MODELLING OF STEROIDINDUSED OSTEORESORPTION IN THE EXPERIMENT DURING INTRODUCTION OF ALLOGENIC HYDROXYAPATITE

The main spectrum of biochemical indices of blood serum in rats was investigated during steroid-induced osteoresorption. We have found the changes of bone metabolism markers under the influence of glucocortiсoids. It is established that the introduction of allogenic hydroxyapatite decrease the influence of glucocortiсoids on bone tissue.

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Significance of biochemical markers in diagnosis of bone remodeling disturbances among diabetic mellitus persons

Perm Medical Journal ◽

10.17816/pmj35324-31 ◽

2018 ◽

Vol 35 (3) ◽

pp. 24-31

Author(s):

S. S. Safarova

Keyword(s):

Bone Resorption ◽

Bone Metabolism ◽

Bone Tissue ◽

Bone Remodeling ◽

Serum Markers ◽

Control Group ◽

Bone Resorption Marker ◽

Cross Sectional ◽

Bone Metabolism Markers ◽

Bone Mass Loss

Aim. To assess the influence of changes, observed in men and women with type 1and 2 diabetes mellitus (DM1, DM2) on the state of bone metabolism markers; to determine the directions of changes in bone remodeling serum markers among patients of both genders, suffering from this disease. Materials and methods. The cross-sectional study of patients, diagnosed DM1 (n = 98) and DM2 (n = 137) was conducted; the control group included 82 persons. In all patients, calciotropic hormones, the serum markers of bone remodeling, were studied. Results. The obtained results, regarding assessment of bone metabolism markers content in blood of DM1 and DM2 patients compared to the control, indicated the presence of pathological changes in bone remodeling processes in the form of decrease in osteogenesis marker PINP for patients with DM1 by 16 %, DM 2 – by 12 %, compared with the control group, and increase in bone resorption marker b-CTx in 32 % of patients with DM1 and 25 % with DM2; inconsistency of changes in bone remodeling processes in DM1 patients, with preferential alterations of bone resorption indices, was determined in 28 % of cases. Patients with DM2 had lower PINP and b-CTx levels that reflects the lower bone tissue metabolism, compared to DM1 patients, irrespective of age and duration of disease. Conclusions. The bone mass loss in the majority of the examined patients with diabetes is connected with suppression of osteogenesis and to a significantly lesser extent – with bone tissue resorption. Bone remodeling marker values in patients with DM2 are lower than with DM1. Such factors as glycemic profile compensation, duration of diabetes and presence of diabetic nephropathy are able to influence bone metabolism.

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Performance Results and Concentrations of Biochemical Indices and Mineral Elements in Blood Serum of Fatteners Fed Diets Containing Mixtures of Raw Seeds of Pea (Pisum sativum L.) or Blue Lupin (Lupinus angustifolius L.)

Animals ◽

10.3390/ani10050858 ◽

2020 ◽

Vol 10 (5) ◽

pp. 858 ◽

Cited By ~ 1

Author(s):

Marcin Sońta ◽

Martyna Batorska ◽

Justyna Więcek ◽

Anna Rekiel

Keyword(s):

Blood Serum ◽

Mineral Elements ◽

Control Group ◽

Genetically Modified Soybean ◽

Pisum Sativum L ◽

Study Results ◽

Lupin Seeds ◽

Biochemical Indices ◽

Performance Results ◽

Similar Growth

Two experiments were conducted with fatteners (♀ (Landrace × Yorkshire) × ♂ duroc), 50 animals each (10 pigs per group). The fatteners from the control group (C) were administered feed mixtures with genetically modified soybean meal (SBM-GM) used as the only protein source; whereas these from experimental groups (E1–E4) received feed mixtures in which the SBM-GM was replaced with increasing amounts of raw seeds of pea (Experiment I) or blue lupin (Experiment II): E1—5.0%, E2—10.0%, E3—15.0%, and E4—17.5%. Once the fattening period was completed, production results were determined, and selected blood serum indices were assayed to establish the effect of the nutritional factor on body homeostasis and health status of the animals. Pigs from all groups revealed a similar growth rate and meatiness (p > 0.05). In Experiment I serum analyses showed lower (p < 0.001) concentrations of: cholesterol in E1, E3 and E4; creatinine in E1 and E4 and urea in E3 and E4, compared to the C. In Experiment II, lower (p < 0.001) concentrations of aspartate aminotransferase, alanine-aminotransferase, total protein, and Mg were determined in the serum of fatteners from E1–E4 compared to the C. Even though values of all analyzed blood markers differed among the groups, in most cases they fitted within reference values for the species, which indicates the maintenance of body homeostasis. Study results show that there are no contraindications to the use of pea and blue lupin seeds as alternative feed materials to SBM-GM in pig fattening.

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Mineral-bone metabolism markers in young hemodialysis patients

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2011.08.1143 ◽

2011 ◽

Vol 44 (17-18) ◽

pp. 1425-1428 ◽

Cited By ~ 10

Author(s):

Alvaro Osorio ◽

Esperanza Ortega ◽

Jesús M. Torres ◽

Pilar Sanchez ◽

Estrella Ruiz-Requena

Keyword(s):

Bone Metabolism ◽

Hemodialysis Patients ◽

Bone Metabolism Markers

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Protective effect of vitamin D3 on methylprednisolone acetate (MPA) induced loss of bone metabolism markers and bone mineral density in the lumbar spine of rat

Bone ◽

10.1016/j.bone.2006.01.095 ◽

2006 ◽

Vol 38 (3) ◽

pp. 19

Author(s):

A. Sobhani ◽

F. Moradi ◽

P. Pasbakhsh ◽

I.R. Kashani

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Protective Effect ◽

Bone Metabolism ◽

Bone Mineral ◽

Vitamin D3 ◽

Methylprednisolone Acetate ◽

Mineral Density ◽

Bone Metabolism Markers

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Bone metabolism markers and angiogenic cytokines as regulators of human hematopoietic stem cell mobilization

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-017-0853-4 ◽

2017 ◽

Vol 36 (4) ◽

pp. 399-409 ◽

Cited By ~ 3

Author(s):

Pantelis Tsirkinidis ◽

Evangelos Terpos ◽

Georgios Boutsikas ◽

Athanasios Papatheodorou ◽

Konstantinos Anargyrou ◽

...

Keyword(s):

Stem Cell ◽

Bone Metabolism ◽

Hematopoietic Stem Cell ◽

Stem Cell Mobilization ◽

Hematopoietic Stem ◽

Bone Metabolism Markers ◽

Hematopoietic Stem Cell Mobilization ◽

Cell Mobilization ◽

Angiogenic Cytokines

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Native and microwaved bean and pea starch preparations: physiological effects on the intestinal ecosystem, caecal tissue and serum lipids in rats

British Journal Of Nutrition ◽

10.1017/s0007114509992960 ◽

2009 ◽

Vol 103 (8) ◽

pp. 1118-1126 ◽

Cited By ~ 10

Author(s):

Urszula Krupa-Kozak ◽

Jerzy Juśkiewicz ◽

Małgorzata Wronkowska ◽

Maria Soral-Śmietana ◽

Zenon Zduńczyk

Keyword(s):

Blood Serum ◽

Resistant Starch ◽

Microwave Treatment ◽

Atherogenic Index ◽

Cholesterol Concentration ◽

Control Group ◽

Bacterial Enzymes ◽

Pea Starch ◽

Biochemical Indices

Dietary beans and peas provide fibre, resistant starch and other nutrients that are often lacking in the human diet. The influence of native starches of beans and peas (and microwaved preparations) on N utilisation, biochemical indices in blood serum and caecal ecosystem state (SCFA, bacterial enzymes, micro-organisms) was studiedin vivo. The native pea starch contained more resistant starch compared with its bean counterpart (31v.17 %); however, processing decreased these amounts to 25v.10 %. N digestibility was found to decrease considerably in all experimental groups. A considerable reduction was observed in glucose and total cholesterol concentration in rat blood serum as a result of feeding both dietary legume starch preparations under microwave treatment. This indicates that starch of bean origin activated glycolytic bacterial enzymes; however, all the analysed starches were found to reduce the activity of β-glucuronidase. In addition, both dietary bean starches significantly induced the formation of SCFA in the caecal digesta. As compared with the control group, a significant decrease in the pH of caecal and colonic digesta was demonstrated for both bean starch preparations. In comparison with the diet with native pea starch, its microwaved preparation reduced the concentrations of acetic, butyric and propionic acids among caecal SCFA and increased the pH of caecal and colonic digesta. The atherogenic index was significantly lower in rats fed microwaved pea starch. All investigated starch preparations increased the population ofBifidobacteriumspp. in caecal digesta, but were also good substrates for opportunisticEnterococcusorEscherichia coli.

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Evaluation of Serum Calcium Levels in Patients with Epileptic Seizure

Journal of Mahatma Gandhi University of Medical Sciences and Technology ◽

10.5005/jp-journals-10057-0112 ◽

2020 ◽

Vol 5 (2) ◽

pp. 35-37

Author(s):

Bushra Fiza ◽

Maheep Sinha ◽

Shalu Sharma ◽

Sumit Kumar Tiwari

Keyword(s):

Bone Metabolism ◽

Serum Calcium ◽

Epileptic Seizure ◽

Neuronal Excitability ◽

Epileptic Seizures ◽

Bone Metabolism Markers ◽

Mahatma Gandhi ◽

Medical College ◽

The Central Nervous System ◽

Gandhi Medical College

ABSTRACT Introduction Epilepsy is a disorder of the central nervous system, characterized by an epileptic seizure. Epileptic seizures occur due to abnormal synchronous activity in the brain. Calcium is an essential component of bone. Hypocalcemia enhances neuronal excitability, and there are many causes of which include hypocalcemia, vitamin D deficiency, and PTH resistance. Materials and methods The study was conducted in Department of Biochemistry in association with the Department of Neurology of Mahatma Gandhi Medical College and Hospital, Jaipur. Fifty patients diagnosed for epileptic seizure and 50 controls, visiting the inpatient department (IPD) and outpatient department (OPD) of Neurology fulfilling the inclusion criteria, were enrolled for the study. Result The present study showed significantly lower level of serum calcium in patients with epileptic seizure when compared to controls. Conclusion The serum calcium was measured between epileptic seizure and controls. Our present study showed significantly lower value of calcium. It is therefore suggested that there should be regular screening for calcium in patients with epileptic seizure. The serum calcium is biomarker of bone metabolism; so, the correlation can be further studied with some more bone metabolism markers in epileptic seizure patients. How to cite this article Sharma S, Fiza B, Tiwari SK, et al. Evaluation of Serum Calcium Levels in Patients with Epileptic Seizure. J Mahatma Gandhi Univ Med Sci Tech 2020;5(2):35–37.

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Сalcium-phosphorus balance and bone metabolism markers estimation in the combination therapy of patients with chronic generalized severe periodontitis

The actual problems in dentistry ◽

10.18481/2077-7566-2016-12-2-25-29 ◽

2016 ◽

Vol 12 (2) ◽

pp. 25-29

Author(s):

А. Казакова ◽

A. Kazakova ◽

М. Гуртовая ◽

M. Gurtovaya

Keyword(s):

Combination Therapy ◽

Bone Metabolism ◽

Periodontal Diseases ◽

Ionized Calcium ◽

Balance Study ◽

Bone Metabolism Markers ◽

Phosphorus Balance ◽

Low Level ◽

Periodontal Tissues ◽

Severe Periodontitis

<p class="p1"><span class="s1">The serum calcium-phosphorus balance and bone metabolism markers estimation in 72 patients with severe chronic generalized periodontitis and 20 patients of control healthy group at the age of 25 to 55 was performed. A comprehensive laboratory mineral balance study plays an important role in modern diagnostics of periodontal diseases and allows not only to determine the process of bone destruction activity, but also to control the periodontal treatment ef ciency. The rst examination revealed that 19,4% patients with severe periodontitis had low level of serum ionized calcium, its level being 1,05 mmol/l and less. The Drug-induced management of such patients included prescribing osteogenon in their preoperative period which resulted in 12,61% calcium levels increase within 2 months of osteogenon taking. Thus, adding osteogenon to severe periodontitis combination therapy leads to ionized calcium low level recovery in patients’ serum, bene ts bone regeneration and clinical stabilization of periodontal tissues process due to this medicine active components: hydroxyl apatite and ossein, represented by different growth factors, having a direct impact on bone tissue. </span></p>

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