scholarly journals Lesão Tumoral Primária do Pulmão em Adolescente

2020 ◽  
Vol 33 (7-8) ◽  
pp. 512
Author(s):  
Luís Rodrigues ◽  
Rui Domingues ◽  
Diana Amaral ◽  
José Cavaco
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Thoracoscopic Surgery ◽  
Lung Tumors ◽  
Successful Outcome ◽  
Therapeutic Approaches ◽  
Pediatric Age Group ◽  
Primary Lung Tumors ◽  
Children And Young Adults ◽  
Atypical Resection ◽  
Suspicion Index

Primary lung tumors in the pediatric age group are rare, histologically diverse and have different therapeutic approaches. The inflammatory myofibroblastic tumor of the lung accounts for 0.04% - 1.2% of all lung tumors, is more common in children and young adults and its etiology is unknown. The diagnosis is difficult as clinical and radiological findings are highly variable. We report a case of a 15-year-old adolescent who presented with a single pulmonary nodule on a chest radiograph, in the context of a respiratory infection, and whose etiological investigation revealed an inflammatory myofibroblastic tumor of the lung. Atypical resection was performed by video-assisted thoracoscopic surgery, with full recovery. We highlight the rarity of this entity, the need for a high suspicion index and the diagnostic investigation undertaken to reach a definitive diagnosis and a successful outcome.

scholarly journals Osteosarcoma: a review of current and future therapeutic approaches

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xin Zhao ◽  
Qirui Wu ◽  
Xiuqing Gong ◽  
Jinfeng Liu ◽  
Yujie Ma
Keyword(s):  
Bimodal Distribution ◽  
Therapeutic Approaches ◽  
Rapid Disease Progression ◽  
New Ideas ◽  
Degree Of Malignancy ◽  
Primary Bone ◽  
Children And Young Adults ◽  
High Degree ◽  
Single Lesion ◽  
Tubular Bones

AbstractOsteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered as a serious threat to the human health globally. The incidence of OS is common in the metaphysis of long tubular bones, but rare in the spine, pelvis, and sacrum areas; moreover, majority of the OS patients present with only a single lesion. OS has a bimodal distribution pattern, that is, its incidence peaks in the second decade of life and in late adulthood. We examine historical and current literature to present a succinct review of OS. In this review, we have discussed the types, clinical diagnosis, and modern and future treatment methods of OS. The purpose of this article is to inspire new ideas to develop more effective therapeutic options.

COMPUTED TOMOGRAPHIC APPEARANCE OF PRIMARY LUNG TUMORS IN DOGS

2010 ◽  
Vol 52 (2) ◽  
pp. 168-172 ◽  
Author(s):  
ANGELA J. MAROLF ◽  
DEBRA S. GIBBONS ◽  
BRENDAN K. PODELL ◽  
RICHARD D. PARK
Keyword(s):  
Lung Tumors ◽  
Computed Tomographic ◽  
Primary Lung Tumors

PO-1019: Long term outcomes and lung function evolution of primary lung tumors treated with Cyberknife SABR

2020 ◽  
Vol 152 ◽  
pp. S543-S544
Author(s):  
F. Sacino ◽  
N. Jansen ◽  
C. Mievis ◽  
L. Seidel ◽  
S. Cucchiaro ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Tumors ◽  
Long Term Outcomes ◽  
Primary Lung Tumors

scholarly journals Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2798 ◽  
Author(s):  
Thanh Hung Nguyen ◽  
Frederic G. Barr
Keyword(s):  
Skeletal Muscle ◽  
Transcription Factor ◽  
Young Adults ◽  
Soft Tissue ◽  
Chromosomal Translocation ◽  
Murine Models ◽  
Therapeutic Approaches ◽  
Recent Developments ◽  
Children And Young Adults ◽  
Oncogenic Transcription Factor

Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal muscle lineage and predominantly occur in children and young adults. A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been identified as a hallmark of the aggressive alveolar subtype of RMS. PAX3-FOXO1 cooperates with additional molecular changes to promote oncogenic transformation and tumorigenesis in various human and murine models. Its expression is generally restricted to RMS tumor cells, thus providing a very specific target for therapeutic approaches for these RMS tumors. In this article, we review the recent understanding of PAX3-FOXO1 as a transcription factor in the pathogenesis of this cancer and discuss recent developments to target this oncoprotein for treatment of RMS.

scholarly journals Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

2022 ◽  
Vol 11 ◽  
Author(s):  
Jiayi Liu ◽  
Zhijie Bai ◽  
Shuaiqi Li ◽  
Sheng Zeng ◽  
Chuang Li ◽  
...  
Keyword(s):  
Rare Case ◽  
Plasma Cells ◽  
Therapeutic Approaches ◽  
Inflammatory Pseudotumour ◽  
Alk Rearrangement ◽  
Rare Tumour ◽  
Inflammatory Infiltration ◽  
Factors Associated ◽  
Spindle Cells ◽  
Children And Young Adults

Inflammatory myofibroblastic tumour (IMT), also known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. IMT predominantly affects children and young adults, and the age at presentation ranges from 3 to 89 years. We present a very rare case of recurrent testicular IMT without ALK rearrangement. This case highlights the clinical characteristics and diagnostic factors associated with primary and recurrent foci of this rare tumour, along with key therapeutic approaches.

scholarly journals Prognostic factors and clinical outcomes after stereotactic radiotherapy for primary lung tumors

2020 ◽  
Vol 25 (6) ◽  
pp. 943-950
Author(s):  
Isabel Rodrigues ◽  
Tiago Figueiredo ◽  
João Gagean ◽  
Carolina Ferreira ◽  
André Laranja ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Clinical Outcomes ◽  
Stereotactic Radiotherapy ◽  
Lung Tumors ◽  
Primary Lung Tumors

scholarly journals Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3333
Author(s):  
Jun Tang ◽  
Víctor Curull ◽  
Xuejie Wang ◽  
Coral Ampurdanés ◽  
Xavier Duran ◽  
...  
Keyword(s):  
Dna Damage ◽  
Lung Tumor ◽  
Colorimetric Assay ◽  
Thoracoscopic Surgery ◽  
Lung Tumors ◽  
Chronic Obstructive ◽  
Activity Levels ◽  
Copd Patients ◽  
Parp Activity ◽  
Parp 1

(1) Background: Lung cancer (LC) is a major leading cause of death worldwide. Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 are key players in cancer. We aimed to assess PARP-1 and PARP-2 expression and activity and DNA damage in tumors and non-tumor lungs from patients with/without chronic obstructive pulmonary disease (COPD). (2) Methods: Lung tumor and non-tumor specimens were obtained through video-assisted thoracoscopic surgery (VATS) in LC patients with/without underlying COPD (two groups of patients, n = 15/group). PARP-1 and PARP-2 expression (ELISA), PARP activity (PARP colorimetric assay kit) and DNA damage (immunohistochemistry) levels were identified in all samples. (3) Results: Both PARP-1 and PARP-2 expression levels were significantly lower in lung tumors (irrespective of COPD)compared to non-tumor specimens, while DNA damage and PARP activity levels significantly increased in lung tumors compared to non-tumor specimens only in LC-COPD patients. PARP-2 expression was positively correlated with smoking burden in LC-COPD patients. (4) Conclusions: In lung tumors of COPD patients, an overactivation of PARP enzyme was observed. A decline in PARP-1 and PARP-2 protein expression was seen in lung tumors irrespective of COPD. Other phenotypic features (airway obstruction) beyond cancer may account for the increase in PARP activity seen in the tumors of patients with underlying COPD.

scholarly journals Operative management of pediatric empyema: a single center review

2018 ◽  
Vol 21 (1) ◽  
pp. 10-13
Author(s):  
Aakriti Sharma ◽  
Ranjan Sapkota ◽  
Bibhusal Thapa ◽  
Prakash Sayami
Keyword(s):  
Thoracoscopic Surgery ◽  
Treatment Options ◽  
Operative Management ◽  
Successful Outcome ◽  
Open Approach ◽  
Empyema Thoracis ◽  
Transplant Center ◽  
Lung Expansion ◽  
Recorded Data ◽  
Video Assisted Thoracoscopic Surgery

Introduction: Empyema thoracis is an uncommon complication of childhood pneumonias but a common problem faced by a thoracic surgeon. Its management is still controversial, with a range of treatment options available and evolving gradually towards adoption of video-assisted thoracoscopic surgery (VATS) as the most commonly practiced one. Aim: The aim of this study was to review our experience in pediatric empyema thoracis. Methods: It was a retrospective review of the prospectively recorded data, spanning a period of 18 months in the Department of Cardio-Thoracic and Vascular Surgery in Manmohan Cardio-Thoracic Vascular and Transplant Center. Results: A total of 40 consecutive patients, 29 males and 11 females, aged 15 years or less were operated upon for a diagnosis of empyema thoracis made based on clinical, radiological and laboratory evidence. All of them were referred patients, mostly from pediatricians. VATS was undertaken in 36 of them, the remaining four treated by open approach. Deloculation sufficed in majority (26/40; 65%) of the patients which mostly (23/26; 90%) had either acute or subacute presentation. Decortication was required in 35% (14/40) of the patients. However, all of the patients but one had a successful outcome in terms of lung expansion, sterilization of the pleural cavity and absence of recurrence. There was no operative mortality. Conclusion: Surgical management of pediatric thoracic empyema is feasible and safe with favorable outcome. VATS is gradually becoming the more favored modality of operative management.  

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