scholarly journals THE ROLE OF BIOCHEMICAL MARKERS IN THE RISK STRATIFICATION FOR DEVELOPMENT OF PREECLAMPSIA: THE CLINICIAN’S VIEW

2017 ◽  
Vol 4 (4) ◽  
pp. 181-186
Author(s):  
I. V Ignatko ◽  
Violetta S. Florova ◽  
A. C Kuznetsov ◽  
E. Yu Kuzina

Preeclampsia is one of the main causes of maternal mortality and leads to 50-60 thousand deaths annually worldwide, its prevalence in the world is 5-8%. Moreover, this complication is associated with an increased risk of the development of cardiovascular diseases and diabetes in the mother and child. Preeclampsia is a multi-systemic syndrome including hereditary and environmental factors in its pathogenesis and pathophysiology, and the only effective method of the treatment is still delivery. Regardless of the time of debut, preeclampsia is often characterized by the relative well-being of a pregnant woman, right up to the development of severe pre-eclampsia. This review is devoted to biochemical markers of the high risk of pre-eclampsia. Of particular interest there is the balance of proangiogenic (PIGF) and anti-angiogenic (sFlt) growth factors at different gestational ages; both the correct interpretation of the sFlt/PIGF balance and the correlation with the history data already allow us to expand the criteria for the prevention of preeclampsia and open up prospects for optimizing obstetric tactics in the third trimester of pregnancy.

2020 ◽  
Vol 4 (3) ◽  
pp. 01-03
Author(s):  
Miguel Oliveros Donohue

Adolescence is the process that occurs after childhood and before adulthood (15-19) years. Teenage pregnancy is adverse for the mother and her child including low birth weight and high perinatal mortality. Complications between pregnancy and childbirth are the second leading cause of death among girls between the ages of 15 and 19 in the world. Violence against a pregnant woman by her partner is frequent. Adolescent mothers are among the greatest abusers of their children, and abuse can start from fetal life. They are also involved in the death of their newborns. Educational and community empowerment with a family response to educational proposals includes the issue of masculinity and the role of adolescents caring for their children, as well as examining the families' pleasure in the prevention and response to pregnancy.


Author(s):  
Andrew Targowski

The purpose of this study is to develop a comprehensive model of generic civilizations and world civilization, applying the cybernetic technique of analysis and synthesis. Identifying the role of information-communication processes is particularly important for this quest, because these processes strongly influence the progress of civilization at the beginning of the 21st century. Three models, developed by Braudel (1993), Toynbee (1957), and Koneczny (1962), serve as both justification for this type of study and the foundations for a new model. The spectacular progress in technology and living standards achieved by mankind at the beginning of the third millennium prompts research on the grand view of the human condition. Numerous questions need to be answered: 1. What is a civilization? 2. What types of civilizations can be recognized at the beginning of the third millennium? 3. What are the relationships between any particular civilization and the world civilization? 4. What is the role of information and communication in a civilization? 5. What types of laws rule any particular civilization and the world civilization? 6. What are the prospects of the world civilization? Answers to these questions should help us to understand our current condition and the direction of its improvement or perhaps mankind’s further well-being.


1998 ◽  
pp. 124-127
Author(s):  
V. Tolkachenko

One of the most important reasons for such a clearly distressed state of society was the decline of religion as a social force, the external manifestation of which is the weakening of religious institutions. "Religion," Baha'u'llah writes, "is the greatest of all means of establishing order in the world to the universal satisfaction of those who live in it." The weakening of the foundations of religion strengthened the ranks of ignoramuses, gave them impudence and arrogance. "I truly say that everything that belittles the supreme role of religion opens way for the revelry of maliciousness, inevitably leading to anarchy. " In another Tablet, He says: "Religion is a radiant light and an impregnable fortress that ensures the safety and well-being of the peoples of the world, for God-fearing induces man to adhere to the good and to reject all evil." Blink the light of religion, and chaos and distemper will set in, the radiance of justice, justice, tranquility and peace. "


2021 ◽  
pp. 030573562110194
Author(s):  
Amy Visser ◽  
Megan Lee ◽  
Timothy Barringham ◽  
Nasim Salehi

Professional popular musicians are at increased risk of psychological distress, substance use problems, and suicide, yet little evidence is available on effective psychotherapeutic practices to address these issues. This scoping review aims to understand how professional popular musicians perceive, engage with, and respond to mental health interventions. Four databases were searched, garnering a total of 310 articles. Of these, six met inclusion criteria. Four thematic categories were explored: (1) amenability of professional popular musicians to particular therapeutic approaches; (2) attribution of treatment outcomes to tailored approaches; (3) professional popular musicians’ perceived barriers to treatment; and (4) recommendations for treatment approaches. The scoping review supports the importance of considering the characteristics of professional popular musicians as a distinct group with unique well-being needs, challenges, and strengths. There is a clear preference for tailored, affordable, and accessible approaches that consider the uniquities of musicianship and the need to explore the role of nonclinical support, such as friends, family, and industry peers.


IDCases ◽  
2021 ◽  
Vol 24 ◽  
pp. e01068
Author(s):  
Hirokazu Toyoshima ◽  
Miki Hagimoto ◽  
Motoaki Tanigawa ◽  
Hiroyuki Tanaka ◽  
Yuki Nakanishi ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hetti von Hellens ◽  
Leea Keski-Nisula ◽  
Heidi Sahlman

Abstract Background The maternal use of paracetamol during pregnancy has been associated with the development of preeclampsia. This study aims to clarify whether the connection is causal or whether it is due to reverse causation. Methods This study is a continuation of the retrospective case cohort study examining 2,508 pregnant women using a variety of drugs and the development of preeclampsia (1,252 women with preeclampsia and 1,256 controls). For the purposes of this study, more precise data was collected from several hospital databases of the women among this cohort who had reported taking paracetamol during pregnancy (indications, gestational period etc.); this was evaluated in association with the development of preeclampsia. Results 5.5% (100 cases and 37 controls) of all the study population (2,508) had clearly reported paracetamol use. Women with preeclampsia had used significantly more often paracetamol during pregnancy compared to controls (cases 8.0%, controls 2.9%, p < 0.001). The difference was most evident in the third trimester (after the 29th GW) and the use of paracetamol was associated with both mild and severe preeclampsia. Headache and “general pain” were the most common indications for medication among all paracetamol users. Conclusions The use of paracetamol in the third trimester of pregnancy was associated with preeclampsia. This observation indicates that association between paracetamol use and preeclampsia is probably due to reverse causation, i.e. women with preeclampsia experience more headaches due to preeclampsia symptoms since this association was not detected with the use of paracetamol in earlier stages of pregnancy.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Barbora Vlková ◽  
Ľubica Janovičová ◽  
Petra Pšenková ◽  
Lívia Melníková ◽  
Barbora Balažovjechová ◽  
...  

Abstract Objectives It is not clear, which factors affect extracellular DNA (ecDNA) concentrations in healthy women with singleton uncomplicated pregnancies, although deoxyribonucleases (DNases) are hypothesized to be responsible for the cleavage of plasma ecDNA. The aim of this study was to analyze potential determinants of total ecDNA including plasma DNase activity. Methods Plasma samples were collected from 48 healthy women with singleton uncomplicated pregnancies in the third trimester (gestation week 37). DNA was isolated and quantified using fluorometry and real time PCR. DNase activity was assessed using the single radial enzyme-diffusion method. Results Neither ecDNA, nor DNase activity were affected by maternal age or BMI. DNase activity negatively correlated with total plasma ecDNA (r=−0.40, p=0.007). Similar associations were found for ecDNA of nuclear and mitochondrial origin, but not with fetal DNA quantified using Y-targeted PCR in male fetus-bearing pregnancies. Conclusions The role of plasma ecDNA of fetal and maternal origin is studied in the pathogenesis of pregnancy-complications. The results indicate that plasma DNase activity could negatively regulate ecDNA concentrations and should, thus, be analyzed in preeclampsia, preterm birth and other ecDNA-related pregnancy complications.


1980 ◽  
Vol 10 (1) ◽  
pp. 89-113 ◽  
Author(s):  
Francois Nectoux ◽  
John Lintott ◽  
Roy Carr-Hill

This article is concerned with the way that social statistics reflect particular views of the world, and focuses on the specific case of the Organization for Economic Cooperation and Development's program to develop a set of social indicators. Some illustrations of previous attempts to collect social indicators are given, but the bulk of the article discusses the series of contradictions which regulate the generation and use of statistics by governments, the principal one being between measures which play the ideological role of displaying economic and social “progress” and measures which are of direct use in social planning. This is discussed both for social indicators in general and for social concerns linked to the measurement of health. The article ends with an attempt to evaluate the future of the OECD program within the development of modern capitalism.


2021 ◽  
Vol 14 (1) ◽  
pp. e236106
Author(s):  
Carolina Smet ◽  
Tatiana Gigante Gomes ◽  
Lurdes Silva ◽  
Júlio Matias

Fibroepithelial polyps are benign lesions that may appear in the vulvovaginal region. They usually occur in women of reproductive age and tend to grow up to 5 cm, but there are some rare cases in which they grow up to 20 cm. We report a case of a 22-year-old woman in the third trimester of her first pregnancy with spontaneous bleeding from a pedunculated mass measuring 15 cm in the widest diameter on the right side of the vulva. Features of this case are discussed as well as its implications, especially regarding the decision of labour. Due to the big size of the mass and its propensity to bleed, we decided to perform an elective caesarean section as well as its excision.


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