scholarly journals Genomic Distribution of Sars-Cov-2 Variants - A Tertiary Care Hospital Experience

2021 ◽  
Vol 10 (10) ◽  
pp. 199-203
Author(s):  
T. Sabeetha C. S. Sripriya ◽  
K. Sudha S. Arockia Doss
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Wuhan City ◽  
Genomic Distribution ◽  
The World ◽  
Health Organization ◽  
Second Wave ◽  
Predominant Strain

By 2019 December saw a deadly virus starting to spread across wuhan city in china and started to spread across the globe by 2020 and was named as SARS-CoV-2. The Covid-19 variant spreading in India, namely the Delta variant is found to be more contagious and has been classified as ‘being of concern’ by the World Health Organization. RTPCR positive samples from a tertiary care hospital were subjected to sequencing after fulfilling the criteria as per the standard protocol. Out of 70 samples sequenced, B.1.617.2, AY.4, AY.6, AY.12 & Delta like variants were detected. The Delta variant B.1.617.2 was found to be the predominant strain. The sub lineage of Delta variant strain like AY.6 (1.4%), AY.4 (12 %), AY.12 (14%) were also detected. Delta –like variant was found in 20% of the samples sequenced. The results of sequencing might help to understand the characteristics of the strains prevalent during second wave of SARS-CoV-2 and would be helpful to tackle further infection of COVID.

scholarly journals EVALUATION OF USE OF ANALGESICS IN PAIN MANAGEMENT AMONG SURGEONS IN A TERTIARY CARE HOSPITAL

2018 ◽  
Vol 11 (11) ◽  
pp. 124
Author(s):  
Jayshree Dawane ◽  
Kalyani Khade ◽  
Yamini Ingale ◽  
Vijaya Pandit
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
World Health ◽  
Moderate Intensity ◽  
Study Group ◽  
Care Hospital ◽  
Analog Scale ◽  
The World ◽  
Hospital Patients ◽  
Health Organization

Objective: The objective of this study is to evaluate pain and to assess if analgesic prescriptions are according to the World Health Organization guidelines. Methods: The study was conducted in the Department of Surgery in a tertiary care hospital. Patients with age >18 years, of either sex, admitted to surgery ward were included in the study. Pain assessment was done using a visual analog scale and McGill questionnaire. Information obtained from case paper sheets was recorded, such as name of analgesics, the generic name of prescribed analgesics, dosage, route of administration, frequency, number of analgesics per prescription, and non-pharmacological techniques. Data generated from the questionnaire were entered into an Excel sheet, and percentages were calculated. Results: A total of eight different analgesics were prescribed in the study group. Paracetamol was the maximally prescribed drug (40%). In 48% of cases, antacids were given along with analgesics. A majority of analgesics were prescribed in generic names (52%). No drug was prescribed to almost 18% cases even though the pain intensity was of mild-to-moderate intensity. Conclusion: Commonly prescribed drugs were paracetamol + tramadol. Prescription pattern of analgesics is partially deviating from standard guidelines. Generic names were written in the majority of prescriptions, which is in accordance with standard prescription writing.

scholarly journals ANALYSIS OF ADVERSE DRUG REACTION IN A TERTIARY CARE HOSPITAL: A RETROSPECTIVE STUDY

2016 ◽  
Vol 10 (1) ◽  
pp. 347
Author(s):  
Dolly Roy ◽  
Ayan Purkayastha ◽  
Rohit Tigga
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Anaphylactic Reaction ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Iron Sucrose ◽  
World Health ◽  
Care Hospital ◽  
Monitoring Centre ◽  
Health Organization

ABSTRACTObjectives: Adverse drug reaction (ADR) is an important cause of morbidity, mortality, and prolonged hospitalization. The objective of this study is tomeasure the incidence, types, and nature of ADR in a tertiary care hospital located in Silchar, Assam.Methods: A retrospective noninterventional analysis of all ADRs reported by ADR Monitoring Centre, Department of Pharmacology, Silchar MedicalCollege, from March 2014 to February 2015 was performed. A total of 162 predesigned forms were used for collection of data. All forms were dulychecked for completeness, if not, they were rejected.Results: A total of 162 forms were assessed of which 96 (59%) were females and 66 (41%) were males. The distribution of ADRs in different age groupswere found to be 3 (1.85%) in 0-15 years, 71 (43.82%) in 16-30 years, 65 (40.12%) in 31-45 years, 8 (4.93%) in 46-60 years, and 15 (9.25%) in agegroup >60 years. 150 (92.6%) of the ADRs were serious and 12 (7.4%) were not serious. As per the World Health Organization causality assessmentscale, 120 (74.07%) were probable and 42 (25.92%) were possible. The most common ADR was anaphylactic reaction (AR) in 69 (42.59%) patients.The drugs which commonly caused ADR were iron sucrose infusions, nevirapine, cephalosporins, antiprotozoals, nonsteroidal anti-inflammatorydrugs, and quinolones followed by others.Conclusion: The majority of ADRs were probable. The most common ADR was AR caused by iron sucrose infusion. Different drugs caused differentADRs. ADRs thereby increase morbidity and mortality in patients as well as socioeconomic burden.Keywords: Adverse drug reaction, Anaphylactic reaction, Iron sucrose infusion, Noninterventional, Retrospective analysis.

scholarly journals A PROSPECTIVE STUDY OF ADVERSE DRUG REACTIONS DUE TO PLATINUM ANALOGS - CHEMOTHERAPY IN A TERTIARY CARE HOSPITAL

2018 ◽  
Vol 11 (6) ◽  
pp. 215
Author(s):  
Sumit Kumar ◽  
Badruddeen Badruddeen ◽  
Singh S P ◽  
Mohammad Irfan Khan
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Drug Reactions ◽  
Medical College ◽  
Health Organization ◽  
A Prospective Study ◽  
Platinum Analogs

Objective: The objective of this study was to analyze the types of adverse drug reactions (ADRs) associated with platinum analogs (cisplatin, carboplatin and oxaliplatin) used for cancer chemotherapy in a tertiary care hospital and determine their causal relationship with the offending drug.Methods: This prospective, observational, non-interventional study was conducted in a tertiary care hospital at GSVM Medical College Kanpur, India, for 4 months. Patients of all age and either sex were included in the study. ADRs were reported by the physicians of oncology department of the hospital and ADRs were assessed for different parameters -causality, outcome, and seriousness of ADR as per the World Health Organization (WHO), type of ADRs as per expanded Rawlins and Thompson’s classification, predictability using council for international organization of medical sciences guidelines and severity using modified Hartwig’s scale. Descriptive statistics were used for data analysis.Results: A total of 140 ADRs were reported from platinum analogs following treatment of different types of cancer in hospital. The burden of ADRs in each patient was 2.41. Most of the ADRs were observed in the age group of 40–60 years. Vomiting (27 ADRs) was commonly reported reaction. Among platinum analogs, cisplatin leads to 82 ADRs (58.57%) followed by carboplatin with 53 ADRs (37.86%) and least with oxaliplatin 5 ADRs (3.57%). Most of the ADRs on causality assessment were possible (104, 74.29%) and probable (36, 25.71%) in nature. Type -A ADRs account for 4/5th of the total reported ADRs, followed by Type-B and C. Severity of 90.71% ADRs was found to be mild followed by moderate, with no case of severe and serious nature. Nearly, most of the ADRs were of predictable type (97.14%).Conclusion: The potential of platinum analogs to cause ADRs is high; thus, the need of effective ADRs monitoring is highly emphasized.

scholarly journals Drug Prescription in the Department of Medicine of a Tertiary Care Hospital according to the World Health Organization/International Network for Rational Use of Drugs Core Indicators: A Descriptive Cross-sectional Survey

2021 ◽  
Vol 59 (240) ◽  
Author(s):  
Jyoti Tara Manandhar Shrestha ◽  
Saurabh Tiwari ◽  
Dilip Kumar Kushwaha ◽  
Pratigya Bhattarai ◽  
Ruchi Shrestha
Keyword(s):  
Drug Use ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
International Network ◽  
Rational Use ◽  
The World

Introduction: To establish appropriate health care services in developing countries, rationalization of drug use holds utmost importance. Drug use patterns can be found out using Core Indicators of the World Health Organisation in collaboration with the International Network of Rational Use of Drugs. With the help of the indicators, this study aimed to find out the way the drugs were prescribed in the Medicine out-patient department of a tertiary care hospital. Methods: A descriptive cross-sectional survey was conducted from October 2019 to March 2020 in a tertiary care hospital. The ethical approval was taken from the Institutional Review Committee of the Dhulikhel hospital (reference number 198/19). Convenient sampling was done. After taking consent from the patient, data was collected from prescriptions written on the patient's card. The data were analysed using Statistical Package for the Social Sciences Version 25. Descriptive statistics were applied and the results were expressed as frequency and percentage, mean and standard deviation. Results: A total of 559 prescriptions were analysed, of which a total of 1427 medicines were found to be prescribed with an average number of medicines per the prescription of 2.55±1.388. Drugs prescribed by generic name were 820 (57.5%), antibiotics were 138 (9.7%) and injections were 8 (0.6%). Drugs prescribed from the Essential Drug List of Nepal was 939 (65.8%). Conclusions: Our study revealed that despite some results being up to the mark, there is a requisite for the proper regulation of prescribing and dispensing drugs in order to promote rationalisation.

scholarly journals Glucocorticoids: Boon or Bane-An assessment of safety proϐiling of steroids in a tertiary care hospital

2021 ◽  
Vol 12 (2) ◽  
pp. 1611-1619
Author(s):  
Sadhana N Holla
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care Hospital ◽  
Adverse Drug Reaction Reporting ◽  
Tertiary Care ◽  
Careful Consideration ◽  
World Health ◽  
Care Hospital ◽  
Drug Reactions ◽  
Relative Risks ◽  
Health Organization

Glucocorticoids are used in therapy empirically, but undesirable effects occur with large doses or prolonged administration. The aim of the study is to assess the pattern of adverse drug reactions of glucocorticoids in a tertiary care hospital. A retrospective analysis of adverse drug reactions (ADRs) following administration of glucocorticoids was conducted in the ADR monitoring center, Department of Pharmacology, Kasturba Medical College, Manipal. Clinical and treatment data were collected from the patient case records in the suspected adverse drug reaction reporting form as per the World Health Organization guidelines.  ADRs were assessed for Causality, Preventability and Severity using WHO causality assessment scale, Modified Schumock and Thornton’s scale and Hartwig’s severity scale, respectively. 100 ADRs were observed in 85 patients, with 51% males and 49% females. Prednisolone (53%) was the most common drug responsible for ADRs, followed by betamethasone (9%) and dexamethasone (8%). Hyperglycemia (34%) was the most common ADR, followed by cutaneous adverse reactions (32%). Acne (20%) was common among them. Over 86% reactions were categorized "possible". Among ADRs (91%) treated, only 16 % recovered. About 39% of cases were "probably preventable". The majority of ADRs (72%) were moderate in “severity”. Given the number and severity of side effects, the institution of glucocorticoids requires careful consideration of the relative risks and benefits in each patient.

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