scholarly journals Observation on the Curative Effect of Madopar Combined with Pramipexole in the Treatment of Parkinson’s Diseases

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Yongting Yu ◽  
Min Yang ◽  
Ruihui Chen ◽  
Hongbing Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Tone ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Disease Symptoms ◽  
Loss Of Self ◽  
Abnormal Posture ◽  
Parkinson’S Diseases ◽  
Normal Human

<p>Parkinson’s disease is a common neurological degenerative disease in the elderly. The clinical manifestations are static tremor, increased muscle tone, slow movement, abnormal posture gait, and severe symptoms of loss of self-care. Parkinson’s disease has become a burden to not only patient, but also to his family and to the society. Normal human brain neurotransmitter dopamine and acetylcholine are in a balanced state, the two antagonism can maintain normal body function. The pathological changes of patients with Parkinson’s disease is degeneration and apoptosis of dopaminergic neurons in striatum, resulting in a significant reduction in dopamine levels, and thus lead to an imbalance in the effects of dopamine and acetylcholine, and a decrease in dopamine resistance to acetylcholine Parkinson’s disease symptoms. As such, this article will focus on the analysis of the Madopar and pramipexole in the treatment of Parkinson’s disease symptoms.</p>

Clinical aspects of depression in Parkinson's disease

2016 ◽  
Vol 33 (S1) ◽  
pp. S380-S380
Author(s):  
F. Leite ◽  
H. Salgado ◽  
O. Campos ◽  
P. Carvalho ◽  
M. Pinto da Costa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Depressive Symptoms ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Panic Attacks ◽  
Clinical Aspects ◽  
Motor Symptoms ◽  
Loss Of Self ◽  
Competing Interest

IntroductionParkinson's disease is the most common neurodegenerative movement disorder in the elderly population. The disease is clinically characterized by major motor symptoms that include bradykinesia, rigidity, tremor and postural instability. In addition to the motor symptoms, Parkinson‘s disease is characterized by emotional and cognitive deficits, which reduce quality of life independently from motor manifestations.Objectives/AimsTo discuss the clinical manifestations of depression in Parkinson's disease according to the most recent scientific literature.MethodsOnline search/review of the literature has been carried out, using Medline/Pubmed, concerning, “Parkinson's disease” and “depression”.ResultsDepression is the most frequent psychiatric disorder in Parkinson's disease. In up to 30% of the cases, the depressive symptoms precede the development of motor symptoms. Independently of the age of appearance, duration and severity of the motor symptoms, depression is generally an integral part of the disease. Depression in Parkinson's disease is generally mild or moderate, with premature loss of self-esteem and volition. Although the high rates of suicidal ideation, suicide is rare. There is also a high prevalence of panic attacks and anxiety.ConclusionsIt is difficult to correctly identify depression in Parkinson's disease as some symptoms assigned to Parkinson's disease itself can in fact be the clinical manifestation of a depressive disorder. On the other hand, depressive symptoms may not be recognized as such, but considered manifestations of Parkinson's disease.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals THE RATIONALE FOR A DIFFERENTIATED APPROACH TO ORTHOPEDIC TREATMENT OF THE TEETH WITH A SYSTEMIC PATHOLOGY

2020 ◽  
Vol 75 (3) ◽  
pp. 79-82
Author(s):  
Yu.A. Makedonova ◽  
◽  
A.E. Kriventsev ◽  
S.A. Veremeenko ◽  
D.Y. Dyachenk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Practice ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Dental Care ◽  
Muscle Tone ◽  
The Elderly ◽  
Orthopedic Treatment ◽  
Systemic Pathology

In the clinical practice of a dentist-orthopedist, patients with various diseases, abnormalities and deformities are often found. In this case, there may often be a relationship between General somatic pathology and manifestations in the oral cavity. Parkinson's disease is no exception. This paper discusses the main features of the course of the disease in the oral cavity and the principles of a differentiated approach to orthopedic treatment. So in patients with Parkinson's disease, sialorrhea (salivation, hypersalivation), dryness of the red border of the lips and oral mucosa, speech changes, «prosthetic» stomatitis are observed. At the same time, these patients have sensory and vegetative disorders, violation of muscle tone, which aggravates the process of prosthetics and creates certain difficulties for a dentist-orthopedist. Due to the spread of this disease among the elderly, who often require dental care, clinicians need to know about this pathology.

scholarly journals Benefits of Vitamins in the Treatment of Parkinson’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Xiuzhen Zhao ◽  
Ming Zhang ◽  
Chunxiao Li ◽  
Xue Jiang ◽  
Yana Su ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Evidence ◽  
Clinical Symptoms ◽  
Antioxidant Properties ◽  
The Elderly ◽  
Vitamin Supplementation ◽  
Biological Functions ◽  
Resting Tremor ◽  
Abnormal Posture

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly, which is clinically characterized by bradykinesia, resting tremor, abnormal posture balance, and hypermyotonia. Currently, the pathogenic mechanism of PD remains unclear. Numerous clinical studies as well as animal and cell experiments have found a certain relationship between the vitamin family and PD. The antioxidant properties of vitamins and their biological functions of regulating gene expression may be beneficial for the treatment of PD. Current clinical evidence indicates that proper supplementation of various vitamins can reduce the incidence of PD in the general population and improve the clinical symptoms of patients with PD; nevertheless, the safety of regular vitamin supplements still needs to be highlighted. Vitamin supplementation may be an effective adjuvant treatment for PD. In this review, we summarized the biological correlations between vitamins and PD as well as the underlying pathophysiological mechanisms. Additionally, we elaborated the therapeutic potentials of vitamins for PD.

scholarly journals Autonomic Dysfunctions in Parkinson’s Disease: Prevalence, Clinical Characteristics, Potential Diagnostic Markers, and Treatment

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Zhe Zhang ◽  
Sheng-Di Chen
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Characteristics ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Disease Prevalence ◽  
Autonomic Dysfunctions

Parkinson’s disease (PD) is a common neurodegenerative disease in the middle-aged and the elderly. Symptoms of autonomic dysfunctions are frequently seen in PD patients, severely affecting the quality of life. This review summarizes the epidemiology, clinical manifestations, and treatment options of autonomic dysfunctions. The clinical significance of autonomic dysfunctions in PD early diagnosis and differential diagnosis is also discussed.

scholarly journals An Innovative Personalised Management Program for Older Adults with Parkinson’s Disease: New Concepts and Future Directions

2021 ◽  
Vol 11 (1) ◽  
pp. 43
Author(s):  
Piyush Varma ◽  
Lakshanaa Narayan ◽  
Jane Alty ◽  
Virginia Painter ◽  
Chandrasekhara Padmakumar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Older Persons ◽  
Clinical Manifestations ◽  
Clinical Syndrome ◽  
Management Program ◽  
Older Person ◽  
Care Needs ◽  
Future Directions ◽  
New Concepts

Introduction: Parkinson’s disease is a heterogeneous clinical syndrome. Parkinson’s disease in older persons presents with a diverse array of clinical manifestations leading to unique care needs. This raises the need for the healthcare community to proactively address the care needs of older persons with Parkinson’s disease. Though it is tempting to categorise different phenotypes of Parkinson’s disease, a strong evidence based for the same is lacking. There is considerable literature describing the varying clinical manifestations in old age. This article aims to review the literature looking for strategies in personalising the management of an older person with Parkinson’s disease.

Multitarget therapeutic approaches for Alzheimer's and Parkinson's diseases: an opportunity or an illusion?

2021 ◽  
Author(s):  
Maria João Matos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Therapeutic Options ◽  
Therapeutic Approaches ◽  
Recent Information ◽  
Temporary Relief ◽  
Parkinson’S Diseases ◽  
Innovative Approaches

Alzheimer's and Parkinson's disease are the most prevalent neurodegenerative diseases and the leading causes of dementia worldwide. The etiology of these multifactorial pathologies is not completely known. The available therapeutic approaches can cause temporary relief of symptoms but cannot slow down their progression or cure them. Life-changing therapeutic solutions are urgently needed, as the number of people suffering from these pathologies has been increasing quickly over the last few decades. Several targets are being studied, and innovative approaches are being pursued to find new therapeutic options. This overview is focused on the most recent information regarding the paradigm of using multitarget compounds to treat both Alzheimer's and Parkinson's disease.

Time Trends and Geographical Variation in Parkinson's Disease in Scotland

1992 ◽  
Vol 37 (4) ◽  
pp. 112-115 ◽  
Author(s):  
W.C.S. Smith ◽  
W.J. Mutch
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Time Trends ◽  
Geographical Variation ◽  
The Elderly ◽  
Epidemiological Studies ◽  
Space Distribution ◽  
Mortality Data ◽  
Time And Space ◽  
Factors Affecting

Parkinson's disease is a common and disabling condition which principally affects the elderly. The time and space distribution of Parkinson's disease has been examined to determine if it provides clues as to aetiology and factors affecting its distribution. Previous studies have used mortality data,1 data from epidemiological studies,2 and pre scribing information particularly with regard to the use of levodopa.3 These studies have looked within countries and between countries.

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