scholarly journals The experience of using Frinosole in the early postoperative period in patients after endonasal endoscopic operations

2020 ◽  
Vol 19 (3) ◽  
pp. 100-104
Author(s):  
T. A. Mashkova ◽  
◽  
A. B. Maltsev ◽  
Keyword(s):  
Nasal Cavity ◽  
Mucous Membrane ◽  
Nasal Mucosa ◽  
Postoperative Period ◽  
Respiratory Epithelium ◽  
Early Postoperative Period ◽  
Absorption Capacity ◽  
Postoperative Treatment ◽  
Surgical Trauma ◽  
Postoperative Changes

The effectiveness of the drug Frinosole in the complex treatment of early postoperative changes in the nasal mucosa after endonasal endoscopic surgery was studied. It has been confirmed that during surgical trauma of the mucous membrane of the nasal cavity, inhibition of the main functions of the respiratory epithelium occurs with a sharp increase in the absorption capacity of the mucous membrane of the nasal cavity. These changes correlate with the clinical picture of the early postoperative period. The data presented indicate a high efficacy of the drug in complex postoperative treatment and make it possible to recommend it for wider use in order to minimize the duration of the postoperative healing stages and prevent possible complications associated with excessive granulation and scarring of the nasal mucosa in the surgical areas.

scholarly journals Structural reconstruction of the nasal mucosa and paranasal sinuses in patients with polypous rhinosinusitis according to cytological and histological studies

2021 ◽  
Vol 5 (7) ◽  
pp. 479-485
Author(s):  
N.M. Zakharova ◽  
◽  
I.P. Shabalova ◽  
V.I. Egorov ◽  
E.Yu. Savushkina ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Mucous Membrane ◽  
Nasal Mucosa ◽  
Paranasal Sinuses ◽  
Pathological Process ◽  
Respiratory Epithelium ◽  
Epithelial Proliferation ◽  
Optical Level ◽  
Cut Surface ◽  
Morphological Patterns

Aim: to study the morphological patterns of polypous tissue according to cytology and histology. Pateints and methods: 78 patients with a confirmed diagnosis of polypoid rhinosinusitis (PRS) were selected for the study, including 50 men and 28 women aged 25 to 74 years. The material for cytology was scraped from the surface of nasal cavity and paranasal sinus (PNS) polyps, as well as touch smears from the cut surface of removed polyps, and the material for histology was pieces of removed polypous tissue. Results: in the course of the study, the following comparative analysis of the obtained results was made: a) with polyps with a fibrous component in touch smears, there are expressed signs of chronic inflammation along with signs of respiratory epithelial cells proliferation; b) edematous and myxoid polyps are commonly combined with an allergic condition; c) analysis of cytomorphological signs of the respiratory epithelium of the nasal cavity and PNS in PRS indicates a structural alteration of the mucous membrane in this disease. The epithelial proliferation is associated with the activation of stroma components — fibroblasts and leukocytes. At the light-optical level, the characteristics of compensatory and adaptive changes that contribute to the morphofunctional cell unity preservation of the mucous membrane that counteract the pathological process are revealed. Conclusions: according to the method of sampling material for cytology, the most informative are touch smears from the cut surface of the removed polyp, which help to identify more morphological patterns of the polypous tissue. The analysis of cytomorphological features of the respiratory epithelium of the nasal cavity and PNS in PRS indicates the remodeling of the mucous membrane in this disease. The epithelial proliferation is associated with the activation of stroma components — fibroblasts and leukocytes. At the light-optical level, the characteristics of compensatory and adaptive changes that contribute to the morphofunctional cell unity preservation of the mucous membrane that counteract the pathological process are revealed. The obtained results will help to understand the mechanisms of structural and functional alteration in the nasal mucosa and PNS in PRS. KEYWORDS: polypoid rhinosinusitis, cytology, histology, paranasal sinuses, smears, fibroblasts, eosinophils, leukocytes, respiratory epithelium. FOR CITATION: Zakharova N.M., Shabalova I.P., Egorov V.I. et al. Structural reconstruction of the nasal mucosa and paranasal sinuses in patients with polypous rhinosinusitis according to cytological and histological studies. Russian Medical Inquiry. 2021;5(7): 479–485 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-479-485.

scholarly journals Results of use of seawater spray with brown algae extract in the early postoperative period in children after adenotomy

2020 ◽  
Vol 65 (1) ◽  
pp. 128-132
Author(s):  
D. V. Konischev ◽  
A. M. Elovikov ◽  
A. I. Ivanov ◽  
D. V. Shabunin
Keyword(s):  
Nasal Cavity ◽  
Postoperative Period ◽  
Brown Algae ◽  
Sea Water ◽  
Early Postoperative Period ◽  
Study Group ◽  
Nasal Breathing ◽  
Scale Scores ◽  
Isotonic Sodium Chloride ◽  
Group 2

Adenotomy is one of the most common surgeries on the part of ENT organs in childhood, it is usually performed under endotracheal anesthesia.Purpose. To evaluate the effectiveness of the spray containing sea water and brown algae extract in the early postoperative period in children after adenotomy.Characteristics of the children and research methods. 24 patients aged from 4 to 10 years (12 boys and 12 girls) were examined and treated in the Otorhinolaryngology Department of the Perm Regional Children’s Clinical Hospital. All patients underwent adenotomy due to hypertrophy of the pharyngeal tonsil of the II–III degree, they received antibiotics for 5 days after surgery. The patients were divided into 2 groups: Group 1 (study group, n=12) used, Aqualor Protect spray for irrigation therapy of the nasal cavity and nasopharynx; Group 2 (comparison group, n=12) used a spray with isotonic sodium chloride solution for irrigation therapy. 2 doses of saline solution were sprayed into each nostril 4 times for 4 days. Results. According to the medical examination, the study group demonstrated more pronounced improvement of the following indicators (visual analogue scale scores): overall health (p<0.05), swelling of the nasal cavity (p<0.05), hyperemia of the mucous membrane of the nasal cavity (p<0.05), improved nasal breathing (p<0.034), the presence of mucous-hemorrhagic crusts in the nasal cavity (p<0.0001), general feelings (p<0.02). Conclusion. The spray with seawater and brown algae extract is more effective than nasal spray with isotonic solution in the early postoperative period in children after adenotomy. 

scholarly journals Frailty syndrome as an independent predictor of unfavorable outcome in patients undergoing coronary artery bypass grafting

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
K E Krivoshapova ◽  
O L G A Barbarash ◽  
V L Masenko ◽  
A N Kokov ◽  
N A Terentyeva
Keyword(s):  
Atrial Fibrillation ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Postoperative Period ◽  
Artery Bypass ◽  
Early Postoperative Period ◽  
Postoperative Treatment ◽  
Bypass Grafting ◽  
Artery Bypass Grafting

Abstract Purpose To assess the prevalence of frailty in the preoperative period and to evaluate its effect on the risk of complications and adverse outcomes in patients undergoing coronary artery bypass grafting (CABG). Methods 387 patients undergoing preoperative management for elective primary CABG were recruited in the study. The study cohort was divided into three groups depending on the “Age is no disqualification” scores suggesting the presence or absence of frailty and the presence of prefrailty. Demographic and clinical data were collected for each patient, including surgery data, pre- and postoperative treatment, intra- and postoperative complications and outcomes of CABG. Statistical analysis was performed using the commercially available software package IBM SPSS Statistics 26.0.0. Results 74 (19%) patients had frailty, while 225 (58%) patients were diagnosed with prefrailty and 88 (23%) patients did not have any signs of frailty. All three groups had significant age differences, patients without frailty – 56 [63–67] years old, prefrailty group – 59 [65–69] years old, patients with frailty – 62 [66–72] years old, p=0,003. Patients with frailty or prefrailty more often suffered from diabetes mellitus (patients without frailty – 14,8%, prefrailty group – 25,8% and frailty group – 36,5%, p=0,006), atrial fibrillation or flutter (16,7%, 14,3% and 35,6%, respectively, p=0,05) and cerebral atherosclerosis (45,5%, 62,2% and 60,8%, respectively, p=0,02). Three groups were comparable in main clinical and demographic parameters. There were no significant differences found in the incidence of infections (3,4%, 2,2% and 4%, respectively, p=0,655) and haemorrhagic complications (1,2%, 1% and 0,5%, respectively, p=0,680). Patients with frailty or prefrailty in the intra- and early postoperative period after CABG had significantly higher incidence of low output syndrome (1,2%, 7,6% and 13,5%, respectively, p=0,01, OR 8,5, 95% CI, 1,1–63,5) and postoperative atrial fibrillation or flutter (5,7%, 16% and 12,2%, respectively, p=0,04, OR 2,9, 95% CI, 1,1–7,5). The incidence of myocardial infarction in the intra- and early postoperative period after CABG did not differ significantly between the groups (0%, 0,5% and 1,5%, respectively, p=0,476) as well as the incidence of stroke (2,3%, 1,8% and 4,1%, respectively, p=0,523). Patients with frailty and prefrailty had significantly higher cerebrovascular and cardiovascular mortality compared to those without frailty (1%, 0% and 5,4%, respectively, p=0,04, OR 2,6, 95% CI, 1,1–5,9). Conclusion Almost 19% of patients referred to CABG suffered from frailty. The presence of prefrailty or frailty increases the risk of death in the early postoperative period after CABG. FUNDunding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation

scholarly journals Possibilities for forecasting and preventing early postoperative complications

2020 ◽  
pp. 63-71
Author(s):  
Igor A. Saraev ◽  
Vladimir N. Mishustin
Keyword(s):  
Neural Network ◽  
Postoperative Period ◽  
Anesthetic Management ◽  
Early Postoperative Period ◽  
Surgical Trauma ◽  
Network Technology ◽  
Neural Network Approach ◽  
Surgical Interventions ◽  
Endoscopic Cholecystectomy ◽  
Neural Network Technology

Objective. The article provides information on how to improve the forecast of the early postoperative period by additional individualization of anesthetic management of patients during emergency surgical interventions on the gallbladder using artificial neural network technologies. Materials and methods. The course of combined anesthesia and the features of the postoperative period were analyzed in 92 patients with an endoscopic cholecystectomy performed for urgent indications. The prediction of the variant of the postoperative stage of hospitalization was realized using the analysis of the significance of 20 different-modal variables selected for the description of patients using fuzzy logic technologies. The possibility of changing the forecast to a more favorable one was achieved on the basis of the developed algorithm for evaluating the results of training neural networks on the Neuro Pro 0.2 neuroimitator. Results. According to the generally accepted criteria, all patients had endoscopic cholecystectomy and anesthesia wit out complications. At the postoperative stage, 2 groups of persons were identified - with the expected short hospitalization (72 cases - 6.7±2.1 days) and with the clinic, which led to its reliable prolongation (20 cases - 12.2±3.5 days). It has been shown that the use of a neural network approach makes it possible with a confidence of more than 80% to assume cases with a high probability of postoperative disorders and in half of such patients to improve the prognosis within the framework of neural network technology and the developed algorithm for selecting the severity of the selected 5 variable factors related to the method of conducting anesthesia. Conclusion. Neural network technology makes it possible to predict cases with individual “unpredictable” responses to surgical trauma. Assessing the significance of the factors used and varying their severity create the basis for the individualization of anesthetic management of patients, prevention of postoperative reactions and a reduction in the period of hospitalization.

scholarly journals Special features of early postoperative period in herniaplasty with different position of the prosthetic mesh

2011 ◽  
Vol 4 (1) ◽  
pp. 17-20
Author(s):  
Alexey Vladimirovoch Kuznetsov ◽  
Yury Vladimirovich Kuznetsov ◽  
Boris Semenovich Dobryakov ◽  
Boris Viktorovich Alexeev ◽  
Vyacheslav Vasilievich Shestakov ◽  
...  
Keyword(s):  
Hernia Repair ◽  
Ventral Hernia ◽  
Postoperative Period ◽  
Ventral Hernia Repair ◽  
Early Postoperative Period ◽  
Prosthetic Mesh ◽  
Surgical Trauma ◽  
Mesh Placement ◽  
Duration Of Operation

In clinic they are studing peculiarities of early postoperative period in patients with ventral hernia repair using different polypropylene prosthetic mesh placement were studied. Observations were made with regards to complications analysis, surgical trauma course, duration of operation and mesh consumption. Effectivety of sublay and underlay prosthetic mesh placement was proven.

scholarly journals Factors affecting the early postoperative period of cochlear implantation

2020 ◽  
Vol 19 (6) ◽  
pp. 57-63
Author(s):  
Yu. S. Preobrazhenskaya ◽  
◽  
M. V. Drozdova ◽  
S. B. Sugarova ◽  
D. D. Kalyapin ◽  
...  
Keyword(s):  
Postoperative Period ◽  
Cochlear Implantation ◽  
Epstein Barr Virus ◽  
Molecular Genetic ◽  
Early Postoperative Period ◽  
Surgical Trauma ◽  
Herpesvirus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
The Impact

Persistence of viral infections ((Epstein–Barr virus (EBV), cytomegalovirus (CMV)) contributes to the development of inflammatory pathology of the upper respiratory tract, as well as dystrophic processes in hepatocytes. The impact of this fact on the early postoperative period during cochlear implantation remains poorly understood. A clinical and audiological examination of 100 children with high-grade sensorineural hearing loss was performed. Within the framework of the work, a serological and molecular genetic examination of patients for herpesvirus infections (Epstein–Barr virus, cytomegalovirus) was performed. Two comparison groups are highlighted. The first group included 58 patients with detected latent infections. In the second group 42 patients did not have serological and molecular genetic markers of infection with herpesvirus infection. There is evidence in the literature that surgical trauma combined with general anesthesia can cause reactivation of persistent herpesvirus infection. In 4% (n = 4), markers of an active infectious process were detected. The analysis of the course of the postoperative period in children in two study groups after cochlear implantation was performed. In the hemostatic system, hypocoagulation disorders were found in a number of children. Persistent herpesvirus infection can be a trigger for the development of both inflammatory and non-inflammatory complications after surgical treatment.

scholarly journals PECULIARITIES OF THE REHABILITATION PROGRAM IN ELDERLY PATIENTS IN THE POST-OPERATIVE PERIOD WITH ACUTE CALCULOUS CHOLECYSTITIS

2021 ◽  
pp. 108-113
Author(s):  
I. K. Churpiy ◽  
V. K. Churpiy ◽  
K. L. Churpiy ◽  
N. R. Golod ◽  
L. P. Fedorivska
Keyword(s):  
Surgical Treatment ◽  
Postoperative Complications ◽  
Postoperative Period ◽  
Rehabilitation Program ◽  
Early Postoperative Period ◽  
The Body ◽  
Maximum Efficiency ◽  
Surgical Trauma ◽  
Acute Calculous Cholecystitis ◽  
Calculous Cholecystitis

Currently, the elderly and senile account for 10 to 25% of all hospitalized for acute calculous cholecystitis. High operative-anesthetic risk, concomitant diseases and low resistance to surgical trauma are the cause of high frequency of postoperative complications and fatalities in this category of patients. In recent years, a reduction in postoperative mortality in acute cholecystitis, which is currently 0.28-2.9%, with gangrenous cholecystitis, it is higher to 17.8%. The aim of the study is to analyze and develop a rehabilitation program in the postoperative period in elderly and senile patients after surgery with acute calculous cholecystitis. Materials and methods We conducted an analysis of surgical treatment of 53 elderly and senile patients with acute calculous cholecystitis. In all patients, this diagnosis was confirmed intraoperatively and histologically. The age of all patients ranged from 61 to 89 years (mean 72.4 ± 8.7 years). Among the examined sick men there were 12 (22.6%), women - 41 (77.4%). The main criteria for assessing and creating a rehabilitation program in patients after surgery with acute calculous cholecystitis were the following processes: improving the general condition of patients, restoring intestinal motility, restoring or improving all impaired cardiovascular and respiratory functions, prevention of general complications (cardiovascular, respiratory, urinary, digestive and other systems), local (from the wound), normalization of blood parameters, One of the important components of successful surgical treatment of patients in the postoperative period is the timely restoration of respiratory, cardiovascular, digestive system after surgery. a guarantee of prevention of probable postoperative complications which are formed in the first 3-5 days after surgery. Objectives of the rehabilitation program in the early postoperative period in elderly and senile patients with acute calculous cholecystitis: to reduce the impact of drugs and accelerate the excretion of toxic substances from the body; restore adequate respiration and oxygen saturation; improve external respiration function, bronchial patency and bronchial drainage function; stabilize central hemodynamics to reduce peripheral circulatory disorders; prevent complications from the gastrointestinal tract, thromboembolic complications; prevent complications from the postoperative wound. Conclusions: Development of a rehabilitation program is a mandatory component in operated patients. Particular attention is paid to elderly and senile patients, who require a set of rehabilitation measures to be minimal, but sufficient to restore lost or reduced body functions in the early postoperative period, but at the same time, it should not exceed the patient's capabilities and ensure maximum efficiency. restoration. Start a rehabilitation program (breathing exercises, kinesiotherapy, massage, inhalation in combination with physiotherapy procedures) should be 12 - 16 hours after surgery. Prospects for further development Continue to develop a rehabilitation program for elderly and senile patients, taking into account the functional capabilities of the body in the long period of rehabilitation.

scholarly journals TRANSUMBILICAL LAPAROSCOPIC CHOLECYSTECTOMY VERSUS STANDARD 4-PORT LAPAROSCOPIC CHOLECYSTECTOMY – RESULTS FROM PROSPECTIVE RANDOMIZED TRIAL AND 7 YEARS OF FOLLOW-UP

2020 ◽  
Vol 18 (Suppl.1) ◽  
pp. 97-102
Author(s):  
G. Ganchev ◽  
A. Saroglu ◽  
A. Julianov
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Postoperative Period ◽  
Intraoperative Complications ◽  
Gallbladder Disease ◽  
Gallstone Disease ◽  
Early Postoperative Period ◽  
Surgical Trauma ◽  
Cosmetic Results ◽  
Umbilical Incision ◽  
The Mean

PURPOSE: Laparoscopic cholecystectomy is a standard of care for patients with benign gallbladder disease. Recently single-incision techniques gained popularity in order to decrease surgical trauma and to improve cosmetic results and patient satisfaction. The aim of this study is to compare the results of our own modification of transumbilical cholecystectomy versus standard 4-port cholecystectomy in patients with uncomplicated gallstone disease. METHODS: 80 patients (14 male, 66 female) at a mean age of 35±2,5 years (range 18-80) were randomly assigned to either standard 4-port cholecystectomy (n=40) or transumbilical cholecystectomy (n=40). Operative times, intraoperative complications, conversion rate, postoperative complications, pain, vomiting and cosmetic results were compared between two groups. RESULTS: The total mean operative time in the SILC group was 43.63 ± 7.49 min., while in the SLC group it was 37.95 ±8.06 min., (p=0.002). Intraoperative complications and conversions were not recorded in this series. The mean postoperative pain assessed by VAS was: at 6th hour 3.35 (2-5) vs. 3.53 (2-6) (p=0.439), at 24th hour 2.58 (1-4) vs. 2.2 (1-5) (p=0.04), at 48th hour 1.63 (1-3) vs. 1.78 (1-5) (p=0.544). The mean 10-point pain scores for SILC patients at 6 hours was 5.78 (3-9) vs. 6.33 (1-10) in SLC (p=0.161), at 24 hours 4.05 (1-7) vs. 3.58 (1-5) (p=0.122), at 48 hour 2.83 (1-5) vs. 2.4 (1-5) (p=0.093). Postoperative vomiting was observed in 2 (5%) of patients with SILC and 3 (7.5%) of those with SLC by the end of the second hour after surgery. In the early postoperative period up to 72h, no complications were reported. In the late postoperative period up to 7 years 1 (2.5%) operative wound surgery in the area of umbilical incision was reported in the SLC group and the presence of an umbilical hernia in 2 (5%) of patients with SILC. Results of the cosmetic result evaluation at the end of the first month - Body Image Score - mean score of 10.35 ± 1.48 (min. 7, max. 12) for SILC and 10.38 ± 1.41 (min. 6, max. 13) for SLC (p = 0.776). Cosmetic score - mean of the sum of points 20 ± 1,87 (min.17-max. 24) for SILC and 19.08 ± 2,1 (min. 14-max. 23) for SLC (p = 0,577). On a scale of 1 to 10, where 1 is "very ugly" and 10 is "almost imperceptible" (question N8), the mean for patients in the SILC group is 8.3 ± 0.79 (min. 7-max. 10) and at SLC 7.93 ± 0.73 (min. 6-max. 9) (p = 0.125). CONCLUSION: The results of this study demonstrated that both transumbilical cholecystectomy and standard 4-port cholecystectomy are equally safe and effective in the treatment of uncomplicated gallstone disease.

scholarly journals Stimulation of kidneys’ adaptive capabilities in patients with urolithiasis

2019 ◽  
Vol 9 (3) ◽  
pp. 13-20
Author(s):  
Olga S. Streltsova ◽  
Dmitry P. Pochtin ◽  
Tatiana A. Gorbunova ◽  
Valery F. Lazukin ◽  
Ilya L. Sidnev
Keyword(s):  
Cystatin C ◽  
Postoperative Period ◽  
Significant Risk ◽  
Early Postoperative Period ◽  
Main Group ◽  
Control Group ◽  
Surgical Trauma ◽  
Operative Trauma ◽  
Adaptive Capabilities ◽  
Inflammatory Changes

Inflammatory changes in the kidney that occurred in the early postoperative period due to surgical trauma, deterioration of microcirculation, hypoxia, are significant risk factors for the development of renal function violation. The aim of this work is to study the effect of the combined drug Uriclar (Asfarma-Ros) on the kidneys adaptive capability in the early postoperative period as a response to operative trauma of patients with complicated urolithiasis. The effect of surgical intervention percutaneous puncture nephrolithotripsy on the blood content of proteins of the acute phase of inflammation and cystatin C was studied. The results of examination of 35 patients (20 the main group and 15 the control group) were analyzed. The median age was 51 8.4 years. 20 patients of the main group began receiving Uriclar 2 capsules (430 mg) twice a day for 5 days before surgery and continued it for 1 month after surgery. Patients from the control group in the pre- and postoperative periods didnt receive Uriclar. The median age was 51 8.4 years. There was a statistically significant increase in the level of cystatin C and changes in biochemical markers in the patients of the main group only that indicates the presence of adaptogenic effect of Uriclar. Thus, the inclusion of a combined drug Uriclar in a complex treatment of patients with urolithiasis allows disturbed biological and adaptive functions of the kidneys to be corrected in the early postoperative period.

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