scholarly journals Poly(acrylic acid-co-methyl methacrylate)/metronidazole systems: synthesis and complexation.

1970 ◽  
Vol 60 (4) ◽  
Author(s):  
Katarzyna Bialik-Wąs ◽  
Krzysztof Pielichowski
Keyword(s):  
Acrylic Acid ◽  
Methyl Methacrylate ◽  
Active Substance ◽  
Subsequent Stage ◽  
Complexation Reaction ◽  
Release Behavior ◽  
H Nmr ◽  
Ft Ir ◽  
Phosphate Buffered Saline ◽  
Poly Acrylic Acid

We report on preparation of poly(acrylic acid-co-methyl methacrylate) (PAM) micro- and nanoparticles and, in the subsequent stage, complexation reaction with the active substance - metronidazole (MET). The drug release behavior of MET - loaded PAM micro- and nanoparticles was evaluated in water and phosphate buffered saline (PBS, 0.9% NaCl) at 37ºC. It has been found that introduction of MET into PAM micro- and nanoparticles enabled gradual and controlled release of the active substance. Structural analysis using FT-IR (ATR) and (1)H NMR, as well as surface morphology assessment by SEM, were performed.

Reactions of macroions with ester and carboxylic groups of polymers

1987 ◽  
Vol 52 (9) ◽  
pp. 2194-2203
Author(s):  
Miloslav Kučera ◽  
Dušan Kimmer ◽  
Karla Majerová ◽  
Josef Majer
Keyword(s):  
Maleic Anhydride ◽  
Acrylic Acid ◽  
Methyl Methacrylate ◽  
Bond Formation ◽  
Covalent Bond ◽  
The Other ◽  
Poly Methyl Methacrylate ◽  
Other Hand ◽  
Carboxylic Groups ◽  
Poly Acrylic Acid

In the reaction of dianions with poly(methyl methacrylate), only an insignificant amount of insoluble crosslinked product is obtained. If, however, the concentration of grafting dianions approaches that of ester groups, the amount of poly(methyl methacrylate) which may thus be crosslinked becomes quite significant. Dications, too, can bring about crosslinking of only an insignificant number of poly(methyl methacrylate) chains. Carboxylic groups in poly(acrylic acid) react with dianions and dications in an anhydrous medium similarly to ester groups. On the other hand, in the presence of a cocatalytic amount of water dications are more readily bound to carboxylic groups, forming a covalent bond. The relatively highest efficiency was observed in the bond formation between dication and the poly[styrene-alt-(maleic anhydride)], both in an anhydrous medium and in the presence of H2O.

Synthesis of poly(methyl methacrylate)-b-poly(acrylic acid) by DPE method

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Dong Chen ◽  
Ruixue Liu ◽  
Zhifeng Fu ◽  
Yan Shi
Keyword(s):  
Molecular Weight ◽  
Acrylic Acid ◽  
Methyl Methacrylate ◽  
Diblock Copolymer ◽  
Self Assembly ◽  
Gel Permeation Chromatography ◽  
Amphiphilic Diblock Copolymer ◽  
Poly Methyl Methacrylate ◽  
Copolymer Poly ◽  
Poly Acrylic Acid

AbstractAmphiphilic diblock copolymer poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) was prepared by 1,1-diphenylethene (DPE) method. Firstly, free radical polymerization of methyl methacrylate was carried out with AIBN as initiator in the presence of DPE, giving a DPE-containing PMMA precursor with controlled molecular weight. tert-Butyl acrylate (tBA) was then polymerized in the presence of the PMMA precursor, and PMMA-b-PtBA diblock copolymer with controlled molecular weight was prepared. Finally, amphiphilic diblock copolymer PMMA-b-PAA was obtained by hydrolysis of PMMA-b-PtBA. The formation of PMMA-b-PAA was confirmed by 1H NMR spectrum and gel permeation chromatography. Transmission electron microscopy and dynamic light scattering were used to detect the self-assembly behavior of the amphiphilic diblock polymers in methanol.

Immobilization of urease in poly(1-vinyl imidazole)/poly(acrylic acid) network

2010 ◽  
Vol 64 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Mehmet Şenel ◽  
Agah Coşkun ◽  
M. Fatih Abasıyanık ◽  
Ayhan Bozkurt
Keyword(s):  
Acrylic Acid ◽  
Enzyme Immobilization ◽  
Storage Stability ◽  
Polymer Network ◽  
Ft Ir ◽  
Basic Characteristics ◽  
And Storage ◽  
Menten Constant ◽  
Ft Ir Spectroscopy ◽  
Poly Acrylic Acid

AbstractIn this study, urease was immobilized in a polymer network obtained by complexation of poly(1-vinyl imidazole) (PVI) with poly(acrylic acid) (PAA). Preparation of the polymer network was monitored by FT-IR spectroscopy. Scanning electron microscopy (SEM) revealed that enzyme immobilization had a strong effect on film morphology. Proton conductivity of the PVI/PAA network was measured via impedance spectroscopy under humidified conditions. Values of the Michaelis-Menten constant (K M) for immobilized urease were higher than for the free enzyme, indicating a decreased affinity of the enzyme to its substrate. The basic characteristics (pHopt, pHstability, T opt, T stability, reusability, and storage stability) of immobilized urease were determined. The results show that the PAA/PVI polymer network is suitable for enzyme immobilization.

Dual-Charge Nanofiber Mats Made of Chitosan(CS)/Poly(Vinyl Alcohol) (PVA) and Poly-(Acrylic Acid-Co-Maleic Acid) (PAMA)/PVA

2019 ◽  
Vol 819 ◽  
pp. 145-150
Author(s):  
Thapakorn Chareonying ◽  
Junnasir M. Sakilan ◽  
Theerasak Rojanarata ◽  
Prasopchai Patrojanasophon ◽  
Prasert Akkaramongkolporn ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Maleic Acid ◽  
Vinyl Alcohol ◽  
Electrospinning Process ◽  
Poly Vinyl Alcohol ◽  
Water Capacity ◽  
Ft Ir ◽  
Nanofiber Mats ◽  
Positively Charged ◽  
Poly Acrylic Acid

Nanofibers have been widely used for tissue engineering. Using charged polymers for the preparation of nanofibers can be useful for the loading of substances or macromolecules. Dual charge nanofiber mats are expected to be able to immobilize both positively charged and negatively charged substances in one versatile nanofiber mat. The purpose of this study was to prepare and characterize dual-charge nanofibers generated from poly (vinyl alcohol) (PVA)/poly-(acrylic acid-co-maleic acid) (PAMA) and chitosan (CS)/PVA. The polymer solutions of PAMA/PVA (1:1.63 w/w) and CS/PVA (1:2.33 w/w) were electrospun to form the nanofibers using dual-jet electrospinning process. The obtained dual-charge nanofibers were thermally crosslinked by leaving the nanofibers in the oven at 110-130 °C for 0.5, 1, 3, 5 h. The appearance of the nanofiber mat was characterized by a scanning electron microscope (SEM), and the diameter of nanofibers were determined by an image analysis software (J-micro vision®). The percentage water insolubilization and FT-IR spectra were also determined. The dual-size nanofiber mats with smooth and bead-free fibers were obtained. The diameter of the PAMA/PVA and CS/PVA fibers was 574.54 ± 142.98 nm and 225.69 ± 41.92 nm, respectively. The desirable temperature and time for the crosslink of the dual-charge nanofiber mats was 130 °C for 1 h which could provide a high insolubilization with water capacity of 93.22 ± 2.23%.

scholarly journals Nanogels of poly(acrylic acid): Uptake and release behavior with fluorescent oligothiophene-labeled bovine serum albumin

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Simona Argentiere ◽  
Laura Blasi ◽  
Giuseppe Ciccarella ◽  
Giovanna Barbarella ◽  
Roberto Cingolani ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Acrylic Acid ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Acid Uptake ◽  
Release Behavior ◽  
Uptake And Release ◽  
Poly Acrylic Acid

scholarly journals Structural analysis of microbial poly(ɛ-L-lysine)/poly(acrylic acid) complex by FT-IR, DSC, and solid-state 13C and 15N NMR

2011 ◽  
Vol 44 (2) ◽  
pp. 200-203 ◽  
Author(s):  
Shiro Maeda ◽  
Yasuhiro Fujiwara ◽  
Chizuru Sasaki ◽  
Ko-Ki Kunimoto
Keyword(s):  
Solid State ◽  
Structural Analysis ◽  
Acrylic Acid ◽  
15N Nmr ◽  
Acid Complex ◽  
Ft Ir ◽  
Poly Acrylic Acid

Synthesis and Characteristics of Interpenetrating Polymer Network Hydrogels Based on Konjac Glucomannan with Different Molecular Weights and Poly(acrylic acid)

2011 ◽  
Vol 393-395 ◽  
pp. 1004-1007
Author(s):  
Xue Yao ◽  
Xue Gang Luo ◽  
Ben Chao Han
Keyword(s):  
Acrylic Acid ◽  
Enzymatic Degradation ◽  
Drug Carrier ◽  
Polymer Network ◽  
Konjac Glucomannan ◽  
Interpenetrating Polymer Network ◽  
Swelling Ratio ◽  
Molecular Weights ◽  
Ft Ir ◽  
Poly Acrylic Acid

Konjac glucomannan with different molecular weights/poly(acrylic acid) hydrogels were prepared in this paper. The structure of the IPN hydrogels was characterized by FT-IR and SEM. The swelling ratio of these hydrogels showed they had pH-sensitive properties and the enzymatic degradation tests showed the hydrogels retain the enzymatic degradation character of KGM. Furthermore, hydrogel composed of native KGM degraded sharply in enzymatic degradation test and it had bigger swelling ratio and weight loss ratio than those hydrogels which composed of lower molecular weights KGM. Therefore, hydrogels composed of lower molecular weight might release drug more stable when they were used as drug carrier.

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