Assisted reproductive technologies in married couples at high risk for genetic disorders. Preimplantation genetic screening

For many commentators in bioethics and the law, safety is the fulcrum for evaluating the ethics of human reproductive cloning. Carson Strong has argued that if cloning were effective and safe it should be available to married couples who have tried to have children through various assisted reproductive technologies (ARTs) but been unable to do so. On his view, cloning should be available only as reproductive last resort. I challenged that limited use by trying to show that the arguments Strong adduces in favor of reproductive somatic nuclear transfer (SNT) for married couples extend to same-sex couples as well, who face a different kind of infertility. I also went on to argue that his justifications would in fact extend the legitimate use of SNT to any couples regardless of whether they had fertility difficulties or not.

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Risk factors for renewal of fertility in married couples with male infertility using the assisted reproductive technologies

Health of Man ◽

10.30841/2307-5090.3(58).2016.104880 ◽

2016 ◽

Vol 0 (3(58)) ◽

pp. 170-173

Author(s):

Ю. М. Гурженко ◽

А. О. Куценко

Keyword(s):

Risk Factors ◽

Male Infertility ◽

Assisted Reproductive Technologies ◽

Married Couples ◽

Reproductive Technologies

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Embryologist's Job in Assisted Reproductive Technologies and in Vitro Fertilization

International Journal of Scientific Research in Science and Technology ◽

10.32628/ijsrst218521 ◽

2021 ◽

pp. 108-115

Author(s):

Harsimrat Kaur ◽

Ram Dayal ◽

Kamla Singh

Keyword(s):

Genetic Screening ◽

Assisted Reproductive Technologies ◽

Genetic Diagnosis ◽

Reproductive Technologies ◽

Fertility Treatment ◽

Medical Professionals ◽

Vitro Fertilization ◽

Laboratory Environment ◽

Reproductive Research

What exactly does an embryologist do? is one of the most common question asked by patients and the possible answer could be that embryologist is the child’s first watchperson. The ability to grow embryos in laboratory environment was a huge scientific achievement. Scientists and Embryologists are involved in reproductive research and fertility treatment. The embryologist has a huge role to play in IVF/ICSI process and the contribution of embryologist is no less than infertility consultant. They might not be doctors, but they are highly trained medical professionals, holding a master’s degree or Ph.D. due to specialized nature of work. They are responsible for management and maintenance of laboratory used in creating embryos as well as monitoring those embryos. The important activities that embryologist does are maintaining the embryology lab (temperature, humidity, CO2 cylinder, diffusion gas and pH), oocyte screening during ovum pickup (OPU), incubation and checking of fertilization, embryo transfer, vitrification and embryo biopsy for pre-implantation genetic screening (PGS) or pre-implantation genetic diagnosis (PGD).

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NON-INVASIVE METHODS FOR STUDYING THE POTENTIAL OF HUMAN EMBRYO FOR IMPLANTATION

СИСТЕМНЫЙ АНАЛИЗ И УПРАВЛЕНИЕ В БИОМЕДИЦИНСКИХ СИСТЕМАХ ◽

10.36622/vstu.2021.20.4.005 ◽

2021 ◽

pp. 29-37

Author(s):

Василий Николаевич Попов ◽

Роман Борисович Стукалин ◽

Валерия Александровна Грибанова

Keyword(s):

Assisted Reproductive Technologies ◽

Culture Media ◽

Uterine Cavity ◽

Married Couples ◽

Reproductive Technologies ◽

Preimplantation Embryos ◽

Preimplantation Genetic Testing ◽

Vitro Fertilization ◽

Non Invasive

В статье проводится анализ представленных на сегодня инвазивных и неинвазивных методов исследования преимплантационных эмбрионов. Показана эффективность преимплантационного генетического тестирования эмбрионов до переноса в полость матки. Также рассмотрены альтернативные менее инвазивные варианты изучения жизнеспособности эмбрионов, которые могли бы являться маркерами успешной имплантации. Проблема бесплодного брака с каждым годом становится все более и более значимой. Для части супружеских пар единственной возможностью рождения ребенка становится лечение методами вспомогательных репродуктивных технологий, эффективность которых остается на сегодняшний день не более 50 %. Особенно важным является поиск новых методик, позволяющих повысить результативность процедур экстракорпорального оплодотворения. В этом направлении крайне интересным является изучение неизвазивных методов оценки имплантационного потенциала эмбрионов. В анализе представлены работы по изучению протеома, метаболома и транскриптома эмбриона. Понимание молекулярного состава культуральных сред, в которых происходило развитие эмбриона до пятых суток культивирования, позволит глубже понять физиологию раннего развития, а также установить неивазивные критерии отбора эмбриона с лучшим имплантационным потенциалом и тем самым повысить эффективность проводимых программ вспомогательных репродуктивных технологий The article analyzes the currently presented invasive and non-invasive methods for studying preimplantation embryos. The efficiency of preimplantation genetic testing of embryos before transfer to the uterine cavity has been shown. Also considered are alternative less invasive options for studying the viability of embryos, which could be markers of successful implantation. The problem of sterile marriage is becoming more and more significant every year. For some married couples, the only possibility of having a child is treatment with methods of assisted reproductive technologies, the effectiveness of which remains at most 50% today. It is especially important to search for new techniques to improve the effectiveness of in vitro fertilization procedures. In this direction, it is extremely interesting to study non-invasive methods for assessing the implantation potential of embryos. The analysis presents works on the study of the proteome, metabolome and transcriptome of the embryo. Understanding the molecular composition of the culture media in which the development of the embryo took place until the fifth day of cultivation will allow a deeper understanding of the physiology of early development and also establish non-invasive criteria for the selection of embryos with the best implantation potential and thereby increase the efficiency of the programs of assisted reproductive technologies

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The features of emotional response in men in a sterile marriage

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) ◽

10.33920/med-01-2105-02 ◽

2021 ◽

pp. 339-345

Author(s):

Zhanna Robertovna Gardanova ◽

Nikita Igorevich Petrov ◽

Dmitriy Fedorovich Khritinin

Keyword(s):

Coping Strategies ◽

Emotional Response ◽

Assisted Reproductive Technologies ◽

Personal Characteristics ◽

Married Couples ◽

Reproductive Technologies ◽

Infertility Treatment ◽

Art Program ◽

Anxiety Depression ◽

Personal Questionnaire

The problem of infertility treatment is currently relevant for married couples who have not had a pregnancy within a year of regular sexual activity. The possibility of infertility treatment using assisted reproductive technologies allows couples to get the desired pregnancy. The emotional response of men in infertile marriage was researched in this study, and it was shown that some men have an increased level of anxiety and depression, while preferred coping strategies allow going through the entire infertility treatment program, taking into account personal characteristics. The study involved 52 married men, aged 35-43 years. Psychodiagnostic testing using techniques to determine the level of anxiety, depression, coping strategies, and a personal questionnaire was conducted. As a result of the obtained data, the need for psychodiagnostic testing is justified in order to identify the level of emotional expression and the possibility of participation in the ART program.

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