scholarly journals The demographic features, clinicopathologic characteristics, treatment outcome and disease-specific prognostic factors of solitary fibrous tumor: a population-based analysis

Oncotarget ◽  
2015 ◽  
Vol 6 (39) ◽  
pp. 41875-41883 ◽  
Author(s):  
Alimujiang Wushou ◽  
Yi-Zhou Jiang ◽  
Yi-Rong Liu ◽  
Zhi-Ming Shao
Keyword(s):  
Treatment Outcome ◽  
Prognostic Factors ◽  
Solitary Fibrous Tumor ◽  
Population Based ◽  
Clinicopathologic Characteristics ◽  
Fibrous Tumor ◽  
Disease Specific ◽  
Demographic Features

Primary Thyroid Lymphoma: A Retrospective IELSG and IIL Analysis of Clinical Characteristics, Prognostic Factors, Treatment Outcome and Somatic Hypermutation for Localized Diffuse Large B-Cell Lymphoma (DLBCL).

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3432-3432
Author(s):  
Sergio Cortelazzo ◽  
Gianluca Gaidano ◽  
Michael Mian ◽  
Annarita Conconi ◽  
Andrea Rossi ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Prognostic Factors ◽  
B Cell ◽  
Clinical Characteristics ◽  
Somatic Hypermutation ◽  
B Cell Lymphoma ◽  
Biological Study ◽  
Disease Specific Survival ◽  
Bulky Disease ◽  
Disease Specific

Abstract We compared clinical characteristics, prognostic factors and treatment outcome of primary thyroid DLBCL (PTL) with those of other locations of primary extranodal head and neck lymphomas (PEHNL) and we further analyzed somatic hypermutation in pts with PTL. From December 1990 to June 2004, 48 PTL out of 478 PEHNL patients (pts) (10%) were enrolled in this study, including 10 males and 38 females, with a median age of 73 years (range, 34–90 years). In comparison with other locations PTL cases had more frequently advanced age (>60 yrs), female sex, bulky disease, poor ECOG-PS, elevated LDH and >1 adverse factors according to stage-modified IPI (MIPI). The commonest treatment was a short course of anthracycline-based chemotherapy (CHT) ± involved field radiotherapy (IFRT). Forty-two percent of PTL pts also underwent surgery. Clonal IGHVDJ rearrangements were analyzed in 17/48 cases. The CR rate of PTL pts (85%) was comparable to those of other locations. After a median follow-up of 41 months (range 1–154.months), 5-yr OS, EFS and DFS were 51%, 46% and 86%, respectively. The OS compared unfavourably with other locations (75%), while the disease-specific survival rate was similar in both groups (80%). Moreover, MIPI was not predictive of survival, probably due to a high mortality unrelated to disease (19% Vs 7%). Regarding treatment PTL pts seem to benefit more from surgery in combination with chemotherapy and/or IFRT than from other treatments not including partial or complete thyroid resection (p=0.04). Somatic hypermutation of IGHV genes was observed in the majority of PTL cases, suggesting that they derive from germinal center experienced B-cell, while the unmutated status in a fraction of pts indicates a different histogenetic and pathogenetic pathway. The significant clustering of S and R mutations in CDRs and FRs in a fraction of cases with high homologous CDR3 suggests that antigen stimulation may have an important role in the pathogenesis of these lymphomas. In conclusion, in spite of more adverse features at presentation PTL pts showed a favorable disease-specific survival, comparable to that of other PEHN. Biological study in PTL pts suggests different histogenetic and pathogenetic pathway. The comparison of thyroid biological profile with that of other PEHNL could help to clarify the different clinical behaviour of this uncommon malignancy.

scholarly journals Head & neck acinar cell carcinoma: a population-based study using the seer registry

2020 ◽  
Author(s):  
Feiluore Yibulayin ◽  
Lei Feng ◽  
Meng Wang ◽  
Meng-meng Lu ◽  
Yuan Luo ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Acinar Cell ◽  
Acinar Cell Carcinoma ◽  
Population Based ◽  
Clinicopathologic Characteristics ◽  
Population Based Study ◽  
Ajcc Stage ◽  
Significant Difference ◽  
Grade Iii

Abstract Background: to explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively. Methods: A population-based study was conducted using data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression. Results: A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR = 0.13, P = 0.0092 and HR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis. Conclusion: Surgery was the only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

scholarly journals Head & Neck Acinar Cell Carcinoma: A Population-Based Study Using the Seer Registry

2020 ◽  
Author(s):  
Feiluore Yibulayin ◽  
Meng Wang ◽  
Meng-meng Lu ◽  
Yuan Luo ◽  
Hui Liu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Acinar Cell ◽  
Acinar Cell Carcinoma ◽  
Population Based ◽  
Clinicopathologic Characteristics ◽  
Population Based Study ◽  
Ajcc Stage ◽  
Significant Difference ◽  
Grade Iii

Abstract Background:to explorethe clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively.Methods:A population-based study was conductedusing data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression.Results:A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR= 0.13, P = 0.0092 andHR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis.Conclusion:Surgerywasthe only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

Solitary-fibrous tumor/hemangiopericytoma of the central nervous system: a population-based study

2018 ◽  
Vol 138 (1) ◽  
pp. 173-182 ◽  
Author(s):  
Connor J. Kinslow ◽  
Samuel S. Bruce ◽  
Ali I. Rae ◽  
Sameer A. Sheth ◽  
Guy M. McKhann ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Solitary Fibrous Tumor ◽  
Population Based ◽  
Population Based Study ◽  
System A ◽  
The Central Nervous System ◽  
Fibrous Tumor

scholarly journals Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor

2020 ◽  
Vol 154 (1) ◽  
pp. 15-22
Author(s):  
Everton Freitas de Morais ◽  
Hélder Domiciano Dantas Martins ◽  
Katianne Soares Rodrigues ◽  
Glória Maria de França ◽  
Éricka Janine Dantas da Silveira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Therapeutic Modality ◽  
Biological Behavior ◽  
Clinicopathologic Characteristics ◽  
Long Term Follow Up ◽  
Mean Size ◽  
Fibrous Tumor

Abstract Objectives The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior. Methods We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included. Results Seventy-three published articles were included in our systematic review, corresponding to a total of 154 cases. SFT showed a slight female predilection (53.2%), and the cheek mucosa/cheek, tongue, and palate were the most affected anatomical sites. The mean size of SFT in the oral cavity and maxillofacial region at diagnosis was 1.4 cm. Histologic features of malignancy by morphologic analysis (P < .001) were significantly associated with a larger tumor size. Surgical excision was the most frequent therapeutic modality. Recurrence and metastasis were uncommon findings in our sample. Conclusions Histologic features of malignancy can be important parameters of tumor behavior. Adequate surgical treatment and long-term follow-up are required for these cases.

Clinical Features, Management and Prognostic Factors of Intracranial Solitary Fibrous Tumor

2021 ◽  
Author(s):  
Jingdian Liu ◽  
Sisi Wu ◽  
Junwen Wang ◽  
Kai Shu ◽  
Ting Lei
Keyword(s):  
Prognostic Factors ◽  
Survival Rate ◽  
Clinical Features ◽  
Solitary Fibrous Tumor ◽  
Study Patient ◽  
Ki 67 ◽  
Who Grade ◽  
Female Ratio ◽  
Fibrous Tumor ◽  
Grade Iii

Abstract Purpose Due to low incidence and the constantly changing diagnostic and classification criteria, the clinical features, management and prognostic factors of intracranial solitary fibrous tumor (ISFT) remain unclear and were thus analyzed in this study. Methods A total of 38 patients who were diagnosed as ISFT in our institution were enrolled in this study. Patient data including age, gender, clinical presentation, histopathological features, immunohistochemistry staining, tumor location, tumor size, treatment methods, and prognosis were extracted and retrospectively analyzed. Results The median age at diagnosis was 45.5 years (range 28-66 years) and the male to female ratio was 1:1.53 in our series. The 3-, 5-, and 10-year progression-free survival rate was 82.2%, 62.8%, and 21.4%, respectively; and the 3-, 5-, and 10-year overall survival rate was 97.1%, 86.9% and 64.2%, respectively. Patients with high WHO grade (grade III) ISFTs had impaired PFS (p<0.05) and OS (p<0.01). Subtotal resection (STR) was associated with shorter PFS and OS (p<0.001, respectively). Postoperative radiotherapy (PORT) significantly improved PFS but not OS in patients with WHO grade III ISFTs (P=0.025). The PFS of patients with STR+PORT was improved compared with those who received STR alone, although not significant. Moreover, CD34-negative immunostaining and high Ki-67 index (>10%) were associated with impaired PFS in ISFTs.Conclusion Our study provides evidence that high tumor grade, subtotal tumor resection, CD34 negative immunostaining and high Ki-67 index (>10%) were independent predictors for poor prognosis of ISFTs. PORT should be recommended for patients with high grade ISFTs or STR.

scholarly journals Clinicopathologic characteristics, survival, and treatments for gastric adenosquamous carcinoma: a population-based study

2020 ◽  
Vol 27 (6) ◽  
Author(s):  
H.S. Li ◽  
M.Y. Zhang ◽  
K. Cheng ◽  
Y. Chen ◽  
Y.W. Zhou ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Adenosquamous Carcinoma ◽  
Advanced Disease ◽  
Population Based ◽  
Tumour Invasion ◽  
Chemotherapy Treatment ◽  
Curative Surgery ◽  
Clinicopathologic Characteristics ◽  
Population Based Study ◽  
Significant Difference

Background Gastric adenosquamous carcinoma (gasc) is a rare entity with distinctive characteristics that are not fully understood. In the present study, we evaluated the characteristics of this rare disease. Methods The U.S. Surveillance, Epidemiology, and End Results program database was searched to determine the clinicopathologic features, prognostic factors, and treatments for 246 patients with gasc and 42,735 patients with gastric adenocarcinoma (gac). Results Relative to gac, gasc is associated with higher proportions of cardia involvement, high-grade tumours, deep tumour invasion, metastatic lymph nodes, and chemotherapy treatment. In patients who underwent potentially curative surgery (pcs), gasc was associated with a higher proportion of radiotherapy use and poorer overall survival (p < 0.001), although no significant difference (p = 0.802) was observed after propensity score matching (psm). Multi­variate analysis after psm revealed that the independent prognostic factors for gasc were TNM stage [hazard ratio (hr): 1.512; p = 0.021] and regional nodes examined (hr: 0.588; p = 0.02). In patients with advanced disease, no significant difference in survival between gasc and gac was observed (p = 0.212), although survival was significantly poorer for gasc after psm (p = 0.019). Multivariate analysis after psm revealed that the independent prognostic factors for gasc were invasion depth (hr: 1.303; p = 0.036) and chemotherapy (hr: 0.444; p < 0.001). Conclusions Relative to gac, gasc was associated with more aggressive features, although survival outcomes were similar after pcs. Chemotherapy remains a mainstay of treatment for patients with advanced gasc, but its role remains unclear for patients who are undergoing pcs.

Treatment outcome and prognostic factors in male patients with stage IV breast cancer: A population-based study.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 572-572
Author(s):  
Ying Huang ◽  
Wei Chen ◽  
Sean Szeja ◽  
Sandra S. Hatch ◽  
Andrew M Farach ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Outcome ◽  
Prognostic Factors ◽  
Stage Iv ◽  
Population Based ◽  
Population Based Study ◽  
Stage Iv Breast Cancer ◽  
Male Patients
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