Betamethasone Gel and Lignocaine Jelly Applied Over Endotracheal Tube to Reduce Post-Operative Sore Throat and Hoarseness of Voice - A Comparative Study

2021 ◽  
Vol 8 (27) ◽  
pp. 2423-2427
Author(s):  
Sridevi Boddu ◽  
Chenna Kesava Swamy Kakaraparthi
Keyword(s):  
Endotracheal Tube ◽  
General Anaesthesia ◽  
Sore Throat ◽  
Endotracheal Intubation ◽  
Orotracheal Intubation ◽  
P Value ◽  
Post Anaesthesia Care Unit ◽  
Grade 3 ◽  
American Society ◽  
Anaesthesia Care

BACKGROUND Although post-operative sore throat, cough and hoarseness of voice (HOV) are minor sequelae after general anaesthesia (GA), these can be troublesome to the patient. This study was done to compare the efficacy of betamethasone gel and lignocaine jelly as lubricants in reducing post-operative sore throat and hoarseness of voice in patients operated under general anaesthesia with orotracheal intubation. METHODS This interventional study compares the incidence of post-operative sore throat and hoarseness of voice after endotracheal intubation on applying betamethasone gel (betamethasone group) or lignocaine jelly (lignocaine group) on the tracheal tube. 120 American Society of Anaesthesiologist (ASA) class I and class II patients who had undergone elective surgeries under general anaesthesia were divided into two groups: betamethasone group and lignocaine group. All patients were enquired on post-operative sore throat and hoarseness of voice at 1, 6 and 24 hours after extubation in the post-anaesthesia care unit. RESULTS The incidence of no sore throat, mild, moderate and severe post-operative sore throat at 24 hours after extubation in betamethasone group was 75.0 %, 23.3 %, 1.7 % and 0 % respectively compared to lignocaine group which was 33.3 %, 53.3 %, 6.7 % and 6.7 % respectively (P value < 0.05). The incidence of sore throat was found lower in the betamethasone group than in lignocaine group at intervals 1, 6, 24 hours post extubation with P value < 0.05. The incidence of no HOV, grade 1 HOV, grade 2 HOV and grade 3 HOV in betamethasone group was 46.7 %, 48.3 %, 5.0 % and 0 % respectively compared to lignocaine group which was 25.0 %, 46.7 %, 25.0 % and 3.3 % respectively with P value < 0.05. CONCLUSIONS This study proves that betamethasone gel, when used for lubrication of endotracheal tube pre-operatively, has shown to be effective in decreasing postoperative sore throat and hoarseness of voice. KEYWORDS Betamethasone, Lignocaine, Sore Throat, Hoarseness of Voice, Endotracheal Intubation

STUDY ON BETAMETHASONE GELAND LIGNOCAINE JELLY APPLIED OVER ENDOTRACHEAL TUBE TO REDUCE POST OPERATIVE SORE THROAT, COUGH ANDHOARSENESS OF VOICE

2021 ◽  
pp. 15-16
Author(s):  
Stalin Ramamoorthy ◽  
Muthukumar Thangaraj
Keyword(s):  
Endotracheal Tube ◽  
General Anaesthesia ◽  
Sore Throat ◽  
Orotracheal Intubation ◽  
Control Group ◽  
Postoperative Sore Throat ◽  
Lidocaine Group ◽  
Group B ◽  
Anaesthesia Care ◽  
And Control

Background and Objectives: Controlled comparison between 0.05% betamethasone gel, 2% lidocaine jelly, lubricating gel applied over endotracheal tube to reduce postoperative sore throat, cough, and hoarseness of voice at 0,6,&24 hrs Materials And Methods: This study compares the incidence of postoperative sore throat, cough, and hoarseness ovoice after general anaesthesia when applying betamethasone gel (betamethasone group-B) or lidocaine jelly( lidocaine group -L) on the tracheal tube. 120 ASAclass I and II patients undergoing elective surgeries under general anaesthesia with orotracheal intubation were randomized into three groups: betamethasone gel, lidocaine jelly, and control groups (C group). In the post-anaesthesia care unit, all patients were interviewed on postoperative sore throat, cough, and hoarseness of voice at 0, 6, and 24 h after surgery. Results and Conclusion:Awide spread application of betamethasone gel (B) on the endotracheal tube decreases the incidence and severity of postoperative sore throat, cough, and hoarseness of voice as compared to lignocaine group(L) and control group (c).

scholarly journals To Compare the Efficacy of Betamethasone Gel and Lignocaine Gel Applied over Endotracheal Tube to Reduce Post Operative Sore Throat and Cough

2021 ◽  
pp. 469-475
Author(s):  
S. Imayaval ◽  
K. V. L. Sanjana
Keyword(s):  
Endotracheal Tube ◽  
General Anaesthesia ◽  
Sore Throat ◽  
Elective Surgery ◽  
Statistical Significance ◽  
Study Groups ◽  
Orotracheal Intubation ◽  
P Value ◽  
Intracuff Pressure ◽  
Double Blind Study

Background: Post-operative sore throat, cough and hoarseness of the voice are often common, uncomfortable sequelae after tracheal intubation with inflammation being the most common pathogenesis. Post operative sore throat and cough has a multifactorial aetiology that includes patient-related factors such as age, sex, and smoking, as well as intubation factors such as technique, duration, tube size, intracuff pressure, cuff design, trauma to the pharyngolaryngeal mucosa and various factors. Objectives: To compare the incidence of post operative sore throat, cough after endotracheal tube intubation when applying betamethasone gel and lignocaine jelly. Materials and Methods: At Saveetha Medical College and Hospital in Thandalam, Chennai, a prospective controlled double blinded study was done among patients who were scheduled for elective procedures under general anaesthesia with orotracheal intubation. The study comprised 60 patients who met the study's inclusion and exclusion criteria. The 60 patients were divided into two study groups each enrolled with 30 patients. Before the study could begin, approval from the institutional research board was required. Before the study began, an informed, written consent was obtained. The method used was Qualitative observational randomised double blind study by using a computer-generated random number table and the sealed envelope approach, patients were assigned to one of two equal groups. Following a pre-anaesthetic evaluation, 60 patients of either sex, aged 18 to 60 years, with an ASA physical status of I or II, who were undergoing elective surgery (likely to last up to 240 minutes) under general anaesthesia with orotracheal intubation and met the above inclusion criteria were included in the study. The differences between the study groups were analysed by chi square test and the “p” value used as a cut off for estimating statistical significance between groups is 0.05. Results: The incidence and severity of post operative sore throat and cough after endotracheal intubation during 6 and 24 hours was found to be statistically significantly in patients in whom betamethasone was used. The results are significant at p<0.05. At 6 hours the incidence of post operative sore throat for betamethasone and lignocaine was 12% and 30% respectively. At 24 hours the incidence of post operative sore throat for betamethasone and lignocaine was 9.36% and 25.2% respectively. At 6 hours the incidence of post operative cough for betamethasone and lignocaine was 8.4% and 24%.At 24 hours the incidence of post operative cough for betamethasone and lignocaine was 7.2% and 21.6% respectively. Conclusion: The use of 0.05 percent betamethasone gel to lubricate the endotracheal tube before intubation helps to reduce the time it takes for symptoms to resolve.

scholarly journals Effect of Preoperative Nebulized Ketamine on Incidence and Severity of Postoperative Sore Throat in Patient Undergoing General Anaesthesia with Endotracheal Intubation

2020 ◽  
Vol 42 (1) ◽  
pp. 12-16
Author(s):  
Prajjwol D Bhatta ◽  
Bigen M Shakya ◽  
Navindra R Bista ◽  
Moda N Marhatta ◽  
Ninadini Shrestha
Keyword(s):  
General Anaesthesia ◽  
Sore Throat ◽  
Endotracheal Intubation ◽  
Controlled Trial ◽  
P Value ◽  
Postoperative Sore Throat ◽  
American Society ◽  
Double Blinded ◽  
American Society Of Anesthesiologists ◽  
Undesirable Outcome

Introduction Postoperative sore throat (POST) has a reported incidence of up to 62% following general anaesthesia. POST was rated by patients as the eighth most undesirable outcome in the postoperative period. The objective of this study was to compare the incidence and severity of postoperative sore throat after saline and ketamine nebulization in patients undergoing general anaesthesia with endotracheal intubation. MethodsThe study was prospective double blinded randomized controlled trial . One hundred patients belonging to American Society of Anesthesiologists physical status I–II undergoing surgery under general anaesthesia with endotracheal intubation were randomized into two groups; group Saline (S) received nebulization with 5 ml of normal saline and group Ketamine (K) received nebulization with 1 ml of ketamine of concentration 50 mg/ml mixed with 4 ml saline. POST was assessed at zero hour, two hour, four hour, six hour, eight hour and 24 hour. ResultsThe overall incidence of POST was 28%. Twenty two (44%) patients in group S and six (12%) patients in group K had postoperative sore throat at some point of the study. The POST was significantly reduced in group K at zero hour 3(6%), two hour 3(6%), four hour 4(8%), six hour 5(10%) and eight hour 3(6%) with p value <0.05 . The severity of POST was also significantly decreased in group K at zero hour, two hour, four hour, six hour, eight hour with p value <0.05. ConclusionPreoperative nebulization with ketamine reduces the incidence and severity of POST after general anaesthesia with endotracheal intubation.

EFFECT OF DEXAMETHASONE GARGLE AND MgSO4 GARGLE ON INCIDENCE AND SEVERITY OF POST OPERATIVE SORE THROAT IN PATIENTS UNDERGOING SURGERY UNDER GA : A RANDOMISED COMPARATIVE STUDY

2021 ◽  
pp. 40-42
Author(s):  
Tamanna Baktier ◽  
Akash Gupta ◽  
Neeharika Arora ◽  
Ankur Garg ◽  
Ekta Singh ◽  
...  
Keyword(s):  
Comparative Study ◽  
General Anaesthesia ◽  
Sore Throat ◽  
Magnesium Sulphate ◽  
Lower Incidence ◽  
Post Anaesthesia Care Unit ◽  
Duration Of Surgery ◽  
The Mean ◽  
Anaesthesia Care ◽  
To Receive

BACKGROUND: Post operative sore throat (POST) is an unpleasant and troublesome sequelae after endotracheal intubation . The present study compares the efcacy of dexamethasone gargle versus magnesium sulphate gargle on incidence and severity of post operative sore throat in patients under General Anaesthesia. METHODS : 60 patients were randomly allocated to receive either magnesium sulphate gargle or dexamethasone gargle . 15 mins prior to induction of GA , the dexamethasone gargle group (n=30) received 8mg dexamethasone dissolved in 20ml of 5% dextrose whereas the magnesium sulphate gargle group received 1 gm of MgSO4 dissolved in 20ml of 5% of dextrose. Patients were assessed for incidence and severity of post operative sore throat , cough and hoarseness of voice in post anaesthesia care unit at 0hr, 2hrs, 4hrs, 6hrs and 24 hrs . RESULTS : Our study revealed that there was signicant (p<0.01) difference in the severity of sore throat between the groups at 0 hr, 2 hrs, 4 hrs , 6 hrs with patients receiving MgSO4 gargles showing decreased severity than gargling with dexamethasone. The two groups were found to be demographically comparable . In our current study , the mean duration of surgery in both groups was 2-2.5 hours and difference was statistically insignicant . SUMMARY : Among patients who gargled with 1gm of MgSO4 exhibited lower incidence and severity of POST as compared to patients who gargled with 8mg of dexamethasone

scholarly journals Betamethasone Gel versus Intravenous Dexamethasone as Prophylaxis against Postoperative Sore Throat

2018 ◽  
Vol 6 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Muhammad Sazzad Hossain ◽  
Mamunur Rashid ◽  
Anisur Rahman Babu ◽  
Devashis Saha ◽  
Debasish Banik
Keyword(s):  
Endotracheal Tube ◽  
General Anaesthesia ◽  
Sore Throat ◽  
Endotracheal Intubation ◽  
Lower Incidence ◽  
Control Group ◽  
Postoperative Sore Throat ◽  
Dexamethasone Group ◽  
Significant Difference ◽  
And Control

Background: Postoperative sore throat (POST) though a minor sequel after general anaesthesia with endotracheal intubation, it can be distressing to the patient.Objective: The effectiveness of lubricating endotracheal tube with 0.05% betamethasone gel or intravenous dexamethasone in reducing the postoperative sore throat was compared.Materials and method: This was a prospective study carried out among ninety ASA I and II informed consenting patients aged 20-50 years undergoing elective surgery under general anaesthesia with endotracheal intubation. The patients were randomly divided into three groups with thirty subjects in each group. Betamethasone gel (0.05%) was applied over endotracheal tube over 15 cm mark from the tip in group I, intravenous dexamethasone was given in group II and group III was taken as control. In post-anaesthesia care unit, an anesthesiologist interviewed all patients on postoperative sore throat at 1 hour, 6 hours and 24 hours after operation.Results: At 24 hours following extubation, there was statistically significant lower incidence of post-operative sore throat (POST) in betamethasone group compared to other two groups (betamethasone group 3.33%, dexamethasone group 20% and control group 26.66%, p<0.05). When the groups were compared in pairs at 24 hours, there was statistically significant difference in the incidence of POST between betamethasone group and dexamethasone group and also betamethasone group and control group with lower incidence of POST in betamethasone group, p<0.05. It was also observed that there was no significant difference of POST between dexamethasone and control group at 1 hour, 6 hours or 24 hours, p>0.05.Conclusion: It can be concluded that the use of 0.05% betamethasone gel to lubricate widely the endotracheal tube prior to intubation effectively reduces postoperative sore throat, compared to intravenous dexamethasone administration.Delta Med Col J. Jan 2018 6(2): 73-77

scholarly journals Effects of Ketamine Gargle for Post-operative Sore Throat, Hoarseness of Voice and Cough Under General Anaesthesia- A Randomised Control Study

2021 ◽  
Author(s):  
Dinesh Chauhan ◽  
Ankit Mankad ◽  
Jigisha Mehta ◽  
Tejash H Sharma
Keyword(s):  
General Anaesthesia ◽  
Endotracheal Intubation ◽  
Normal Saline ◽  
Healing Process ◽  
Voice Quality ◽  
Controlled Study ◽  
P Value ◽  
Time Duration ◽  
C 30 ◽  
Randomised Controlled

Introduction: Majority of the patient undergo endotracheal intubation for various time duration, when given general anaesthesia. Injury in airway mucosa or vocal cords due to endotracheal intubation can be a contributing factor. Ketamine without affecting local healing process has an anti-proinflammatory effect as it limits exacerbation of systemic inflammation. Aim: To study the role of ketamine gargles as a pharmacological measure in order to attenuate POST, HOV and cough followed by endotracheal intubation during surgeries under general anaesthesia. Materials and Methods: A randomised controlled study was carried out for a duration of 22 months from the institutional ethical committee (Study Approval No. SVIEC/ON/MEDI/BNPG18/D19046), on 50 patients of American Society of Anaesthesiologists (ASA) grade I and II. They were allocated into two groups of 25 patients. Group (K): ketamine 50 mg in 29 mL 0.9% normal saline and Group (C): 30 mL 0.9% normal saline. Patients were advised to gargle for 30 seconds just 5 minutes prior to induction of anaesthesia. Patients were intubated with appropriate size of the endotracheal tube and were extubated when fully awake and conscious. Pateints were shifted to postoperative ward and were kept in propped up position with oxygen. Pateints were assessed at 1,2,4,24 hours for incidence of POST, HOV and cough. Assessment was made as per the 4 point scale grading system. The statistical analysis was performed using unpaired t-test, p<0.05 considered statistically significant. Results: In terms of POST grading in both K and C groups p-value was statistically significant (p<0.05) at 1 and at 2 hours postoperatively. In terms of HOV, in group K voice quality issues were reduced till 24 hours, (p<0.05). In terms of cough, in group K there was a significant reduction in complaints of cough till 4 hours postoperatively, (p<0.05). Conclusion: Ketamine gargles is effective in attenuating POST and cough till 2 hours and HOV till 4 hours postoperatively in patients following endotracheal intubation.

scholarly journals Incidence of hypoxemia in a post-anaesthesia care unit and relevant risk factors: a retrospective study of 14604 patients with general anaesthesia

2019 ◽  
Author(s):  
Shuai Tang ◽  
Liangyan Zhang ◽  
Wei Han ◽  
Yang Xue ◽  
Yi Tian ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Retrospective Study ◽  
Retrospective Cohort ◽  
Post Anaesthesia Care Unit ◽  
Postoperative Hypoxemia ◽  
Total Incidence ◽  
American Society ◽  
Anaesthesia Care

Abstract Background This article is aim to investigate the incidence and risk factors for postoperative hypoxemia in a post-anaesthesia care unit (PACU). Methods The retrospective cohort assessed 14604 postoperative patients who were admitted to PACU between January 2015 and December 2015. A pulse oximeter was used to monitor and record pulse oxygen saturation (SpO2) every 5 minutes. Clinical data were collected for all these patients, and the incidence of and risk factors for postoperative hypoxemia were analysed. Results The total incidence of hypoxemia was 21.83% (SpO2 ≤ 95%) and 2.79% (SpO2 ≤ 90%). Multiple regression analysis indicated that the risk factors were age ≥50-year old, body mass index (BMI) ≥25kg/m2, American Society of Anaesthesiologists (ASA) II and III, limb surgery, and thoracic surgery. Conclusions Therefore, hypoxemia was common in postoperative patients in the PACU. Age, BMI, ASA classification, and surgical site are associated with postoperative hypoxemia. More attention should be paid to these patients to prevent hypoxemia in the PACU.

Effects of lignocaine on pressor response to laryngoscopy and endotracheal intubation during general anaesthesia in rigid suspension laryngoscopy

2014 ◽  
Vol 129 (1) ◽  
pp. 79-85 ◽  
Author(s):  
I S Kocamanoglu ◽  
S Cengel Kurnaz ◽  
A Tur
Keyword(s):  
Heart Rate ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
General Anaesthesia ◽  
Endotracheal Intubation ◽  
Pressor Response ◽  
Physiological Saline ◽  
American Society ◽  
Rate Ratios ◽  
Suspension Laryngoscopy

AbstractObjective:This study aimed to compare the effects of topical and systemic lignocaine on the circulatory response to direct laryngoscopy performed under general anaesthesia.Methods:Ninety-nine patients over 20 years of age, with a physical status of I–II (classified according to the American Society of Anesthesiologists), were randomly allocated to 3 groups. One group received 5 ml of 0.9 per cent physiological saline intravenously, one group received 1.5 mg/kg lignocaine intravenously, and another group received seven puffs of 10 per cent lignocaine aerosol applied topically to the airway. Mean arterial pressures, heart rates and peripheral oxygen saturations were recorded, and changes in mean arterial pressure and heart rate ratios were calculated.Results:Changes in the ratios of mean arterial pressure and heart rate were greater in the saline physiological group than the other groups at 1 minute after intubation. Changes in the ratios of mean arterial pressure (at the same time point) were greater in the topical lignocaine group than in the intravenous lignocaine group, but this finding was not statistically significant.Conclusion:Lignocaine limited the haemodynamic responses to laryngoscopy and endotracheal intubation during general anaesthesia in rigid suspension laryngoscopy.

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