A Markov Chain Model for the Dynamics of Cognitive Decline in an Elderly USA Population Using Data from the Health and Retirement Study

2013 ◽  
Vol 2 (3) ◽  
pp. 9-21
Author(s):  
Gerardo Soto-Campos ◽  
Andrew Pavelyev ◽  
Carlos A. Soto
2021 ◽  
Vol 13 (10) ◽  
pp. 5690
Author(s):  
Chengyuan Mao ◽  
Lewen Bao ◽  
Shengde Yang ◽  
Wenjiao Xu ◽  
Qin Wang

Pedestrian violations pose a danger to themselves and other road users. Most previous studies predict pedestrian violation behaviors based only on pedestrians’ demographic characteristics. In practice, in addition to demographic characteristics, other factors may also impact pedestrian violation behaviors. Therefore, this study aims to predict pedestrian crossing violations based on pedestrian attributes, traffic conditions, road geometry, and environmental conditions. Data on the pedestrian crossing, both in compliance and in violation, were collected from 10 signalized intersections in the city of Jinhua, China. We propose an illegal pedestrian crossing behavior prediction approach that consists of a logistic regression model and a Markov Chain model. The former calculates the likelihood that the first pedestrian who decides to cross the intersection illegally within each signal cycle, while the latter computes the probability that the subsequent pedestrians who decides to follow the violation. The proposed approach was validated using data gathered from an additional signalized intersection in Jinhua city. The results show that the proposed approach has a robust ability in pedestrian violation behavior prediction. The findings can provide theoretical references for pedestrian signal timing, crossing facility optimization, and warning system design.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 282-282
Author(s):  
Douglas Hanes ◽  
Sean Clouston

Abstract Relationship status is thought to be associated with cognitive health in older adults, with married persons performing better on memory assessments than unmarried-cohabitating, single, divorced, and widowed persons. However, questions remain about whether relationship termination causes cognitive decline, is a result of it, or whether they share a cause; and the mechanisms by which such a relationship might operate. To address this gap in the literature, we hypothesized that relationship termination could affect cognition via the following five pathways: (1) post-termination depression; (2) loss of distributed-cognition partner; (3) cognitive depletion from caring for partner in declining and ultimately terminal health; (4) divorce to preserve assets to qualify for Medicaid to cover healthcare for cognitive decline; and (5) post-termination changes in neuropsychiatric symptoms alongside a pre-existing neurodegenerative condition that also causes cognitive decline. Using data from the 2000–2016 waves of the Health and Retirement Study (HRS; N = 23,393), we found that relationship termination, whether due to divorce or widowhood, was associated with cognitive decline. Using mixed-effects regression we found that the rate of cognitive decline increased after relationship termination (widowhood: □ = -0.587, p <0.001; divorce: □ = -0.221, p <0.001), supporting mechanism (5). Using HRS data for respondents and their spouses’ mental and physical health, health insurance, and activities of daily living, we also find support for mechanisms (1) and (3). Relationship termination is a critical juncture in a person’s life course that has multiple implications and may, ultimately, worsen patients’ conditions.


2004 ◽  
Vol 68 (2) ◽  
pp. 346 ◽  
Author(s):  
Keijan Wu ◽  
Naoise Nunan ◽  
John W. Crawford ◽  
Iain M. Young ◽  
Karl Ritz

Author(s):  
R. Jamuna

CpG islands (CGIs) play a vital role in genome analysis as genomic markers.  Identification of the CpG pair has contributed not only to the prediction of promoters but also to the understanding of the epigenetic causes of cancer. In the human genome [1] wherever the dinucleotides CG occurs the C nucleotide (cytosine) undergoes chemical modifications. There is a relatively high probability of this modification that mutates C into a T. For biologically important reasons the mutation modification process is suppressed in short stretches of the genome, such as ‘start’ regions. In these regions [2] predominant CpG dinucleotides are found than elsewhere. Such regions are called CpG islands. DNA methylation is an effective means by which gene expression is silenced. In normal cells, DNA methylation functions to prevent the expression of imprinted and inactive X chromosome genes. In cancerous cells, DNA methylation inactivates tumor-suppressor genes, as well as DNA repair genes, can disrupt cell-cycle regulation. The most current methods for identifying CGIs suffered from various limitations and involved a lot of human interventions. This paper gives an easy searching technique with data mining of Markov Chain in genes. Markov chain model has been applied to study the probability of occurrence of C-G pair in the given   gene sequence. Maximum Likelihood estimators for the transition probabilities for each model and analgously for the  model has been developed and log odds ratio that is calculated estimates the presence or absence of CpG is lands in the given gene which brings in many  facts for the cancer detection in human genome.


Author(s):  
Pavlos Kolias ◽  
Nikolaos Stavropoulos ◽  
Alexandra Papadopoulou ◽  
Theodoros Kostakidis

Coaches in basketball often need to know how specific rotation line-ups perform in either offense or defense and choose the most efficient formation, according to their specific needs. In this research, a sample of 1131 ball possession phases of Greek Basket League was utilized, in order to estimate the offensive and defensive performance of each formation. Offensive and defensive ratings for each formation were calculated as a function of points scored or received, respectively, over possessions, where possessions were estimated using a multiple regression model. Furthermore, a Markov chain model was implemented to estimate the probabilities of the associated formation’s performance in the long run. The model could allow us to distinguish between overperforming and underperforming formations and revealed the probabilities over the evolution of the game, for each formation to be in a specific rating category. The results indicated that the most dominant formation, in terms of offense, is Point Guard-Point Guard-Small Forward-Power Forward-Center, while defensively schema Point Guard-Shooting Guard-Small Forward-Center-Center had the highest rating. Such results provide information, which could operate as a supplementary tool for the coach’s decisions, related to which rotation line-up patterns are mostly suitable during a basketball game.


2021 ◽  
pp. 1-11
Author(s):  
Yuan Zou ◽  
Daoli Yang ◽  
Yuchen Pan

Gross domestic product (GDP) is the most widely-used tool for measuring the overall situation of a country’s economic activity within a specified period of time. A more accurate forecasting of GDP based on standardized procedures with known samples available is conducive to guide decision making of government, enterprises and individuals. This study devotes to enhance the accuracy regarding GDP forecasting with given sample of historical data. To achieve this purpose, the study incorporates artificial neural network (ANN) into grey Markov chain model to modify the residual error, thus develops a novel hybrid model called grey Markov chain with ANN error correction (abbreviated as GMCM_ANN), which assembles the advantages of three components to fit nonlinear forecasting with limited sample sizes. The new model has been tested by adopting the historical data, which includes the original GDP data of the United States, Japan, China and India from 2000 to 2019, and also provides predications on four countries’ GDP up to 2022. Four models including autoregressive integrated moving average model, back-propagation neural network, the traditional GM(1,1) and grey Markov chain model are as benchmarks for comparison of the predicted accuracy and application scope. The obtained results are satisfactory and indicate superior forecasting performance of the proposed approach in terms of accuracy and universality.


Sign in / Sign up

Export Citation Format

Share Document