scholarly journals COMPUTED TOMOGRAPHY ATTENUATION OF THE UPPER AND LOWER JAW BONE TISSUE IN PATIENTS WITH DIABETES MELLITUS ASSESSED BY DENTAL COMPUTED TOMOGRAPHY

2021 ◽  
Vol 17 (2) ◽  
pp. 148-155
Author(s):  
Natalia Prozorova ◽  
Roman Fadeyev ◽  
Viktor Veber ◽  
Marina Chibisova ◽  
Irina Prozorova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Computed Tomography ◽  
Bone Tissue ◽  
Optical Density ◽  
Bone Destruction ◽  
Lower Jaw ◽  
Patients With Diabetes ◽  
Qualitative Measure ◽  
Dental Computed Tomography

Type 1 and 2 diabetes are associated with deteriorated bone remodeling due to microangiopathy and acidosis, as well as non-fermentative glycosylation of bone proteins re-sulting in the apoptosis of osteocytes. Another complication of diabetes mellitus is diabetic arthropathy which is common among patients suffering from 1 type diabetes. Degenerative processes in periodontal tissue can be associated with diabetes mellitus and reduce the strength of the tooth joints. The result of insulin deficiency is a reduction in collagen synthesis and alkaline phosphatase, as well as hypocalcemia — these states also lead to bone resorption. Considering the effect of the combination of the processes which take place in the bone tissue, it should be taken into account that the alveolar processes of the upper and lower jaws are dif-ferent from the rest of the skeleton by accelerated metabolism. This specificity makes it nec-essary to investigate changes in the optical density of teeth and alveolar processes of the lower jaw among patients with diabetes mellitus. The purpose of research is to determine peculiarities of the optical density of bone tissue of the alveolar processes of the jaw using dental computed tomography in patients with diabetes mellitus. Article describes the analysis of the optical density of the bone tissue of the alveolar processes of the lower jaws. Dental computed tomography allows quantitative and qualitative measure-ment of bone tissue density of the jaw and is an effective method for assessing the state of bone tissue in diabetes mellitus. It was shown that the structure and density of bone tissue de-pends on the severity of diabetes, the presence of complications. Marked decrease in the opti-cal density of bone tissue in the neck of the teeth in individuals with diabetes was noted, less pronounced changes were observed in the middle third of the roots of the teeth. And slight changes or even an increase in optical density were observed in the region of the apices of the teeth. Diagnosis of bone destruction of the upper and lower jaws in diabetes mellitus is most in-formative using dental computed tomography.

EVALUATING OPTICAL DENSITY OF ALVEOLAR BONE IN PATIENTS WITH DIABETES MELLITUS USING CONE-BEAM COMPUTED TOMOGRAPHY

2021 ◽  
Vol 11 (2) ◽  
pp. 108-117
Author(s):  
Natalya Prozorova ◽  
Roman Fadeev ◽  
Victor Weber ◽  
Marina Chibisova ◽  
Natalia Robakidze ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Computed Tomography ◽  
Bone Tissue ◽  
Optical Density ◽  
Cone Beam Computed Tomography ◽  
Alveolar Bone ◽  
Cone Beam ◽  
Root Tips ◽  
Patients With Diabetes ◽  
Tomography Data

The study involved an analysis of optical density of the maxillary and mandibular bone tissue based on cone-beam computed tomography data. It has been shown that the structure and bone tissue density depend on the severity of diabetes mellitus and complications. The results of the study revealed a significant decrease in the bone tissue optical density at the tooth necks in people suffering from diabetes mellitus, whereas fewer changes were manifested at the middle third of the dental roots. Minor changes or even an increase in the optical density were observed at the dental root tips.

Model estimates of the results of diabetes patients using modern glucometers with tri-color technology for displaying test results

2019 ◽  
pp. 81-89
Author(s):  
Larisa Dmitrievna Popovich ◽  
Svetlana Valentinovna Svetlichnaya ◽  
Aleksandr Alekseevich Moiseev
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Economic Benefits ◽  
Test Results ◽  
Self Monitoring ◽  
Patients With Diabetes ◽  
The Impact

Diabetes – a disease in which the effect of the treatment substantially depends on the patient. Known a study showed that the use of glucometers with the technology of three-color display of test results facilitates self-monitoring of blood sugar and leads to a decrease in glycated hemoglobin (HbAlc). Purpose of the study: to modeling the impact of using of a glucometer with a color-coded display on the clinical outcomes of diabetes mellitus and calculating, the potential economic benefits of reducing the hospitalization rate of patients with diabetes. Material and methods. Based on data from two studies (O. Schnell et al. and M. Baxter et al.) simulation of the reduction in the number of complications with the use of a glucometer with a color indication. In a study by O. Schnell et al. a decrease of HbA1c by 0.69 percent is shown when using the considered type of glucometers, which was the basis of the model. Results. In the model, the use of a glucometer with a color-coded display for type 1 diabetes led to a decrease in the total number of complications by 9.2 thousand over 5 years per a cohort of 40 thousand patients with different initial levels of HbA1c. In a cohort of 40 thousand patients with type 2 diabetes, the simulated number of prevented complications was 1.7 thousand over 5 years. When extrapolating these data to all patients with diabetes included in the federal register of diabetes mellitus (FRD), the number of prevented complications was 55.4 thousand cases for type 1 diabetes and 67.1 thousand cases for type 2 diabetes. The possible economic effect from the use of the device by all patients with a diagnosis of diabetes, which are included in the FRD, estimated at 1.5 billion rubles for a cohort of patients with type 1 diabetes and 5.3 billion rubles for patients with type 2 diabetes. Conclusion. Improving the effectiveness of self-monitoring, which is the result of the use of glucometers with color indicators, can potentially significantly reduce the incidence of complications in diabetes and thereby provide significant economic benefits to society.

scholarly journals A literature review and meta-analysis of safety profiles of SGLT2 inhibitors in Japanese patients with diabetes mellitus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junichi Mukai ◽  
Shinya Kanno ◽  
Rie Kubota
Keyword(s):  
Diabetes Mellitus ◽  
Meta Analysis ◽  
Japanese Patients ◽  
Sglt2 Inhibitors ◽  
Patients With Diabetes ◽  
Language Restriction ◽  
Calculated Risk ◽  
Favorable Safety ◽  
Type 1 Dm

AbstractThe safety profiles of sodium-glucose co-transporter 2 (SGLT2) inhibitors may depend on races/ethnicities. We aimed to assess the safety profiles of SGLT2 inhibitors in Japanese patients with diabetes mellitus (DM). The electronic databases MEDLINE, CENTRAL, and Ichushi-web were searched for studies with no language restriction from their inception to August 2019. Trials were included in the analysis if they were randomized controlled trials (RCTs) comparing the effects of SGLT2 inhibitors with a placebo in Japanese patients with DM > 18 years and reporting HbA1c and at least 1 adverse event. We calculated risk ratios with 95% CIs and used a random-effects model. Of the 22 RCTs included in our review, only 1 included patients with type 1 DM. The durations of RCTs ranged between 4 and 24 weeks. In comparison with a placebo, SGLT2 inhibitors were associated with similar risks of hypoglycemia, urinary tract infection, genital infection, hypovolemia, and fracture. The outcomes of treatment with SGLT2 inhibitors among Japanese patients with DM suggest favorable safety profiles. However, further evidence from studies with a longer duration, involving more diverse populations, such as patients with different types of DM, or including individual SGLT2 inhibitors is needed to resolve the limitations of the present study.

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