scholarly journals Effect of Sodium Butyrate on Working Memory and Serum Level Expression of Neural Growth Factor in an Animal Model of Prenatal Stress

2016 ◽  
Vol 4 (3) ◽  
pp. 9-17
Author(s):  
Forough Akrami ◽  
Mohammad Amin Edalatmanesh ◽  
◽  
2020 ◽  
Vol 19 (7) ◽  
pp. 503-508
Author(s):  
Maiko Hayashida ◽  
Sadayuki Hashioka ◽  
Kenji Hayashida ◽  
Shoko Miura ◽  
Keiko Tsuchie ◽  
...  

Background: Fibroblast growth factor (FGF) 2 (also referred to as basic FGF) is a multifunctional growth factor that plays a pivotal role in the pro-survival, pro-migration and pro-differentiation of neurons. Method: Because alterations in FGF2 levels are suggested to contribute to the pathogenesis schizophrenia, we investigated serum levels of FGF2 in the Gunn rat, a hyperbilirubinemia animal model of schizophrenic symptoms. Results: The enzyme-linked immunosorbent assay showed that the serum levels of FGF2 in Gunn rats were 5.09 ± 0.236 pg/mL, while those in the normal strain Wistar rats were 11.90 ± 2.142 pg/mL. The serum FGF2 levels in Gunn rats were significantly lower than those in Wistar rats. We also measured serum levels of unconjugated bilirubin (UCB) and found a significant negative correlation between UCB and FGF2 at serum levels in all the rats studied. Conclusion: Since it is known that FGF2 regulates dopaminergic neurons and have anti-neuroinflammatory effects, our finding suggests that low FGF2 levels may contribute to the pathogenesis of schizophrenia, in which disbalanced dopamin-ergic signaling and neuroinflammation are supposed to play certain roles.


2011 ◽  
Vol 63 (2) ◽  
pp. 593-594
Author(s):  
Ewa Szczęsny ◽  
Agnieszka Basta-Kaim ◽  
Aneta Dardzińska ◽  
Monika Leśkiewicz ◽  
Magdalena Regulska ◽  
...  

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