scholarly journals Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.

2001 ◽  
Vol 48 (1) ◽  
pp. 277-282 ◽  
Author(s):  
A Drzewiecka ◽  
K Urbańska ◽  
Z Matuszak ◽  
M Pineiro ◽  
L G Arnaut ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Biological Effect ◽  
Photophysical Properties ◽  
Red Light ◽  
Human Melanoma ◽  
Oxygen Production ◽  
Absorption And Emission ◽  
Emission Properties

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

Linear and high-molecular-weight poly-porphyrins for efficient photodynamic therapy

2021 ◽  
Author(s):  
Nan Zheng ◽  
Xiahui Li ◽  
Shangwei Huangfu ◽  
Kangkai Xia ◽  
Ruofei Yue ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
High Molecular Weight ◽  
Linear Poly ◽  
High Molecular Weight Poly

A linear poly-porphyrin with high Mw and conjugated by PEG and acetazolamide was developed with enhanced singlet oxygen quantum yield, improved photo-toxicity and excellent in vivo photodynamic therapy.

Effects of electron-withdrawing groups in imidazole-phenanthroline ligands and their influence on the photophysical properties of EuIII complexes for white light-emitting diodes

2017 ◽  
Vol 41 (18) ◽  
pp. 9826-9839 ◽  
Author(s):  
Boddula Rajamouli ◽  
Rachna Devi ◽  
Abhijeet Mohanty ◽  
Venkata Krishnan ◽  
Sivakumar Vaidyanathan
Keyword(s):  
Thin Film ◽  
Quantum Yield ◽  
White Light ◽  
Light Emitting Diode ◽  
Photophysical Properties ◽  
Red Light ◽  
Europium Complexes ◽  
Light Emitting ◽  
White Light Emitting Diodes ◽  
Phenanthroline Ligands

The red light emitting diode (LED) was fabricated by using europium complexes with InGaN LED (395 nm) and shown digital images, corresponding CIE color coordinates (red region) as well as obtained highest quantum yield of the thin film (78.7%).

The Photophysical Properties of Pyropheophorbide-a in Different Laser Light and PDT Efficiency for Eca-109 Cell In Vitro

2011 ◽  
Vol 393-395 ◽  
pp. 1029-1032
Author(s):  
Hui Jing Mao ◽  
Zhi Long Chen ◽  
Ying Ye
Keyword(s):  
Singlet Oxygen ◽  
Laser Light ◽  
Photophysical Properties ◽  
Oxygen Probe ◽  
Oxygen Production ◽  
Light Power ◽  
Oxygen Generation ◽  
Pyropheophorbide A ◽  
Single Oxygen

Pyropheophorbid-a (PyroPheo) is one of the well-known photosensitizers which can be useful for future clinical applications. This work is aimed to compare and measure generation rates of single oxygen through activation of pyropheophorbide-a by four different wavelength, and observe the sensitivity of pyropheophorbide-a mediated photodynamic therapy for eca-109 cell. Methods: UV-vis spectrophotometrics was used to measure decrease of singlet oxygen probe 9,10-dimethylanthracene(DPBF) so as to evaluate singlet oxygen production generation. The Eca-109 cells were were exposed to light (650nm) with a constant light power of 200mW/cm2, at a distance of 5cm, for 25 to 200 seconds. The results were measured by MTT assay. Results: pyropheophorbide-a in DMF solution irradiation by different light power can produce singlet oxygen quickly. Comparison of single oxygen generation rate has proved that photodynamic effect at 532nm is fastest, followed by 650nm, 635nm, 690nm which has correlation with absorbance of pyropheophorbide-a. The survival rate of cells dropped after irradiation by light what was significantly different from other groups. Conclusion: pyropheophorbide-a is an excellent photosensitizer and prooxidant. Through activated by different wavelength it could be apply to different disease

New peripherally substituted lutetium mono and bis phthalocyanines: Synthesis and comparative photophysical and photochemical properties

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1542-1550
Author(s):  
Nagihan Kocaağa ◽  
Öznur Dülger Kutlu ◽  
Ali Erdoğmuş
Keyword(s):  
Mass Spectrometry ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photophysical Properties ◽  
Quantum Yields ◽  
Synthesis And Characterization ◽  
Type Ii ◽  
H Nmr ◽  
Photochemical Properties

In this study, the synthesis and characterization of mono-(phthalocyaninato) lutetium(III) (1-Cl and 1-F) [Lu[Formula: see text](AcO)(Pc)] (Pc [Formula: see text] phthalocyaninato, AcO [Formula: see text] acetate) and bis-(phthalocyaninato) lutetium(III) (2-Cl and 2-Br) [Lu[Formula: see text]Pc[Formula: see text]] bearing halogenated (F, Cl and Br) phenoxy–phenoxy groups are described and verified by IR, [Formula: see text]H-NMR, UV-vis and mass spectrometry. Photochemical and photophysical properties of 1-F, 1-Cl 2-Cl and 2-Br in DMSO are also presented. A comparison between photophysical and photochemical parameters of mono and bis derivatives showed that mono phthalocyanines are better photosensitizers than bis phthalocyanines. Photophysical and photochemical properties of phthalocyanines are very useful for photodynamic therapy applications. Singlet oxygen quantum yields [Formula: see text] give an indication of the potential of the complexes as photosensitizers in photodynamic therapy applications. The chloro, fluoro, bromo-phenoxy–phenoxy substituted mono-(phthalocyaninato) lutetium(III) complexes (1-Cl and 1-F) gave good singlet oxygen quantum yields (from 0.86 to 0.80) in DMSO. Thus, these complexes show potential as Type II photosensitizers for PDT of cancer.

scholarly journals Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Ariane Felgenträger ◽  
Tim Maisch ◽  
Daniel Dobler ◽  
Andreas Späth
Keyword(s):  
Methylene Blue ◽  
Singlet Oxygen ◽  
Direct Detection ◽  
Photophysical Properties ◽  
Red Light ◽  
Quantum Yields ◽  
Antimicrobial Efficiency ◽  
Highly Active ◽  
Light Region ◽  
Multiresistant Bacteria

Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria. Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in the red-light region ( ca. 600–680 nm,  L mol−1 cm−1), their low toxicity, and their attachment/penetration abilities. Except simple substituents like alkyl or hydroxyalkyl residues, nearly no modifications of the phenothiaziniums have been pursued at the auxochromic sites. By this, the properties of methylene blue derivatives and their fields of application are limited; it remains unclear if their potential antimicrobial efficacy may be enhanced, also to compete with porphyrins. We prepared a set of six mainly novel methylene blue derivatives with the ability of additional hydrogen bonding and/or additional cationic charges to study the substituents’ effect on their activity/toxicity profiles and photophysical properties. Direct detection of singlet oxygen was performed at 1270 nm and the singlet oxygen quantum yields were determined. In suspensions with both, Gram-positive and Gram-negative bacteria, some derivatives were highly active upon illumination to inactivateS. aureusandE. coliup to 7 log10steps (99.99999%) without inherent toxicities in the nonirradiated state.

A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

2019 ◽  
Vol 17 (21) ◽  
pp. 5367-5374 ◽  
Author(s):  
Mengqian Yang ◽  
Jingran Deng ◽  
Ding Guo ◽  
Jie Zhang ◽  
Lixia Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Targeting ◽  
Porphyrin Complex ◽  
Platinum Porphyrin ◽  
Targeting Ability

A new folate-conjugated platinum porphyrin complex was synthesized, which displayed high singlet oxygen quantum yield and strong targeting ability.

Photophysical properties of microencapsulated phthalocyanines

2010 ◽  
Vol 14 (03) ◽  
pp. 278-283 ◽  
Author(s):  
Virginia E. Diz ◽  
Gabriela A. Gauna ◽  
Cristian A. Strassert ◽  
Josefina Awruch ◽  
Lelia E. Dicelio
Keyword(s):  
Differential Scanning Calorimetry ◽  
Light Scattering ◽  
Quantum Yield ◽  
Fluorescence Quantum Yield ◽  
Photophysical Properties ◽  
Oxygen Production ◽  
Electronic Microscopy ◽  
Scanning Calorimetry ◽  
Singlet Molecular Oxygen ◽  
Photophysical Parameters

Lipophilic substituted zinc(II) phthalocyanines: 2,3,9,10,16,17,23,24-octakis[(N,N-dimethylaminoethylsulfanyl)]phthalocyaninatozinc(II) (S1) and tetrakis(N,N-dibutylaminoethoxy)phthalocyaninatozinc(II) (3) were incorporated into soybean L-α-phosphatidylcholine (SPC) liposomes of 100 nm diameter. Liposomes were characterized by static light scattering (SLS), transmission electronic microscopy (TEM), and differential scanning calorimetry. The fluorescence quantum yield and singlet molecular oxygen production of 3 are Φ F = 0.15 and ΦΔ = 0.24, respectively, whereas the same photophysical parameters for S1 are Φ F = 0.13 and ΦΔ = 0.51. Higher values of Φ F and ΦΔ are obtained in organic solvent for both dyes. Synthesis of compound 3 has also been reported.

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