Role of Prothrombin time International normalized ratio and activated partial thromboplastin time in beta thalassemia major: A cross sectional study

Objective: The aim of this study was to find the association of postprandial blood glucose with hypercoagulability in comparison to fasting blood sugars(FBS) in diabetic and healthy patients.Methods: The present study involved a total of 156 patients, of which 78 were taken as cases (diabetics) and other 78 as controls (non-diabetics). Laboratory analysis included prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen assay done along with fasting, and postprandial sugars.Results: Platelets in diabetics and healthy controls were in normal range. Decrease in PT and partial thromboplastin time was noted in diabetics compared to non-diabetic controls. Fibrinogen levels were increased in cases compared to controls. Changes in PT values were more significant with postprandial blood sugar (PPBS) levels when compared to FBS levels, and APTT follows the same pattern with more in PPBS levels and FBS levels in diabetics. PPBS showed elevated fibrinogen when compared to FBS in diabetics as well as non-diabetics.Conclusion: Type 2 diabetes mellitus is a hypercoagulable state as proven by the following results of our study.

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Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Hypertensive Patients Attending a Tertiary Hospital in Calabar, Nigeria

Advances in Hematology ◽

10.1155/2014/932039 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Nnamani Nnenna Adaeze ◽

Anthony Uchenna Emeribe ◽

Idris Abdullahi Nasiru ◽

Adamu Babayo ◽

Emmanuel K. Uko

Keyword(s):

Blood Pressure ◽

Prothrombin Time ◽

Partial Thromboplastin Time ◽

Tertiary Hospital ◽

Cross Sectional Study ◽

Activated Partial Thromboplastin Time ◽

Cross Sectional ◽

Hypertensive Patients ◽

Duration Of Illness ◽

Normotensive Subjects

Introduction. Several biomedical findings have established the effects of hypertension on haemostasis and roles of blood coagulation products in the clinical course of hypertension.Methods. This cross-sectional study aimed at determining effects of hypertension on prothrombin time (PT) and activated partial thromboplastin time (APTT) in hypertensive patients in comparison with normotensive subjects attending a tertiary hospital in Calabar. Forty-two (42) hypertensive patients and thirty-nine (39) normotensive control subjects were investigated for PT and APTT using Quick one-stage methods.Results. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) correlated positively with APTT (r=0.3072,r=0.4988;P<0.05) in hypertensive patients. DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P<0.05). DBP correlated negatively with duration of illness (r=-0.3097;P<0.05) in hypertensive patients and positively with age of normotensive subjects (r=0.3523;P<0.05).Conclusion. The results obtained indicated that measurements of PT and APTT may serve as indices for evaluating hemostatic abnormalities in hypertensive patients and guide for antihypertensive therapy. However, to have better understanding of hemostatic activities in hypertension, it is recommended to conduct D-dimer, platelet factors, and protein assays.

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Endocrine complications of beta-thalassemia major patients—Cross-sectional study

International Journal of Blood Transfusion and Immunohematology ◽

10.5348/100051z02ak2020ak ◽

2020 ◽

Vol 10 ◽

pp. 1

Author(s):

Attanayaka Mudiyanse Dilhara Sewwandi Karunaratna ◽

Rasnayaka Mudiyanselage Mudiyanse

Keyword(s):

Thalassemia Major ◽

Cross Sectional Study ◽

Beta Thalassemia ◽

Sectional Study ◽

Cross Sectional ◽

Beta Thalassemia Major ◽

Endocrine Complications

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Renal damages in patients with major β-thalassemia

Journal of Nephropharmacology ◽

10.15171/npj.2020.02 ◽

2019 ◽

Vol 9 (1) ◽

pp. e02-e02

Author(s):

Malihe Najafpour ◽

Majid Farshdousti-Hagh ◽

Ali Akbar Movasagpoor-Akbari ◽

Abbas-Ali Hosein-Pour Feyzi ◽

Majid Malaki

Keyword(s):

Renal Function ◽

Renal Dysfunction ◽

Urine Analysis ◽

Thalassemia Major ◽

Cross Sectional Study ◽

Iron Chelators ◽

Beta Thalassemia ◽

Sectional Study ◽

Cross Sectional ◽

Healthy Control

Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.

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Prevalence of Malocclusion in Patients with Thalassemia Major: A Cross-sectional Study

Iranian Journal of Orthodontics ◽

10.5812/ijo.117155 ◽

2021 ◽

Vol 15 (2) ◽

Author(s):

Parastoo Namdar ◽

Atena Shiva ◽

Tahura Etezadi ◽

Jamshid Yazdani Charati ◽

Hossein Karami ◽

...

Keyword(s):

Thalassemia Major ◽

Cross Sectional Study ◽

Iranian Population ◽

Beta Thalassemia ◽

Practical Training ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference ◽

Adolescents And Adults ◽

And Gender

Background: Iran lies in the world's thalassemia belt; accordingly, the beta‐thalassemia gene is carried by 4% of the Iranian population. Due to the dearth of research and literature available on the prevalence of malocclusions in the Iranian population with beta-thalassemia major, this study was conducted to determine the prevalence and severity of facial abnormalities among patients who were referred to Bu-Ali Sina Hospital, Sari, Iran. Methods: This descriptive cross-sectional study was conducted on 200 patients with thalassemia major who were referred to the care unit of Bu-Ali Sina teaching and therapeutic Hospital, Sari, Iran, in 2018. The patients were then visited by a trained dentist who had been given the necessary theoretical and practical training. Malocclusion was classified based on Angle's classification. Spacing, overcrowding, overjet, and overbite were measured, and the distances were recorded based on a checklist. Results: The prevalence of malocclusions obtained was 87.5%, which included malocclusions of Class I (34%), Class II (31%), and Classes III (22%) amongst patients. There was no significant relationship between the type of malocclusion and gender (P = 0.77). Moreover, no significant difference was observed among patients with thalassemia major and different classes of malocclusions in terms of age both in males (P = 0.49) and females (P = 0.58). Conclusions: Malocclusions are common among adolescents and adults with thalassemia, which is not associated with age or gender. Therefore, patients should be regularly visited and followed up by a dentist to manage and control their dental problems. In addition, effective and preventive measures, as well as health education should be seriously considered in these patients.

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