scholarly journals Respective characteristic from vascular and degenerative mild cognitive impairments

2009 ◽  
Vol 8 (3(2)) ◽  
pp. 8-11
Author(s):  
S. G. Bugrova

42 patients with dyscirculatory encephalopathy (DE) and 42 patients with Alzheimer desease were investigated. From neurologycal and neuropsychologycal tests and multyspiral computer tomography and electroencephalography it was exposed that vascular mild cognitive impairments (MCI) have dysfunction from neuroregulation and leucoareosis and lacunar inpharcts and hydrocephalia. Alzheimer desease MCI have cortical brain atrophy.

2009 ◽  
Vol 8 (1(2)) ◽  
pp. 59-63
Author(s):  
A. Ye. Novikov ◽  
T. V. Labutina ◽  
S. G. Bugrova

144 patients with dyscirculatory encephalopathy (DE) I and 386 patients with DE II were investigated. The control groups included 76 subjects with no cerebrovascular disease. From neurologycal and neuropsychologycal tests and multyspiral computer tomography and electroencephalography it was exposed that vascular mild cognitive impairments have dysfunction from neuroregulation. Neurophisiological and neurovisualisation exponents have diagnostic information from vascular mild cognitive impairments.


2021 ◽  
pp. 1-9
Author(s):  
Gihwan Byeon ◽  
Min Soo Byun ◽  
Dahyun Yi ◽  
Jun Ho Lee ◽  
So Yeon Jeon ◽  
...  

Background: Both elevated blood homocysteine and diabetes mellitus (DM) are related to cognitive impairments or dementia. A previous study also demonstrated that the association between homocysteine and cognitive decline was much stronger in individuals with DM than in those without DM. Objective: This study aimed to examine the interactive effect of blood homocysteine and DM on brain pathological changes including brain atrophy, amyloid-β and tau deposition, and small vessel disease (SVD) related to cognitive impairments. Methods: A total of 430 non-demented older adults underwent comprehensive clinical assessment, measurement of serum homocysteine level, [11C] Pittsburgh Compound B (PiB) PET, [18F] AV-1451 PET, and brain MRI. Results: The interactive effect of homocysteine with the presence of DM on brain atrophy, especially in aging-related brain regions, was significant. Higher homocysteine concentration was associated with more prominent brain atrophy in individuals with DM, but not in those without DM. In contrast, interaction effect of homocysteine and DM was found neither on Alzheimer’s disease (AD) pathologies, including amyloid-β and tau deposition, nor white matter hyperintensity volume as a measure of SVD. Conclusion: The present findings suggest that high blood homocysteine level and DM synergistically aggravate brain damage independently of AD and cerebrovascular disease. With regard to preventing dementia or cognitive decline in older adults, these results support the importance of strictly controlling blood glucose in individuals with hyperhomocysteinemia and lowering blood homocysteine level in those with DM.


2005 ◽  
Vol 90 (6) ◽  
pp. 3262-3267 ◽  
Author(s):  
Stefan M. Gold ◽  
Isabel Dziobek ◽  
Kimberley Rogers ◽  
Abdul Bayoumy ◽  
Pauline F. McHugh ◽  
...  

Chronically elevated cortisol levels have been associated with elevated blood pressure, brain atrophy, and cognitive impairments. In this cross-sectional exploratory study, we assessed whether hypertension was related to hypothalamo-pituitary-adrenal axis hyperactivity and whether this may in part explain prefrontal brain atrophy and cognitive impairments in this population. We studied 27 patients with hypertension and 27 normotensive control subjects. Glucocorticoid feedback was assessed using the combined dexamethasone-CRH test. All participants completed a neuropsychological battery and received brain magnetic resonance imaging for volumetric measurement of frontal and medial temporal lobe regions. Hypertension was significantly associated with impaired glucocorticoid feedback control after statistically controlling for age, gender, and body mass index (P = 0.01). Hypertensive patients also showed a trend toward reductions in frontal lobe volume (P = 0.09) and had significantly lower scores in one of two tests of executive function (P = 0.03). Significant correlations were observed between hypothalamo-pituitary-adrenal hyperactivity and frontal lobe atrophy. Our data indicate that impaired glucocorticoid feedback control may partly account for the prefrontal volume reductions present in patients with hypertension. Future studies assessing the impact of hypertension on the brain should include cortisol assessments.


2020 ◽  
Vol 18 (5) ◽  
pp. 105-109
Author(s):  
E. A. PRASKURNICHIY ◽  
◽  
A. N. KNYAZEV ◽  
I. I. BEGUNOVA ◽  
◽  
...  

The purpose — to compare the diagnostic potential of multispiral computer tomography and ultrasound dopplerography in the assessment of atherosclerotic lesions of the cerebral arteries in metabolic syndrome. Material and methods. The study included 78 patients. The group consisted of 44 men (56,4%) and 34 women (43,6%); the average age was 62 ± 1,2 years. Coronary heart disease was detected in 54 (69,2%), and no signs were registered in 24 (30,8%). Anamnestically, 19 (24,4%) people were diagnosed with a stroke, and 18 (23%) people had a myocardial infarction. 42 people (53,8%) had verified dyscirculatory encephalopathy of various degrees. 34 (43,6%) people suffered from hypertension. 42 people had disorders of carbohydrate metabolism: 12 (15,3%) — type 2 diabetes, 30 (38,4%) — metabolic syndrome. The patients were divided into 3 groups: 1) persons without metabolic syndrome — 48 people (61.5% of the total number of examined); 2) persons with metabolic syndrome without type 2 diabetes — 18 people (23,1% of the total number of examined); 3) persons with type 2 diabetes — 12 people (15,4% of the total number of examined). Results. Atherosclerotic plaques in the carotid arteries were detected in 78 people by multispiral computer tomography and in 51 patients by ultrasound dopplerography of these vessels. Conclusions. In general, the use of multispiral computer tomography to detect atherosclerotic lesions of the vascular bed is the most preferable in comparison with ultrasound dopplerography, especially in patients with a high risk of cardiovascular events. While for patients who do not belong to this group, ultrasound dopplerography (a simple, accessible, informative technique) can be used as the primary screening.


2014 ◽  
Vol 23 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Tanya Rose Curtis

As the field of telepractice grows, perceived barriers to service delivery must be anticipated and addressed in order to provide appropriate service delivery to individuals who will benefit from this model. When applying telepractice to the field of AAC, additional barriers are encountered when clients with complex communication needs are unable to speak, often present with severe quadriplegia and are unable to position themselves or access the computer independently, and/or may have cognitive impairments and limited computer experience. Some access methods, such as eye gaze, can also present technological challenges in the telepractice environment. These barriers can be overcome, and telepractice is not only practical and effective, but often a preferred means of service delivery for persons with complex communication needs.


2008 ◽  
Author(s):  
Elizabeth McCallum ◽  
Ara J. Schmitt ◽  
Dana Keener ◽  
Kathleen Dingus ◽  
Jody Vergari

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