Bone turnover markers in the obese children – relation to gender, body composition and leptin level

Background. Peripheral fat tissue is known to positively influence bone health. However, evidence exists that the risk of non-vertebral fractures can be increased in postmenopausal women with obesity as compared to healthy controls. The role of sclerostin, the SOST gene protein product, and body composition in this condition is unknown. Methods. We studied 28 severely obese premenopausal (age, 44.7 ± 3.9 years; BMI, 46.0 ± 4.2 kg/m2) and 28 BMI-matched post-menopausal women (age, 55.5 ± 3.8 years; BMI, 46.1 ± 4.8 kg/m2) thorough analysis of bone density (BMD) and body composition by dual X-ray absorptiometry (DXA), bone turnover markers, sclerostin serum concentration, glucose metabolism, and a panel of hormones relating to bone health. Results. Postmenopausal women harbored increased levels of the bone turnover markers CTX and NTX, while sclerostin levels were non-significantly higher as compared to premenopausal women. There were no differences in somatotroph, thyroid and adrenal hormone across menopause. Values of lumbar spine BMD were comparable between groups. By contrast, menopause was associated with lower BMD values at the hip (p < 0.001), femoral neck (p < 0.0001), and total skeleton (p < 0.005). In multivariate regression analysis, sclerostin was the strongest predictor of lumbar spine BMD (p < 0.01), while menopausal status significantly predicted BMD at total hip (p < 0.01), femoral neck (p < 0.001) and total body (p < 0.05). Finally, lean body mass emerged as the strongest predictor of total body BMD (p < 0.01). Conclusions. Our findings suggest a protective effect of obesity on lumbar spine and total body BMD at menopause possibly through mechanisms relating to lean body mass. Given the mild difference in sclerostin levels between pre- and postmenopausal women, its potential actions in obesity require further investigation.

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Effectsof aerobic and resistance trainings on relation between blood biochemical parameters and body compositionwith bone turnover markers in overweight men

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v27i5.1522 ◽

2019 ◽

Author(s):

M. Rostamizadeh ◽

A. Elmieh ◽

F. Rahmani nia

Keyword(s):

Body Composition ◽

Resistance Training ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Biochemical Parameters ◽

Exercise Group ◽

Blood Samples ◽

Blood Biochemical Parameters ◽

Blood Biochemical ◽

Turnover Markers

Introdution: The cells rolled in the formation of bone, regulated glucose metabolism, and increased insulin secretion from pancreatic beta cells and modulated the insulin resistance. Therefore, the present study aimed to study the effects of aerobic and resistance exercises on relation between blood biochemical parameters and body composition with bone turnover markers in overweight men. Method: In this quasi-experimental study, a total of 36 overweight, young healthy men (age range28-35 years) were randomly assigned to the control (n=14), aerobic exercise (n=11) and resistance exercise (n=11) groups. In the aerobic exercise group, excercisetraining was performedfor 8weeks, three sessions per week (at 55-85% of HRR), and in the resistance exercise group,exercise training was perfprmed in 8weeks for three sessions per week(at 55-75% of 1RM). Body composition and blood samples were assessed from fasting blood samples before and after the 8-week exercise programme. Data wereanalyzed by t-test and ANOVA by SPSS ver.25 Software. Results: Paired t-test and one-way ANOVA showed that aerobic and resistance training cause the reduction of body composition (P <0.05), increasing the osteocalcin (P = 0.001 and P <0.001) as well as a significant decrease in blood biochemical parameters (P <0.05). Also, Pearson correlation showed that there was no correlation between osteocalcin and blood biochemical parameters and body composition (P <0.05). Conclusion: The results of this study showed that 8 -week exercise trainings increase osteocalcin levels, which is associated with a decrease in body weight and body fat percentage, particularly lipid profiles. However, despite the differences in mean, there was no statistically significant difference between aerobic and resistance training.

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Bone turnover markers and bone mineral density after 12-month weight loss therapy in obese children

Bone Abstracts ◽

10.1530/boneabs.4.p4 ◽

2015 ◽

Author(s):

Joanna Gajewska ◽

Witold Klemarczyk ◽

Jadwiga Ambroszkiewicz ◽

Magdalena Chelchowska ◽

Halina Weker

Keyword(s):

Bone Mineral Density ◽

Weight Loss ◽

Bone Turnover ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Obese Children ◽

Mineral Density ◽

Turnover Markers ◽

Weight Loss Therapy

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Factors associated with bone turnover and speed of sound in early and late-pubertal females

Applied Physiology Nutrition and Metabolism ◽

10.1139/h11-085 ◽

2011 ◽

Vol 36 (5) ◽

pp. 707-714 ◽

Cited By ~ 6

Author(s):

Panagiota Klentrou ◽

Izabella A. Ludwa ◽

Bareket Falk

Keyword(s):

Physical Activity ◽

Body Composition ◽

Bone Turnover ◽

Dietary Intake ◽

Speed Of Sound ◽

Bone Turnover Markers ◽

Serum Levels ◽

Daily Energy Intake ◽

Daily Energy ◽

Turnover Markers

This cross-sectional study examines whether maturity, body composition, physical activity, dietary intake, and hormonal concentrations are related to markers of bone turnover and tibial speed of sound (tSOS) in premenarcheal (n = 20, 10.1 ± 1.1 years) and postmenarcheal girls (n = 28, aged 15.0 ± 1.4 years). Somatic maturity was evaluated using years from age of peak height velocity (aPHV). Daily dietary intake was assessed with a 24-h recall interview, and moderate to very vigorous physical activity (MVPA) was measured using accelerometry. Plasma levels of 25-OH vitamin D, serum levels of insulin-like growth-factor 1 (IGF-1) and leptin, and serum levels of bone turnover markers including osteocalcin (OC), bone-specific alkaline phosphatase (BAP) and cross-linked N-teleopeptide of type I collagen (NTX) were measured using ELISA. OC, BAP, and NTX were significantly higher while IGF-1 and tSOS were lower in the premenarcheal group. The premenarcheal girls were more active and had higher daily energy intake relative to their body mass but there were no group differences in body mass index percentile. Maturity predicted 40%–57% of the variance in bone turnover markers. Additionally, daily energy intake was a significant predictor of OC, especially in the postmenarcheal group. IGF-1 and MVPA were significant predictors of BAP in the group as a whole. However, examined separately, IGF-1 was a predictor of BAP in the premenarcheal group while MVPA was a predictor in the postmenarcheal group. Adiposity and leptin were both negative predictors of tSOS, with leptin being specifically predictive in the postmenarcheal group. In conclusion, while maturity was the strongest predictor of bone markers and tSOS, dietary intake, physical activity, body composition, and hormonal factors further contribute to the variance in bone turnover and bone SOS in young Caucasian females. Further, the predicting factors of bone turnover and tSOS were different within each maturity group.

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RELATIONSHIP OF IGF-I, BONE TURNOVER MARKERS, DIET AND BODY COMPOSITION TO BONE MINERAL DENSITY.

Medicine & Science in Sports & Exercise ◽

10.1097/00005768-200305001-00432 ◽

2003 ◽

Vol 35 (Supplement 1) ◽

pp. S79

Author(s):

M M. Murphy ◽

B C. Nindl ◽

R K. Evans ◽

C J. Baker-Fulco ◽

K M. Sheehan ◽

...

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Bone Turnover ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Mineral Density ◽

Igf I ◽

Turnover Markers ◽

Relationship Of

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Bone turnover markers, bone mineral density and body composition in Tunisian patients with chronic obstructive pulmonary disease

10.1183/13993003.congress-2021.pa1949 ◽

2021 ◽

Author(s):

Meriem Mjid ◽

Amir Taboubi ◽

Sameh Hadj Taieb ◽

Abir Hedhli ◽

Yacine Ouahchi ◽

...

Keyword(s):

Bone Mineral Density ◽

Chronic Obstructive Pulmonary Disease ◽

Body Composition ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Chronic Obstructive ◽

Mineral Density ◽

Obstructive Pulmonary Disease ◽

Tunisian Patients ◽

Turnover Markers

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The Effects of Season-Long Vitamin D Supplementation on Collegiate Swimmers and Divers

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.23.5.431 ◽

2013 ◽

Vol 23 (5) ◽

pp. 431-440 ◽

Cited By ~ 30

Author(s):

Regina M. Lewis ◽

Maja Redzic ◽

D. Travis Thomas

Keyword(s):

Vitamin D ◽

Body Composition ◽

Bone Turnover ◽

Inflammatory Cytokines ◽

Bone Turnover Markers ◽

Female Athletes ◽

Vitamin D Supplementation ◽

Mineral Density ◽

Turnover Markers ◽

Total Body

The purpose of this 6-month randomized, placebo-controlled trial was to determine the effect of season-long (September–March) vitamin D supplementation on changes in vitamin D status, which is measured as 25(OH) D, body composition, inflammation, and frequency of illness and injury. Forty-five male and female athletes were randomized to 4,000 IU vitamin D (n = 23) or placebo (n = 22). Bone turnover markers (NTx and BSAP), 25(OH)D, and inflammatory cytokines (TNF-alpha, IL-6, and IL1-β) were measured at baseline, midpoint, and endpoint. Body composition was assessed by DXA and injury and illness data were collected. All athletes had sufficient 25(OH)D (> 32 ng/ml) at baseline (mean: 57 ng/ml). At midpoint and endpoint, 13% and 16% of the total sample had 25(OH)D < 32 ng/ml, respectively. 25(OH)D was not positively correlated with bone mineral density (BMD) in the total body, proximal dual femur, or lumbar spine. In men, total body (p = .04) and trunk (p = .04) mineral-free lean mass (MFL) were positively correlated with 25(OH)D. In women, right femoral neck BMD (p = .02) was positively correlated with 25(OH)D. 25(OH)D did not correlate with changes in bone turnover markers or inflammatory cytokines. Illness (n = 1) and injury (n = 13) were not related to 25(OH)D; however, 77% of injuries coincided with decreases in 25(OH)D. Our data suggests that 4,000 IU vitamin D supplementation is an inexpensive intervention that effectively increased 25(OH)D, which was positively correlated to bone measures in the proximal dual femur and MFL. Future studies with larger sample sizes and improved supplement compliance are needed to expand our understanding of the effects of vitamin D supplementation in athletes.

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Association between Bone Turnover Markers, Leptin, and Nutritional Status in Girls with Adolescent Idiopathic Scoliosis (AIS)

Nutrients ◽

10.3390/nu12092657 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2657

Author(s):

Edyta Matusik ◽

Jacek Durmala ◽

Magdalena Olszanecka-Glinianowicz ◽

Jerzy Chudek ◽

Pawel Matusik

Keyword(s):

Body Composition ◽

Adolescent Idiopathic Scoliosis ◽

Bone Turnover ◽

Bone Metabolism ◽

Bone Turnover Markers ◽

Z Score ◽

Scoliotic Curve ◽

Cobb’S Angle ◽

Turnover Markers ◽

Curve Severity

The link between scoliotic deformity and bone metabolism in adolescent idiopathic scoliosis (AIS) has not been well researched. Moreover, the data concerning the cross-talk between fat tissue content/hormonal activity and bone markers in this group of patients are lacking. The aim of the study was to assess whether there exists a significant relationship between the severity of AIS and bone turnover markers and leptin levels. The study group was consisted of 77 AIS girls, aged 14.7 ± 2.17 years. Scoliotic curve severity assessed by Cobb’s angle was categorized as mild (10–19°), moderate (20–39°), or severe (≥40°). Corrected height, weight, and waist and hip circumferences were measured and body mass index (BMI), corrected height Z-score, BMI Z-score, and waist/height ratio (WHtR) were calculated for the entire group. Body composition parameters: fat mass (FAT), fat-free mass (FFM), and predicted muscle mass (PMM) were determined using a bioelectrical impedance analyzer. Bone turnover markers (osteocalcin (OC) and amino terminal of collagen cross-links (NTx) and leptin levels were assessed in serum. Multiple regression analysis showed that, OC, NTx (negatively with p < 0.05), and leptin (positively with p < 0.01) were significantly associated with curve severity in AIS girls. Moreover, Cobb’s angle was positively correlated with W/HtR (p < 0.01) and FAT (p < 0.05). One-way analysis of variance (ANOVA) revealed significant differences in leptin (p < 0.05 vs. mild only), OC (p < 0.05 vs. mild and moderate), and W/HtR (p < 0.01 and p < 0.05 vs. mild and moderate, respectively) between the three AIS severity subgroups. OC was significantly lower in the severe AIS subgroup, while leptin and W/HtR were significantly higher. Significant correlations between leptin and anthropometrical parameters as BMI z-score and W/HtR were shown. Leptin level correlated also significantly with BMI z score (p < 0.001), W/HtR (p < 0.0001), and body composition parameters (p < 0.000001). Moreover, there was a significant negative correlation between NTx and leptin level (p < 0.05). Bone metabolism in AIS girls seems to be altered and significantly related to the scoliotic curve severity. Leptin may be a crucial link in the cross-talk between bone turnover and body composition in this group of patients. Further studies concerning interrelationship between nutritional status and bone metabolism in patients with AIS are warranted.

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