PATHOGENETIC JUSTIFICATION OF NEW APPROACHES TO THE ASSESSMENT OF THE STATE OF ORAL CAVITY IN CHRONIC GENERALIZED PARODONTITIS

Introduction. A variety of concepts and approaches to the analysis of the etiology and pathogenesis of temporomandibular joint dysfunctions, results in increased interest in the search for highly informative diagnostic methods, especially at the stage of pre-clinical manifestations. Objectives. The aim of the study was to analyze the possibilities of modern technologies in diagnostics of temporomandibular joint dysfunctions. Materials and methods. We studied original papers on the diagnostics of temporomandibular joint dysfunctions from several databases: Russian State Library, eLibrary, PubMed, The Cochrane Library, Google Scholar. Results. The review presents both generally accepted and alternative approaches to the diagnostics of different clinical manifestations in temporomandibular joint dysfunctions. We described the diagnostic value of occlusal disorders analysis in universal articulators, virtual articulators, T-scan system. Capabilities of teleroentgenography, axiography, electromyography, computed and magnetic resonance imaging were estimated as well. Conclusions. The literature review on the problem of diagnosing the temporomandibular joint dysfunctions showed a scientifically based spectrum of diagnostic capabilities of modern dentistry, a trend in the development of highly informative digital diagnostic technologies. Due to the diversity of the etiology and pathogenesis of the temporomandibular joint dysfunctions further in-depth studies of this issue are required.

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Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3

Journal of International Medical Research ◽

10.1177/0300060518798257 ◽

2018 ◽

Vol 47 (1) ◽

pp. 159-172 ◽

Cited By ~ 2

Author(s):

Alexandra Stoica ◽

Victoriţa Şorodoc ◽

Cătălina Lionte ◽

Irina M. Jaba ◽

Irina Costache ◽

...

Keyword(s):

Emergency Department ◽

High Risk ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Clinical Manifestations ◽

Diagnostic Value ◽

Left Ventricular ◽

Diagnostic Methods ◽

Left Ventricular Ejection ◽

Galectin 3

Objective This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays. Methods This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission. The patients were divided into two groups according to the etiology of their clinical manifestations: cardiac and non-cardiac dyspnea. The patients’ New York Heart Association functional class, left ventricular ejection fraction, and discharge status were assessed. Results Diagnostic criteria for acute heart failure were fulfilled in 61.1% of the patients. NT-proBNP and galectin-3 were strongly and significantly correlated. Receiver operating characteristic analysis revealed similar areas under the curve for both markers in the entire group of patients as well as in the high-risk subsets of patients. Conclusions The diagnostic performance of NT-proBNP and galectin-3 is comparable for both the total population and high-risk subsets. Galectin-3 adds diagnostic value to the conventional NT-proBNP in patients with acute cardiac dyspnea, and its utility is of major interest in uncertain clinical situations.

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Difficulties in diagnosing heart base tumor in dogs (case study)

Russian veterinary journal ◽

10.32416/article_5d5a9d1cab3cf4.44853182 ◽

2019 ◽

Vol 2019 (4) ◽

pp. 26-29

Author(s):

Владислава Илларионова ◽

Vladislava Illarionova

Keyword(s):

Clinical Manifestations ◽

Diagnostic Methods ◽

High Tech ◽

Myocardial Biopsy ◽

Immunohistochemical Examination ◽

Wide Range ◽

Primary Neoplasm ◽

Heart Tumors ◽

Diagnostic Capabilities

Tumors of the heart are a rare and, until recently, poorly studied pathology in humans and animals. Currently, the frequency of intravital detection of heart tumors and their successful treatment is increasing due to the use of high-tech diagnostic methods, such as echocardiography, computed tomography and magnetic resonance imaging, myocardial biopsy with histological and immunohistochemical examination of the tumor. However, in some cases, even the use of a wide range of diagnostic capabilities of intravital diagnostics does not provide sufficient data and confirmation of the diagnosis is possible only by the results of postmortem autopsy. The clinical manifestations of tumor growth in the heart are variable and depend on the type of tumor and its location. The most common primary neoplasm of the heart is hemangiosarcoma, the second most frequent tumor is the base of the heart tumor - nonchromophinous paraganglioma (chemodectoma). Our clinical case indicates possible difficulties in the diagnosing of heart base tumors, even with the use of a wide range of high-tech diagnostic methods.

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Trochanteric pain in patients undergoing total hip arthroplasty: A protocol for a systematic review

10.7287/peerj.preprints.27293 ◽

2018 ◽

Author(s):

Daniel Axelrod ◽

Kim Madden ◽

Laura Banfield ◽

Mitchell Winemaker ◽

Justin deBeer ◽

...

Keyword(s):

Systematic Review ◽

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Diagnostic Methods ◽

Cochrane Library ◽

Future Research ◽

Total Hip ◽

Review Management ◽

The Cochrane Library ◽

Study Designs

Background: Total hip arthroplasty (THA) is one of the most common surgical procedures. Although THA surgeries are typically very successful, between 3% and 17% of all patients experience trochanteric pain after surgery. Unfortunately, there remains little high quality and reproducible evidence surrounding this disorder, especially following total hip replacement. The objectives of this review are to describe, among pre-operative or post-operative primary THA patients the prevalence, treatments, prognosis, risk factors, and diagnostic methods available for trochanteric pain. Methods: This is a protocol for a descriptive systematic review of trochanteric pain among THA patients. We will include studies of all study designs, with the exception of non-systematic reviews and expert opinion, with no date limits. We will search Medline, Embase, CINAHL, and the Cochrane Library using the Ovid search interface. We will also search the reference lists of included studies for possible missed studies. We will use the systematic review management software Rayyan to assist with study screening. Two reviewers will independently review studies for inclusion and extract data into a study-specific database. Discussion: This study will add to the literature by comprehensively and systematically evaluating the available literature on trochanteric pain after THA. Previous studies have been conducted on the topic but they were not comprehensive or did not review the literature systematically. Additionally, our study will critically evaluate the methodological quality of the included studies, adding an evidence-based component to the review. This review will help orthopaedic surgeons better care for patients with trochanteric pain after THA, and will identify knowledge gaps for future research. Registration: This protocol will be registered on PROSPERO

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Trochanteric pain in patients undergoing total hip arthroplasty: A protocol for a systematic review

10.7287/peerj.preprints.27293v1 ◽

2018 ◽

Author(s):

Daniel Axelrod ◽

Kim Madden ◽

Laura Banfield ◽

Mitchell Winemaker ◽

Justin deBeer ◽

...

Keyword(s):

Systematic Review ◽

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Diagnostic Methods ◽

Cochrane Library ◽

Future Research ◽

Total Hip ◽

Review Management ◽

The Cochrane Library ◽

Study Designs

Background: Total hip arthroplasty (THA) is one of the most common surgical procedures. Although THA surgeries are typically very successful, between 3% and 17% of all patients experience trochanteric pain after surgery. Unfortunately, there remains little high quality and reproducible evidence surrounding this disorder, especially following total hip replacement. The objectives of this review are to describe, among pre-operative or post-operative primary THA patients the prevalence, treatments, prognosis, risk factors, and diagnostic methods available for trochanteric pain. Methods: This is a protocol for a descriptive systematic review of trochanteric pain among THA patients. We will include studies of all study designs, with the exception of non-systematic reviews and expert opinion, with no date limits. We will search Medline, Embase, CINAHL, and the Cochrane Library using the Ovid search interface. We will also search the reference lists of included studies for possible missed studies. We will use the systematic review management software Rayyan to assist with study screening. Two reviewers will independently review studies for inclusion and extract data into a study-specific database. Discussion: This study will add to the literature by comprehensively and systematically evaluating the available literature on trochanteric pain after THA. Previous studies have been conducted on the topic but they were not comprehensive or did not review the literature systematically. Additionally, our study will critically evaluate the methodological quality of the included studies, adding an evidence-based component to the review. This review will help orthopaedic surgeons better care for patients with trochanteric pain after THA, and will identify knowledge gaps for future research. Registration: This protocol will be registered on PROSPERO

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Diagnosis, Rehabilitation and Preventive Strategies for Pudendal Neuropathy in Cyclists, A Systematic Review

Journal of Functional Morphology and Kinesiology ◽

10.3390/jfmk6020042 ◽

2021 ◽

Vol 6 (2) ◽

pp. 42

Author(s):

Rita Chiaramonte ◽

Piero Pavone ◽

Michele Vecchio

Keyword(s):

Systematic Review ◽

Therapeutic Strategies ◽

Diagnostic Methods ◽

Cochrane Library ◽

Future Research ◽

Pudendal Neuropathy ◽

Preventive Strategies ◽

Therapeutic Approaches ◽

Therapeutic Protocol ◽

The Cochrane Library

This systematic review aims to provide an overview of the diagnostic methods, preventive strategies, and therapeutic approaches for cyclists suffering from pudendal neuropathy. The study defines a guide in delineating a diagnostic and therapeutic protocol using the best current strategies. Pubmed, EMBASE, the Cochrane Library, and Scopus Web of Science were searched for the terms: “Bicycling” OR “Bike” OR “Cyclists” AND “Neuropathy” OR “Pudendal Nerve” OR “Pudendal Neuralgia” OR “Perineum”. The database search identified 14,602 articles. After the titles and abstracts were screened, two independent reviewers analyzed 41 full texts. A total of 15 articles were considered eligible for inclusion. Methodology and results of the study were critically appraised in conformity with PRISMA guidelines and PICOS criteria. Fifteen articles were included in the systematic review and were used to describe the main methods used for measuring the severity of pudendal neuropathy and the preventive and therapeutic strategies for nerve impairment. Future research should determine the validity and the effectiveness of diagnostic and therapeutic strategies, their cost-effectiveness, and the adherences of the sportsmen to the treatment.

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Endometriosis diagnosis and medical treatment: Present and future

Gaceta Médica de Caracas - Supplement 1 ◽

10.47307/gmc.2021.129.2.12 ◽

2021 ◽

Vol 129 (2) ◽

pp. 381-403

Author(s):

José T. Núñez Troconis

Keyword(s):

Medical Treatment ◽

Latin American ◽

Diagnostic Methods ◽

Google Scholar ◽

Cochrane Library ◽

Medical Treatments ◽

Keywords Endometriosis ◽

New Treatment ◽

The Cochrane Library ◽

Ectopic Endometrium

The objective was to review the different diagnostic methods and medical treatments for endometriosis. It was reviewed the Latin-American and international bibliography using the Pub-Med, Google Scholar, Springer, the Cochrane Library, Embase, Scielo, Imbiomed-L, Redalyc, and Latindex websites. The searches included the keywords: endometriosis, endometriotic, endometrial and ectopic endometrium, angiogenesis, angiogenesis and endometriosis, endometriosis, and medical treatment, endometriosis, and new treatment.

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Thyrotoxicosis. Clinical guidelines for diagnosis and treatment. Part ІІ

Український радіологічний та онкологічний журнал ◽

10.46879/ukroj.3.2020.273-286 ◽

2020 ◽

Vol 28 (3) ◽

pp. 273-286

Author(s):

N. S. Pidchenko ◽

L. Ya. Vasylyev ◽

G. V. Grushka ◽

O. M. Astapieva ◽

A. S. Savchenko

Keyword(s):

Clinical Guidelines ◽

Clinical Manifestations ◽

Diagnosis And Treatment ◽

Cochrane Library ◽

American Thyroid Association ◽

Endocrine Society ◽

Appropriate Treatment ◽

Thyrotoxic Crisis ◽

Medical Radiology ◽

The Cochrane Library

Background. Recently they have reported an increased rate of thyrotoxicosis, which is characterized by polyetiology, a variety of clinical manifestations and potential treatment. Appropriate treatment requires an accurate diagnosis and depends on the comorbidities and preferences of the patient. Purpose. To highlight the key points of clinical guidelines for diagnosis and treatment of thyrotpxicosis provided by the American Thyroid Association and the American Association of Clinical Endocrinologists, US Endocrine Society dealing with diagnosis and treatment of thyroid diseases as well as the local clinical protocols of SO «Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine». Materials and methods. Based on the search of contributions in the electronic databases over the last 5 years, which are included in the Cochrane Library, PUBMED and MEDLINE databases. Clinical guidelines are based on expert consensus and assessing the significance according to the international guidelines for thyrotoxicosis. Results and discussion. The paper deals with up-to-date guidelines on diagnosis, management and treatment of patients with different forms of thyrotoxicosis. It presents a detailed strategy for those patients depending on etiology of the disease. The therapeutic approaches to treating Graves’ disease, autoimmune ophthalmopathy, thyrotoxic crisis, gravidae as well as the peculiarities of treating patients with subclinical hyperthyroidism and iodine-induced thyrotoxicosis have been substantiated. Conclusions. The treatment of thyrotoxicosis remains a challenging issue of modern internal medicine. Despite the existing numerous clinically proven protocols for the treatment of this pathology, the comorbid background of patients complicates following them. The implementation of the provided protocol elements will make it possible to introduce the principles of a customized approach in thyrotoxicosis patients.

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Thyrotoxicosis. Clinical recommendations for diagnosis and treatment Part І

Український радіологічний та онкологічний журнал ◽

10.46879/ukroj.2.2020.154-163 ◽

2020 ◽

Vol 28 (2) ◽

pp. 154-163

Author(s):

N. S. Pidchenko

Keyword(s):

Internal Medicine ◽

Clinical Guidelines ◽

American Association ◽

Clinical Manifestations ◽

Diagnosis And Treatment ◽

Cochrane Library ◽

Clinical Protocols ◽

Appropriate Treatment ◽

Key Points ◽

The Cochrane Library

Background. Currently submitted an increased rate of thyrotoxicosis, which is characterized by polyetiology, a variety of clinical manifestations and potential treatments. Appropriate treatment requires an accurate diagnosis and depends on the comorbidities and preferences of the patient. The aim of the study was to consider the pathogenesis, clinical picture and diagnosis of thyrotoxicosis. Purpose. To highlight the key points of clinical guidelines on thyrotoxicosis diagnosis and treatment provided by the American Thyroid Association and the American Association of Clinical Endocrinologists, US Endocrine Society dealing with diagnosis and treatment of thyroid diseases as well as the local clinical protocols of SO «Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine». Materials and methods. Based on the research in the electronic databases of last 5 years publications, which are included in the Cochrane Library, PUBMED and MEDLINE databases. Clinical guidelines are based on expert consensus and assessing the significance according to the international guideline of thyrotoxicosis. Conclusions. Thyrotoxicosis treatment remains a challenging issue of modern internal medicine. Despite the existing numerous clinically proven protocols for the treatment of this pathology, the comorbid background of patients complicates following them. The implementation of the provided protocol elements will make it possible to introduce the principles of a customized approach in thyrotoxicosis patients.

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The clinical diagnostic value of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis in gastric aspirates

Bioscience Reports ◽

10.1042/bsr20200138 ◽

2020 ◽

Vol 40 (6) ◽

Author(s):

Hong-Kun Tan ◽

Shu-Jin Fan ◽

Yu-Cheng Xu ◽

Jiong-Jiong Zhou ◽

Yuan-Zhi Chen ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Publication Bias ◽

Operating Characteristic ◽

Characteristic Curve ◽

Diagnostic Odds Ratio ◽

Diagnostic Value ◽

Cochrane Library ◽

Clinical Samples ◽

Summary Receiver Operating Characteristic ◽

The Cochrane Library

Abstract Background: At present, the infection and prevalence rates of tuberculosis (TB) are still high in worldwide. The Xpert MTB/RIF technology has improved the diagnosis speed of Mycobacterium tuberculosis (MTB) and facilitated the rapid treatment of TB patients. Methods: We searched experimental data derived from Xpert MTB/RIF for detecting MTB in gastric aspirates in PubMed, Embase, Web Of Science, and the Cochrane Library databases between January 2012 to April 2019. A summary receiver operating characteristic curve (SROC curve) was used to analyze the pooled sensitivity, pooled specificity, PLR, NLR, and DOR for determining the accuracy of the test. Results: Our database search resulted in 10 relevant articles. The pooled sensitivity of Xpert MTB/RIF for detecting TB in GA was 86% (95% CI, 83–89%), and I2 = 93.4%. The pooled specificity was 92% (95% CI, 90–93%) and I2 = 97.8%. In addition, the positive LR was 12.12 (95% CI, 5.60–26.21), negative LR was 0.20 (95% CI, 0.11–0.36), and the diagnostic odds ratio (DOR) was 147.04 (95% CI, 37.20–581.19). Using the SROC curve, the AUC was 0.9730 and Q* was 0.9248 (SE = 0.0261). The publication bias was P=0.517 (P>0.05). Conclusions: The Xpert MTB/RIF for detecting MTB in gastric aspirates was highly accurate. In addition, we observed that the publication bias in the present study was low. Hence, the Xpert MTB/RIF technology is highly accurate and has the advantage of rapid testing for MTB in clinical samples.

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