scholarly journals Karakteristik dan Stabilitas Fisik NLC-Koenzim Q10 dalam Sleeping Mask dengan Minyak Nilam

2021 ◽  
Vol 8 (2) ◽  
pp. 178
Author(s):  
Fransisca Dita Mayangsari ◽  
Tristiana Erawati ◽  
Widji Soeratri ◽  
Noorma Rosita
Keyword(s):  
Nanostructured Lipid Carriers ◽  
High Shear ◽  
High Shear Homogenization

Pendahuluan: Minyak nilam memiliki efek antioksidan dan peningkat penetrasi. Minyak tersebut berpotensi meningkatkan efektivitas produk sleeping mask dengan Koenzim Q10 (KoQ10) yang dimuat dalam Nanostructured Lipid Carriers (NLC) sebagai kosmetik anti-penuaan. Tujuan: Membandingkan karakteristik dan stabilitas fisik dari NLC-KoQ10 yang dimuat dalam sleeping mask dengan dan tanpa minyak nilam. Metode: Preparasi NLC-KoQ10 menggunakan metode High Shear Homogenization. NLC-KoQ10 dicampur dengan hydrogel dan minyak nilam, untuk F2. Sedangkan untuk F1 tanpa minyak nilam. Setelah itu diamati karakteristik dan stabilitas fisiknya yang meliputi organoleptik, pH, dan viskositas. Uji stabilitas fisik diamati pada suhu ruang selama 90 hari. Hasil: Uji karakteristik fisik menunjukkan bahwa F1 memiliki bau seperti oleum cacao, sedangkan F2 memiliki bau khas minyak nilam dan sedikit bau seperti oleum cacao. F1 memiliki nilai pH 6,036 ± 0,011, sedangkan F2 memiliki nilai pH 6,062 ± 0,020. Tidak ada perbedaan yang signifikan. Namun, F1 dan F2 memiliki nilai viskositas yang berbeda. F1 memiliki nilai viskositas 199,2 ± 0,7 cp, sedangkan F2 memiliki nilai viskositas 175,6 ± 7,9 cp. Uji stabilitas fisik menunjukkan bahwa F1 dan F2 memiliki skala nilai pH berkisar 6,055 - 6,336 dan viskositas 175,6 - 239,7 cp. Nilai viskositas F1 mengalami peningkatan setelah hari ke-60, sedangkan F2 pada hari ke-90. Kesimpulan: Berdasarkan uji karakteristik dan stabilitas fisik dapat disimpulkan bahwa F1 dan F2 memiliki bau dan viskositas yang berbeda, dan F2 lebih stabil daripada F1.

Effect of Solid Lipid and Liquid Oil Ratios on Properties of Nanostructured Lipid Carriers for Oral Curcumin Delivery

2014 ◽  
Vol 1060 ◽  
pp. 62-65 ◽  
Author(s):  
Yaowaporn Sangsen ◽  
Punsupang Laochai ◽  
Pravara Chotsathidchai ◽  
Ruedeekorn Wiwattanapatapee
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Sustained Release ◽  
Physicochemical Properties ◽  
Nanostructured Lipid Carriers ◽  
Loading Capacity ◽  
High Shear ◽  
Solid Lipid ◽  
High Shear Homogenization ◽  
Xrd Techniques

In this study, three nanostructured lipid carriers (NLC) formulations comprised of varying ratios of lipid (Compritol® 888 ATO) and oil (Labrafac® CC) including 4:1, 3:2, and 2.5:2.5, were developed by high shear homogenization technique. The effect of different ratios on the physicochemical properties and release profiles of the formulations were investigated. Increasing the amount of liquid oil increased the particle size and zeta potential whereas decreased size distribution of the blank and curcumin loaded NLC. However, the entrapment efficacy and loading capacity of the NLC for curcumin were not increased following such ratios. The different ratios were not influence on the sequence of sustained release of curcumin from the NLC over 60 h. Moreover, the amorphous curcumin and crystalline behavior of the optimized NLC were characterized by DSC and XRD techniques. Thus, the effect of the proportions of solid lipid and liquid oil in the formulations should be considered for development of suitable NLC system for oral curcumin delivery.

scholarly journals Olanzapine Loaded Nanostructured Lipid Carriers via High Shear Homogenization and Ultrasonication

2021 ◽  
Vol 89 (2) ◽  
pp. 25
Author(s):  
Adejumoke Lara Ajiboye ◽  
Uttom Nandi ◽  
Martin Galli ◽  
Vivek Trivedi
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Particle Diameter ◽  
Phosphate Buffer Solution ◽  
Nanostructured Lipid Carriers ◽  
High Shear ◽  
Buffer Solution ◽  
High Shear Homogenization

The aim of this study was to understand the effect of high shear homogenization (HSH) and ultrasonication (US) on the physicochemical properties of blank and olanzapine loaded nanostructured lipid carriers (NLCs) along with their drug loading potential and drug release profiles from formulated particles. NLCs were prepared with different ratios of Compritol and Miglyol as the solid and liquid lipids, respectively, under changing HSH and US times between 0 to 15 minutes. The surfactants (Poloxamer 188 (P188) and tween 80) and the drug content was kept constant in all formulations. The prepared NLCs were evaluated for particle size, polydispersity index, zeta potential, drug crystallinity and chemical interactions between lipids and OLZ. The in-vitro drug release was performed using dialysis tube method in phosphate buffer solution (PBS) at pH 7.4. The formulated NLCs were negatively charged, spherically shaped and monodisperse, with particle sizes ranging from 112 to 191 nm. There was a significant influence of US time on the preparation of NLCs in comparison to HSH, where a significant reduction in the mean particle diameter was seen after 5 min of sonication. An increase of Miglyol content in NLCs led to an increase in particle size. In general, application of US led to decrease in particle size after HSH but an increase in particle diameter of low Miglyol containing preparation was also observed with longer sonication time. OLZ was successfully encapsulated in the NLCs and a total release of 89% was achieved in 24 hours in PBS at pH 7.4.

scholarly journals INFLUENCE OF FORMULATION FACTORS ON THE SIZE OF NANOSTRUCTURED LIPID CARRIERS AND NANOEMULSIONS PREPARED BY HIGH SHEAR HOMOGENIZATION

2018 ◽  
Vol 10 (4) ◽  
pp. 61 ◽  
Author(s):  
Ahmed R. Gardouh ◽  
Samar H. Faheim ◽  
Ahmed T. Noah ◽  
Mamdouh M. Ghorab
Keyword(s):  
Particle Size ◽  
Tween 80 ◽  
Homogenization Method ◽  
Nanostructured Lipid Carriers ◽  
High Shear ◽  
High Shear Homogenization ◽  
Formulation Factors ◽  
Concentration Ratios

Objective: The main purpose of this work was to elucidate the effect of certain formulation factors on the size of nanostructured lipid carriers (NLCs) and nanoemulsions (NEs) by using high shear homogenization method.Methods: NLCs and NEs were prepared by high shear homogenization method using different liquid lipids types such as (Dermarol DCO® and Dermarol CCT®) at different concentrations. The effect of different concentration ratios of Tween 80 to Span 20 (2.5/1, 5/1, 10/1, 15/1) w/w % and different homogenization speeds (12 000, 18 000 rpm) on the resulted particle size were also studied.Results: The results revealed that the optimum NLCs and NEs resulted when we use Dermarol CCT® with a concentration of 90 % as liquid lipid and decreasing surfactant ratio to (2.5/1) w/w % with increasing the homogenization speed to 18 000 rpm. Conclusion: NLCs and NEs were successfully prepared, and from this study, it can be concluded that NLCs have the optimum particle size than Nanoemulsions.

Determination of Nitrite and Nitrate in Brazilian Meats Using High Shear Homogenization

2011 ◽  
Vol 5 (4) ◽  
pp. 637-642 ◽  
Author(s):  
Elisabete Alves Pereira ◽  
João F. S. Petruci ◽  
Arnaldo Alves Cardoso
Keyword(s):  
High Shear ◽  
High Shear Homogenization

Optimization of Curcumin Loaded Lipid Nanoparticles Formulated Using High Shear Homogenization (HSH) and Ultrasonication (US) Methods

2013 ◽  
Vol 13 (10) ◽  
pp. 6888-6893 ◽  
Author(s):  
Carmelo Puglia ◽  
Alessia Offerta ◽  
Luisa Rizza ◽  
Giuseppe Zingale ◽  
Francesco Bonina ◽  
...  
Keyword(s):  
Lipid Nanoparticles ◽  
High Shear ◽  
High Shear Homogenization

scholarly journals Caseinate-Stabilized Emulsions of Black Cumin and Tamanu Oils: Preparation, Characterization and Antibacterial Activity

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1951 ◽  
Author(s):  
Urbánková ◽  
Kašpárková ◽  
Egner ◽  
Rudolf ◽  
Korábková
Keyword(s):  
Nigella Sativa ◽  
Antibacterial Properties ◽  
Sodium Caseinate ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
High Shear ◽  
Disk Diffusion Method ◽  
Black Cumin ◽  
Spoilage Bacteria ◽  
High Shear Homogenization

Caseinate-stabilized emulsions of black cumin (Nigella sativa) and tamanu (Calophyllum inophyllum) oils were studied in terms of preparation, characterization, and antibacterial properties. The oils were described while using their basic characteristics, including fatty acid composition and scavenging activity. The oil-in-water (o/w) emulsions containing the studied oils were formulated, and the influence of protein stabilizer (sodium caseinate (CAS), 1–12 wt%), oil contents (5–30 wt%), and emulsification methods (high-shear homogenization vs sonication) on the emulsion properties were investigated. It was observed that, under both preparation methods, emulsions of small, initial droplet sizes were predominantly formed with CAS content that was higher than 7.5 wt%. Sonication was a more efficient emulsification procedure and was afforded emulsions with smaller droplet size throughout the entire used concentration ranges of oils and CAS when compared to high-shear homogenization. At native pH of ~ 6.5, all of the emulsions exhibited negative zeta potential that originated from the presence of caseinate. The antibacterial activities of both oils and their emulsions were investigated with respect to the growth suppression of common spoilage bacteria while using the disk diffusion method. The oils and selected emulsions were proven to act against gram positive strains, mainly against Staphylococcus aureus (S. aureus) and Bacillus cereus (B. cereus); regrettably, the gram negative species were fully resistant against their action.

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