scholarly journals Potential Application of Ionic Liquids in Pharmaceutical Dosage Forms for Small Molecule Drug and Vaccine Delivery System

2020 ◽  
Vol 23 ◽  
pp. 158-176 ◽  
Author(s):  
Mohammad Nasir Uddin ◽  
Debasish Basak ◽  
Robert Hopefl ◽  
Babak Minofar
Keyword(s):  
Ionic Liquids ◽  
Physical Properties ◽  
Small Molecule ◽  
Targeted Delivery ◽  
Potential Application ◽  
Room Temperature ◽  
Green Solvents ◽  
Formulation Development ◽  
Liquid Form ◽  
Pharmaceutical Dosage Forms

Ionic liquids are salts in which the ions are poorly coordinated, which causes them to exist in liquid form below 100°C, or at room temperature. Therefore, these are also defined as room temperature ionic liquids (RTILs). In ionic liquids, at least one ion has a delocalized charge and one component is organic, which prevents the formation of a stable solid form of crystal lattice. Physical properties of ionic liquids, such as melting point, viscosity, and solubility of starting materials and other solvents, are impacted by the substituents on the organic component and by the counterions. Many ionic liquids have even been developed to address specific synthetic problems and that is the reason these are also termed as "designer solvents". Ionic liquids are considered as “green solvents” that exhibit several unique characteristics such as high ionic conductivity, high solvation power, thermal stability, low volatility, and recyclability. Although very useful with several advantages, ionic liquids have some limitations that include high cost and ease of recycling. Moreover, the toxicity and biodegradability of ionic liquids are not yet well understood. Nonetheless, ionic liquids can potentially be used in the field of pharmacy in drug design and formulation development. In drug or vaccine dosage formulation development, ionic liquids can be used as a solubility enhancer, permeability enhancer, stabilizer, targeted delivery inducer, stealth property provider or bioavailability enhancer. In this article we reviewed the physical properties of ionic liquids and potential application of ionic liquids in developing formulations for vaccines and small molecule drugs (A table has been added).

scholarly journals Ionic liquid promoted Diels-Alder Reaction between anthrone and maleimides

2010 ◽  
Vol 8 (2) ◽  
pp. 356-360 ◽  
Author(s):  
Nitin Mirgane ◽  
Sandip Kotwal ◽  
Anil Karnik
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Room Temperature ◽  
Alder Reaction ◽  
Dual Role ◽  
Diels Alder ◽  
Environmentally Benign ◽  
Green Solvents ◽  
Imidazolium Ionic Liquid ◽  
Diels Alder Reaction

AbstractIonic liquids (IL) are gaining importance as green solvents. Imidazolium ionic liquid [bmim]+[Cl]−, an environmentally benign solvent, was found to promote the Diels-Alder reaction between anthrone and maleimides at room temperature with excellent yields. The ionic liquid played a dual role as solvent and catalyst.

Strong Hydrogen Bonds Are Not Shielded in Ionic Liquids

2019 ◽  
Author(s):  
Teresa Naranjo ◽  
Rubén Álvarez-Asencio ◽  
Patricia Pedraz ◽  
Belén Nieto-Ortega ◽  
Enrique Burzurí ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Melting Point ◽  
Hydrogen Bonds ◽  
Physical Properties ◽  
Organic Solvents ◽  
Electrostatic Interactions ◽  
Room Temperature ◽  
Noncovalent Interactions ◽  
Binding Constants ◽  
Information Storage

Hydrogen bonds are arguably the most important of noncovalent interactions. The physical properties of water and the information storage in DNA depend on H-bonding, for instance. To this day, the balance between the Coulombic and covalent contributions to H-bonds is still under debate. Here, we show that H-bonded host-guest systems associate in ionic liquids, pure salts with melting point below room temperature, in which dipole-dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (<i>K</i><sub>a</sub>) obtained from titrations of four H-bonded host-guest systems in two organic solvents and two ionic liquids yield smaller yet comparable <i>K</i><sub>a</sub>values in ionic liquids than in organic solvents. We also detect the association event using force spectroscopy. Our results indicate that strong H-bonds are only moderately affected by surroundings composed entirely of charges, suggesting that the balance of Coulombic to covalent forces is not tipped towards the former.

Strong Hydrogen Bonds Are Not Shielded in Ionic Liquids

2019 ◽  
Author(s):  
Teresa Naranjo ◽  
Rubén Álvarez-Asencio ◽  
Patricia Pedraz ◽  
Belén Nieto-Ortega ◽  
Enrique Burzurí ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Melting Point ◽  
Hydrogen Bonds ◽  
Physical Properties ◽  
Organic Solvents ◽  
Electrostatic Interactions ◽  
Room Temperature ◽  
Noncovalent Interactions ◽  
Binding Constants ◽  
Information Storage

Hydrogen bonds are arguably the most important of noncovalent interactions. The physical properties of water and the information storage in DNA depend on H-bonding, for instance. To this day, the balance between the Coulombic and covalent contributions to H-bonds is still under debate. Here, we show that H-bonded host-guest systems associate in ionic liquids, pure salts with melting point below room temperature, in which dipole-dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (<i>K</i><sub>a</sub>) obtained from titrations of four H-bonded host-guest systems in two organic solvents and two ionic liquids yield smaller yet comparable <i>K</i><sub>a</sub>values in ionic liquids than in organic solvents. We also detect the association event using force spectroscopy. Our results indicate that strong H-bonds are only moderately affected by surroundings composed entirely of charges, suggesting that the balance of Coulombic to covalent forces is not tipped towards the former.

scholarly journals Combinatorial discovery of small-molecule 1,2,3-triazolium ionic liquids exhibiting lower critical solution temperature phase transition

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yen-Ho Chu ◽  
Mou-Fu Cheng ◽  
Yung-Hsin Chiang
Keyword(s):  
Phase Transition ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Phase Transitions ◽  
Small Molecule ◽  
Room Temperature ◽  
Solution Temperature ◽  
Temperature Phase ◽  
Critical Solution Temperature ◽  
True Value

Abstract Both lower and upper critical solution temperature (LCST and UCST) systems are two typical phase behaviors of thermoresponsive materials with solvents, in which LCST is far less common than UCST. Recent studies on ionic liquids carrying LCST phase transitions have predominantly focused on quaternary ammonium- and phosphonium-based ionic salts. Based on the 1,2,3-triazole core structure assemblable by azide-alkyne cycloaddition click reaction, this work reports the combinatorial synthesis of 1,3,4-trialkylated 1,2,3-triazolium ionic liquids in three libraries with a total of 160 ionic liquids and demonstrates, for the first time, their values in temperature-switchable phase transition with water. In this work, the successful discovery of a new thermoresponsive ionic liquid b26, based on the structure-and-phase separation study of b8 and b9, perfectly exemplified the true value of the tunability of ionic liquid fine structures. For all 160 ionic liquids synthesized, 155 are liquid at room temperature and 22 room-temperature ionic liquids were found to exhibit thermoresponsive phase transitions having low Tc values in water. To the best of our knowledge, this comprehensive study is the first report of small-molecule 1,2,3-triazolium ionic liquids that exhibit LCST property in water.

scholarly journals Determination of the Physical Properties of Room Temperature Ionic Liquids Using a Love Wave Device

2011 ◽  
Vol 83 (17) ◽  
pp. 6717-6721 ◽  
Author(s):  
F. Fouzia Ouali ◽  
Nicola Doy ◽  
Glen McHale ◽  
Christopher Hardacre ◽  
Rile Ge ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Physical Properties ◽  
Love Wave ◽  
Room Temperature ◽  
Room Temperature Ionic Liquids ◽  
Wave Device

Room-Temperature Ionic Liquids in Glycoscience: Opportunities and Challenges+

2021 ◽  
Vol 25 ◽  
Author(s):  
Sanchayita Rajkhowa ◽  
Raju R. Kale ◽  
Jyotirmoy Sarma ◽  
Abhijeet Kumar ◽  
Prabhu P. Mohapatra ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Room Temperature ◽  
Materials Science ◽  
High Yield ◽  
Easy Access ◽  
Room Temperature Ionic Liquids ◽  
Green Solvents ◽  
Diverse Range ◽  
Biologically Relevant ◽  
Wide Range

: Carbohydrates are fascinating molecular scaffolds known for their diverse applications in chemistry, biology, medicine, technology, and materials science. In addition, owing to the notable features of room-temperature ionic liquids (RTILs) such as high yield, short reaction time, simple handling, excellent recyclability, and environmentally benign nature, they have been extensively utilized as green solvents, catalysts, or both in a wide range of organic transformation methodologies for easy access of a diverse range of biologically relevant molecules. This review highlights the importance of RTILs that offer promising solutions in glycoscience, particularly in relevance to the dissolution, functionalization, glycosylation, and modification of carbohydrates as well as their challenges, impact, and future perspectives.

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