scholarly journals Is There Any Association Between the MEF2A Gene Changes and Coronary Artery Disease?

2020 ◽  
Author(s):  
Soodeh Omidi ◽  
Serwa Ghasemi ◽  
Samira Kalayinia
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
In Silico ◽  
Cardiac Development ◽  
In Silico Analysis ◽  
High Rate ◽  
Myocyte Enhancer Factor 2 ◽  
Calcium Dependent ◽  
Artery Disease ◽  
Silico Analysis

Coronary artery disease (CAD) is a common multifactorial disease with a high rate of morbidity and mortality worldwide. The MEF2A gene transcription factor belongs to the myocyte enhancer factor-2 (MEF2) family and is involved in critical processes such as calcium-dependent signaling pathways and cardiac development. Although the variants of the MEF2A gene were studied in different CAD and myocardial infarction (MI) populations, the reality of this gene association with CAD is still unclear. This study reports the first in silico investigation on MEF2A variants. All reported variants in CAD/MI patients were collected from eleven countries. Their pathogenicity and variant position conservation were surveyed by online prediction tools, including Mutation-Taster, Polyphen-2, PROVEAN, SIFT, CADD, and GERP. In silico analysis did not confirm the pathogenic effect of 21-bp deletion, which was introduced as a monogenic cause of CAD. c.704C>A (p.S235Y), c.812C>G (p.P271R), c.836C>T (p.P279L) and c.848G>A (p.G283D) missenses, c.1315C>T (p.R439X) nonsense, and seven out-of-frame deletions were predicted as disease-causing variants. Although some variants of the MEF2A gene affect protein structure, the MEF2A variation studies in CAD/MI patients and in silico analysis do not approve the association and pathogenicity of MEF2A variants in the familial/sporadic CAD. © 2020 Tehran University

scholarly journals A Novel Polymorphism in the Promoter of theCYP4A11Gene Is Associated with Susceptibility to Coronary Artery Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Svetlana Sirotina ◽  
Irina Ponomarenko ◽  
Alexander Kharchenko ◽  
Marina Bykanova ◽  
Anna Bocharova ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Transcription Factors ◽  
Coronary Artery ◽  
In Silico Analysis ◽  
Healthy Individuals ◽  
Epistatic Interactions ◽  
Increased Risk ◽  
Artery Disease ◽  
Silico Analysis ◽  
Age And Sex

Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of theCYP4A11andCYP4F2genes are associated with the risk of CAD in Russian population. DNA samples from 1323 unrelated subjects (637 angiographically confirmed CAD patients and 686 age- and sex-matched healthy individuals) were genotyped for polymorphisms rs3890011, rs9332978, and rs9333029 ofCYP4A11and rs3093098 and rs1558139 ofCYP4F2by using the Mass-ARRAY 4 system. SNPs rs3890011 and rs9332978 ofCYP4A11were associated with increased risk of CAD in women: OR = 1.26, 95% CI: 1.02–1.57,P=0.004, andQ=0.01and OR = 1.45, 95% CI: 1.13–1.87,P=0.004, andQ=0.01, respectively. Haplotype G-C-A ofCYP4A11was associated with increased risk of CAD (adjusted OR = 1.41, 95% CI: 1.12–1.78, andP=0.0036). Epistatic interactions were found between rs9332978 ofCYP4A11and rs1558139 ofCYP4F2(Pinteraction=0.025). In silico analysis allowed identifying that SNP rs9332978 is located at a binding site for multiple transcription factors; many of them are known to regulate the pathways involved in the pathogenesis of CAD. This is the first study in Europeans that reported association between polymorphism rs9332978 ofCYP4A11and susceptibility to coronary artery disease.

scholarly journals In-silico studies of HMG-Co A reductase inhibitors present in fruits of Withania coagulans Dunal (Solanaceae)

2020 ◽  
Vol 19 (2) ◽  
pp. 305-312
Author(s):  
Tooba Lateef ◽  
Sadaf Naeem ◽  
Shamim A. Qureshi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
In Silico ◽  
Chemical Constituents ◽  
Hmg Coa Reductase ◽  
Docking Score ◽  
Molegro Virtual Docker ◽  
Withania Coagulans ◽  
Artery Disease ◽  
Coa Reductase

Purpose: To evaluate the antihypercholesterolemic effect of chemical constituents of W. coagulans by determining inhibitory effect of the compounds against HMG-CoA reductase, using in-silico methods. Method: Docking simulations of twenty-one chemical constituents, found in the fruits of W. coagulans were performed against HMGCR(PDB ID: 2Q1L) using Molegro Virtual Docker software. The best docked poses were then selected, based on the docking score and amino acids involved in the interaction within the ligand and active site of protein. Results: Five compounds viz. Coagulin D (comp no. 11), Ergosta-5,25-diene-3β,24ε-diol (comp no. 13), Withacoagulin (comp no. 15), and Withaferin (comp no. 16), showed the highest MolDock scores. These compounds with highest docking score, also formed hydrogen bond interactions with His (752), Lys (692, 735), Asp (690), Glu (559) within the binding site of HMG-CoA reductase, thus, halting enzyme activity. Whereas, Withanolide D (comp no. 17) with high MolDock score did not show hydrogen bonding interactions. Conclusion: The high MolDock score and maximum binding with catalytic region of the enzyme indicate that compounds selected from the fruits of W. coagulans are potential blockers of HMG-CoA reductase. Thus, the compounds may be useful for the management of hypercholesterolemia, which untreated, often leads to coronary artery disease. Keywords: Withania coagulans, Coronary artery disease, HMG-CoA reductase, Molegro virtual docker, Hypercholesterolemia, In silico studies

ASSESSMENT OF THE MICROBIAL CONTENT OF PERIODONTAL POCKETS IN PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS AND CORONARY ARTERY DISEASE

2021 ◽  
Vol 74 (10) ◽  
pp. 2428-2432
Author(s):  
Olesya І. Hodovana ◽  
Oksana V. Skybchyk ◽  
Tetiana M. Solomenchuk ◽  
Tetiana M. Rumynska
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Comparison Group ◽  
Pathological Process ◽  
High Rate ◽  
Prevotella Intermedia ◽  
Periodontal Pathogens ◽  
Microbiological Study ◽  
Periodontal Tissues ◽  
Artery Disease

The aim: To study the rate of detection of specific periodontopathogenic microbiota in patients with chronic generalized periodontitis (CGP) and coronary artery disease (CAD) and assessment of the risk of periodontal pathogens in the development of CAD. Materials and methods: A microbiological study of the content of periodontal pockets was carried out in 64 patients with CGP and CAD of the study group (mean age – 56.9±7.9 years) and 20 patients of the comparison group (mean age – 45.2±11,8 years) who were not burdened with CAD. Results: It was established that in patients with CGP and CAD the following periodontal pathogens were found more frequently than in the comparison group: Aggregatibacter actinomycetemcomitans (56.3±6.20% vs 25.0±9.68%; p=0.01), Prevotella intermedia (54.7±6.22% vs. 20.0±8.94%; p=0.01), and Fusobacterium spp. (34.4±5.94 vs. 10.0±6.71%; p=0.04). The increase in the percentage of the association of the periodontal pathogens was revealed in patients with CAD, which increased with the severity of the pathological process in periodontal tissues. The results of the study indicate the association of A. actinomycetemcomitans, P. intermedia, Fusobacterium spp. with CAD: A. actinomycetemcomitans: OR=3.86 (95% CI: 1.25-11.90), p=0.015; P. intermedia: OR=4.83 (95% CI: 1.45-16.05), p=0.007; Fusobacterium spp.: OR=4.71 (95% CI: 1.00-22.20), p=0.035. Conclusions: Analysis of the microbiological study indicates a high rate of detection of specific periodontal pathogens in patients with CGP and CAD. It can be assumed that the presence of such periodontal pathogens as A. actinomycetemcomitans, P. intermedia, Fusobacterium spp., significantly increases the risk of CAD.

scholarly journals In Silico Investigation of Traditional Chinese Medicine for Potential Lead Compounds as SPG7 Inhibitors against Coronary Artery Disease

Molecules ◽  
2016 ◽  
Vol 21 (5) ◽  
pp. 588 ◽  
Author(s):  
Kuen-Bao Chen ◽  
Kuan-Chung Chen ◽  
Ya-Lin Chang ◽  
Kun-Lung Chang ◽  
Pei-Chun Chang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
In Silico ◽  
Lead Compounds ◽  
Artery Disease

scholarly journals Correlation between prediabetes and coronary artery disease severity in patients undergoing elective coronary angiography

2019 ◽  
Vol 71 (1) ◽  
Author(s):  
Ahmed Muhammed ◽  
Mohamed Tarek Zaki ◽  
Ahmed Shawky Elserafy ◽  
Sameh Attia Amin
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Diabetic Group ◽  
High Rate ◽  
Gensini Score ◽  
Atherosclerotic Burden ◽  
Significant Difference ◽  
Artery Disease

Abstract Background Diabetes is a chronic disease that is responsible for a high rate of morbidity and mortality which can be attributed to atherosclerosis and cardiovascular disease. Diabetes is heralded by prediabetes which not only indicates a higher risk of developing diabetes but also increases the burden of cardiovascular disease. The objective was to observe the effect of prediabetes on the severity of coronary artery disease in patients undergoing elective coronary angiography. Seven hundred and thirty-one patients were admitted for elective coronary angiography and/or PCI starting from September 2017 to August 2018. Patients were divided into group A (normoglycemic group, N = 228), group B (prediabetes group, N = 177), and group C (diabetic group, N = 326). Coronary artery disease (CAD) severity including number of vessels affected and atherosclerotic burden by Gensini score were compared among different groups. Results The number of vessels affected as well as left main (LM) disease was higher in the prediabetes group when compared to the normoglycemic group (P,=0.001, P = 0.009, respectively) and was comparable to the diabetes group (P = 0.4, P = 0.6, respectively). Prediabetes showed a Gensini score higher than the normoglycemic group (P = 0.0001) with no significant difference when compared to the diabetic group (P = 0.9). Conclusion Prediabetes is associated with high atherosclerotic burden and coronary artery disease complexity that is similar to diabetic than normoglycemic individuals.

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