A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

2019 ◽  
Vol 17 (21) ◽  
pp. 5367-5374 ◽  
Author(s):  
Mengqian Yang ◽  
Jingran Deng ◽  
Ding Guo ◽  
Jie Zhang ◽  
Lixia Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Targeting ◽  
Porphyrin Complex ◽  
Platinum Porphyrin ◽  
Targeting Ability

A new folate-conjugated platinum porphyrin complex was synthesized, which displayed high singlet oxygen quantum yield and strong targeting ability.

scholarly journals Correction: A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

2020 ◽  
Vol 18 (3) ◽  
pp. 569-569
Author(s):  
Mengqian Yang ◽  
Jingran Deng ◽  
Ding Guo ◽  
Jie Zhang ◽  
Lixia Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Targeting ◽  
Porphyrin Complex ◽  
Platinum Porphyrin

Correction for ‘A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy’ by Mengqian Yang et al., Org. Biomol. Chem., 2019, 17, 5367–5374.

Linear and high-molecular-weight poly-porphyrins for efficient photodynamic therapy

2021 ◽  
Author(s):  
Nan Zheng ◽  
Xiahui Li ◽  
Shangwei Huangfu ◽  
Kangkai Xia ◽  
Ruofei Yue ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
High Molecular Weight ◽  
Linear Poly ◽  
High Molecular Weight Poly

A linear poly-porphyrin with high Mw and conjugated by PEG and acetazolamide was developed with enhanced singlet oxygen quantum yield, improved photo-toxicity and excellent in vivo photodynamic therapy.

scholarly journals Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.

2001 ◽  
Vol 48 (1) ◽  
pp. 277-282 ◽  
Author(s):  
A Drzewiecka ◽  
K Urbańska ◽  
Z Matuszak ◽  
M Pineiro ◽  
L G Arnaut ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Biological Effect ◽  
Photophysical Properties ◽  
Red Light ◽  
Human Melanoma ◽  
Oxygen Production ◽  
Absorption And Emission ◽  
Emission Properties

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

Photophysicochemical properties and photodynamic therapy activity of chloroindium(III) tetraarylporphyrins and their gold nanoparticle conjugates

2019 ◽  
Vol 23 (01n02) ◽  
pp. 34-45 ◽  
Author(s):  
Rodah C. Soy ◽  
Balaji Babu ◽  
David O. Oluwole ◽  
Njemuwa Nwaji ◽  
James Oyim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Dose Range ◽  
Heavy Atom ◽  
Therapeutic Window ◽  
Quantum Yields ◽  
Yield Values ◽  
Yield Formula

Novel chloroindium(III) complexes of tetra(4-methylthiophenyl)porphyrin (2a) and tetra-2-thienylporphyrin (2b) dyes have been synthesized and characterized. The main goal of the project was to identify fully symmetric porphyrin dyes with Q-band regions that lie partially in the therapeutic window that are suitable for use in photodynamic therapy (PDT). 2a and 2b were found to have fluorescence quantum yield values [Formula: see text] 0.01 and moderately high singlet oxygen quantum yields (0.54−0.73) due to heavy atom effects associated with the sulfur and indium atoms. The dark toxicity and PDT activity against epithelial breast cancer cells (MCF-7) were investigated over a dose range of 3.0−40 [Formula: see text]g [Formula: see text] mL[Formula: see text]. The in vitro dark cytotoxicity of 2a is significantly lower than that of 2b at [Formula: see text] 40 [Formula: see text]g [Formula: see text] mL[Formula: see text]. 2a was conjugated with gold nanoparticles (AuNPs) to form a nanoconjugate (2a-AuNPs), which exhibited a higher singlet oxygen quantum yield ([Formula: see text] value and PDT activity than was observed for 2a alone. The results suggest that the AuNPs nanoconjugates of readily synthesized fully symmetric porphyrin dyes are potentially suitable for PDT applications, if meso-aryl substituents that provide scope for nanoparticle conjugation can be introduced that shift the Q bands into the therapeutic window.

scholarly journals New Cy5 photosensitizers for cancer phototherapy: low singlet-triplet gap provides high quantum yield of singlet oxygen

2021 ◽  
Author(s):  
He Ma ◽  
Saran Long ◽  
Jianfang Cao ◽  
Feng Xu ◽  
PanWang Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Reactive Oxygen ◽  
Intersystem Crossing ◽  
High Quantum Yield ◽  
High Quantum ◽  
Highly Efficient

Highly efficient triplet photosensitizers (PSs) have attracted increasing attention in cancer photodynamic therapy where photo-induced reactive oxygen (ROS, such as singlet oxygen) produces via singlet-triplet intersystem crossing (ISC) of the...

scholarly journals Photosensitizer synergistic effects: D–A–D structured organic molecule with enhanced fluorescence and singlet oxygen quantum yield for photodynamic therapy

2018 ◽  
Vol 9 (8) ◽  
pp. 2188-2194 ◽  
Author(s):  
Jianhua Zou ◽  
Zhihui Yin ◽  
Peng Wang ◽  
Dapeng Chen ◽  
Jinjun Shao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Diagnosis ◽  
Organic Molecule ◽  
Synergistic Effects ◽  
Quantum Yields ◽  
Enhanced Fluorescence ◽  
Strong Fluorescence

Novel photosensitizers have been developed with high 1O2 quantum yields and strong fluorescence for cancer diagnosis and PDT.

scholarly journals Evaluation of Polyhedral Oligomeric Silsesquioxane Porphyrin Derivatives on Photodynamic Therapy

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4965
Author(s):  
Paolo Siano ◽  
Alexis Johnston ◽  
Paula Loman-Cortes ◽  
Zaneta Zhin ◽  
Juan L. Vivero-Escoto
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Functional Groups ◽  
Steric Hindrance ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Porphyrin Derivatives ◽  
And Performance ◽  
Oligomeric Silsesquioxane

Polyhedral oligomeric silsesquioxane (POSS) is a promising scaffold to be used as delivery system. POSS can modify the properties of photosensitizers to enhance their efficacy toward photodynamic therapy (PDT). In this work, we designed, synthesized and characterized five different POSS porphyrin (POSSPs 1–5) derivatives containing hydrophobic (1–3) and hydrophilic (4 and 5) functional groups. In general, all the POSSPs showed a better singlet oxygen quantum yield than the parent porphyrins due to the steric hindrance from the POSS unique structure. POSSPs 1 and 3 containing isobutyl groups showed better PDT performance in cancer cells at lower concentrations than POSSPs 4 and 5. However; at higher concentrations, the POSSP4 containing hydrophilic groups has an enhanced PDT efficiency as compared with the parent porphyrin. We envision that the chemical tunability of POSSs can be used as a promising option to improve the delivery and performance of photosensitizers.

scholarly journals Photophysical study and in vitro approach against Leishmania panamensis of dicloro-5,10,15,20-tetrakis(4-bromophenyl)porphyrinato Sn(IV)

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 379
Author(s):  
Fabián Espitia-Almeida ◽  
Carlos Diaz-Uribe ◽  
William Vallejo ◽  
Doris Gómez-Camargo ◽  
Arnold R. Romero Bohórquez ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Complex Compounds ◽  
Visible Range ◽  
Electromagnetic Spectrum ◽  
Metal Free ◽  
Porphyrin Complex ◽  
Ft Ir ◽  
Metal Insertion

Background: Photodynamic therapy activity against different biological systems has been reported for porphyrins. Porphyrin modifications through peripheral groups and/or by metal insertion inside the ring are main alternatives for the improvement of its photo-physical properties. In this study, we synthesized and characterized 5,10,15,20-tetrakis(4-bromophenyl)porphyrin and the dicloro-5,10,15,20-tetrakis(4-bromophenyl)porphyrinato Sn(IV). Methods: Metal-free porphyrin was synthesized using the Alder method, while the Sn(IV)-porphyrin complex was prepared by combining metal-free porphyrin with stannous chloride in DMF; the reaction yields were 47% and 64% respectively. Metal-free porphyrin was characterized by UV-Vis, FT-IR, ESI-mass spectrometry and 13C-NMR. Additionally, the Sn(IV) -porphyrin complex was characterized using UV-Vis and FT-IR. Cyclic voltammetry tests in four different solvents. The fluorescence quantum yield (Φf) was measured using fluorescein as a standard, the singlet oxygen quantum yield (ΦD) was estimated using the standard 5,10,15,20-(tetraphenyl)porphyrin (H2TPP) and the quencher of singlet oxygen 1,3-diphenylisobenzofuran (DPBF). Results: UV-Vis assay showed typical Q and Soret bands for porphyrin and its metallo-porphyrin complex. Compounds showed photoluminescence at the visible range of electromagnetic spectrum. The inclusion of the metal in the porphyrin core changed the Φf from 0.15 to 0.05 and the ΦD increased from 0.55 to 0.59. Finally, the effect of the compounds on the viability of L. panamensis was evaluated by means of the MTT test. The results showed that both compounds decreased the viability of the parasite; this inhibitory activity was greater under light irradiation; the porphyrin compound had IC50 of 16.5 μM and the Sn(IV)-porphyrin complex had IC50 of 19.2 μM. Conclusion: The compounds were synthesized efficiently, their characterization was carried out by different spectroscopy techniques and their own signals were evidenced for both structures, both compounds decreased the cell viability of L. panamensis.

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