scholarly journals DEVELOPMENT AND VALIDATION OF THE TECHNIQUE DEFINITION OF THE INDICATOR «RESIDUAL ORGANIC SOLVENTS» IN SUBSTANCE GSB-106

2020 ◽  
Vol 73 (1) ◽  
pp. 46-50
Author(s):  
M.E. Dudenkova ◽  
◽  
L.N. Grushevskaja ◽  
M.S. Sergeeva ◽  
L.M. Gaevaja ◽  
...  
Keyword(s):  
Organic Solvents ◽  
Definition Of ◽  
Development And Validation ◽  
Residual Organic Solvents

Development and Validation of a Method for Assay of Residual Organic Solvents in Kemantane Substance by Gas Liquid Chromatography

2015 ◽  
Vol 49 (1) ◽  
pp. 59-64 ◽  
Author(s):  
A. V. Tolkacheva ◽  
L. N. Grushevskaya ◽  
N. I. Avdyunina ◽  
B. M. Pyatin ◽  
V. I. Prokof’eva ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Organic Solvents ◽  
Gas Liquid Chromatography ◽  
Development And Validation ◽  
Residual Organic Solvents

Development and Validation of a Green Analytical Method for the Determination of Norfloxacin in Raw Material by FTIR Spectrophotometry

2016 ◽  
Vol 99 (6) ◽  
pp. 1533-1536 ◽  
Author(s):  
Jéssica Sayuri Hisano Natori ◽  
Eliane Gandolpho Tótoli ◽  
Hérida Regina Nunes Salgado
Keyword(s):  
Urinary Tract ◽  
Organic Solvents ◽  
Analytical Method ◽  
Environmentally Friendly ◽  
Raw Material ◽  
Waste Generation ◽  
Ftir Spectrophotometry ◽  
Tract Infections ◽  
Development And Validation

Abstract Norfloxacin is a broad-spectrum antimicrobial agent, widely used in humans and animals for the treatment of urinary tract infections. It is a second-generation fluoroquinolone. Several analytical methods to analyze norfloxacin have been described in the literature. However, most of them are complex and require the use of large amounts of organic solvents. This paper describes the development and validation of a green analytical method for the determination of norfloxacin in raw material by FTIR spectrophotometry. This method does not require the use of organic solvents, minimizing waste generation in the process and its environmental impacts. The development of methods that promote the reduction, prevention, or elimination of waste generation has become highly attractive to the pharmaceutical industry because of the growing demand from civil society and government authorities for environmentally friendly products and services. The FTIR spectrophotometry method was validated according to International Conference on Harmonization guidelines, showing adequate linearity (r = 0.9936), precision, accuracy, and robustness. This validated method can be used as an environmentally friendly alternative for the quantification of norfloxacin in raw material in QC routine analysis.

scholarly journals Proposta de Uma Escala Portuguesa para a Avaliação da Qualidade do Aconselhamento Genético: Uma Nova Ferramenta para os Profissionais da Saúde

2018 ◽  
Vol 31 (6) ◽  
pp. 321 ◽  
Author(s):  
Milena Paneque ◽  
Catarina Costa ◽  
Carolina Lemos ◽  
Miguel Alves-Ferreira ◽  
Jorge Sequeiros ◽  
...  
Keyword(s):  
Quality Assessment ◽  
Genetic Counselling ◽  
Quality Of Healthcare ◽  
Psychometric Validation ◽  
International Studies ◽  
Five Dimensions ◽  
Counselling Practice ◽  
Definition Of ◽  
Development And Validation

Introduction: The lack of tools for quality assessment of genetic counselling is recognized in national and international studies. The correlation of quality of healthcare practice with greater satisfaction of patients and affected families is also well established. The present study describes the development and validation of the first Portuguese scale for quality assessment of genetic counselling practice. It encompasses a proposal of a new tool for the evaluation of the process by professionals.Material and Methods: The definition of an initial pool of items and their organization was based on a literature review and identification of the main genetic counselling dimensions as well as the theoretical dimensions of the Reciprocal Engagement Model. After a pre-test validation the scale was submitted to psychometric validation using a sample of 30 participants who evaluated 81 genetic counselling sessions.Results: Based on statistical and empirical criteria the best items were selected. The final 50 items- version comprises five dimensions: education, counselees’ characteristics and decision-making, therapeutic relationship, effects of the process on the counselees andservices organization.Discussion: Results showed consistent psychometric properties of the scale supported on theoretical and practice concepts of genetic counseling. The reduced number of participants involved in psychometric validation is a limitation of the study, which reflected thereduced number of professionals in genetic healthcare services.Conclusion: The scale proposed at this study is a novel and multidimensional instrument that aimed to contribute to the improvement of genetic counselling practice in Portugal.

scholarly journals Business Model Development and Validation in Digital Entrepreneurship

2020 ◽  
pp. 71-85
Author(s):  
Lutz Göcke ◽  
Robin Weninger
Keyword(s):  
Business Models ◽  
Model Development ◽  
Scarce Resources ◽  
Digital Business Models ◽  
The Face ◽  
Definition Of ◽  
Development And Validation ◽  
Structured Approach ◽  
High Uncertainty ◽  
Lean Startup

AbstractEvery venture is developed under high uncertainty and causal ambiguity. A large majority of digital startups leverage the lean startup approach to validate the attractiveness of their venture, to reduce avoidable investments of scarce resources, and to structure the venturing process. Digital entrepreneurs highlight that prioritization and the definition of MVPs are two challenges that entrepreneurs face when applying the lean startup approach. We provide support on these particular challenges through a structured approach—the venture pyramid—to (in)validate digital business models in the face of high uncertainty. Furthermore, we map different types of digital business models with patterns of minimum viable products to inspire digital entrepreneurs and scientists alike. To illustrate our thoughts, we have developed two case studies of German startups that applied a process of rigorous iteration and learning to their venturing processes.

scholarly journals Development and validation of an individual sustainable diet index in the NutriNet-Santé study cohort

2019 ◽  
Vol 121 (10) ◽  
pp. 1166-1177 ◽  
Author(s):  
Louise Seconda ◽  
Julia Baudry ◽  
Philippe Pointereau ◽  
Camille Lacour ◽  
Brigitte Langevin ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Food Systems ◽  
Study Cohort ◽  
Post Secondary ◽  
Sustainable Diets ◽  
Sustainable Diet ◽  
Current Context ◽  
Highly Correlated ◽  
Definition Of ◽  
Development And Validation

AbstractIn the current context of unsustainable food systems, we aimed to develop and validate an index, the sustainable diet index (SDI), assessing the sustainability of dietary patterns, including multidimensional individual indicators of sustainability. Based on the FAO’s definition of sustainable diets, the SDI includes seven indicators categorised into four standardised sub-indexes, respectively, environmental, nutritional, economic and sociocultural. The index (range: 4–20) was obtained by summing the sub-indexes. We computed the SDI for 29 388 participants in the NutriNet-Santé cohort study, estimated its validity and identified potential socio-demographic or lifestyle differences across the SDI quintile. In our sample, the SDI (mean=12·10/20; 95 % CI 12·07, 12·13) was highly correlated to all the sub-indexes that exerted substantial influence on the participants’ ranking. The environmental and economical sub-indexes were the most and less correlated with the SDI (Pearson R2 0·66 and 0·52, respectively). Dietary patterns of participants with a high SDI (considered as more sustainable) were concordant with the already published sustainable diets. Participants with high SDI scores were more often women (24 %), post-secondary graduates (22 %) and vegetarians or vegans (7 %), without obesity (16 %). Finally, the SDI could be a useful tool to easily assess the sustainability-related changes in dietary patterns, estimate the association with long-term health outcomes and help guide future public health policies.

Talent quotient: development and validation of a measurement scale

2020 ◽  
Vol 39 (3) ◽  
pp. 306-323
Author(s):  
J.A. Yogalakshmi ◽  
M.V. Supriya
Keyword(s):  
Convergent Validity ◽  
Management Practice ◽  
Reliability And Validity ◽  
Precise Definition ◽  
Measurement Scale ◽  
Primary Data ◽  
Content Type ◽  
Definition Of ◽  
The Individual ◽  
Development And Validation

PurposeThe aim of the current study was to develop and validate a measure for identifying talent in the workplace. This is a gap long identified by researchers in this field.Design/methodology/approachHinkins methodology was adopted for the establishment of a psychometrically sound measure. A 16-item scale for assessing the construct was developed. The reliability and validity were established by analyzing content adequacy, convergent validity, divergent validity and external validity. Primary data were collected from employees signaled as talent by their organization.FindingsThe study yielded a six-factor structure scale for the construct. These factors accounted for 66.8 percent of observed variance. All six dimensions, namely, calling orientation, critical insight, continuous learning, collaboration, cohesiveness and challenge drive established acceptable reliability and validity.Social implicationsThe research provides a precise definition of the talent construct. Identification and retention of individuals with a high talent quotient is a critical challenge to organizations. Identifying talent is made possible through this measurement scale.Originality/valueThis research made an attempt to develop a reliable and valid measurement scale for the talent construct. The scale provides a precise definition of the talent construct. This simple sound scale could be useful at both the individual and organizational levels. It helps individuals to identify and focus on critical areas for achieving talent status. Organizations benefit through better human resource management practice. Identification and retention of talent are essential to career management. Overall, it also satisfies the urgent need in talent management research for a clear definition of the talent construct.

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