scholarly journals EFFECT OF COGNITIVE BEHAVIORAL THERAPY FOR SEROTONIN LEVEL, DEPRESSION SCORE AND QUALITY OF LIFE IN CERVICAL CANCER PATIENTS

2017 ◽  
Vol 52 (3) ◽  
pp. 231
Author(s):  
Soetrisno Soetrisno ◽  
Sri Sulistyowati ◽  
Supriyadi Hari Respati ◽  
Muhamad Nasrudin
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Patients ◽  
Standard Therapy ◽  
Behavioral Therapy ◽  
Depression Score ◽  
Serotonin Level ◽  
Advanced Cervical Cancer ◽  
Life Score

Cervical cancer is the most common cause of death among gynaecological neoplasms. Management of advanced cervical cancer currently has not been able to improve the prognosis. Standard intervention therapy, chemotherapy and radiotherapy, as well as the emerging pain could lead to psychological stress till depression, thus reduce patients’ quality of life. CBT for psychological stress and depression is expected to improve the fruitfulness of standard therapy. Serotonin is a neurotransmitter which plays a role in the patophysiology of depression. The aim of this study is to analyze the effect of cognitive behavioral therapy on serotonin level, depression score and quality of life in advanced cervical cancer patient with experimental quasi pre and post test design methods. The samples are 15 subjects in both intervention and control groups. Intervention group was given CBT and standard therapy, while control group was given standard therapy only. Study was held in Department of Obstetric and Gynecologic Dr. Moewardi Hospital Surakarta and Prodia Laboratory, in January to March 2015. Independent variable was advanced cervical cancer patients underwent CBT intervention and dependent variables were serotonin level, depression score and quality of life score. The result, serotonin level and quality of life scores were higher after intervention compared with control, (219.43±33,42 vs 89.57±23.23) and (85.13±14.62 vs 41.86±7.24), respectively. Depression score was lower after intervention than without CBT intervention (11.20±4.94 vs 17.00±4.86) and statistically significant (p < 0.05). So, there were effects of cognitive behavioural therapy on serotonin level, depression score and quality of life score in cervical cancer patients and were statistically significant.

Quality of life and psychological distress in locally advanced cervical cancer patients administered pre-operative chemoradiotherapy

2008 ◽  
Vol 111 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Mariagrazia Distefano ◽  
Silvia Riccardi ◽  
Giovanni Capelli ◽  
Barbara Costantini ◽  
Marco Petrillo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Psychological Distress ◽  
Cancer Patients ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer

scholarly journals The Influence of Psychocurative on Cortisol Level, Anxiety, and Quality of Life in Advanced Stage Cervical Cancer Patients

2019 ◽  
Vol 55 (3) ◽  
pp. 202
Author(s):  
Soetrisno Soetrisno ◽  
Sri Mulyani ◽  
Hafi Nurinasari ◽  
Hafi Nurinasari ◽  
Erindra Budi
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Patients ◽  
Hpa Axis ◽  
Cortisol Level ◽  
Standard Therapy ◽  
Serum Cortisol ◽  
Serum Cortisol Level ◽  
Advanced Stage

Every year, there are 500.000 new cases and more than 250.000 deaths caused by cervical cancerworldwide. Cervical cancer patients faced physical and psychological problems several times that it activate stress mechanism such as hypothalamus-pituitary-adrenal (HPA) axis. These recurrent activations caused HPA axis disruption and adverse clinical effects. Several symptoms of endocrine stress response are the change of circadian cortisol rhythm. Cortisol is known as a stress hormone that involves an organism's response to stress and anxiety that influence the quality of life. This research aims to analyze the differences among serum cortisol level, anxiety, and quality of life in cervical cancer patients before and after psychocurative intervention in obstetrics and gynecology wards and polyclinic in RSUD Dr. Moewardi Surakarta. This research is an experimental double-blind randomized controlled clinical trial pre-test post-test group design study. The subjects were advance stage (IIB-IV)cervical cancer patients. The subjects were randomly chosen into fifteen subjects that given standard therapy and psychocurative, while the other fifteen subjects as a control only got standard therapy. Data were obtained from measurement of serum cortisol level, anxiety questionnaire DASS 42 and WHO quality of life questionnaire. Data were analyzed using SPSS 21 using difference test. The difference mean test result of cortisol serum level, anxiety, quality of life from the controlled group and uncontrolled group showed a significant difference (p < 0.05). In conclusion, psychocurative is significant to reduce cortisol level, anxiety, and improve the quality of life in advanced stage cervical cancer patients.

Quality of life and survival in advanced cervical cancer: A Gynecologic Oncology Group study

2012 ◽  
Vol 125 (2) ◽  
pp. 315-319 ◽  
Author(s):  
Dana M. Chase ◽  
Helen Q. Huang ◽  
Lari Wenzel ◽  
David Cella ◽  
Richard McQuellon ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Gynecologic Oncology ◽  
Gynecologic Oncology Group ◽  
Advanced Cervical Cancer ◽  
Oncology Group ◽  
Oncology Group Study

scholarly journals Predictive factors of posttreatment fracture by definitive radiotherapy for uterine cervical cancer

2020 ◽  
Author(s):  
Kazuki Ishikawa ◽  
Tsuneo Yamashiro ◽  
Takuro Ariga ◽  
Takafumi Toita ◽  
Wataru Kudaka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Cervical Cancer ◽  
Multivariate Analysis ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Univariate Analysis ◽  
Uterine Cervical Cancer

Abstract Purpose Fractures are known to shorten life expectancy and worsen the quality of life. The risk of fractures after radiation therapy in cervical cancer patients is known to be multifactorial. In this study, we examined risk factors for fractures in cervical cancer patients, especially by evaluating bone densities and DVH parameters for fractured bones. Materials and Methods For 42 patients, clinical characteristics, pretreatment CT bone densities, and radiation dose were compared between patients with and without fractures. Results Posttreatment fractures occurred in 25 bones among ten patients. Pretreatment CT bone densities were significantly lower in patients with fractures (P < 0.05–0.01 across sites, except for the ilium and the ischium). Although DVH parameters were also significantly associated with fractures in univariate analysis, only CT densities were significantly associated with fractures in multivariate analysis. Conclusion Pretreatment CT densities of spinal and pelvic bones, which may reflect osteoporosis, have a significant impact on the risk for posttreatment fractures.

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