scholarly journals Subchronic effects of different doses of Zinc oxide nanoparticle on reproductive organs of female rats: An experimental study

2019 ◽  
Vol 17 (2) ◽  
pp. 107 ◽  
Author(s):  
Seyed Mohammad Hosseini ◽  
Amir Hossein Moshrefi ◽  
Reza Amani ◽  
Seyed Vahid Razavimehr ◽  
Mohammad Hasan Aghajanikhah2 ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Inflammatory Cells ◽  
Reproductive Organs ◽  
Female Rats ◽  
Dependent Manner ◽  
Adult Rats ◽  
Zinc Oxide Nanoparticle ◽  
Toxicological Studies ◽  
Oxide Nanoparticle ◽  
Different Doses

Background: Zinc performs many biochemical and physiological functions; however,toxicological studies demonstrate that Nano-zinc oxide has harmful effects on humanhealth and environmental species in high concentrations.Objective: The aim of this study was to investigate the toxicity of zinc oxidenanoparticles on reproductive tissues of female rat.Materials and Methods: Eighty female Wistar adult rats weighing 180–200 gr, dividedinto eight groups (n= 10 in each group) including control, sham (treated with saline),and six groups injected with different doses of zinc oxide nanoparticle with 10–30nanometer size (4, 8, 25, 50, 100, and 200 mg/kg) twice a week for four weeks. Atthe end of the study, the rats were bled and slaughtered; the Ovary and Uterus weretaken for histopathology studies and blood samples were transferred to the laboratoryfor biochemical analysis.Results: Microscopic diagnoses in ovary tissue were included; increase in the corpusluteum, follicular cysts, inflammatory cells infiltration and fibrosis. Histopathologicalchanges in ovary in a dose-dependent manner. In uterus tissue the lesions consisted;epithelial destruction, hyperplasia of endometrial glands. The Estrogen and Progesteronelevel in the serum of rats increased in low doses and reduced in a dosedependentmanner at high doses.Conclusion: The results of the current study proved the toxicity of zinc oxidenanoparticles on the ovary and uterus organs at high concentrations, so furtherinvestigation is needed to reduce these effects.

PHYSIOLOGICAL EFFECTS OF THE PINEAL GLAND IN ANDROGEN-STERILIZED FEMALE RATS

1970 ◽  
Vol 63 (4) ◽  
pp. 667-678 ◽  
Author(s):  
Russel J. Reiter
Keyword(s):  
Pineal Gland ◽  
Reproductive Organs ◽  
Female Rats ◽  
Inhibitory Influence ◽  
Light Deprivation ◽  
Vaginal Smears ◽  
Adult Rats ◽  
Androgen Treatment ◽  
Postnatal Treatment ◽  
Cervical Ganglia

ABSTRACT The influence of early androgen treatment, light deprivation (by blinding), pinealectomy and superior cervical ganglionectomy on the reproductive system of female rats was tested. Early postnatal treatment of rats with testosterone propionate caused adult rats to exhibit the characteristic signs of androgen sterilization; these included polyfollicular ovaries, normal-sized uteri and persistent vaginal cornification. If early androgentreated rats also were blinded the ovaries were smaller in size and contained fewer follicles, the uteri were greatly reduced in size and the incidence of vaginal oestrus was decreased by approximately 50% If in addition to blinding, androgen-sterilized animals were subjected to either removal of the pineal gland or superior cervical ganglia, the reproductive organs and the vaginal smears were indistinguishable from those of testosterone-treated rats with eyes. These data indicate that the inhibitory influence of blinding on the pituitary-ovarian axis was mediated through the sympathetic nervous system and the pineal gland. The restraining influence of light deprivation on the growth of the reproductive organs was not permanent as illustrated by the fact that if these animals were kept to 120 days of age the ovaries and uteri grew to the same level as those of pinealectomized control rats.

Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice

2019 ◽  
Vol 14 (1) ◽  
pp. 59-76
Author(s):  
Hailong Hu ◽  
Qian Guo ◽  
Xingpei Fan ◽  
Xiangjuan Wei ◽  
Daqian Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Zinc Oxide ◽  
Molecular Mechanisms ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals A critical review of synthesis parameters affecting the properties of zinc oxide nanoparticle and its application in wastewater treatment

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
E. Y. Shaba ◽  
J. O. Jacob ◽  
J. O. Tijani ◽  
M. A. T. Suleiman
Keyword(s):  
Zinc Oxide ◽  
Metal Oxides ◽  
Zinc Oxide Nanoparticles ◽  
Textural Properties ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Synthesis Parameters ◽  
Metal Precursors ◽  
Removal Of Heavy Metals ◽  
Oxide Nanoparticle

AbstractIn this era, nanotechnology is gaining enormous popularity due to its ability to reduce metals, metalloids and metal oxides into their nanosize, which essentially alter their physical, chemical, and optical properties. Zinc oxide nanoparticle is one of the most important semiconductor metal oxides with diverse applications in the field of material science. However, several factors, such as pH of the reaction mixture, calcination temperature, reaction time, stirring speed, nature of capping agents, and concentration of metal precursors, greatly affect the properties of the zinc oxide nanoparticles and their applications. This review focuses on the influence of the synthesis parameters on the morphology, mineralogical phase, textural properties, microstructures, and size of the zinc oxide nanoparticles. In addition, the review also examined the application of zinc oxides as nanoadsorbent for the removal of heavy metals from wastewater.

scholarly journals Mechanisms and effects of zinc oxide nanoparticle transformations on toxicity to zebrafish embryos

2021 ◽  
Author(s):  
Gyudong Lee ◽  
Byongcheun Lee ◽  
Ki-Tae Kim
Keyword(s):  
Zinc Oxide ◽  
Physicochemical Properties ◽  
Zebrafish Embryos ◽  
Zinc Ions ◽  
Zno Nps ◽  
Zinc Oxide Nanoparticle ◽  
Toxicity Reduction ◽  
Oxide Nanoparticle

Environmental transformations modify the physicochemical properties of ZnO NPs, modulate their ability to reduce zinc ions, and determine the degree of toxicity reduction in zebrafish embryos.

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