scholarly journals Adverse event following platelet rich plasma injection for the management of early Osteoarthritis of knee – A report of 4 cases

2021 ◽  
Vol 7 (1) ◽  
pp. 42-45
Author(s):  
Buddhadeb Nayak ◽  
Harshal S Sakale ◽  
Alok Chandra Agrawal ◽  
Bikram Kar ◽  
Rudra Narayan Dash ◽  
...  
Keyword(s):  
Acute Inflammation ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Outpatient Basis ◽  
Early Osteoarthritis ◽  
Cell Growth And Migration ◽  
Chronic Disability ◽  
Plasma Injection ◽  
And Migration ◽  
Protein Transcription

Osteoarthritis is the leading cause of chronic disability affecting more than 80% of people over the age of 55. Several treatment options are there for early Osteoarthritis (OA) knee, like- rest, ice, brace, NSAIDs, intra-articular corticosteroid, Intra-Articular Hyaluronic Acid (IAHA), and intra-articular platelet-rich plasma (PRP) injection. Growth factors in PRP (PDGF, IGF, VEGF) promote matrix synthesis, cell growth, and migration, thus facilitating protein transcription. Several studies regarding PRP injection in the management of OA knee support this line of management without any documented complications of PRP at the knee joint.We report 4 cases of acute inflammation related to PRP injection for the treatment of OA knee. Two patients developed mild inflammation which was treated with oral medication on an outpatient basis. Another two patients developed moderate to severe inflammation which warranted surgical intervention.Intraarticular PRP injection has been reported in the literature as a successful modality of treatment in OA knee without any significant adverse effect. We are reporting four cases of adverse events following intraarticular PRP injection. Two cases were mild inflammations while the other two were moderate to severe. All four patients recovered and the outcome was satisfactory compared to the pre-injection status. The exact cause for the reaction after PRP injection in the knee is not known. Further study is needed for the cause of the inflammatory reaction.

PLATELET-RICH PLASMA INJECTION IN EARLY OSTEOARTHRITIS KNEE FOLLOW-UP 1 YEAR

2021 ◽  
pp. 6-8
Author(s):  
Abdul Hassan Khan ◽  
Prasanta Kumar Pujari ◽  
Bikramjit Gayen ◽  
Dipak Kumar Jha ◽  
Debarshi Jana
Keyword(s):  
Conservative Treatment ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Repair Process ◽  
Plasma Injection ◽  
Osteoarthritis Knee ◽  
The One ◽  
Tissue Recovery ◽  
Natural Healing ◽  
Better Than

Background: Osteoarthritis (OA) knee is one of the most prevalent musculoskeletal disorders in elderly population. It has got various treatment options but most are unsatisfactory. In recent years Platelet-rich plasma (PRP) is emerged as a promising treatment modality and classied as “Orthobiologics”. PRPenhances tissue recovery, by catalysing the body's natural healing response and tissue repair process. Aim And Objectives:Tocompare the efcacies oftreatmentwithPRPinjectionandconservative treatmentwithNSAIDSandexercise inOAknee. Materials And Methods:This was a observational study in which comparisons of different outcomes were made on the efcacies of the treatments with PRPinjection and compared to conservative treatment with NSAIDS and exercise in OAknee. The study was conducted in the Department of Orthopedics in Ramkrishna Mission SevaPratisthan. Atotal number of 60 patients with power 80% were randomly selected from the patients with OA attended OPD during the period from June 2019 to June 2021. The patients were divided into two groups of 30 patients in each group. The patients of the one group were treated with intra-articular PRPinjection and the patients of another group were treated conservatively with NSAIDS and exercise. After the completion of treatment, the patients were followed-up for 1 year and the outcomes of the treatments were assessed by WOMAC (The Western Ontario and McMaster Universities Osteoarthritis Index) knee assessment scoring system. Results:At 1 year the completion of treatments it was found that both clinical and functional improvements of the patients were signicantly better than the initiation of treatments (p<0.0001). However, the improvements of the patients treated with PRPinjection were signicantly better than the patients treated conservatively with NSAIDS and exercise (p<0.001). Conclusion: From the results of the study it may be concluded that PRP injection is better than conservative treatment with NSAIDS and exercise to treat OAknee

scholarly journals Conservative Treatment of Ankle Osteoarthritis

2021 ◽  
Vol 10 (19) ◽  
pp. 4561
Author(s):  
Sergio Tejero ◽  
Estefanía Prada-Chamorro ◽  
David González-Martín ◽  
Antonio García-Guirao ◽  
Ahmed Galhoum ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Clinical Studies ◽  
Platelet Rich Plasma ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Pharmacological Treatments ◽  
Ankle Osteoarthritis ◽  
Knee Oa ◽  
Plasma Injection ◽  
Inflammatory Drugs

Despite the disabling nature of ankle osteoarthritis (OA), there is poor scientific evidence for a conservative treatment compared to the hip and knee OA. In this regard, most of the treatment options in use are not based on clinical studies of the ankle, and they are extracted from evidence obtained from clinical studies of other lower limb joints. However, this does not seem to be a good idea, since the aetiology of ankle OA is quite different from that of the hip or knee. Nonpharmacological and pharmacological treatments such as nonsteroidal anti-inflammatory drugs, hyaluronic acid, corticosteroid, platelet-rich plasma injection and mesenchymal stem cells injections have been reported. However, further research is required in this field to obtain a specific clinical practice guideline for the conservative treatment of ankle OA.

Arthroscopic Debridement Versus Platelet Rich Plasma Injection in Treatment of Moderate knee Osteoarthritis.

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yousef El Shahat Abo El Fadl ◽  
Riad Megahed ◽  
Mohammed Abdel Fattah ◽  
Mohamed Nasef
Keyword(s):  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Arthroscopic Debridement ◽  
Plasma Injection

scholarly journals Classifying gastric cancer using FLORA reveals clinically relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis

Oncogene ◽  
2021 ◽  
Author(s):  
Yiyun Chen ◽  
Wing Yin Cheng ◽  
Hongyu Shi ◽  
Shengshuo Huang ◽  
Huarong Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Noncoding Rna ◽  
Molecular Subtype ◽  
Sequencing Data ◽  
Cell Growth And Migration ◽  
Protein Coding ◽  
Over Expression ◽  
And Migration ◽  
Patient Prognosis ◽  
Subtype 3

AbstractMolecular-based classifications of gastric cancer (GC) were recently proposed, but few of them robustly predict clinical outcomes. While mutation and expression signature of protein-coding genes were used in previous molecular subtyping methods, the noncoding genome in GC remains largely unexplored. Here, we developed the fast long-noncoding RNA analysis (FLORA) method to study RNA sequencing data of GC cases, and prioritized tumor-specific long-noncoding RNAs (lncRNAs) by integrating clinical and multi-omic data. We uncovered 1235 tumor-specific lncRNAs, based on which three subtypes were identified. The lncRNA-based subtype 3 (L3) represented a subgroup of intestinal GC with worse survival, characterized by prevalent TP53 mutations, chromatin instability, hypomethylation, and over-expression of oncogenic lncRNAs. In contrast, the lncRNA-based subtype 1 (L1) has the best survival outcome, while LINC01614 expression further segregated a subgroup of L1 cases with worse survival and increased chance of developing distal metastasis. We demonstrated that LINC01614 over-expression is an independent prognostic factor in L1 and network-based functional prediction implicated its relevance to cell migration. Over-expression and CRISPR-Cas9-guided knockout experiments further validated the functions of LINC01614 in promoting GC cell growth and migration. Altogether, we proposed a lncRNA-based molecular subtype of GC that robustly predicts patient survival and validated LINC01614 as an oncogenic lncRNA that promotes GC proliferation and migration.

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