scholarly journals Correlation features of oral mucosits and psychological status in patients with squamous cell carcinoma of the oral mucosa at the stage of chemoradiation therapy

2021 ◽  
Vol 11 (2) ◽  
pp. 100-105
Author(s):  
A. A. Dzhereley ◽  
I. G. Romanenko ◽  
К. A. Arakelyan ◽  
D. Y. Kryuchkov ◽  
S. М. Gorobets ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Squamous Cell ◽  
Chemoradiation Therapy ◽  
Psychological Status ◽  
Limiting Factor ◽  
High Dose ◽  
Psychological Reactions ◽  
Anticancer Treatment

Mucosits of the oral mucosa as a complication of cancer treatment remains an urgent problem. The risk of developing mucosits is classically directly related to the type, intensity of anticancer treatment, and type of psychological response. Combination therapy increases the severity of mucosits. The frequency of mucosits 3–4 degrees according to the WHO scale reaches 85 % and is considered severe among patients receiving high-dose radiation therapy to the head and neck area. In squamous cell carcinoma of the oral mucosa, oral mucosits is the main limiting factor in chemo radiation therapy.It is often necessary to resort to enteral nutritional support and the use of morphine-type analgesics to complete the planned exposure, or to interrupt therapy. In order to prevent mucosits, we studied the correlation between its degree and psychological reactions. The studied psychosomatic status of patients with squamous cell carcinoma of oral mucosa, who are at the stage of chemoradiation therapy, complicated by mucosits, showed a direct relationship between these indicators. 

scholarly journals Outcomes of Post-Operative Treatment with Concurrent Chemoradiotherapy (CRT) in High-Risk Resected Oral Cavity Squamous Cell Carcinoma (OCSCC): A Multi-Institutional Collaboration

2021 ◽  
Vol 28 (4) ◽  
pp. 2409-2419
Author(s):  
Arslan Babar ◽  
Neil M. Woody ◽  
Ahmed I. Ghanem ◽  
Jillian Tsai ◽  
Neal E. Dunlap ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Demographic Data ◽  
Disease Free Survival ◽  
Total Sample ◽  
High Dose ◽  
Pathologic Features

Adjuvant chemoradiation (CRT), with high-dose cisplatin remains standard treatment for oral cavity squamous cell carcinoma (OCSCC) with high-risk pathologic features. We evaluated outcomes associated with different cisplatin dosing and schedules, concurrent with radiation (RT), and the effect of cumulative dosing of cisplatin. An IRB-approved collaborative database of patients (pts) with primary OCSCC (Stage I–IVB AJCC 7th edition) treated with primary surgical resection between January 2005 and January 2015, with or without adjuvant therapy, was established from six academic institutions. Patients were categorized by cisplatin dose and schedule, and resultant groups compared for demographic data, pathologic features, and outcomes by statistical analysis to determine disease free survival (DFS) and freedom from metastatic disease (DM). From a total sample size of 1282 pts, 196 pts were identified with high-risk features who were treated with adjuvant CRT. Administration schedule of cisplatin was not significantly associated with DFS. On multivariate (MVA), DFS was significantly better in patients without perineural invasion (PNI) and in those receiving ≥200 mg/m2 cisplatin dose (p < 0.001 and 0.007). Median DFS, by cisplatin dose, was 10.5 (<200 mg/m2) vs. 20.8 months (≥200 mg/m2). Our analysis demonstrated cumulative cisplatin dose ≥200 mg/m2 was associated with improved DFS in high-risk resected OCSCC pts.

scholarly journals Preservation of swallowing function with de-intensified chemoradiation therapy for HPV-associated oropharyngeal squamous cell carcinoma

2018 ◽  
Vol 3 (3) ◽  
pp. 356-365 ◽  
Author(s):  
Greg D. Judy ◽  
Rebecca Green ◽  
Shannon L. Aumer ◽  
Robert J. Amdur ◽  
Xianming Tan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chemoradiation Therapy ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Swallowing Function
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