus older patients (17.6 vs. 5.7%, p = 0.002). Targeted therapy was given to 15/84 (17.9%) younger and 28/138 (20.3%) older patients based on results of mutational profiling. Finally, no significant difference was seen in OS between younger and older patients (22.9 vs 22.7 months, p = 0.89). Conclusions: Younger patients with CCA may have different risk factors, tumor biology, and tolerance of systemic therapy compared to older patients. Further study is needed as referral patterns to tertiary care centers and motivation of younger patients to seek tertiary care may impact these results.

scholarly journals Risk factor analysis and angiographic findings in young myocardial infarction patients in tertiary care centre of rural population in South India

2019 ◽  
Vol 6 (1) ◽  
pp. 160
Author(s):  
J.M. Ravichandran Edwin ◽  
E. Thirulogachandar ◽  
Heber Anandan
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Lifestyle Modification ◽  
Tertiary Care ◽  
Young Patients ◽  
Tertiary Care Centre ◽  
Vessel Disease ◽  
History Of ◽  
Artery Disease ◽  
Angiographic Findings

Background: Coronary Artery Disease (CAD) is the leading cause of death and accounts for around 12million deaths annually worldwide. The pattern of coronary artery involvement and clinical outcome varies with age suggesting different underlying pathophysiology. Better understanding this specific problem will lead to further improvement in management. The aim was to study the risk factors and angiographic findings in young patients with acute myocardial infarction.Methods: Thirty-nine patients were included in this study. Patients included in the study underwent elective angiographic performed by the percutaneous femoral approach using standard angiographic techniques. Echo and lipid profile were done to all patients. Data were analysed using MS-Excel.Results: In this study, 39 patients were included, 37 male and 2 female patients, the average age of the patients was 35.12 years. 59% of patients had hypertriglyceridemia, 23.1% of patients hypercholesteremia. 45.9% of male patients were having a history of smoking and alcoholism. 84.6% of patients had obstructive CAD, single vessel disease was observed in 59%, double vessel disease in 7.7%, triple vessel in 2.6% patients.Conclusions: Acute myocardial infarction in young predominantly affects males. Dyslipidemia, smoking and alcoholism were found to be common associated factors in young MI. This emphasizes the need for lifestyle modification for primary prevention. Coronary angiography revealed normal coronaries in 12% suggesting different underlying process other than atherosclerosis. With timely intervention and appropriate management, prognosis is good in young MI patients.

scholarly journals Combined venous and arterial thrombosis revealing underlying myeloproliferative disorder in a young patient: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Rime Benmalek ◽  
Hanane Mechal ◽  
Hatim Zahidi ◽  
Karim Mounaouir ◽  
Salim Arous ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arterial Thrombosis ◽  
Sinus Thrombosis ◽  
Myeloproliferative Neoplasms ◽  
Young Patients ◽  
Janus Kinase ◽  
World Health ◽  
Circumflex Artery ◽  
St Segment Elevation ◽  
Left Circumflex Artery

Abstract  Background Myeloproliferative neoplasms (MPNs) such as polycythemia Vera (PV) and Essential Thrombocythemia (ET) can be associated with a high risk of both venous and arterial thrombosis. However, the co-existence between these two complications is very rare and has never been described before, especially in young adults with no known history of MPNs. Case presentation We report the case of a 39 year-old Caucasian Moroccan male patient without cardiovascular risk factors (CVRF), who presented with acute chest pain. He also suffered from a severe headache since 2 weeks. Electrocardiogram (ECG) showed ST segment elevation myocardial infarction in the posterolateral leads. Cerebral Computed Tomography (CT) scan revealed subarachnoid hemorrhage (SAH), and cerebral Magnetic Resonance Angiography (MRA) found a Superior Sagittal Sinus Thrombosis (SSST). Routine blood tests showed raised hemoglobin and hematocrit in addition to leukocytosis and thrombocythemia. His coronary angiography revealed a thrombus in the ostial left circumflex artery (LCX). Further testing revealed positive Janus kinase 2 (JAK2) V617F mutation and low erythropoietin level, confirming the diagnosis of PV according to the 2008 World Health Organization (WHO) criteria. Antithrombotic and anti-ischemic treatments, in addition to myelosuppressive therapy with hydroxyurea, were initiated with a good clinical and biological evolution. Conclusion This case shows that MPNs are an important cause of thrombosis, especially in young patients with no other risk factors. Early diagnosis and appropriate management are fundamental before the occurrence of life-threatening complications that can sometimes present in unusual forms associating arterial and venous thrombotic events.

Study on Risk Factors and Pattern of Coronary Artery Involvement in Young Acute Coronary Syndrome Patients

2017 ◽  
Vol 32 (1) ◽  
pp. 40-44
Author(s):  
Tanveer Ahmad ◽  
Muhammad Badrul Alam ◽  
Amiruzzaman Khan ◽  
AKM Monwarul Islam ◽  
Zakir Hossain ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Positive Family History ◽  
Young Patients ◽  
Younger Patients ◽  
Coronary Syndrome ◽  
Vessel Disease ◽  
Coronary Artery Involvement ◽  
Triple Vessel Disease

Aims: To compare the risk factors and pattern of coronary artery involvement in young acute coronary syndrome patients with that of the elderly.Methods: This was a cross sectional analytic study done in the Department of Cardiology, Sir Salimullah Medical College and Mitford Hospital during November 2015 to October 2016.Results: Study population was divided into two subgroups, those 18-40 years were considered as young and those >40 years were considered as elderly. Young patients had greater prevalence of smoking, dyslipidemia and positive family history of Ischemic Heart Disease (IHD), whereas hypertension was more prevalent in the elderly. Younger patients mainly presented with STEMI and predominantly had single vessel disease (SVD), whereas elderly patients frequently presented with NSTEMI and Unstable angina and had higher incidence of double vessel disease (DVD) and triple vessel disease (TVD).Conclusion: Younger patients had a different pattern of risk factors and coronary artery involvement in comparision to the elderly.Bangladesh Heart Journal 2017; 32(1) : 40-44

Hypoplastic Left Circumflex Coronary Artery: Imaging Findings with Coronary Computed Tomography Angiography - A Case Report

2019 ◽  
Vol 15 (4) ◽  
pp. 427-429
Author(s):  
Asli Tanrivermis Sayit ◽  
Cetin Celenk
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Coronary Computed Tomography Angiography ◽  
Coronary Artery Imaging ◽  
Circumflex Coronary Artery ◽  
Circumflex Artery ◽  
Coronary Computed Tomography ◽  
True Incidence ◽  
Left Circumflex Artery ◽  
Artery Disease

<P>Background: Hypoplastic coronary artery disease is a rare congenital coronary artery anomaly. It is often detected incidentally, and its true incidence in the general population is not known. </P><P> Discussion: Symptoms of HCAD are syncope, palpitations, dyspnea, and chest pain. Also, arrhythmia and myocardial infarction can be seen; these can cause sudden death, especially in athletes and young people. Diagnosis is often made at autopsy. Conclusion: Here, we present the case of a 39-year-old male with isolated hypoplasia of the left circumflex artery detected by coronary Computed Tomography (CT) angiography who complained of palpitation.</P>

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