scholarly journals Intrauterine device and cervical cancer

2020 ◽  
Vol 28 (3) ◽  
pp. 140
Author(s):  
Brahmana Askandar Tjokroprawiro
Keyword(s):  
Cervical Cancer ◽  
Intrauterine Device ◽  
Invasive Cervical Cancer ◽  
Cervical Cancer Prevention ◽  
Normal Cells ◽  
Step Process ◽  
Long Time ◽  
Cancer Inflammation ◽  
Cervical Cells

From normal epithelial cells to invasive cervical cancer take a long time. It needs a step-by-step process. Normal cervical cells may be infected with the high-risk human papillomavirus (HPV). The infection may persist or be cleared. The HPV persistence may change normal cells to invasive cancer. Recent findings showed that the intrauterine device (IUD) might have a protective effect on cervical cancer. Inflammation in the cervix induces the immune response that may alter normal cells' progression to cervical cancer. This article will explain the change from normal cells to invasive cervical cancer, the role of the IUD in cervical cancer prevention.

The role of human papillomavirus vaccines in cervical cancer: Prevention and treatment

2018 ◽  
Vol 122 ◽  
pp. 92-97 ◽  
Author(s):  
Giorgio Bogani ◽  
Umberto Leone Roberti Maggiore ◽  
Mauro Signorelli ◽  
Fabio Martinelli ◽  
Antonino Ditto ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Prevention ◽  
Cervical Cancer Prevention ◽  
Papillomavirus Vaccines ◽  
Human Papillomavirus Vaccines ◽  
Prevention And Treatment

Deregulation of miR-21 and miR-29a in Cervical Cancer Related to HPV Infection

MicroRNA ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 110-115 ◽  
Author(s):  
Sara Zamani ◽  
Amir Sohrabi ◽  
Seyed Masoud Hosseini ◽  
Marjan Rahnamaye-Farzami ◽  
Abolfazl Akbari
Keyword(s):  
Cervical Cancer ◽  
Cancer Progression ◽  
Expression Patterns ◽  
Invasive Cervical Cancer ◽  
Hpv Infection ◽  
Micro Rna ◽  
Internal Reference ◽  
Specific Primers ◽  
Papilloma Virus

Background:Early diagnosis is an important factor to improve the survival of Invasive Cervical Cancer (ICC) patients. Molecular biomarkers such as micro RNA (miRNA) can be used in the early detection of ICC. The expression of miR-21 and miR-29a are deregulated in many types of human cancers.Objective:The aim of this study was to investigate the differences in miR-21 and miR-29a expression patterns in the Human Papilloma Virus (HPV) infection and various grades of cervical cancer among Iranian women.Methods:Small RNAs were extracted from positive for HPV, cervical cancer and healthy samples from 43, 50 and 46 individuals, respectively. Expression levels of miR-21 and miR-29a were analyzed by SYBR Green real-time RT-PCR using specific primers, and 5s rRNA as the internal reference gene.Results:Results have shown a significant increase in miR-21 and decrease in miR-29 in cancerous samples in comparison with the control groups (P < 0.0001).Conclusion:This study illustrated that miR-21 and miR-29a could be operated as an oncogene and tumor-suppressor in cervical cancer progression. More studies are needed to demonstrate the role of miR-21 and miR-29a as potential biomarkers for the diagnosis of cervical cancer in future investigations.

Role of pap-test in cervical cancer prevention: a systematic review and meta-analysis

2014 ◽  
Vol 24 (suppl_2) ◽  
Author(s):  
B Unim ◽  
A Meggiolaro ◽  
L Semyonov ◽  
E Maffongelli ◽  
G La Torre
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Cancer Prevention ◽  
Meta Analysis ◽  
Pap Test ◽  
Cervical Cancer Prevention

scholarly journals Cytology screening tests and the incidence of cervical cancer in the Lower Silesia province in 2005-2014

2018 ◽  
Vol 72 ◽  
pp. 13-20
Author(s):  
Dominika Zielecka ◽  
Krystian Lichoń ◽  
Adam Maciejczyk ◽  
Jerzy Błaszczyk ◽  
Dawid Błaszczyk ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Invasive Cervical Cancer ◽  
Population Based ◽  
Cervical Cancer Prevention ◽  
Screening Tests ◽  
Positive Effects ◽  
Detection Program ◽  
Early Detection Program ◽  
The Impact ◽  
Lower Silesia

Introduction: Cervical cancer is the sixth most common malignant cancer in Poland, whereas in most EU countries it has not been included in the top ten in many years. The aim of this paper was to evaluate the impact of screening on the incidence of invasive and preinvasive cervical cancer in the Lower Silesia Province in 2005-2014. Material/Methods: 3,298 cervical cancer cases were analyzed (2,563 invasive cervical cancers and 735 preinvasive cancers) in women in the Lower Silesia Province, registered at the Lower Silesian Cancer Registry in 2005-2014. Results: Since the “Population-Based Cervical Cancer Prevention and Early Detection Program” was introduced in 2006, there has been a steady decrease in the incidence of invasive cervical cancer in the Lower Silesia Province in the group of women (aged 25-59) who receive screening tests. Unfortunately, there has also been a systematic increase in the number of women diagnosed with cervical cancer in the over-59 age group. In women who had screening tests in 2006-2014, cancer in situ accounted for 20-43% of all cervical cancer cases, while in women aged over 60 it was only 3-11%. Discussion: Analysis of trends in the incidence of invasive and preinvasive cervical cancer suggests positive effects of screening for early signs of cervical cancer, even though only a small percentage of the population receives such tests. In the entire Lower Silesian population of women, a downward trend (6 fewer cases per year) in the incidence of invasive cancer, and an upward trend (4 more cases per year) in the incidence of preinvasive cervical cancer are observed.

scholarly journals Peran Suami Dan Petugas Kesehatan Dengan Deteksi Dini Kanker Serviks

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Mariene Wiwin Dolang ◽  
Christina - Leasa
Keyword(s):  
Cervical Cancer ◽  
Early Detection ◽  
Health Workers ◽  
Well Being ◽  
Cross Sectional ◽  
Factors Associated ◽  
Abnormal Vaginal Discharge ◽  
Cervical Cells ◽  
Age Of Marriage

Reproductive Health is a state of complete physical, mental and social well-being that is not solely free from diseases related to the reproductive system. Cervical cancer is cancer that grows from cervical cells, cervical cancer can originate from cells in the cervix but can also grow from cervical cells. This situation is usually accompanied by bleeding and abnormal vaginal discharge. The purpose of this study was to analyze the factors associated with early detection of cervical cancer in fertile age women at Puskesmas Benteng. The design of this study was an observational analytic study with a cross sectional approach. The sample in this study was WUS aged 15-49 years old who were in the Puskesmas Benteng area as many as 135 respondents. The results showed there was a relationship between knowledge (p = 0.004), first age of marriage (p = 0.014), husband's support (p = 0.005), and the role of health workers (p = 0.005) with early detection of cervical cancer in fertile age women at Puskesmas Benteng.DETERMINAN DETEKSI DINI KANKER SERVIKS PADA WANITA USIA SUBUR

Role of induction chemotherapy in invasive cervical cancer

1991 ◽  
Vol 41 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Tchan Kyu Park ◽  
Dong Hee Choi ◽  
Soo Nyung Kim ◽  
Chang Hoon Lee ◽  
Young Tae Kim ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Induction Chemotherapy ◽  
Invasive Cervical Cancer

Protective Effects of Downregulating Estrogen Receptor Alpha Expression in Cervical Cancer

2019 ◽  
Vol 18 (14) ◽  
pp. 1975-1982 ◽  
Author(s):  
Ping Yu ◽  
Yuping Wang ◽  
Chuanxun Li ◽  
Li Lv ◽  
Jihong Wang
Keyword(s):  
Cervical Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Cervical Cancer Prevention ◽  
Protective Effects ◽  
Receptor Alpha ◽  
Estrogen Receptor Modulators ◽  
Cancer Pathogenesis ◽  
Cervical Cells ◽  
Online Library

Background: The cause of cervical cancer can be traced to Human Papilloma Virus (HPV) along with other, nonviral factors. The uterine cervix is reactive to hormones, and female hormones have been implicated in cervical cancer pathogenesis. Previous studies have indicated that malignant cervical cells tend to lose Estrogen Receptor alpha (ER-α) expression in the cervical epithelium while maintaining ER-α expression in the stromal cells. Method: We searched the Web of Science, Embase, PubMed, and Wiley Online Library databases to identify potentially relevant articles up to July 4, 2018. Keywords include uterine cervical neoplasms; receptors, estrogen; estrogen receptor alpha; estrogen receptor modulators; estrogens; cervical cancer and estrogen receptor. Result: Discussions on molecular transitions and drug therapies offer insights into cervical cancer and the functions of estrogen receptors. We focus on molecular transitions and drug therapies for cervical cancer and ER-α targets. Finally, the targeting of downstream gene products and/or receptors to aid in cervical cancer prevention and therapy is discussed. Conclusion: Downregulating ER-α expression may be a potential treatment regimen for cervical cancer patients and will be of great significance for patients with cervical cancer who are receiving conventional treatment for nonsurgical treatments.

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