scholarly journals A new drug for xerostomia combination therapy

2016 ◽  
Vol 12 (2) ◽  
pp. 2-10
Author(s):  
С. Григорьев ◽  
S. Grigoryev ◽  
А. Козьменко ◽  
A. Kozmenko
Keyword(s):  
Clinical Trial ◽  
Dental Plaque ◽  
Oral Care ◽  
Plaque Formation ◽  
Effectiveness Study ◽  
Oral Diseases ◽  
Study Results ◽  
Medical University ◽  
Therapy Department

<p class="p1"><span class="s1">The article presents the effectiveness study results of the foam «Oral Care Foam 2 in 1» with the aim of moisturizing the mucous tunic of the mouth and preventing oral diseases for patients with xerostomia caused by medication taking. The clinical trial was conducted at the premises of the Dental Therapy Department of the Ural State Medical University. There was analyzed thedata on 60 patients having the signs of a dry mouth, having bacterial test provenoral moniliosis. On the basis of the study ndings one can conclude that usingthe foam «Oral Care Foam 2 in 1» regularly improves the quality of oral hygiene care, slows down the process of dental plaque formation and growth in patients with xerostomia caused by medication taking; causes no irritation and can be used for moisturizing purposes. </span></p>

scholarly journals Colchicine in the Treatment of Recurrent Oral Aphthous Ulcer -Open Clinical Trial in Bangladesh

1970 ◽  
Vol 39 (3) ◽  
Author(s):  
A Hassan ◽  
Z Ahmed ◽  
R Ali ◽  
F Ara ◽  
N Ahmed ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Oral Mucosa ◽  
Colchicine Treatment ◽  
Aphthous Ulcer ◽  
College Hospital ◽  
Medical College ◽  
Aphthous Ulceration ◽  
Benign Nature ◽  
Medical University

Background: Recurrent aphthous Ulceration (RAU) is characterized by necrotizing ulcers of the oral mucosa that persist, remit, and recur for variable periods of time. Despite the benign nature of the disease, RAU frequently affects quality of life as a result of long lasting and recurrent episodes of burning pain.Aim and objective: the aim of the study was to determine the efficacy of colchicine in treatment of recurrent oral aphthous ulcer.Methods: A clinical trial was conducted among 30 samples in the department of dermatology and venereology of Bangabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital, Dhaka. Study was performed among those who fulfilled the inclusion criteria. Data was collected from 1st September 2007 to 29th February. 2008 and enrolled data was analyzed by using statistical SPSS win 13.Results: Among 30 patients, 24 (80%) were male and 6(20%) were female. Mean age of the patients was 26.20 (±6.65) years. 26(87.7%) patients found ulcer in oral mucosa and 4(13.3%)in tongue, but previous family history was present in only 20% cases out of 30 patients. All patients experienced a marked decrease in symptoms during colchicine treatment in where; mean aphthae count was 3.27 (±1.05) before treatment and 0.43 (±0.68) during treatment. Pain score also reduced during treatment from 6.80 (±2.12) to 1.13 (±.1.11) which was statistically highly significant.Conclusions: Colchicine may be a promising modality of treatment in the therapeutic armamentarium for RAU.DOI: http://dx.doi.org/10.3329/bmj.v39i3.9948 BMJ 2010; 39(3)

scholarly journals An introductory report on the effect of use of dextranase-containing mouthwash on oral health status of human volunteers

2020 ◽  
Vol 11 (1) ◽  
pp. 22-25
Author(s):  
Nucharee Juntarachot ◽  
Bhagavathi Sundaram Sivamaruthi ◽  
Sasithorn Sirilun ◽  
Piyachat Tongpong ◽  
Phakkharawat Sittiprapaporn ◽  
...  
Keyword(s):  
Oral Health ◽  
Sensory Evaluation ◽  
Dental Plaque ◽  
Oral Health Status ◽  
Plaque Index ◽  
Oral Diseases ◽  
Beneficial Effects ◽  
Study Results ◽  
Before And After ◽  
The Impact

Background: Dextran is a branched polysaccharide and one of the polymers, present in the biofilm matrix. The dextran plays a perilous role in dental plaque formation, which is involved in the development of some common oral diseases like dental caries. The dextran-hydrolyzing enzymes are under investigation to treat and manage the dental plaques. Aims and Objective: The present study reporting the preliminary observations on the effect of the use of dextranase-containing mouthwash (DMW) on dental plaque and oral health. Materials and Methods: DMW was prepared with food-grade dextranase, preservatives, gellingagents, and water as detailed. Four weeks of experimental design was employed in fourteen healthy volunteers. The selected volunteers were recommended to use DMW for at least twice a day. The plaque index (PI), probing depth (PD), gingival index (GI) and bleeding on probing (BOP) of the volunteer's teeth have been assessed before and after four weeks of DMW use. Results:The volunteers were insisted to use a DMW solution twice a day for four weeks. The PI, PD, GI, and BOP was measured before and after the treatment. The plaque index of the subject at baseline and after treatment was 2.22 ± 0.48, and 1.88 ± 0.50, respectively. PI was significantly reduced after the use of DMW solution for four weeks. The value of PD was 2.00 and 2.00 at baseline and after the use of DMW, respectively. The value of PD was not changed when compared to the baseline values. The sensory evaluation of DMW was performed using questionnaires. Conclusion: The preliminary study results suggested that the use of DMW solution for four weeks (twice a day) notably reduced the PI without any change in PD. However, GI and BOP values were not affected after the use of DMW. The participants, based on the sensory evaluation, accepted the prepared DMW solution. Additional detailed research on the impact of DMW on oral hygiene is needed to confirm the beneficial effects of DMW.

scholarly journals Effects of home-based mirror therapy and cognitive therapeutic exercise on the improvement of the upper extremity functions in patients with severe hemiparesis after a stroke: a protocol for a pilot randomised clinical trial

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035768
Author(s):  
Josefa Gonzalez-Santos ◽  
Raul Soto-Camara ◽  
Paula Rodriguez-Fernández ◽  
Maria Jimenez-Barrios ◽  
Jeronimo Gonzalez-Bernal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Upper Extremity ◽  
Randomised Clinical Trial ◽  
Therapeutic Exercise ◽  
Mirror Therapy ◽  
Link Type ◽  
Home Based ◽  
Study Results ◽  
Task Oriented

IntroductionNeuroplasticity is defined as the capacity of the brain to reorganise new neuronal pathways. Mirror therapy (MT) and cognitive therapeutic exercise (CTE) are two neurorehabilitation techniques based on neuroplasticity and designed to improve the motor functions of the affected upper extremity in patients with severe hemiparesis after a stroke. Home-based interventions are an appropriate alternative to promote independence and autonomy. The objective of this study is to evaluate which of these techniques, MT and CTE, combined with task-oriented training, is more effective in functional recovery and movement patterns of the upper extremities in patients with severe hemiparesis after a stroke.Methods and analysisThis is a home-based, single-blind, controlled, randomised clinical trial with three parallel arms, including 154 patients who had a stroke aged above 18 years. The primary outcome will be the functionality of the affected upper extremity measured using the Fugl-Meyer Assessment. Secondary variables will include cognitive performance, emotional state, quality of life and activities of daily living. During 6 weeks, one of the intervention groups will receive a treatment based on MT and the other one on CTE, both combined with task-oriented training. No additional interventions will be provided to the control group. To assess the progress of patients who had a stroke in the subacute phase, all variables will be evaluated at different visits: initial (just before starting treatment and 4 weeks post-stroke), post-intervention (6 weeks after initial) and follow-up (6 months).Ethics and disseminationThis protocol has been approved by the Institutional Review Board (CEIm-2.134/2.019) and registered at ClinicalTrials.gov (NCT04163666). The results will be disseminated through open-access peer-reviewed journals, conference presentation, broadcast media and a presentation to stakeholders. These study results will provide relevant and novel information on effective neurorehabilitation strategies and improve the quality of intervention programmes aimed at patients after a stroke.Trial registration numberClinicalTrials.gov (NCT04163666).

scholarly journals Early Childhood Caries: Epidemiology, Aetiology, and Prevention

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
F. Meyer ◽  
J. Enax
Keyword(s):  
Early Childhood ◽  
Dental Plaque ◽  
Early Childhood Caries ◽  
Oral Care ◽  
Rapid Progression ◽  
Poor Oral Hygiene ◽  
Caries Epidemiology ◽  
Oral Microorganisms ◽  
Childhood Caries

Early childhood caries (ECC) is one of the most prevalent diseases in children worldwide. ECC is driven by a dysbiotic state of oral microorganisms mainly caused by a sugar-rich diet. Additionally, poor oral hygiene or insufficient dental plaque removal leads to the rapid progression of ECC. ECC leads not only to dental destruction and pain with children, but also affects the quality of life of the caregivers. Children with extensive ECC are at high risk to develop caries with the permanent dentition or will have other problems with speaking and/or eating. To prevent ECC, several strategies should be taken into account. Children should brush their teeth with toothpastes containing gentle ingredients, such as mild surfactants and agents showing antiadherent properties regarding oral microorganisms. Parents/caregivers have to help their children with brushing the teeth. Furthermore, remineralizing and nontoxic agents should be included into the toothpaste formulation. Two promising biomimetic agents for children’s oral care are amorphous calcium phosphate [Cax(PO4)ynH2O] and hydroxyapatite [Ca5(PO4)3(OH)].

scholarly journals SUCCESSFUL IMPLEMENTATION OF THE VOLUNTEER PROJECT “HAPPY SMILE” AT THE DENTAL FACULTY OF USMU AS A PART OF THE EDUCATIONAL PROCESS

2020 ◽  
Vol 16 (2) ◽  
pp. 164-171
Author(s):  
Elena Svetlakova ◽  
Yuliya Mandra ◽  
Sergey Zholudev ◽  
Marina Haritonova ◽  
Anastasiya Kotikova ◽  
...  
Keyword(s):  
Dental Health ◽  
Age Groups ◽  
Educational Process ◽  
Professional Competencies ◽  
Successful Implementation ◽  
Oral Diseases ◽  
Preventive Program ◽  
Dental Diseases ◽  
Medical University

Subject. In 2017, the “Happy Smile” project was developed at the dental faculty of the Ural State Medical University and its active implementation began, during which teachers and students conduct preventive measures in educational institutions, shopping centers, hospitals of the city. The goal is to increase the literacy of the population in relation to the prevention of oral diseases, as well as the quality of life of the population by reducing the level of dental morbidity, the formation of professional and super-professional competencies of a modern graduate dentist. Methodology. According to WHO, the prevalence of dental diseases does not tend to decrease. An urgent task today is the development of programs and projects aimed at the health of the population. Results. In 2017, the staff of the Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases of the Ural State Medical University took the initiative to create a Happy Smile preventive project at the faculty. The main objectives of the project were: the creation of a comprehensive preventive program covering all age groups of the population; carrying out activities aimed at updating the preservation and maintenance of dental health; improving the quality of medical (dental) education by involving students in medical volunteering; expansion of the territory of events to nearby cities of the Sverdlovsk region. Conclusions. Participation in the project forms significant professional and supra-professional competencies of students, which helps to improve the quality of training of future dentists. The involvement of students in the implementation of the project will increase their relevance in the labor market. Implementation of the project is a health-saving technology that reduces dental incidence in Yekaterinburg and the Sverdlovsk Region.

scholarly journals Dental Plaque Removal by Ultrasonic Toothbrushes

2020 ◽  
Vol 8 (1) ◽  
pp. 28
Author(s):  
Ilya Digel ◽  
Inna Kern ◽  
Eva Maria Geenen ◽  
Nuraly Akimbekov
Keyword(s):  
Oral Health ◽  
Dental Plaque ◽  
Plaque Formation ◽  
Formation Mechanisms ◽  
Oral Diseases ◽  
Gingival Inflammation ◽  
Plaque Removal ◽  
Dental Biofilm ◽  
Physical Effects ◽  
Thematic Review

With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness.

scholarly journals GENDER DIFFERENCES IN ORAL CARE HABITS, ATTITUDES AND BEHAVIOURS OF ADOLESCENTS IN THE CITY OF KLAIPEDA

2018 ◽  
Vol 6 ◽  
pp. 870-875
Author(s):  
Šarūnė Barsevičienė ◽  
Eglė Žymantienė ◽  
Jurgita Andruškienė
Keyword(s):  
Health Care ◽  
Gender Differences ◽  
Oral Health ◽  
Dental Care ◽  
Oral Care ◽  
Oral Diseases ◽  
Care Needs ◽  
Dental Floss ◽  
Medical Needs ◽  
Study Results

Background. For many, the adolescent years can be a difficult emotional period and a time when dental and medical needs may be neglected. Oral health is one of the most unmet health care needs of adolescents. Oral diseases can have a profound effect on overall health, including pain, missed school, heart disease, and even death (Silk and Kwok, 2017).Aim of the survey: to study the gender differences in oral hygiene habits, attitudes and behaviours in Klaipeda city adolescents sample.Methods: There were 1206 questionnaires distributed (response rate 95.3 %). A total of 1150 adolescents participated in the study, with 52.4 % being girls, and the mean age was 13.4 years.Results. The study results demonstrated girls more often brushed their teeth than boys, 86.8 % and 68.5 %, respectively (p<0.001). Almost all the participants (98.5 %) used toothpaste and a toothbrush on a daily basis, but girls more often used dental floss (66.3 % as compared to boys 33.7 %, p<0.001), mouthwash (60.3 % as compared to boys 39.7 %, p<0.001) and other dental care products (79.5 % as compared to boys 20.5 %, p<0.05) for toothbrushing and daily dental care. The girls brushed their teeth in the morning (92.9 %) and before bedtime (91.0 %), as well as the boys (85.0 % and 77.5 %, respectively, p<0.001).Conclusions. Girls demonstrated better oral health care habits, comparing to boys. Boys had greater, as compared to girls, dental fear, restricting them from having regular appointments for check-ups at the dental office. Girls more frequently than boys had an attitude that teeth should be kept clean for aesthetic purposes and in order to ensure their longevity. Girls preferred to seek a dentist’s help as soon as it is needed and to maintain good oral health, because it’s essential to human health in general.

scholarly journals Compliance & dexterity, factors to consider in home care and maintenance procedures

2007 ◽  
Vol 21 (spe) ◽  
pp. 34-38 ◽  
Author(s):  
Victoria Criado ◽  
Andrew Tawse-Smith
Keyword(s):  
Home Care ◽  
Oral Hygiene ◽  
Dental Plaque ◽  
Antimicrobial Agents ◽  
Oral Care ◽  
Oral Diseases ◽  
Preventive Program ◽  
Primary Means ◽  
Dental Professional ◽  
The Individual

Mechanical plaque control appears to be the primary means of controlling supragingival dental plaque build-up. Although daily oral hygiene practices and periodic professional care are considered the basis for any program aimed at the prevention and treatment of oral diseases, these procedures are technically demanding, time consuming and can be affected by the compliance and manual dexterity of the patient. Individual skills and acquired behavior patterns determine effectiveness of a preventive program and oral hygiene practice. Successful preventive programs and home care procedures clearly depend on the interaction and commitment between the dental professional and the patient. Identifying the capacity of the individual to comply with the professional recommendations and evaluating the dexterity of the patient to remove supragingival dental plaque will permit the implementation of an adequate preventive program and can help on the selection of adjunctive antimicrobial agents and devices needed to reach an effective oral care routine.

scholarly journals Impacts of sleep on the characteristics of dental biofilm

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maki Sotozono ◽  
Nanako Kuriki ◽  
Yoko Asahi ◽  
Yuichiro Noiri ◽  
Mikako Hayashi ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Dental Caries ◽  
Oral Cavity ◽  
Periodontal Disease ◽  
Oral Care ◽  
Tooth Surface ◽  
Oral Diseases ◽  
Dental Biofilm

AbstractDental biofilm present on the tooth surface is associated with oral diseases, such as dental caries and periodontal disease. Because bacterial numbers rapidly increase in saliva during sleep, oral care before sleeping is recommended for the prevention of chronic oral diseases. However, temporal circadian changes in the quantity and quality of dental biofilms are poorly understood. This study aimed to investigate the impacts of sleeping on dental biofilm amounts and compositions by using an in situ model. The use of this in situ model enabled us to investigate dental biofilm formed in the oral cavity and to perform a quantitative analysis. Subjects began wearing oral splints in the morning or before sleeping, and biofilm samples were collected at 8, 16, and 24 h after the subjects began wearing oral splints; these samples were then used in various experiments. No significant changes in the numbers of biofilm-forming bacteria were caused by sleep. However, the relative abundances of genera related to periodontitis (i.e., Fusobacterium and Prevotella) increased after awakening. In conclusion, the numbers of biofilm-forming bacteria were not affected by sleep, and the abundances of obligate anaerobes increased after sleep. This research may aid in defining efficacious preventive oral care.

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