scholarly journals Assessment of incidence and severity of adverse drug reactions in multidrug resistant tuberculosis patients

2019 ◽  
Vol 7 (4) ◽  
Author(s):  
G. Akhil ◽  
Keyword(s):  
Adverse Drug Reactions ◽  
Multidrug Resistant ◽  
Drug Reactions ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

Occurrence, Management, and Risk Factors for Adverse Drug Reactions in Multidrug Resistant Tuberculosis Patients

2018 ◽  
Vol 25 (5) ◽  
pp. e533-e540 ◽  
Author(s):  
Nafees Ahmad ◽  
Arshad Javaid ◽  
Syed Azhar Syed Sulaiman ◽  
Afsar Khan Afridi ◽  
Zainab ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Drug Reactions ◽  
Multidrug Resistant ◽  
Drug Reactions ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

Adverse drug reactions and risk factors for discontinuation of multidrug-resistant tuberculosis regimens in Gujarat, western India

2020 ◽  
Vol 33 (1) ◽  
pp. 10
Author(s):  
KhushaliDharmesh Parikh ◽  
MihirPrafulbhai Rupani ◽  
JignaD Dave ◽  
VijayB Parmar ◽  
ManindraPratap Singh
Keyword(s):  
Risk Factors ◽  
Adverse Drug Reactions ◽  
Multidrug Resistant ◽  
Western India ◽  
Drug Reactions ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Frequency and type of adverse drug reactions related to multidrug-resistant tuberculosis therapy

2021 ◽  
Author(s):  
Afaq Ahmed ◽  
Ashok Kumar Gudagunti ◽  
Shylendra . ◽  
Veena Hagalur Nayak ◽  
H. Mallikarjun Swamy
Keyword(s):  
Adverse Drug Reactions ◽  
Prospective Observational Study ◽  
Multidrug Resistant ◽  
Drug Reactions ◽  
Tb Treatment ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Initiation Of Therapy ◽  
Tuberculosis Therapy

Background: Adverse drug reactions (ADRs) are inevitable consequences of multidrug-resistant tuberculosis drug therapy. Reporting of ADR in India is poor and inadequate. ADRs monitoring forms an integral part of pharmacovigilance. ADRs with second line anti-tuberculous therapy (ATT) have been mentioned as obstacles in the management of multidrug-resistant tuberculosis (MDR-TB). Objectives of the study was to study the frequency and type of adverse drug reaction related to MDR-TB therapy.Methods: 72 patients diagnosed as MDR-TB and enrolled for DOTS-PLUS (CAT.IV) regimen at NTEP centre, KIMS HUBLI were included. This was a prospective observational study. All patients were followed up for a period of 9 months from the day of commencement of treatment. Adverse drug reactions were determined by monthly clinical and biochemical monitoring of patients to identify ADRs.Results: Among 72 Patients, 42 (58.3%) were males. 44 out of 72 patients experienced at least one type of ADRs (61.1%). Mean age was 35.86±12.62 and mean weight was 42.00±9.05. Four most common ADRs reported were Gastro-intestinal symptoms (29.2%), anorexia (15.3%), giddiness (12.5%), and pain at injection site (11.1%). Highest percentage of ADRs were seen in patients of age group>60 years (66.7%). ADRs were most commonly reported in first 3 months of initiation of therapy. 9 out of 72 patients (12.5%) or 20.5% of 44 patients who showed ADRs required change of treatment. There was a significant impact of ADRs on treatment among those with ADRs (p=0.01).Conclusion: ADRs of varying severity are common in patients of MDR-TB on DOTS-PLUS regimen, occurring in more than half of the cases, with around one fifth requiring change of MDR-TB treatment.

Biobank for multidrug-resistant tuberculosis research: Importance of sequential samples

2021 ◽  
Author(s):  
Yoohyun Hwang ◽  
Jiyeon Kim ◽  
Seungkyu Park ◽  
Sungweon Ryoo
Keyword(s):  
International Research ◽  
Multidrug Resistant ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
National Tuberculosis ◽  
Sequential Samples ◽  
Resistant Strains

Abstract Since 2013, Masan National Tuberculosis Hospital has collected standardized specimens from its tuberculosis patients, which include a large number of multidrug-resistant strains. The repository collects matched participants and their bacilli samples, compiling sequential samples from the beginning of treatment. The repository aims to provide resources for in-depth international research.

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